Conformational Plasticity of the 2A Proteinase from Enterovirus 71

Journal of Virology

Volumn 87, Issue 13, 2013, Pages 7348-7356

  Cai, Qixu ^a   Yameen, Muhammad ^c   Liu, Weihua ^a   Gao, Zhenting ^b   Li, Yaozong ^b   Peng, Xuanjia ^b   Cai, Yaxian ^b   Wu, Caiming ^a   Zheng, Qian ^a   Li, Jian ^b   Lin, Tianwei ^a  

^a XIAMEN UNIVERSITY   (China)

^b WUXI APPTEC   (China)

^c GOVERNMENT COLLEGE UNIVERSITY   (Pakistan)

Author keywords

[No Author keywords available]

Indexed keywords

2A PROTEINASE; CYSTEINE PROTEINASE; UNCLASSIFIED DRUG; VIRUS PRECURSOR POLYPROTEIN; VIRUS PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BETA SHEET; CONFORMATIONAL PLASTICITY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; COXSACKIE VIRUS B4; CRYSTALLOGRAPHY; DRUG TARGETING; ENTEROVIRUS 71; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME SUBSTRATE COMPLEX; HINGE REGION; HUMAN RHINOVIRUS; HUMAN RHINOVIRUS 2; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROCESSING; STRUCTURE ANALYSIS; VIROGENESIS; VIRUS CELL INTERACTION;

AMINO ACID SEQUENCE; CRYSTALLOGRAPHY, X-RAY; CYSTEINE ENDOPEPTIDASES; ENTEROVIRUS A, HUMAN; ESCHERICHIA COLI; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENETIC VECTORS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; POLYMERASE CHAIN REACTION; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT;

EID: 84880367155     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.03541-12     Document Type: Article

References (41)

1. Racaniello VR. 2006. Picornavirdae: the viruses and their replication, p 795. In Knipe DM, Howley PM (ed), Fields virology, 5th ed. Lippincott Williams & Wilkins Publishers, Hagerstown, MD.
2. Pallansch M, Roos R. 2006. Enteroviruses: polioviruses, coxsackieviruses, echoviruses, and newer enteroviruses, p 839. In Knipe DM, Howley PM (ed), Fields virology, 5th ed. Lippincott Williams & Wilkins Publishers, Hagerstown, MD.
3. Bible JM, Pantelidis P, Chan PK, Tong CY. 2007. Genetic evolution of enterovirus 71: epidemiological and pathological implications. Rev. Med. Virol. 17:371-379.
4. Solomon T, Lewthwaite P, Perera D, Cardosa MJ, McMinn P, Ooi MH. 2010. Virology, epidemiology, pathogenesis, and control of enterovirus 71. Lancet Infect. Dis. 10:778 -790.
5. Weng KF, Chen LL, Huang PN, Shih SR. 2010. Neural pathogenesis of enterovirus 71 infection. Microbes Infect. 12:505-510.
6. Deibel R, Gross LL, Collins DN. 1975. Isolation of a new enterovirus (38506). Proc. Soc. Exp. Biol. Med. 148:203-207.
7. Ho M, Chen ER, Hsu KH, Twu SJ, Chen KT, Tsai SF, Wang JR, Shih SR. 1999. An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group. N. Engl. J. Med. 341:929 -935.
8. Brown BA, Oberste MS, Alexander JP, Jr, Kennett ML, Pallansch MA. 1999. Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998. J. Virol. 73:9969 -9975.
9. Chinese Center for Disease Control and Prevention and Office of the World Health Organization in China. 2008, posting date. Report on the hand, foot and mouth disease outbreak in Fuyang City, Anhui Province and the prevention and control in China. http://www2.wpro.who.int/NR/rdonlyres/591D6A7B-FB15-4 E94-A1E9-1D3381847D60/0/HFMDCCDC20080515ENG.pdf.
10. Koroleva GA, Gracheva LA, Voroshilova MK. 1978. Isolation of type 71 enterovirus from patients with a poliomyelitis-like disease during an outbreak in Bulgaria. Voprosy Virusolog ii:611- 618.
11. Melnick JL. 1984. Enterovirus type 71 infections: a varied clinical pattern sometimes mimicking paralytic poliomyelitis. Rev. Infect. Dis. 6(Suppl 2):S387-S390.
12. Nagy G, Takatsy S, Kukan E, Mihaly I, Domok I. 1982. Virological diagnosis of enterovirus type 71 infections: experiences gained during an epidemic of acute CNS diseases in Hungary in 1978. Arch. Virol. 71:217- 227.
13. Samuda GM, Chang WK, Yeung CY, Tang PS. 1987. Monoplegia caused by enterovirus 71: an outbreak in Hong Kong. Pediatr. Infect. Dis. J. 6:206 -208.
14. Shimizu H, Utama A, Yoshii K, Yoshida H, Yoneyama T, Sinniah M, Yusof MA, Okuno Y, Okabe N, Shih SR, Chen HY, Wang GR, Kao CL, Chang KS, Miyamura T, Hagiwara A. 1999. Enterovirus 71 from fatal and nonfatal cases of hand, foot and mouth disease epidemics in Malaysia, Japan and Taiwan in 1997-1998. Jpn. J. Infect. Dis. 52:12-15.
15. Shindarov LM, Chumakov MP, Voroshilova MK, Bojinov S, Vasilenko SM, Iordanov I, Kirov ID, Kamenov E, Leshchinskaya EV, Mitov G, Robinson IA, Sivchev S, Staikov S. 1979. Epidemiological, clinical, and pathomorphological characteristics of epidemic poliomyelitis-like disease caused by enterovirus 71. J. Hyg. Epidemiol. Microbiol. Immunol. 23: 284-295.
16. Yang F, Ren L, Xiong Z, Li J, Xiao Y, Zhao R, He Y, Bu G, Zhou S, Wang J, Qi J. 2009. Enterovirus 71 outbreak in the People's Republic of China in 2008. J. Clin. Microbiol. 47:2351-2352.
17. Ho M. 2000. Enterovirus 71: the virus, its infections and outbreaks. J. Microbiol. Immunol. Infect. 33:205-216.
18. Gradi A, Svitkin YV, Imataka H, Sonenberg N. 1998. Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection. Proc. Natl. Acad. Sci. U. S. A. 95:11089 -11094.
19. Lloyd RE, Grubman MJ, Ehrenfeld E. 1988. Relationship of p220 cleavage during picornavirus infection to 2A proteinase sequencing. J. Virol. 62:4216-4223.
20. Badorff C, Lee GH, Lamphear BJ, Martone ME, Campbell KP, Rhoads RE, Knowlton KU. 1999. Enteroviral protease 2A cleaves dystrophin: evidence of cytoskeletal disruption in an acquired cardiomyopathy. Nat. Med. 5:320 -326.
21. Gustin KE, Sarnow P. 2001. Effects of poliovirus infection on nucleocytoplasmic trafficking and nuclear pore complex composition. EMBO J. 20:240 -249.
22. Gustin KE, Sarnow P. 2002. Inhibition of nuclear import and alteration of nuclear pore complex composition by rhinovirus. J. Virol. 76:8787- 8796.
23. Park N, Katikaneni P, Skern T, Gustin KE. 2008. Differential targeting of nuclear pore complex proteins in poliovirus-infected cells. J. Virol. 82: 1647-1655.
24. Almstead LL, Sarnow P. 2007. Inhibition of U snRNP assembly by a virus-encoded proteinase. Genes Dev. 21:1086 -1097.
25. McCoy AJ, Grosse-Kunstleve RW, Adams PD, Winn MD, Storoni LC, Read RJ. 2007. Phaser crystallographic software. J. Appl. Crystallogr. 40: 658-674.
26. Emsley P, Lohkamp B, Scott WG, Cowtan K. 2010. Features and development of Coot. Acta Crystallogr. D Biol. Crystallogr. 66:486 -501.
27. Brunger AT. 2007. Version 1.2 of the Crystallography and NMR system. Nat. Protoc. 2:2728 -2733.
28. Brunger AT, Adams PD, Clore GM, DeLano WL, Gros P, Grosse-Kunstleve RW, Jiang JS, Kuszewski J, Nilges M, Pannu NS, Read RJ, Rice LM, Simonson T, Warren GL. 1998. Crystallography & NMR system: a new software suite for macromolecular structure determination. Acta Crystallogr. D Biol. Crystallogr. 54:905-921.
29. Murshudov GN, Skubak P, Lebedev AA, Pannu NS, Steiner RA, Nicholls RA, Winn MD, Long F, Vagin AA. 2011. REFMAC5 for the refinement of macromolecular crystal structures. Acta Crystallogr.DBiol. Crystallogr. 67:355-367.
30. Murshudov GN, Vagin AA, Dodson EJ. 1997. Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr. D Biol. Crystallogr. 53:240 -255.
31. Matayoshi ED, Wang GT, Krafft GA, Erickson J. 1990. Novel fluorogenic substrates for assaying retroviral proteases by resonance energy transfer. Science 247:954 -958.
32. Petersen JF, Cherney MM, Liebig HD, Skern T, Kuechler E, James MN. 1999. The structure of the 2A proteinase from a common cold virus: a proteinase responsible for the shut-off of host-cell protein synthesis. EMBO J. 18:5463-5475.
33. Baxter NJ, Roetzer A, Liebig HD, Sedelnikova SE, Hounslow AM, Skern T, Waltho JP. 2006. Structure and dynamics of coxsackievirus B4 2A proteinase, an enyzme involved in the etiology of heart disease. J. Virol. 80:1451-1462.
34. Krissinel E, Henrick K. 2004. Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. Acta Crystallogr. D Biol. Crystallogr. 60:2256 -2268.
35. Schechter I, Berger A. 1967. On the size of the active site in proteases. I. Papain. Biochem. Biophys. Res. Commun. 27:157-162.
36. Wu C, Cai Q, Chen C, Li N, Peng X, Cai Y, Yin K, Chen X, Wang X, Zhang R, Liu L, Chen S, Li J, Lin T. 2013. Crystal structure of an enterovirus 3C proteinase (strain: E2004104-TW-CDC) and its complex with rupintrivir. Acta Crystallogr. D Biol. Crystallogr. 69:866-871.
37. Birtley JR, Knox SR, Jaulent AM, Brick P, Leatherbarrow RJ, Curry S. 2005. Crystal structure of foot-and-mouth disease virus 3C protease. New insights into catalytic mechanism and cleavage specificity. J. Biol. Chem. 280:11520 -11527.
38. Sweeney TR, Roque-Rosell N, Birtley JR, Leatherbarrow RJ, Curry S. 2007. Structural and mutagenic analysis of foot-and-mouth disease virus 3C protease reveals the role of the beta-ribbon in proteolysis. J. Virol. 81:115-124.
39. Zunszain PA, Knox SR, Sweeney TR, Yang J, Roque-Rosell N, Belsham GJ, Leatherbarrow RJ, Curry S. 2010. Insights into cleavage specificity from the crystal structure of foot-and-mouth disease virus 3C protease complexed with a peptide substrate. J. Mol. Biol. 395:375-389.
40. Sommergruber W, Ahorn H, Zophel A, Maurer-Fogy I, Fessl F, Schnorrenberg G, Liebig HD, Blaas D, Kuechler E, Skern T. 1992. Cleavage specificity on synthetic peptide substrates of human rhinovirus 2 proteinase 2A. J. Biol. Chem. 267:22639 -22644.
41. Lu G, Qi J, Chen Z, Xu X, Gao F, Lin D, Qian W, Liu H, Jiang H, Yan J, Gao GF. 2011. Enterovirus 71 and coxsackievirus A16 3C proteases: binding to rupintrivir and their substrates and anti-hand, foot, and mouth disease virus drug design. J. Virol. 85:10319 -10331.