Introduction of a strong temperature-sensitive phenotype into enterovirus 71 by altering an amino acid of virus 3D polymerase

Virology

Volumn 396, Issue 1, 2010, Pages 1-9

  Kung, Yen Hua ^a   Huang, Sheng Wen ^a   Kuo, Pin Hwa ^b   Kiang, David ^e   Ho, Mei Shang ^c   Liu, Ching Chung ^b   Yu, Chun Keung ^a   Su, Ih Jen ^d   Wang, Jen Ren ^a,d  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

^c INSTITUTE OF MOLECULAR BIOLOGY   (Taiwan)

^d NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^e California Department of Public Health   (United States)

Author keywords

Enterovirus 71; RNA polymerase; Temperature susceptibility

Indexed keywords

FIREFLY LUCIFERASE; ISOLEUCINE; RNA POLYMERASE; THREONINE; VALINE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENTEROVIRUS 71; ENZYME ACTIVITY; GENE MUTATION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; IN VITRO STUDY; INCUBATION TEMPERATURE; MOUSE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; REPLICON; SEQUENCE ANALYSIS; SPECIES INTRODUCTION; TEMPERATURE SENSITIVE CLONE; TEMPERATURE SENSITIVITY; THERMAL STIMULATION; VIRUS ISOLATION; VIRUS MUTANT; VIRUS REPLICATION; VIRUS VIRULENCE; WILD TYPE;

ANIMALS; DNA-DIRECTED RNA POLYMERASES; ENTEROVIRUS A, HUMAN; HAND, FOOT AND MOUTH DISEASE; HUMANS; MICE; MUTATION; PHENOTYPE; RNA, VIRAL; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE; VIRULENCE;

HUMAN ENTEROVIRUS 71; MUS;

EID: 70649113050     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2009.10.017     Document Type: Article

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