MicroRNA-23b inhibits enterovirus 71 replication through downregulation of EV71 VPl protein

Intervirology

Volumn 56, Issue 3, 2013, Pages 195-200

  Wen, Bai Ping ^a   Dai, Hong Jian ^a   Yang, Yue Huang ^a   Zhuang, Yu ^a   Sheng, Ru ^a  

^a Kunming Children's Hospital   (China)

Author keywords

Enterovirus 71; EV71 VPl protein; MicroRNAs; miR 23b

Indexed keywords

LUCIFERASE; MICRORNA; MICRORNA 23B; PROTEIN VP1; UNCLASSIFIED DRUG; ENTEROVIRUS 71 VPI PROTEIN; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; COMPUTER PROGRAM; CONTROLLED STUDY; DOWN REGULATION; ENTEROVIRUS; ENTEROVIRUS 71; GENE EXPRESSION; GENE FUNCTION; GENE SEQUENCE; GENETIC TRANSFECTION; HAND FOOT AND MOUTH DISEASE; HOST; HUMAN; NONHUMAN; POSTTRANSCRIPTIONAL GENE SILENCING; PREDICTION; PRIORITY JOURNAL; VIRUS INFECTION; VIRUS INHIBITION; VIRUS REPLICATION; 3' UNTRANSLATED REGION; CYTOPATHOGENIC EFFECT; ENTEROVIRUS 71 INFECTION; ENTEROVIRUS INFECTION; GENE TARGETING; LUCIFERASE ASSAY; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; RNA ANALYSIS; UPREGULATION; VERO CELL LINE; WESTERN BLOTTING;

ANIMALS; CERCOPITHECUS AETHIOPS; DOWN-REGULATION; ENTEROVIRUS A, HUMAN; GENE EXPRESSION; HOST-PATHOGEN INTERACTIONS; HUMANS; MICRORNAS; VERO CELLS; VIRAL PROTEINS; VIRUS REPLICATION;

HUMAN ENTEROVIRUS 71;

EID: 84878016291     PISSN: 03005526     EISSN: 14230100     Source Type: Journal    
DOI: 10.1159/000348504     Document Type: Article

References (27)

1. Schmidt NJ, Lennette EH, Ho HH: An apparently new enterovirus isolated from patients with disease of the central nervous system. J Infect Dis 1974; 129: 304-309.
2. Zhang Y, Tan XJ, Wang HY, Yan DM, Zhu SL, Wang DY, Ji F, Wang XJ, Gao YJ, Chen L, An HQ, Li DX, Wang SW, Xu AQ, Wang ZJ, Xu WB: An outbreak of hand, foot, and mouth disease associated with subgenotype c4 of human enterovirus 71 in Shandong, China. J Clin Virol 2009; 44: 262-267.
3. Huang CC, Liu CC, Chang YC, Chen CY, Wang ST, Yeh TF: Neurologic complications in children with enterovirus 71 infection. N Engl J Med 1999; 341: 936-942.
4. Phuektes P, Chua BH, Sanders S, Bek EJ, Kok CC, McMinn PC: Mapping genetic determinants of the cell-culture growth phenotype of enterovirus 71. J Gen Virol 2011; 92: 1380-1390.
5. Carrington JC, Ambros V: Role of microRNAs in plant and animal development. Science 2003; 301: 336-338.
6. Kurzyńska-Kokorniak A, Jackowiak P, Figlerowicz M: Human- and virus-encoded microRNAs as potential targets of antiviral therapy. Mini Rev Med Chem 2009; 9: 927-937.
7. Kelly EJ, Hadac EM, Greiner S, Russell SJ: Engineering microRNA responsiveness to decrease virus pathogenicity. Nat Med 2008; 14: 1278-1283.
8. Kelly EJ, Hadac EM, Cullen BR, Russell SJ: MicroRNA antagonism of the picornaviral life cycle: Alternative mechanisms of interference. PLoS Pathog 2010; 6:e1000820.
9. Wang X, Tang S, Le SY, Lu R, Rader JS, Meyers C, Zheng ZM: Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth. PLoS One 2008; 3:e2557.
10. Au Yeung CL, Tsang TY, Yau PL, Kwok TT: Human papillomavirus type 16 E6 induces cervical cancer cell migration through the p53/microRNA-23b/urokinase- type plasmino gen activator pathway. Oncogene 2011; 30: 2401-2410.
11. Schmittgen TD, Livak KJ: Analyzing realtime PCR data by the comparative C(T) method. Nat Protoc 2008; 3: 1101-1108.
12. Chua BH, Phuektes P, Sanders SA, Nicholls PK, McMinn PC: The molecular basis of mouse adaptation by human enterovirus 71. J Gen Virol 2008; 89: 1622-1632.
13. Nijhuis M, van Maarseveen N, Schuurman R, Verkuijlen S, de Vos M, Hendriksen K, van Loon AM: Rapid and sensitive routine detection of all members of the genus enterovirus in different clinical specimens by real-time PCR. J Clin Microbiol 2002; 40: 3666-3670.
14. Lecellier CH, Dunoyer P, Arar K, Lehmann-Che J, Eyquem S, Himber C, Saïb A, Voinnet O: A cellular microRNA mediates antiviral defense in human cells. Science 2005; 308: 557-560.
15. Gottwein E, Cullen BR: Viral and cellular microRNAs as determinants of viral pathogenesis and immunity. Cell Host Microbe 2008; 3: 375-387.
16. Grey F, Tirabassi R, Meyers H, Wu G, Mc-Weeney S, Hook L, Nelson JA: A viral microRNA down-regulates multiple cell cycle genes through MRNA 5 ′ UTRs. PLoS Pathog 2010; 6:e1000967.
17. Cui L, Guo X, Qi Y, Qi X, Ge Y, Shi Z, Wu T, Shan J, Shan Y, Zhu Z, Wang H: Identification of microRNAs involved in the host response to enterovirus 71 infection by a deep sequencing approach. J Biomed Biotechnol 2010; 2010: 425939.
18. Cui L, Qi Y, Li H, Ge Y, Zhao K, Qi X, Guo X, Shi Z, Zhou M, Zhu B, Guo Y, Li J, Stratton CW, Tang YW, Wang H: Serum microRNA expression profile distinguishes enterovirus 71 and coxsackievirus 16 infections in patients with hand-foot-and-mouth disease. PLoS One 2011; 6:e27071.
19. Du J, Gao S, Luo J, Zhang G, Cong G, Shao J, Lin T, Cai X, Chang H: Effective inhibition of foot-and-mouth disease virus (FMDV) replication in vitro by vector-delivered microRNAs targeting the 3d gene. Virol J 2011; 8: 292.
20. Ahluwalia JK, Khan SZ, Soni K, Rawat P, Gupta A, Hariharan M, Scaria V, Lalwani M, Pillai B, Mitra D, Brahmachari SK: Human cellular microRNA hsa-miR-29a interferes with viral Nef protein expression and HIV-1 replication. Retrovirology 2008; 5: 117.
21. Sung TL, Rice AP: MiR-198 inhibits HIV-1 gene expression and replication in monocytes and its mechanism of action appears to involve repression of cyclin T1. PLoS Pathog 2009; 5:e1000263.
22. Song L, Liu H, Gao S, Jiang W, Huang W: Cellular microRNAs inhibit replication of the H1N1 influenza A virus in infected cells. J Virol 2010; 84: 8849-8860.
23. Othumpangat S, Walton C, Piedimonte G: MicroRNA-221 modulates RSV replication in human bronchial epithelium by targeting NGF expression. PLoS One 2012; 7:e30030.
24. Tan EL, Tan TM, Tak Kwong Chow V, Poh CL: Inhibition of enterovirus 71 in virus-infected mice by RNA interference. Mol Ther 2007; 15: 1931-1938.
25. Wu Z, Yang F, Zhao R, Zhao L, Guo D, Jin Q: Identification of small interfering RNAS which inhibit the replication of several enterovirus 71 strains in china. J Virol Methods 2009; 159: 233-238.
26. Ho BC, Yu SL, Chen JJ, Chang SY, Yan BS, Hong QS, Singh S, Kao CL, Chen HY, Su KY, Li KC, Cheng CL, Cheng HW, Lee JY, Lee CN, Yang PC: Enterovirus-induced miR-141 contributes to shutoff of host protein translation by targeting the translation initiation factor eIF4E. Cell Host Microbe 2011; 9: 58-69.
27. Liu J, Yang Y, Xu Y, Ma C, Qin C, Zhang L: Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication. Virol J 2011; 8: 483.