Serum cytokine profiles of children with human enterovirus 71-associated hand, foot, and mouth disease

Journal of Medical Virology

Volumn 86, Issue 8, 2014, Pages 1377-1385

  Han, Jun ^a   Wang, Ying ^a   Gan, Xing ^a   Song, Juan ^a   Sun, Peng ^a   Dong, Xiao Ping ^a,b  

^a ZHEJIANG UNIVERSITY   (China)

^b INSTITUTE OF MICROBIOLOGY   (China)

Author keywords

Cytokine; Hand, foot, and mouth disease; Human enterovirus 71; Immunoglobulin M

Indexed keywords

CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN M; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; VIRUS ANTIBODY;

ABNORMAL RESPIRATORY SOUND; ADOLESCENT; ARTICLE; CAUSE OF DEATH; CHILD; CHILDHOOD DISEASE; CONVULSION; COUGHING; CYANOSIS; DEPRESSION; DISEASE COURSE; DISEASE DURATION; DISEASE SEVERITY; DROWSINESS; DYSPHORIA; DYSPNEA; ENTEROVIRUS 71; ENTEROVIRUS INFECTION; FEMALE; FEVER; GASTROINTESTINAL SYMPTOM; HAND FOOT AND MOUTH DISEASE; HOSPITALIZATION; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; INFANT; LETHARGY; LUNG EDEMA; MAJOR CLINICAL STUDY; MALE; MOUTH ULCER; RASH; RESPIRATORY FAILURE; TACHYCARDIA; VESICULAR RASH; VOMITING; BLOOD; CHEMISTRY; ENTEROVIRUS; IMMUNOLOGY; PATHOLOGY; PRESCHOOL CHILD; SERUM; TIME;

ADOLESCENT; ANTIBODIES, VIRAL; CHILD; CHILD, PRESCHOOL; CYTOKINES; ENTEROVIRUS A, HUMAN; FEMALE; HAND, FOOT AND MOUTH DISEASE; HUMANS; IMMUNOGLOBULIN M; INFANT; MALE; SERUM; TIME FACTORS;

EID: 84901821168     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.23929     Document Type: Article

References (32)

1. Aiba H, Mochizuki M, Kimura M, Hojo H. 2001. Predictive value of serum interleukin-6 level in influenza virus-associated encephalopathy. Neurology 57:295-299.
2. Anderson VE, Nguyen Y, Weinberg JB. 2009. Effects of allergic airway disease on mouse adenovirus type 1 respiratory infection. Virology 391:25-32.
3. Cassatella MA, Meda L, Bonora S, Ceska M, Constantin G. 1993. Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1 beta in mediating the production of IL-8 triggered by lipopolysaccharide. J Exp Med 178:2207-2211.
4. Chang SC, Li WC, Chen GW, Tsao KC, Huang CG, Huang YC, Chiu CH, Kuo CY, Tsai KN, Shih SR, Lin TY. 2012. Genetic characterization of enterovirus 71 isolated from patients with severe disease by comparative analysis of complete genomes. J Med Virol 84:931-939.
5. Gong X, Zhou J, Zhu W, Liu N, Li J, Li L, Jin Y, Duan Z. 2012. Excessive proinflammatory cytokine and chemokine responses of human monocyte-derived macrophages to enterovirus 71 infection. BMC Infect Dis 12:224.
6. Han J, Ma XJ, Wan JF, Liu YH, Han YL, Chen C, Tian C, Gao C, Wang M, Dong XP. 2010. Long persistence of EV71 specific nucleotides in respiratory and feces samples of the patients with Hand-Foot-Mouth Disease after recovery. BMC Infect Dis 10:178.
7. Han J, Ma XJ, Xu WB, Wan JF, Li Q, Tian C, Gao C, Wang M, Tang LY, Zhang Y, Chen C, Wang YH, Wang F, Gao YJ, Li DX, Dong XP. 2011. EV71 viral secretion by symptomatic hand foot and mouth disease patients and their asymptomatic close contacts. J Infect 62:107-108.
8. Huang CC, Liu CC, Chang YC, Chen CY, Wang ST, Yeh TF. 1999. Neurologic complications in children with enterovirus 71 infection. N Engl J Med 341:936-942.
9. Huang PN, Lin JY, Locker N, Kung YA, Hung CT, Huang HI, Li ML, Shih SR. 2011. Far upstream element binding protein 1 binds the internal ribosomal entry site of enterovirus 71 and enhances viral translation and viral growth. Nucleic Acids Res 39:9633-9648.
10. Ichiyama T, Nishikawa M, Yoshitomi T, Hayashi T, Furukawa S. 1998. Tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 in cerebrospinal fluid from children with prolonged febrile seizures. Comparison with acute encephalitis/encephalopathy. Neurology 50:407-411.
11. Ji Z, Wang X, Zhang C, Miura T, Sano D, Funamizu N, Okabe S. 2012. Occurrence of hand-foot-and-mouth disease pathogens in domestic sewage and secondary effluent in Xi'an, China. Microbes Environ 27:288-292.
12. Knipe DM, Howley PM, Griffin DE, Martin MA, Lamb RA, editors. 2007. Fields virology. 5th edition. Philadelphia: Lippincott/The Williams and Wilkins Co, pp 840-893.
13. Li J, Huo X, Dai Y, Yang Z, Lei Y, Jiang Y, Li G, Zhan J, Zhan F. 2012. Evidences for intertypic and intratypic recombinant events in EV71 of hand, foot and mouth disease during an epidemic in Hubei Province, China, 2011. Virus Res 169:195-202.
14. Lin TY, Chang LY, Huang YC, Hsu KH, Chiu CH, Yang KD. 2002. Different proinflammatory reactions in fatal and non-fatal enterovirus 71 infections: implications for early recognition and therapy. Acta Paediatr 91:632-635.
15. Lin TY, Hsia SH, Huang YC, Wu CT, Chang LY. 2003. Proinflammatory cytokine reactions in enterovirus 71 infections of the central nervous system. Clin Infect Dis 36:269-274.
16. Liu L, Zhang Y, Wang J, Zhao H, Jiang L, Che Y, Shi H, Li R, Mo Z, Huang T, Liang Z, Mao Q, Wang L, Dong C, Liao Y, Guo L, Yang E, Pu J, Yue L, Zhou Z, Li Q. 2013. Study of the integrated immune response induced by an inactivated EV71 vaccine. PLoS ONE 8:e54451.
17. Meurman O. 1983. Detection of antiviral IgM antibodies and its problems-A review. Curr Top Microbiol Immunol 104:101-131.
18. Mulligan MS, Jones ML, Vaporciyan AA, Howard MC, Ward PA. 1993. Protective effects of IL-4 and IL-10 against immune complex-induced lung injury. J Immunol 151:5666-5674.
19. Pfluger M, Kapuscik A, Lucas R, Koppensteiner A, Katzlinger M, Jokela J, Eger A, Jacobi N, Wiesner C, Hofmann E, Onder K, Kopecky J, Schutt W, Hundsberger H. 2013. A combined impedance and AlphaLISA-based approach to identify anti-inflammatory and barrier-protective compounds in human endothelium. J Biomol Screen 18:67-74.
20. Raftery MJ, Kraus AA, Ulrich R, Kruger DH, Schonrich G. 2002. Hantavirus infection of dendritic cells. J Virol 76:10724-10733.
21. Solomon T, Lewthwaite P, Perera D, Cardosa MJ, McMinn P, Ooi MH. 2010. Virology, epidemiology, pathogenesis, and control of enterovirus 71. Lancet Infect Dis 10:778-790.
22. Sosman JA, Verma A, Moss S, Sorokin P, Blend M, Bradlow B, Chachlani N, Cutler D, Sabo R, Nelson M, Bruno E, Gustin D, Viana M, Hoffman R. 2000. Interleukin 10-induced thrombocytopenia in normal healthy adult volunteers: Evidence for decreased platelet production. Br J Haematol 111:104-111.
23. van de Veerdonk FL, Netea MG, Dinarello CA, Joosten LA. 2011. Inflammasome activation and IL-1beta and IL-18 processing during infection. Trends Immunol 32:110-116.
24. Wang SM, Lei HY, Huang KJ, Wu JM, Wang JR, Yu CK, Su IJ, Liu CC. 2003. Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: Roles of cytokines and cellular immune activation in patients with pulmonary edema. J Infect Dis 188:564-570.
25. Wei R, Xu L, Zhang N, Zhu K, Yang J, Yang C, Deng C, Zhu Z, De GA, Altmeyer R, Zeng M, Leng Q. 2013. Elevated antigen-specific Th2 type response is associated with the poor prognosis of hand, foot and mouth disease. Virus Res 177:62-65.
26. Weller M, Stevens A, Sommer N, Melms A, Dichgans J, Wietholter H. 1991. Comparative analysis of cytokine patterns in immunological, infectious, and oncological neurological disorders. J Neurol Sci 104:215-221.
27. Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, Karp CL, Donaldson DD. 1998. Interleukin-13: Central mediator of allergic asthma. Science 282:2258-2261.
28. Wilson J, Rossi CP, Carboni S, Fremaux C, Perrin D, Soto C, Kosco-Vilbois M, Scheer A. 2003. A homogeneous 384-well high-throughput binding assay for a TNF receptor using alphascreen technology. J Biomol Screen 8:522-532.
29. Wolff B, Burns AR, Middleton J, Rot A. 1998. Endothelial cell "memory" of inflammatory stimulation: human venular endothelial cells store interleukin 8 in Weibel-Palade bodies. J Exp Med 188:1757-1762.
30. Xu F, Yan Q, Wang H, Niu J, Li L, Zhu F, He S, Zhang S, Weng Z, Cheng T, Cai Y, He D, Chen Y, Ge S, Yeo AE, Zhang J, Ng MH, Xia N. 2010. Performance of detecting IgM antibodies against enterovirus 71 for early diagnosis. PLoS ONE 5:e11388.
31. Zeng M, Zheng X, Wei R, Zhang N, Zhu K, Xu B, Yang CH, Yang CF, Deng C, Pu D, Wang X, Altmeyer R, Leng Q. 2013. The cytokine and chemokine profiles in patients with hand, foot and mouth disease of different severities in Shanghai, China, 2010. PLoS Negl Trop Dis 7:e2599.
32. Zhang Y, Liu H, Wang L, Yang F, Hu Y, Ren X, Li G, Yang Y, Sun S, Li Y, Chen X, Li X, Jin Q. 2013. Comparative study of the cytokine/chemokine response in children with differing disease severity in enterovirus 71-induced hand, foot, and mouth disease. PLoS ONE 8:e67430.