Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China

Protein and Cell

Volumn 1, Issue 5, 2010, Pages 491-500

  Wu, Yang ^a   Lou, Zhiyong ^b   Miao, Yi ^b   Yu, Yue ^b   Dong, Hui ^b   Peng, Wei ^a   Bartlam, Mark ^c   Li, Xuemei ^a   Rao, Zihe ^a,b,c  

^a INSTITUTE OF BIOPHYSICS   (China)

^b TSINGHUA UNIVERSITY   (China)

^c NANKAI UNIVERSITY   (China)

Author keywords

crystal structure; drug target; enterovirus 71; RNA dependent RNA polymerase

Indexed keywords

GUANOSINE TRIPHOSPHATE; PRIMER RNA; RNA DIRECTED RNA POLYMERASE; URIDINE TRIPHOSPHATE; VIRUS RNA;

ARTICLE; CHINA; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENTEROVIRUS 71; ENZYME STRUCTURE; ENZYME SUBSTRATE; FOOT AND MOUTH DISEASE; FOOT AND MOUTH DISEASE VIRUS; NONHUMAN; POLIOMYELITIS VIRUS; PRIORITY JOURNAL; PROTEIN DOMAIN; RNA REPLICATION;

FOOT-AND-MOUTH DISEASE VIRUS; HUMAN ENTEROVIRUS 71; POLIOVIRUS;

EID: 79952537148     PISSN: 1674800X     EISSN: 16748018     Source Type: Journal    
DOI: 10.1007/s13238-010-0061-7     Document Type: Article

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