메뉴 건너뛰기




Volumn 1859, Issue 1, 2016, Pages 82-92

piRNA biogenesis in the germline: From transcription of piRNA genomic sources to piRNA maturation

Author keywords

Germline; piRNA; piRNA cluster; Piwi; RNA processing; Transcription

Indexed keywords

GENOMIC RNA; PIWI INTERACTING RNA; RNA PRECURSOR; ARGONAUTE PROTEIN; SMALL INTERFERING RNA; TRANSPOSON;

EID: 84953358217     PISSN: 18749399     EISSN: 18764320     Source Type: Journal    
DOI: 10.1016/j.bbagrm.2015.09.002     Document Type: Review
Times cited : (103)

References (139)
  • 1
    • 33947303168 scopus 로고    scopus 로고
    • Transposable elements and the epigenetic regulation of the genome
    • Slotkin R.K., Martienssen R. Transposable elements and the epigenetic regulation of the genome. Nat. Rev. Genet. 2007, 8:272-285.
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 272-285
    • Slotkin, R.K.1    Martienssen, R.2
  • 2
    • 78649679968 scopus 로고    scopus 로고
    • PiRNAs, transposon silencing, and Drosophila germline development
    • Khurana J.S., Theurkauf W. piRNAs, transposon silencing, and Drosophila germline development. J. Cell Biol. 2010, 191:905-913.
    • (2010) J. Cell Biol. , vol.191 , pp. 905-913
    • Khurana, J.S.1    Theurkauf, W.2
  • 3
    • 80755169456 scopus 로고    scopus 로고
    • Uniting germline and stem cells: the function of Piwi proteins and the piRNA pathway in diverse organisms
    • Juliano C., Wang J., Lin H. Uniting germline and stem cells: the function of Piwi proteins and the piRNA pathway in diverse organisms. Annu. Rev. Genet. 2011, 45:447-469.
    • (2011) Annu. Rev. Genet. , vol.45 , pp. 447-469
    • Juliano, C.1    Wang, J.2    Lin, H.3
  • 4
    • 84868589615 scopus 로고    scopus 로고
    • Biology of PIWI-interacting RNAs: new insights into biogenesis and function inside and outside of germlines
    • Ishizu H., Siomi H., Siomi M.C. Biology of PIWI-interacting RNAs: new insights into biogenesis and function inside and outside of germlines. Genes Dev. 2012, 26:2361-2373.
    • (2012) Genes Dev. , vol.26 , pp. 2361-2373
    • Ishizu, H.1    Siomi, H.2    Siomi, M.C.3
  • 5
    • 84855927549 scopus 로고    scopus 로고
    • PiRNAs and their involvement in male germline development in mice
    • Pillai R.S., Chuma S. piRNAs and their involvement in male germline development in mice. Develop. Growth Differ. 2012, 54:78-92.
    • (2012) Develop. Growth Differ. , vol.54 , pp. 78-92
    • Pillai, R.S.1    Chuma, S.2
  • 6
  • 7
    • 84880917068 scopus 로고    scopus 로고
    • PIWI-interacting RNAs: from generation to transgenerational epigenetics
    • Luteijn M.J., Ketting R.F. PIWI-interacting RNAs: from generation to transgenerational epigenetics. Nat. Rev. Genet. 2013, 14:523-534.
    • (2013) Nat. Rev. Genet. , vol.14 , pp. 523-534
    • Luteijn, M.J.1    Ketting, R.F.2
  • 8
    • 84879485043 scopus 로고    scopus 로고
    • PiRNA clusters as a main source of small RNAs in the animal germline
    • Olovnikov I.A., Kalmykova A.I. piRNA clusters as a main source of small RNAs in the animal germline. Biochemistry (Mosc) 2013, 78:572-584.
    • (2013) Biochemistry (Mosc) , vol.78 , pp. 572-584
    • Olovnikov, I.A.1    Kalmykova, A.I.2
  • 9
    • 84922391559 scopus 로고    scopus 로고
    • Posttranscriptional regulation of gene expression by Piwi proteins and piRNAs
    • Watanabe T., Lin H. Posttranscriptional regulation of gene expression by Piwi proteins and piRNAs. Mol. Cell 2014, 56:18-27.
    • (2014) Mol. Cell , vol.56 , pp. 18-27
    • Watanabe, T.1    Lin, H.2
  • 10
    • 84906655373 scopus 로고    scopus 로고
    • PiRNA clusters and open chromatin structure
    • Yamanaka S., Siomi M.C., Siomi H. piRNA clusters and open chromatin structure. Mob. DNA 2014, 5:22.
    • (2014) Mob. DNA , vol.5 , pp. 22
    • Yamanaka, S.1    Siomi, M.C.2    Siomi, H.3
  • 11
    • 84930695555 scopus 로고    scopus 로고
    • PIWI-interacting RNA: its biogenesis and functions
    • Iwasaki Y.W., Siomi M.C., Siomi H. PIWI-interacting RNA: its biogenesis and functions. Annu. Rev. Biochem. 2015, 84:405-433.
    • (2015) Annu. Rev. Biochem. , vol.84 , pp. 405-433
    • Iwasaki, Y.W.1    Siomi, M.C.2    Siomi, H.3
  • 12
    • 79960652605 scopus 로고    scopus 로고
    • Chromatoid body and small RNAs in male germ cells
    • Meikar O., Da Ros M., Korhonen H., Kotaja N. Chromatoid body and small RNAs in male germ cells. Reproduction 2011, 142:195-209.
    • (2011) Reproduction , vol.142 , pp. 195-209
    • Meikar, O.1    Da Ros, M.2    Korhonen, H.3    Kotaja, N.4
  • 13
    • 33746502166 scopus 로고    scopus 로고
    • A distinct small RNA pathway silences selfish genetic elements in the germline
    • Vagin V.V., Sigova A., Li C., Seitz H., Gvozdev V., Zamore P.D. A distinct small RNA pathway silences selfish genetic elements in the germline. Science 2006, 313:320-324.
    • (2006) Science , vol.313 , pp. 320-324
    • Vagin, V.V.1    Sigova, A.2    Li, C.3    Seitz, H.4    Gvozdev, V.5    Zamore, P.D.6
  • 15
    • 0026337934 scopus 로고
    • Female sterile mutations on the second chromosome of Drosophila melanogaster. II. Mutations blocking oogenesis or altering egg morphology
    • Schüpbach T., Wieschaus E. Female sterile mutations on the second chromosome of Drosophila melanogaster. II. Mutations blocking oogenesis or altering egg morphology. Genetics 1991, 129:1119-1136.
    • (1991) Genetics , vol.129 , pp. 1119-1136
    • Schüpbach, T.1    Wieschaus, E.2
  • 16
    • 0030755562 scopus 로고    scopus 로고
    • A novel group of pumilio mutations affects the asymmetric division of germline stem cells in the Drosophila ovary
    • Lin H., Spradling A.C. A novel group of pumilio mutations affects the asymmetric division of germline stem cells in the Drosophila ovary. Development 1997, 124:2463-2476.
    • (1997) Development , vol.124 , pp. 2463-2476
    • Lin, H.1    Spradling, A.C.2
  • 17
    • 0032443562 scopus 로고    scopus 로고
    • A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal
    • Cox D.N., Chao A., Baker J., Chang L., Qiao D., Lin H. A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal. Genes Dev. 1998, 12:3715-3727.
    • (1998) Genes Dev. , vol.12 , pp. 3715-3727
    • Cox, D.N.1    Chao, A.2    Baker, J.3    Chang, L.4    Qiao, D.5    Lin, H.6
  • 18
    • 0032955004 scopus 로고    scopus 로고
    • Genetic and molecular characterization of sting, a gene involved in crystal formation and meiotic drive in the male germ line of Drosophila melanogaster
    • Schmidt A., Palumbo G., Bozzetti M.P., Tritto P., Pimpinelli S., Schäfer U. Genetic and molecular characterization of sting, a gene involved in crystal formation and meiotic drive in the male germ line of Drosophila melanogaster. Genetics 1999, 151:749-760.
    • (1999) Genetics , vol.151 , pp. 749-760
    • Schmidt, A.1    Palumbo, G.2    Bozzetti, M.P.3    Tritto, P.4    Pimpinelli, S.5    Schäfer, U.6
  • 21
    • 0036083480 scopus 로고    scopus 로고
    • Miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis
    • Deng W., Lin H. miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis. Dev. Cell 2002, 2:819-830.
    • (2002) Dev. Cell , vol.2 , pp. 819-830
    • Deng, W.1    Lin, H.2
  • 24
    • 0042124978 scopus 로고    scopus 로고
    • Identification of eight members of the Argonaute family in the human genome
    • Sasaki T., Shiohama A., Minoshima S., Shimizu N. Identification of eight members of the Argonaute family in the human genome. Genomics 2003, 82:323-330.
    • (2003) Genomics , vol.82 , pp. 323-330
    • Sasaki, T.1    Shiohama, A.2    Minoshima, S.3    Shimizu, N.4
  • 25
    • 84904499496 scopus 로고    scopus 로고
    • Small RNA profiling and characterization of piRNA clusters in the adult testes of the common marmoset, a model primate
    • Hirano T., Iwasaki Y.W., Lin Z.Y., Imamura M., Seki N.M., Sasaki E., Saito K., Okano H., Siomi M.C., Siomi H. Small RNA profiling and characterization of piRNA clusters in the adult testes of the common marmoset, a model primate. RNA 2014, 20:1223-1237.
    • (2014) RNA , vol.20 , pp. 1223-1237
    • Hirano, T.1    Iwasaki, Y.W.2    Lin, Z.Y.3    Imamura, M.4    Seki, N.M.5    Sasaki, E.6    Saito, K.7    Okano, H.8    Siomi, M.C.9    Siomi, H.10
  • 26
    • 33947273235 scopus 로고    scopus 로고
    • Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila
    • Brennecke J., Aravin A.A., Stark A., Dus M., Kellis M., Sachidanandam R., Hannon G.J. Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell 2007, 128:1089-1103.
    • (2007) Cell , vol.128 , pp. 1089-1103
    • Brennecke, J.1    Aravin, A.A.2    Stark, A.3    Dus, M.4    Kellis, M.5    Sachidanandam, R.6    Hannon, G.J.7
  • 30
    • 33745336617 scopus 로고    scopus 로고
    • A germline-specific class of small RNAs binds mammalian Piwi proteins
    • Girard A., Sachidanandam R., Hannon G.J., Carmell M.A. A germline-specific class of small RNAs binds mammalian Piwi proteins. Nature 2006, 442:199-202.
    • (2006) Nature , vol.442 , pp. 199-202
    • Girard, A.1    Sachidanandam, R.2    Hannon, G.J.3    Carmell, M.A.4
  • 31
    • 33745621037 scopus 로고    scopus 로고
    • A novel class of small RNAs in mouse spermatogenic cells
    • Grivna S.T., Beyret E., Wang Z., Lin H. A novel class of small RNAs in mouse spermatogenic cells. Genes Dev. 2006, 20:1709-1714.
    • (2006) Genes Dev. , vol.20 , pp. 1709-1714
    • Grivna, S.T.1    Beyret, E.2    Wang, Z.3    Lin, H.4
  • 33
    • 33845436047 scopus 로고    scopus 로고
    • Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans
    • Ruby J.G., Jan C., Player C., Axtell M.J., Lee W., Nusbaum C., Ge H., Bartel D.P. Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans. Cell 2006, 127:1193-1207.
    • (2006) Cell , vol.127 , pp. 1193-1207
    • Ruby, J.G.1    Jan, C.2    Player, C.3    Axtell, M.J.4    Lee, W.5    Nusbaum, C.6    Ge, H.7    Bartel, D.P.8
  • 34
    • 33745599586 scopus 로고    scopus 로고
    • Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes
    • Watanabe T., Takeda A., Tsukiyama T., Mise K., Okuno T., Sasaki H., Minami N., Imai H. Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes. Genes Dev. 2006, 20:1732-1743.
    • (2006) Genes Dev. , vol.20 , pp. 1732-1743
    • Watanabe, T.1    Takeda, A.2    Tsukiyama, T.3    Mise, K.4    Okuno, T.5    Sasaki, H.6    Minami, N.7    Imai, H.8
  • 36
    • 56949089330 scopus 로고    scopus 로고
    • PiRNA-like RNAs in the marsupial Monodelphis domestica identify transcription clusters and likely marsupial transposon targets
    • Devor E.J., Huang L., Samollow P.B. piRNA-like RNAs in the marsupial Monodelphis domestica identify transcription clusters and likely marsupial transposon targets. Mamm. Genome 2008, 19:581-586.
    • (2008) Mamm. Genome , vol.19 , pp. 581-586
    • Devor, E.J.1    Huang, L.2    Samollow, P.B.3
  • 40
    • 70349633516 scopus 로고    scopus 로고
    • Abundant and dynamically expressed miRNAs, piRNAs, and other small RNAs in the vertebrate Xenopus tropicalis
    • Armisen J., Gilchrist M.J., Wilczynska A., Standart N., Miska E.A. Abundant and dynamically expressed miRNAs, piRNAs, and other small RNAs in the vertebrate Xenopus tropicalis. Genome Res. 2009, 19:1766-1775.
    • (2009) Genome Res. , vol.19 , pp. 1766-1775
    • Armisen, J.1    Gilchrist, M.J.2    Wilczynska, A.3    Standart, N.4    Miska, E.A.5
  • 42
    • 70350568326 scopus 로고    scopus 로고
    • Systematic and single cell analysis of Xenopus Piwi-interacting RNAs and Xiwi
    • Lau N.C., Ohsumi T., Borowsky M., Kingston R.E., Blower M.D. Systematic and single cell analysis of Xenopus Piwi-interacting RNAs and Xiwi. EMBO J. 2009, 28:2945-2958.
    • (2009) EMBO J. , vol.28 , pp. 2945-2958
    • Lau, N.C.1    Ohsumi, T.2    Borowsky, M.3    Kingston, R.E.4    Blower, M.D.5
  • 43
    • 83455201571 scopus 로고    scopus 로고
    • The mosquito Aedes aegypti has a large genome size and high transposable element load but contains a low proportion of transposon-specific piRNAs
    • Arensburger P., Hice R.H., Wright J.A., Craig N.L., Atkinson P.W. The mosquito Aedes aegypti has a large genome size and high transposable element load but contains a low proportion of transposon-specific piRNAs. BMC Genomics 2011, 12:606.
    • (2011) BMC Genomics , vol.12 , pp. 606
    • Arensburger, P.1    Hice, R.H.2    Wright, J.A.3    Craig, N.L.4    Atkinson, P.W.5
  • 44
    • 84863273249 scopus 로고    scopus 로고
    • Drastic expression change of transposon-derived piRNA-like RNAs and microRNAs in early stages of chicken embryos implies a role in gastrulation
    • Shao P., Liao J.Y., Guan D.G., Yang J.H., Zheng L.L., Jing Q., Zhou H., Qu L.H. Drastic expression change of transposon-derived piRNA-like RNAs and microRNAs in early stages of chicken embryos implies a role in gastrulation. RNA Biol. 2012, 9:212-227.
    • (2012) RNA Biol. , vol.9 , pp. 212-227
    • Shao, P.1    Liao, J.Y.2    Guan, D.G.3    Yang, J.H.4    Zheng, L.L.5    Jing, Q.6    Zhou, H.7    Qu, L.H.8
  • 45
    • 84862487964 scopus 로고    scopus 로고
    • Identification and characterization of piRNA-like small RNAs in the gonad of sea urchin (Strongylocentrotus nudus)
    • Wei Z., Liu X., Zhang H. Identification and characterization of piRNA-like small RNAs in the gonad of sea urchin (Strongylocentrotus nudus). Mar. Biotechnol. (N.Y.) 2012, 14:459-467.
    • (2012) Mar. Biotechnol. (N.Y.) , vol.14 , pp. 459-467
    • Wei, Z.1    Liu, X.2    Zhang, H.3
  • 46
    • 84878387068 scopus 로고    scopus 로고
    • Cloning, characterization and widespread expression analysis of testicular piRNA-like chicken RNAs
    • Zhang Y., Li J., Chen R., Dai A., Luan D., Ma T., Hua D., Chen G., Chang G. Cloning, characterization and widespread expression analysis of testicular piRNA-like chicken RNAs. Mol. Biol. Rep. 2013, 40:2799-2807.
    • (2013) Mol. Biol. Rep. , vol.40 , pp. 2799-2807
    • Zhang, Y.1    Li, J.2    Chen, R.3    Dai, A.4    Luan, D.5    Ma, T.6    Hua, D.7    Chen, G.8    Chang, G.9
  • 49
    • 70349641600 scopus 로고    scopus 로고
    • Abundant primary piRNAs, endo-siRNAs, and microRNAs in a Drosophila ovary cell line
    • Lau N.C., Robine N., Martin R., Chung W.J., Niki Y., Berezikov E., Lai E.C. Abundant primary piRNAs, endo-siRNAs, and microRNAs in a Drosophila ovary cell line. Genome Res. 2009, 19:1776-1785.
    • (2009) Genome Res. , vol.19 , pp. 1776-1785
    • Lau, N.C.1    Robine, N.2    Martin, R.3    Chung, W.J.4    Niki, Y.5    Berezikov, E.6    Lai, E.C.7
  • 51
    • 84923879619 scopus 로고    scopus 로고
    • Retrotransposons and pseudogenes regulate mRNAs and lncRNAs via the piRNA pathway in the germline
    • Watanabe T., Cheng E.C., Zhong M., Lin H. Retrotransposons and pseudogenes regulate mRNAs and lncRNAs via the piRNA pathway in the germline. Genome Res. 2015, 25:368-380.
    • (2015) Genome Res. , vol.25 , pp. 368-380
    • Watanabe, T.1    Cheng, E.C.2    Zhong, M.3    Lin, H.4
  • 52
    • 84902108866 scopus 로고    scopus 로고
    • The Rhino-Deadlock-Cutoff complex licenses noncanonical transcription of dual-strand piRNA clusters in Drosophila
    • Mohn F., Sienski G., Handler D., Brennecke J. The Rhino-Deadlock-Cutoff complex licenses noncanonical transcription of dual-strand piRNA clusters in Drosophila. Cell 2014, 157:1364-1379.
    • (2014) Cell , vol.157 , pp. 1364-1379
    • Mohn, F.1    Sienski, G.2    Handler, D.3    Brennecke, J.4
  • 54
    • 81255137997 scopus 로고    scopus 로고
    • The Cutoff protein regulates piRNA cluster expression and piRNA production in the Drosophila germline
    • Pane A., Jiang P., Zhao D.Y., Singh M., Schüpbach T. The Cutoff protein regulates piRNA cluster expression and piRNA production in the Drosophila germline. EMBO J. 2011, 30:4601-4615.
    • (2011) EMBO J. , vol.30 , pp. 4601-4615
    • Pane, A.1    Jiang, P.2    Zhao, D.Y.3    Singh, M.4    Schüpbach, T.5
  • 55
    • 0035678559 scopus 로고    scopus 로고
    • Drosophila rhino encodes a female-specific chromo-domain protein that affects chromosome structure and egg polarity
    • Volpe A.M., Horowitz H., Grafer C.M., Jackson S.M., Berg C.A. Drosophila rhino encodes a female-specific chromo-domain protein that affects chromosome structure and egg polarity. Genetics 2001, 159:1117-1134.
    • (2001) Genetics , vol.159 , pp. 1117-1134
    • Volpe, A.M.1    Horowitz, H.2    Grafer, C.M.3    Jackson, S.M.4    Berg, C.A.5
  • 56
    • 0034073993 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae RAI1 (YGL246c) is homologous to human DOM3Z and encodes a protein that binds the nuclear exoribonuclease Rat1p
    • Xue Y., Bai X., Lee I., Kallstrom G., Ho J., Brown J., Stevens A., Johnson A.W. Saccharomyces cerevisiae RAI1 (YGL246c) is homologous to human DOM3Z and encodes a protein that binds the nuclear exoribonuclease Rat1p. Mol. Cell. Biol. 2000, 20:4006-4015.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 4006-4015
    • Xue, Y.1    Bai, X.2    Lee, I.3    Kallstrom, G.4    Ho, J.5    Brown, J.6    Stevens, A.7    Johnson, A.W.8
  • 58
    • 33947641533 scopus 로고    scopus 로고
    • Cutoff and aubergine mutations result in retrotransposon upregulation and checkpoint activation in Drosophila
    • Chen Y., Pane A., Schüpbach T. cutoff and aubergine mutations result in retrotransposon upregulation and checkpoint activation in Drosophila. Curr. Biol. 2007, 17:637-642.
    • (2007) Curr. Biol. , vol.17 , pp. 637-642
    • Chen, Y.1    Pane, A.2    Schüpbach, T.3
  • 59
    • 77957340903 scopus 로고    scopus 로고
    • Identification of a quality-control mechanism for mRNA 5'-end capping
    • Jiao X., Xiang S., Oh C., Martin C.E., Tong L., Kiledjian M. Identification of a quality-control mechanism for mRNA 5'-end capping. Nature 2010, 467:608-611.
    • (2010) Nature , vol.467 , pp. 608-611
    • Jiao, X.1    Xiang, S.2    Oh, C.3    Martin, C.E.4    Tong, L.5    Kiledjian, M.6
  • 60
    • 84876088413 scopus 로고    scopus 로고
    • A mammalian pre-mRNA 5' end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing
    • Jiao X., Chang J.H., Kilic T., Tong L., Kiledjian M. A mammalian pre-mRNA 5' end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing. Mol. Cell 2013, 50:104-115.
    • (2013) Mol. Cell , vol.50 , pp. 104-115
    • Jiao, X.1    Chang, J.H.2    Kilic, T.3    Tong, L.4    Kiledjian, M.5
  • 65
    • 34249849029 scopus 로고    scopus 로고
    • Unique germ-line organelle, nuage, functions to repress selfish genetic elements in Drosophila melanogaster
    • Lim A.K., Kai T. Unique germ-line organelle, nuage, functions to repress selfish genetic elements in Drosophila melanogaster. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:6714-6719.
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 6714-6719
    • Lim, A.K.1    Kai, T.2
  • 66
    • 84870060785 scopus 로고    scopus 로고
    • Transcriptional silencing of transposons by Piwi and Maelstrom and its impact on chromatin state and gene expression
    • Sienski G., Dönertas D., Brennecke J. Transcriptional silencing of transposons by Piwi and Maelstrom and its impact on chromatin state and gene expression. Cell 2012, 151:964-980.
    • (2012) Cell , vol.151 , pp. 964-980
    • Sienski, G.1    Dönertas, D.2    Brennecke, J.3
  • 67
    • 84881081955 scopus 로고    scopus 로고
    • Drosophila Gtsf1 is an essential component of the Piwi-mediated transcriptional silencing complex
    • Dönertas D., Sienski G., Brennecke J. Drosophila Gtsf1 is an essential component of the Piwi-mediated transcriptional silencing complex. Genes Dev. 2013, 27:1693-1705.
    • (2013) Genes Dev. , vol.27 , pp. 1693-1705
    • Dönertas, D.1    Sienski, G.2    Brennecke, J.3
  • 68
    • 84878847013 scopus 로고    scopus 로고
    • A genome-wide RNAi screen draws a genetic framework for transposon control and primary piRNA biogenesis in Drosophila
    • Muerdter F., Guzzardo P.M., Gillis J., Luo Y., Yu Y., Chen C., Fekete R., Hannon G.J. A genome-wide RNAi screen draws a genetic framework for transposon control and primary piRNA biogenesis in Drosophila. Mol. Cell 2013, 50:736-748.
    • (2013) Mol. Cell , vol.50 , pp. 736-748
    • Muerdter, F.1    Guzzardo, P.M.2    Gillis, J.3    Luo, Y.4    Yu, Y.5    Chen, C.6    Fekete, R.7    Hannon, G.J.8
  • 69
    • 84881045635 scopus 로고    scopus 로고
    • DmGTSF1 is necessary for Piwi-piRISC-mediated transcriptional transposon silencing in the Drosophila ovary
    • Ohtani H., Iwasaki Y.W., Shibuya A., Siomi H., Siomi M.C., Saito K. DmGTSF1 is necessary for Piwi-piRISC-mediated transcriptional transposon silencing in the Drosophila ovary. Genes Dev. 2013, 27:1656-1661.
    • (2013) Genes Dev. , vol.27 , pp. 1656-1661
    • Ohtani, H.1    Iwasaki, Y.W.2    Shibuya, A.3    Siomi, H.4    Siomi, M.C.5    Saito, K.6
  • 70
    • 84928013225 scopus 로고    scopus 로고
    • Metazoan Maelstrom is an RNA-binding protein that has evolved from an ancient nuclease active in protists
    • Chen K., Campbell E., Pandey R.R., Yang Z., Mccarthy A., Pillai R.S. Metazoan Maelstrom is an RNA-binding protein that has evolved from an ancient nuclease active in protists. RNA 2015, 21:833-839.
    • (2015) RNA , vol.21 , pp. 833-839
    • Chen, K.1    Campbell, E.2    Pandey, R.R.3    Yang, Z.4    Mccarthy, A.5    Pillai, R.S.6
  • 72
    • 84930272845 scopus 로고    scopus 로고
    • Functional and structural insights into the piRNA factor Maelstrom
    • Sato K., Siomi M.C. Functional and structural insights into the piRNA factor Maelstrom. FEBS Lett. 2015, 589:1688-1693.
    • (2015) FEBS Lett. , vol.589 , pp. 1688-1693
    • Sato, K.1    Siomi, M.C.2
  • 73
    • 61349105400 scopus 로고    scopus 로고
    • Functional insight into Maelstrom in the germline piRNA pathway: a unique domain homologous to the DnaQ-H 3'-5' exonuclease, its lineage-specific expansion/loss and evolutionarily active site switch
    • Zhang D., Xiong H., Shan J., Xia X., Trudeau V.L. Functional insight into Maelstrom in the germline piRNA pathway: a unique domain homologous to the DnaQ-H 3'-5' exonuclease, its lineage-specific expansion/loss and evolutionarily active site switch. Biol. Direct 2008, 3:48.
    • (2008) Biol. Direct , vol.3 , pp. 48
    • Zhang, D.1    Xiong, H.2    Shan, J.3    Xia, X.4    Trudeau, V.L.5
  • 78
    • 84857059151 scopus 로고    scopus 로고
    • The tudor domain protein Kumo is required to assemble the nuage and to generate germline piRNAs in Drosophila
    • Anand A., Kai T. The tudor domain protein Kumo is required to assemble the nuage and to generate germline piRNAs in Drosophila. EMBO J. 2012, 31:870-882.
    • (2012) EMBO J. , vol.31 , pp. 870-882
    • Anand, A.1    Kai, T.2
  • 79
    • 84898661166 scopus 로고    scopus 로고
    • Transcriptional properties and splicing of the flamenco piRNA cluster
    • Goriaux C., Desset S., Renaud Y., Vaury C., Brasset E. Transcriptional properties and splicing of the flamenco piRNA cluster. EMBO Rep. 2014, 15:411-418.
    • (2014) EMBO Rep. , vol.15 , pp. 411-418
    • Goriaux, C.1    Desset, S.2    Renaud, Y.3    Vaury, C.4    Brasset, E.5
  • 85
    • 39249083167 scopus 로고    scopus 로고
    • UAP56 RNA helicase is required for axis specification and cytoplasmic mRNA localization in Drosophila
    • Meignin C., Davis I. UAP56 RNA helicase is required for axis specification and cytoplasmic mRNA localization in Drosophila. Dev. Biol. 2008, 315:89-98.
    • (2008) Dev. Biol. , vol.315 , pp. 89-98
    • Meignin, C.1    Davis, I.2
  • 86
    • 84961289864 scopus 로고    scopus 로고
    • A unique HMG-box domain of mouse Maelstrom binds structured RNA but not double stranded DNA
    • Genzor P., Bortvin A. A unique HMG-box domain of mouse Maelstrom binds structured RNA but not double stranded DNA. PLoS ONE 2015, 10.
    • (2015) PLoS ONE , vol.10
    • Genzor, P.1    Bortvin, A.2
  • 87
    • 0037352528 scopus 로고    scopus 로고
    • Maelstrom, a Drosophila spindle-class gene, encodes a protein that colocalizes with Vasa and RDE1/AGO1 homolog, Aubergine, in nuage
    • Findley S.D., Tamanaha M., Clegg N.J., Ruohola-Baker H. Maelstrom, a Drosophila spindle-class gene, encodes a protein that colocalizes with Vasa and RDE1/AGO1 homolog, Aubergine, in nuage. Development 2003, 130:859-871.
    • (2003) Development , vol.130 , pp. 859-871
    • Findley, S.D.1    Tamanaha, M.2    Clegg, N.J.3    Ruohola-Baker, H.4
  • 91
  • 92
    • 77957793321 scopus 로고    scopus 로고
    • An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in Drosophila
    • Olivieri D., Sykora M.M., Sachidanandam R., Mechtler K., Brennecke J. An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in Drosophila. EMBO J. 2010, 29:3301-3317.
    • (2010) EMBO J. , vol.29 , pp. 3301-3317
    • Olivieri, D.1    Sykora, M.M.2    Sachidanandam, R.3    Mechtler, K.4    Brennecke, J.5
  • 94
    • 84860389782 scopus 로고    scopus 로고
    • A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors
    • Handler D., Olivieri D., Novatchkova M., Gruber F.S., Meixner K., Mechtler K., Stark A., Sachidanandam R., Brennecke J. A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors. EMBO J. 2011, 30:3977-3993.
    • (2011) EMBO J. , vol.30 , pp. 3977-3993
    • Handler, D.1    Olivieri, D.2    Novatchkova, M.3    Gruber, F.S.4    Meixner, K.5    Mechtler, K.6    Stark, A.7    Sachidanandam, R.8    Brennecke, J.9
  • 96
    • 84878851966 scopus 로고    scopus 로고
    • A transcriptome-wide RNAi screen in the Drosophila ovary reveals factors of the germline piRNA pathway
    • Czech B., Preall J.B., McGinn J., Hannon G.J. A transcriptome-wide RNAi screen in the Drosophila ovary reveals factors of the germline piRNA pathway. Mol. Cell 2013, 50:749-761.
    • (2013) Mol. Cell , vol.50 , pp. 749-761
    • Czech, B.1    Preall, J.B.2    McGinn, J.3    Hannon, G.J.4
  • 97
    • 84866864333 scopus 로고    scopus 로고
    • The cochaperone Shutdown defines a group of biogenesis factors essential for all piRNA populations in Drosophila
    • Olivieri D., Senti K.A., Subramanian S., Sachidanandam R., Brennecke J. The cochaperone Shutdown defines a group of biogenesis factors essential for all piRNA populations in Drosophila. Mol. Cell 2012, 47:954-969.
    • (2012) Mol. Cell , vol.47 , pp. 954-969
    • Olivieri, D.1    Senti, K.A.2    Subramanian, S.3    Sachidanandam, R.4    Brennecke, J.5
  • 98
    • 84864042164 scopus 로고    scopus 로고
    • Shutdown is a component of the Drosophila piRNA biogenesis machinery
    • Preall J.B., Czech B., Guzzardo P.M., Muerdter F., Hannon G.J. shutdown is a component of the Drosophila piRNA biogenesis machinery. RNA 2012, 18:1446-1457.
    • (2012) RNA , vol.18 , pp. 1446-1457
    • Preall, J.B.1    Czech, B.2    Guzzardo, P.M.3    Muerdter, F.4    Hannon, G.J.5
  • 99
    • 84868613084 scopus 로고    scopus 로고
    • The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis
    • Ipsaro J.J., Haase A.D., Knott S.R., Joshua-Tor L., Hannon G.J. The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis. Nature 2012, 491:279-283.
    • (2012) Nature , vol.491 , pp. 279-283
    • Ipsaro, J.J.1    Haase, A.D.2    Knott, S.R.3    Joshua-Tor, L.4    Hannon, G.J.5
  • 101
    • 33747369856 scopus 로고    scopus 로고
    • Specific association of Piwi with rasiRNAs derived from retrotransposon and heterochromatic regions in the Drosophila genome
    • Saito K., Nishida K.M., Mori T., Kawamura Y., Miyoshi K., Nagami T., Siomi H., Siomi M.C. Specific association of Piwi with rasiRNAs derived from retrotransposon and heterochromatic regions in the Drosophila genome. Genes Dev. 2006, 20:2214-2222.
    • (2006) Genes Dev. , vol.20 , pp. 2214-2222
    • Saito, K.1    Nishida, K.M.2    Mori, T.3    Kawamura, Y.4    Miyoshi, K.5    Nagami, T.6    Siomi, H.7    Siomi, M.C.8
  • 102
    • 80052991624 scopus 로고    scopus 로고
    • 3' end formation of PIWI-interacting RNAs in vitro
    • Kawaoka S., Izumi N., Katsuma S., Tomari Y. 3' end formation of PIWI-interacting RNAs in vitro. Mol. Cell 2011, 43:1015-1022.
    • (2011) Mol. Cell , vol.43 , pp. 1015-1022
    • Kawaoka, S.1    Izumi, N.2    Katsuma, S.3    Tomari, Y.4
  • 108
    • 84927911941 scopus 로고    scopus 로고
    • The exonuclease Nibbler regulates age-associated traits and modulates piRNA length in Drosophila
    • Feltzin V.L., Khaladkar M., Abe M., Parisi M., Hendriks G.J., Kim J., Bonini N.M. The exonuclease Nibbler regulates age-associated traits and modulates piRNA length in Drosophila. Aging Cell 2015, 14:443-452.
    • (2015) Aging Cell , vol.14 , pp. 443-452
    • Feltzin, V.L.1    Khaladkar, M.2    Abe, M.3    Parisi, M.4    Hendriks, G.J.5    Kim, J.6    Bonini, N.M.7
  • 110
    • 84880220867 scopus 로고    scopus 로고
    • Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline
    • Saxe J.P., Chen M., Zhao H., Lin H. Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline. EMBO J. 2013, 32:1869-1885.
    • (2013) EMBO J. , vol.32 , pp. 1869-1885
    • Saxe, J.P.1    Chen, M.2    Zhao, H.3    Lin, H.4
  • 111
    • 84929380410 scopus 로고    scopus 로고
    • PiRNA-guided transposon cleavage initiates Zucchini-dependent, phased piRNA production
    • Han B.W., Wang W., Li C., Weng Z., Zamore P.D. piRNA-guided transposon cleavage initiates Zucchini-dependent, phased piRNA production. Science 2015, 348:817-821.
    • (2015) Science , vol.348 , pp. 817-821
    • Han, B.W.1    Wang, W.2    Li, C.3    Weng, Z.4    Zamore, P.D.5
  • 112
    • 84929353775 scopus 로고    scopus 로고
    • PiRNA-guided slicing specifies transcripts for Zucchini-dependent, phased piRNA biogenesis
    • Mohn F., Handler D., Brennecke J. piRNA-guided slicing specifies transcripts for Zucchini-dependent, phased piRNA biogenesis. Science 2015, 348:812-817.
    • (2015) Science , vol.348 , pp. 812-817
    • Mohn, F.1    Handler, D.2    Brennecke, J.3
  • 113
    • 34447291602 scopus 로고    scopus 로고
    • The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC
    • Horwich M.D., Li C., Matranga C., Vagin V., Farley G., Wang P., Zamore P.D. The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC. Curr. Biol. 2007, 17:1265-1272.
    • (2007) Curr. Biol. , vol.17 , pp. 1265-1272
    • Horwich, M.D.1    Li, C.2    Matranga, C.3    Vagin, V.4    Farley, G.5    Wang, P.6    Zamore, P.D.7
  • 114
    • 34347378274 scopus 로고    scopus 로고
    • Pimet, the Drosophila homolog of HEN1, mediates 2'-O-methylation of PIWI-interacting RNAs at their 3' ends
    • Saito K., Sakaguchi Y., Suzuki T., Siomi H., Siomi M.C. Pimet, the Drosophila homolog of HEN1, mediates 2'-O-methylation of PIWI-interacting RNAs at their 3' ends. Genes Dev. 2007, 21:1603-1608.
    • (2007) Genes Dev. , vol.21 , pp. 1603-1608
    • Saito, K.1    Sakaguchi, Y.2    Suzuki, T.3    Siomi, H.4    Siomi, M.C.5
  • 116
    • 84903400473 scopus 로고    scopus 로고
    • A comprehensive analysis of piRNAs from adult human testis and their relationship with genes and mobile elements
    • Ha H., Song J., Wang S., Kapusta A., Feschotte C., Chen K.C., Xing J. A comprehensive analysis of piRNAs from adult human testis and their relationship with genes and mobile elements. BMC Genomics 2014, 15:545.
    • (2014) BMC Genomics , vol.15 , pp. 545
    • Ha, H.1    Song, J.2    Wang, S.3    Kapusta, A.4    Feschotte, C.5    Chen, K.C.6    Xing, J.7
  • 117
    • 84919490884 scopus 로고    scopus 로고
    • The initial uridine of primary piRNAs does not create the tenth adenine that is the hallmark of secondary piRNAs
    • Wang W., Yoshikawa M., Han B.W., Izumi N., Tomari Y., Weng Z., Zamore P.D. The initial uridine of primary piRNAs does not create the tenth adenine that is the hallmark of secondary piRNAs. Mol. Cell 2014, 56:708-716.
    • (2014) Mol. Cell , vol.56 , pp. 708-716
    • Wang, W.1    Yoshikawa, M.2    Han, B.W.3    Izumi, N.4    Tomari, Y.5    Weng, Z.6    Zamore, P.D.7
  • 118
    • 84988710964 scopus 로고    scopus 로고
    • The Tudor domain protein Tapas, a homolog of the vertebrate Tdrd7, functions in the piRNA pathway to regulate retrotransposons in germline of Drosophila melanogaster
    • Patil V.S., Anand A., Chakrabarti A., Kai T. The Tudor domain protein Tapas, a homolog of the vertebrate Tdrd7, functions in the piRNA pathway to regulate retrotransposons in germline of Drosophila melanogaster. BMC Biol. 2014, 12:61.
    • (2014) BMC Biol. , vol.12 , pp. 61
    • Patil, V.S.1    Anand, A.2    Chakrabarti, A.3    Kai, T.4
  • 123
    • 84920933929 scopus 로고    scopus 로고
    • Respective functions of two distinct Siwi complexes assembled during PIWI-interacting RNA biogenesis in Bombyx germ cells
    • Nishida K.M., Iwasaki Y.W., Murota Y., Nagao A., Mannen T., Kato Y., Siomi H., Siomi M.C. Respective functions of two distinct Siwi complexes assembled during PIWI-interacting RNA biogenesis in Bombyx germ cells. Cell Rep. 2015, 10:193-203.
    • (2015) Cell Rep. , vol.10 , pp. 193-203
    • Nishida, K.M.1    Iwasaki, Y.W.2    Murota, Y.3    Nagao, A.4    Mannen, T.5    Kato, Y.6    Siomi, H.7    Siomi, M.C.8
  • 125
    • 84910656239 scopus 로고    scopus 로고
    • The DExH box helicase domain of Spindle-E is necessary for retrotransposon silencing and axial patterning during Drosophila oogenesis
    • Ott K.M., Nguyen T., Navarro C. The DExH box helicase domain of Spindle-E is necessary for retrotransposon silencing and axial patterning during Drosophila oogenesis. G3 (Bethesda) 2014, 4:2247-2257.
    • (2014) G3 (Bethesda) , vol.4 , pp. 2247-2257
    • Ott, K.M.1    Nguyen, T.2    Navarro, C.3
  • 127
    • 34249804498 scopus 로고    scopus 로고
    • Using FlyAtlas to identify better Drosophila melanogaster models of human disease
    • Chintapalli V.R., Wang J., Dow J.A. Using FlyAtlas to identify better Drosophila melanogaster models of human disease. Nat. Genet. 2007, 39:715-720.
    • (2007) Nat. Genet. , vol.39 , pp. 715-720
    • Chintapalli, V.R.1    Wang, J.2    Dow, J.A.3
  • 128
    • 84904604049 scopus 로고    scopus 로고
    • AGO3 Slicer activity regulates mitochondria-nuage localization of Armitage and piRNA amplification
    • Huang H., Li Y., Szulwach K.E., Zhang G., Jin P., Chen D. AGO3 Slicer activity regulates mitochondria-nuage localization of Armitage and piRNA amplification. J. Cell Biol. 2014, 206:217-230.
    • (2014) J. Cell Biol. , vol.206 , pp. 217-230
    • Huang, H.1    Li, Y.2    Szulwach, K.E.3    Zhang, G.4    Jin, P.5    Chen, D.6
  • 129
    • 0034925616 scopus 로고    scopus 로고
    • Aubergine encodes a Drosophila polar granule component required for pole cell formation and related to eIF2C
    • Harris A.N., Macdonald P.M. aubergine encodes a Drosophila polar granule component required for pole cell formation and related to eIF2C. Development 2001, 128:2823-2832.
    • (2001) Development , vol.128 , pp. 2823-2832
    • Harris, A.N.1    Macdonald, P.M.2
  • 130
    • 33846478365 scopus 로고    scopus 로고
    • Histone methylation is required for oogenesis in Drosophila
    • Clough E., Moon W., Wang S., Smith K., Hazelrigg T. Histone methylation is required for oogenesis in Drosophila. Development 2007, 134:157-165.
    • (2007) Development , vol.134 , pp. 157-165
    • Clough, E.1    Moon, W.2    Wang, S.3    Smith, K.4    Hazelrigg, T.5
  • 131
    • 48249117935 scopus 로고    scopus 로고
    • DSETDB1 and SU(VAR)3-9 sequentially function during germline-stem cell differentiation in Drosophila melanogaster
    • Yoon J., Lee K.S., Park J.S., Yu K., Paik S.G., Kang Y.K. dSETDB1 and SU(VAR)3-9 sequentially function during germline-stem cell differentiation in Drosophila melanogaster. PLoS ONE 2008, 3.
    • (2008) PLoS ONE , vol.3
    • Yoon, J.1    Lee, K.S.2    Park, J.S.3    Yu, K.4    Paik, S.G.5    Kang, Y.K.6
  • 132
    • 58849147164 scopus 로고    scopus 로고
    • The molecular chaperone Hsp90 is a component of the cap-binding complex and interacts with the translational repressor Cup during Drosophila oogenesis
    • Pisa V., Cozzolino M., Gargiulo S., Ottone C., Piccioni F., Monti M., Gigliotti S., Talamo F., Graziani F., Pucci P., Verrotti A.C. The molecular chaperone Hsp90 is a component of the cap-binding complex and interacts with the translational repressor Cup during Drosophila oogenesis. Gene 2009, 432:67-74.
    • (2009) Gene , vol.432 , pp. 67-74
    • Pisa, V.1    Cozzolino, M.2    Gargiulo, S.3    Ottone, C.4    Piccioni, F.5    Monti, M.6    Gigliotti, S.7    Talamo, F.8    Graziani, F.9    Pucci, P.10    Verrotti, A.C.11
  • 133
    • 81255188693 scopus 로고    scopus 로고
    • Maelstrom coordinates microtubule organization during Drosophila oogenesis through interaction with components of the MTOC
    • Sato K., Nishida K.M., Shibuya A., Siomi M.C., Siomi H. Maelstrom coordinates microtubule organization during Drosophila oogenesis through interaction with components of the MTOC. Genes Dev. 2011, 25:2361-2373.
    • (2011) Genes Dev. , vol.25 , pp. 2361-2373
    • Sato, K.1    Nishida, K.M.2    Shibuya, A.3    Siomi, M.C.4    Siomi, H.5
  • 135
    • 79955366604 scopus 로고    scopus 로고
    • PAPI, a novel TUDOR-domain protein, complexes with AGO3, ME31B and TRAL in the nuage to silence transposition
    • Liu L., Qi H., Wang J., Lin H. PAPI, a novel TUDOR-domain protein, complexes with AGO3, ME31B and TRAL in the nuage to silence transposition. Development 2011, 138:1863-1873.
    • (2011) Development , vol.138 , pp. 1863-1873
    • Liu, L.1    Qi, H.2    Wang, J.3    Lin, H.4
  • 136
    • 84898656910 scopus 로고    scopus 로고
    • Antisense piRNA amplification, but not piRNA production or nuage assembly, requires the Tudor-domain protein Qin
    • Zhang Z., Koppetsch B.S., Wang J., Tipping C., Weng Z., Theurkauf W.E., Zamore P.D. Antisense piRNA amplification, but not piRNA production or nuage assembly, requires the Tudor-domain protein Qin. EMBO J. 2014, 33:536-539.
    • (2014) EMBO J. , vol.33 , pp. 536-539
    • Zhang, Z.1    Koppetsch, B.S.2    Wang, J.3    Tipping, C.4    Weng, Z.5    Theurkauf, W.E.6    Zamore, P.D.7
  • 137
    • 77951288138 scopus 로고    scopus 로고
    • Repression of retroelements in Drosophila germline via piRNA pathway by the tudor domain protein Tejas
    • Patil V.S., Kai T. Repression of retroelements in Drosophila germline via piRNA pathway by the tudor domain protein Tejas. Curr. Biol. 2010, 20:724-730.
    • (2010) Curr. Biol. , vol.20 , pp. 724-730
    • Patil, V.S.1    Kai, T.2
  • 138
    • 0028222187 scopus 로고
    • Localization of vasa protein to the Drosophila pole plasm is independent of its RNA-binding and helicase activities
    • Liang L., Diehl-Jones W., Lasko P. Localization of vasa protein to the Drosophila pole plasm is independent of its RNA-binding and helicase activities. Development 1994, 120:1201-1211.
    • (1994) Development , vol.120 , pp. 1201-1211
    • Liang, L.1    Diehl-Jones, W.2    Lasko, P.3
  • 139
    • 34249309547 scopus 로고    scopus 로고
    • Zucchini and squash encode two putative nucleases required for rasiRNA production in the Drosophila germline
    • Pane A., Wehr K., Schüpbach T. zucchini and squash encode two putative nucleases required for rasiRNA production in the Drosophila germline. Dev. Cell 2007, 12:851-862.
    • (2007) Dev. Cell , vol.12 , pp. 851-862
    • Pane, A.1    Wehr, K.2    Schüpbach, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.