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Volumn 892, Issue , 2016, Pages 327-349

Antifungals: Mechanism of action and drug resistance

Author keywords

Antifungal agents; Azoles; Combination therapy; Drug efflux; Erg11p; Multidrug resistance

Indexed keywords

ABC TRANSPORTER; ALLYLAMINE; ANTIFUNGAL AGENT; ECHINOCANDIN; ERGOSTEROL; MEMBRANE PROTEIN; MFS TRANSPORTER; MORPHOLINE DERIVATIVE; POLYENE; PYRIMIDINE DERIVATIVE; PYRROLE DERIVATIVE; THIOCARBAMIC ACID DERIVATIVE; UNCLASSIFIED DRUG; FUNGAL PROTEIN; OXIDOREDUCTASE;

EID: 84953321231     PISSN: 00652598     EISSN: 22148019     Source Type: Book Series    
DOI: 10.1007/978-3-319-25304-6_14     Document Type: Chapter
Times cited : (136)

References (115)
  • 1
    • 33744504444 scopus 로고    scopus 로고
    • Assessing resistance to the echinocandin antifungal drug caspofungin in Candida albicans by profiling mutations in FKS1
    • Balashov SV, Park S, Perlin DS (2006) Assessing resistance to the echinocandin antifungal drug caspofungin in Candida albicans by profiling mutations in FKS1. Antimicrob Agents Chemother 50:2058-2063
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 2058-2063
    • Balashov, S.V.1    Park, S.2    Perlin, D.S.3
  • 2
    • 67650883152 scopus 로고    scopus 로고
    • Discovery of the parnafungins, antifungal metabolites that inhibit mRNA polyadenylation, from the Fusarium larvarum complex and other Hypocrealean fungi
    • Bills GF, Platas G, Overy DP, Collado J, Fillola A, Jiménez MR et al (2009) Discovery of the parnafungins, antifungal metabolites that inhibit mRNA polyadenylation, from the Fusarium larvarum complex and other Hypocrealean fungi. Mycologia 101:449-472
    • (2009) Mycologia , vol.101 , pp. 449-472
    • Bills, G.F.1    Platas, G.2    Overy, D.P.3    Collado, J.4    Fillola, A.5    Jiménez, M.R.6
  • 3
  • 5
    • 84877133207 scopus 로고    scopus 로고
    • Antifungal activity of azole compounds CPA18 and CPA109 against azole-susceptible and - resistant strains of Candida albicans
    • Calabrese EC, Castellano S, Santoriello M, Sgherri C, Quartacci MF, Calucci L et al (2013) Antifungal activity of azole compounds CPA18 and CPA109 against azole-susceptible and - resistant strains of Candida albicans. J Antimicrob Chemother 68:1111-1119
    • (2013) J Antimicrob Chemother , vol.68 , pp. 1111-1119
    • Calabrese, E.C.1    Castellano, S.2    Santoriello, M.3    Sgherri, C.4    Quartacci, M.F.5    Calucci, L.6
  • 7
    • 0027326490 scopus 로고
    • Anti-Candida activity of cispentacin: The active transport by amino acid permeases and possible mechanisms of action
    • Capobianco JO, Zakula D, Coen ML, Goldman RC (1993) Anti-Candida activity of cispentacin: the active transport by amino acid permeases and possible mechanisms of action. Biochem Biophys Res Commun 190:1037-1044
    • (1993) Biochem Biophys Res Commun , vol.190 , pp. 1037-1044
    • Capobianco, J.O.1    Zakula, D.2    Coen, M.L.3    Goldman, R.C.4
  • 9
    • 0034917716 scopus 로고    scopus 로고
    • The human ATP-binding cassette (ABC) transporter superfamily
    • Dean M, Andrey R, Rando A (2001) The human ATP-binding cassette (ABC) transporter superfamily. Genome Res 11:1156-1166
    • (2001) Genome Res , vol.11 , pp. 1156-1166
    • Dean, M.1    Andrey, R.2    Rando, A.3
  • 11
    • 84455192724 scopus 로고    scopus 로고
    • In vitro effect of malachite green on Candida albicans involves multiple pathways and transcriptional regulators UPC2 and STP2
    • Dhamgaye S, Devaux F, Manoharlal R, Vandeputte P, Shah AH, Singh A et al (2012) In vitro effect of malachite green on Candida albicans involves multiple pathways and transcriptional regulators UPC2 and STP2. Antimicrob Agents Chemother 56:495-506
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 495-506
    • Dhamgaye, S.1    Devaux, F.2    Manoharlal, R.3    Vandeputte, P.4    Shah, A.H.5    Singh, A.6
  • 13
    • 0040837015 scopus 로고    scopus 로고
    • Identification of elongation factor 2 as the essential protein targeted by sordarins in Candida albicans
    • Domínguez JM, Martín JJ (1998) Identification of elongation factor 2 as the essential protein targeted by sordarins in Candida albicans. Antimicrob Agents Chemother 42:2279-2283
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 2279-2283
    • Domínguez, J.M.1    Martín, J.J.2
  • 15
    • 67650723105 scopus 로고    scopus 로고
    • Novel antifungal agents, targets or therapeutic strategies for the treatment of invasive fungal diseases: A review of the literature (2005-2009)
    • Espinel-Ingroff A (2009) Novel antifungal agents, targets or therapeutic strategies for the treatment of invasive fungal diseases: a review of the literature (2005-2009). Rev Iberoam Micol 26:15- 22
    • (2009) Rev Iberoam Micol , vol.26 , pp. 15-22
    • Espinel-Ingroff, A.1
  • 17
    • 84867168091 scopus 로고    scopus 로고
    • Gain-of function mutations in UPC2 are a frequent cause of ERG11 upregulation in azole-resistant clinical isolates of Candida albicans
    • Flowers SA, Barker KS, Berkow EL, Toner G, Chadwick SG, Gygax SE et al (2012) Gain-of function mutations in UPC2 are a frequent cause of ERG11 upregulation in azole-resistant clinical isolates of Candida albicans. Eukaryot Cell 11:1289-1299
    • (2012) Eukaryot Cell , vol.11 , pp. 1289-1299
    • Flowers, S.A.1    Barker, K.S.2    Berkow, E.L.3    Toner, G.4    Chadwick, S.G.5    Gygax, S.E.6
  • 20
    • 84856012205 scopus 로고    scopus 로고
    • The role of combination antifungal therapy in the treatment of invasive aspergillosis: A systematic review
    • Garbati MA, Alasmari FA, Al-Tannir MA, Tleyjeh IM (2012) The role of combination antifungal therapy in the treatment of invasive aspergillosis: a systematic review. Int J Infect Dis 16:e76-e81
    • (2012) Int J Infect Dis , vol.16 , pp. e76-e81
    • Garbati, M.A.1    Alasmari, F.A.2    Al-Tannir, M.A.3    Tleyjeh, I.M.4
  • 21
    • 59749090444 scopus 로고    scopus 로고
    • Correlating echinocandin MIC and kinetic inhibition of fks1 mutant glucan synthases for Candida albicans: Implications for interpretive breakpoints
    • Garcia-Effron G, Park S, Perlin DS (2009) Correlating echinocandin MIC and kinetic inhibition of fks1 mutant glucan synthases for Candida albicans: implications for interpretive breakpoints. Antimicrob Agents Chemother 53:112-122
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 112-122
    • Garcia-Effron, G.1    Park, S.2    Perlin, D.S.3
  • 22
    • 27544514993 scopus 로고    scopus 로고
    • Complete inventory of ABC proteins in human pathogenic yeast, Candida albicans
    • GaurM, Choudhury D, Prasad R (2005) Complete inventory of ABC proteins in human pathogenic yeast, Candida albicans. J Mol Microbiol Biotechnol 9:3-15
    • (2005) J Mol Microbiol Biotechnol , vol.9 , pp. 3-15
    • Gaur, M.1    Choudhury, D.2    Prasad, R.3
  • 25
    • 33947133660 scopus 로고    scopus 로고
    • The yeast Pdr5p multidrug transporter: How does it recognize so many substrates?
    • Golin J, Ambudkar SV, May L (2007) The yeast Pdr5p multidrug transporter: how does it recognize so many substrates? Biochem Biophys Res Commun 356:1-5
    • (2007) Biochem Biophys Res Commun , vol.356 , pp. 1-5
    • Golin, J.1    Ambudkar, S.V.2    May, L.3
  • 26
    • 84865307122 scopus 로고    scopus 로고
    • Importance of the Candida albicans cell wall during commensalism and infection
    • Gow NA, Hube B (2012) Importance of the Candida albicans cell wall during commensalism and infection. Curr Opin Microbiol 15:406-412
    • (2012) Curr Opin Microbiol , vol.15 , pp. 406-412
    • Gow, N.A.1    Hube, B.2
  • 29
    • 14444272050 scopus 로고    scopus 로고
    • Inhibition of fungal sphingolipid biosynthesis by rustmicin, galbonolide B and their new 21-hydroxy analogs
    • Harris GH, Shafiee A, Cabello MA, Curotto JE, Genilloud O, Göklen KE et al (1998) Inhibition of fungal sphingolipid biosynthesis by rustmicin, galbonolide B and their new 21-hydroxy analogs. J Antibiot (Tokyo) 51:837-844
    • (1998) J Antibiot (Tokyo) , vol.51 , pp. 837-844
    • Harris, G.H.1    Shafiee, A.2    Cabello, M.A.3    Curotto, J.E.4    Genilloud, O.5    Göklen, K.E.6
  • 30
    • 73849109145 scopus 로고    scopus 로고
    • An A643T mutation in the transcription factor Upc2p causes constitutive ERG11 upregulation and increased fluconazole resistance in Candida albicans
    • Heilmann CJ, Schneider S, Barker KS, Rogers PD, Morschhäuser J (2010) An A643T mutation in the transcription factor Upc2p causes constitutive ERG11 upregulation and increased fluconazole resistance in Candida albicans. Antimicrob Agents Chemother 54:353-359
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 353-359
    • Heilmann, C.J.1    Schneider, S.2    Barker, K.S.3    Rogers, P.D.4    Morschhäuser, J.5
  • 31
    • 79952438989 scopus 로고    scopus 로고
    • Microbial pathogens in the fungal kingdom
    • Heitman J (2011) Microbial pathogens in the fungal kingdom. Fungal Biol Rev 25:48-60
    • (2011) Fungal Biol Rev , vol.25 , pp. 48-60
    • Heitman, J.1
  • 32
    • 0033807662 scopus 로고    scopus 로고
    • Upregulation of ERG genes in Candida species by azoles and other sterol biosynthesis inhibitors
    • Henry KW, Nickels JT, Edlind TD (2000) Upregulation of ERG genes in Candida species by azoles and other sterol biosynthesis inhibitors. Antimicrob Agents Chemother 44:2693-2700
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 2693-2700
    • Henry, K.W.1    Nickels, J.T.2    Edlind, T.D.3
  • 35
    • 78751695581 scopus 로고    scopus 로고
    • An A643V amino acid substitution in Upc2p contributes to azole resistance in well-characterized clinical isolates of Candida albicans
    • Hoot SJ, Smith AR, Brown RP, White TC (2011) An A643V amino acid substitution in Upc2p contributes to azole resistance in well-characterized clinical isolates of Candida albicans. Antimicrob Agents Chemother 55:940-942
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 940-942
    • Hoot, S.J.1    Smith, A.R.2    Brown, R.P.3    White, T.C.4
  • 36
    • 0025019332 scopus 로고
    • FR109615, a new antifungal antibiotic from Streptomyces setonii. Taxonomy, fermentation, isolation, physicochemical properties and biological activity
    • Iwamoto T, Tsujii E, Ezaki M, Fujie A, Hashimoto S, Okuhara M et al (1990) FR109615, a new antifungal antibiotic from Streptomyces setonii. Taxonomy, fermentation, isolation, physicochemical properties and biological activity. J Antibiot (Tokyo) 43:1-7
    • (1990) J Antibiot (Tokyo) , vol.43 , pp. 1-7
    • Iwamoto, T.1    Tsujii, E.2    Ezaki, M.3    Fujie, A.4    Hashimoto, S.5    Okuhara, M.6
  • 37
    • 41949100293 scopus 로고    scopus 로고
    • PAP inhibitor with in vivo efficacy identified by Candida albicans genetic profiling of natural products
    • Jiang B, Xu D, Allocco J, Parish C, Davison J, Veillette K et al (2008) PAP inhibitor with in vivo efficacy identified by Candida albicans genetic profiling of natural products. Chem Biol 15:363-374
    • (2008) Chem Biol , vol.15 , pp. 363-374
    • Jiang, B.1    Xu, D.2    Allocco, J.3    Parish, C.4    Davison, J.5    Veillette, K.6
  • 38
    • 84893490335 scopus 로고    scopus 로고
    • Enfumafungin derivative MK-3118 shows increased in vitro potency against clinical echinocandin-resistant Candida Species and Aspergillus species isolates
    • Jiménez-Ortigosa C, Paderu P, Motyl MR, Perlin DS (2014) Enfumafungin derivative MK-3118 shows increased in vitro potency against clinical echinocandin-resistant Candida Species and Aspergillus species isolates. Antimicrob Agents Chemother 58:1248-1251
    • (2014) Antimicrob Agents Chemother , vol.58 , pp. 1248-1251
    • Jiménez-Ortigosa, C.1    Paderu, P.2    Motyl, M.R.3    Perlin, D.S.4
  • 39
    • 42949167168 scopus 로고    scopus 로고
    • Efficacy of SPK-843, a novel polyene antifungal, in comparison with amphotericin B, liposomal amphotericin B, and micafungin against murine pulmonary aspergillosis
    • Kakeya H, Miyazaki Y, Senda H, Kobayashi T, Seki M, Izumikawa K et al (2008a) Efficacy of SPK-843, a novel polyene antifungal, in comparison with amphotericin B, liposomal amphotericin B, and micafungin against murine pulmonary aspergillosis. Antimicrob Agents Chemother 52:1868-1870
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 1868-1870
    • Kakeya, H.1    Miyazaki, Y.2    Senda, H.3    Kobayashi, T.4    Seki, M.5    Izumikawa, K.6
  • 41
    • 0027404563 scopus 로고
    • Mer-WF3010, a new member of the papulacandin family. I. Fermentation, isolation and characterization
    • Kaneto R, Chiba H, Agematu H, Shibamoto N, Yoshioka T, Nishida H et al (1993) Mer-WF3010, a new member of the papulacandin family. I. Fermentation, isolation and characterization. J Antibiot (Tokyo) 46:247-250
    • (1993) J Antibiot (Tokyo) , vol.46 , pp. 247-250
    • Kaneto, R.1    Chiba, H.2    Agematu, H.3    Shibamoto, N.4    Yoshioka, T.5    Nishida, H.6
  • 42
    • 0038345493 scopus 로고    scopus 로고
    • In vitro activity of a new polyene SPK-843 against Candida spp, Cryptococcus neoformans and Aspergillus spp. clinical isolates
    • Kantarcioglu AS, Yucel A, Vidotto V (2003) In vitro activity of a new polyene SPK-843 against Candida spp, Cryptococcus neoformans and Aspergillus spp. clinical isolates. J Chemother 15:296-298
    • (2003) J Chemother , vol.15 , pp. 296-298
    • Kantarcioglu, A.S.1    Yucel, A.2    Vidotto, V.3
  • 43
    • 3342996550 scopus 로고    scopus 로고
    • Comparison of gene expression profiles of Candida albicans azole-resistant clinical isolates and laboratory strains exposed to drugs inducing multidrug transporters
    • Karababa M, Coste AT, Rognon B, Bille J, Sanglard D (2004) Comparison of gene expression profiles of Candida albicans azole-resistant clinical isolates and laboratory strains exposed to drugs inducing multidrug transporters. Antimicrob Agents Chemother 48:3064-3079
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 3064-3079
    • Karababa, M.1    Coste, A.T.2    Rognon, B.3    Bille, J.4    Sanglard, D.5
  • 44
    • 0035120054 scopus 로고    scopus 로고
    • Identification and expression of multidrug resistance related ABC transporter genes in Candida krusei
    • Katiyar SK, Edlind TD (2001) Identification and expression of multidrug resistance related ABC transporter genes in Candida krusei. Med Mycol 39:109-116
    • (2001) Med Mycol , vol.39 , pp. 109-116
    • Katiyar, S.K.1    Edlind, T.D.2
  • 47
    • 0036208102 scopus 로고    scopus 로고
    • In vitro low-level resistance to azole in Candida albicans is associated with changes in membrane fluidity and asymmetry
    • Kohli A, Smirti, Mukhopadhyay K, Rattan A, Prasad R (2002) In vitro low-level resistance to azole in Candida albicans is associated with changes in membrane fluidity and asymmetry. Antimicrob Agents Chemother 46:1046-1052
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 1046-1052
    • Kohli, A.1    Smirti, M.K.2    Rattan, A.3    Prasad, R.4
  • 48
    • 0024785652 scopus 로고
    • Cispentacin, a new antifungal antibiotic. I. Production, isolation, physico-chemical properties and structure
    • Konishi M, Nishio M, Saitoh K, Miyaki T, Oki T, Kawaguchi H (1989) Cispentacin, a new antifungal antibiotic. I. Production, isolation, physico-chemical properties and structure. J Antibiot (Tokyo) 42:1749-1755
    • (1989) J Antibiot (Tokyo) , vol.42 , pp. 1749-1755
    • Konishi, M.1    Nishio, M.2    Saitoh, K.3    Miyaki, T.4    Oki, T.5    Kawaguchi, H.6
  • 49
    • 3142672919 scopus 로고    scopus 로고
    • A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains
    • Kusch H, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, HeckerMet al (2004) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains. Mol Genet Genomics 271:554-565
    • (2004) Mol Genet Genomics , vol.271 , pp. 554-565
    • Kusch, H.1    Biswas, K.2    Schwanfelder, S.3    Engelmann, S.4    Rogers, P.D.5    Hecker, M.6
  • 50
    • 0032814526 scopus 로고    scopus 로고
    • Purification, reconstitution, and inhibition of cytochrome P-450 sterol delta22-desaturase from the pathogenic fungus Candida glabrata
    • Lamb DC, Maspahy S, Kelly DE, Manning NJ, Geber A, Bennett JE et al (1999) Purification, reconstitution, and inhibition of cytochrome P-450 sterol delta22-desaturase from the pathogenic fungus Candida glabrata. Antimicrob Agents Chemother 43:1725-1728
    • (1999) Antimicrob Agents Chemother , vol.43 , pp. 1725-1728
    • Lamb, D.C.1    Maspahy, S.2    Kelly, D.E.3    Manning, N.J.4    Geber, A.5    Bennett, J.E.6
  • 53
    • 0034896166 scopus 로고    scopus 로고
    • Rationale for combination antifungal therapy
    • Lewis RE, Kontoyiannis DP (2001) Rationale for combination antifungal therapy. Pharmacotherapy 21:149S-164S
    • (2001) Pharmacotherapy , vol.21 , pp. 149S-164S
    • Lewis, R.E.1    Kontoyiannis, D.P.2
  • 54
    • 18844393429 scopus 로고    scopus 로고
    • Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans
    • Liu TT, Lee REB, Barker KS, Lee RE,Wei L, Homayouni R et al (2005) Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans. Antimicrob Agents Chemother 49:2226-2236
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 2226-2236
    • Liu, T.T.1    Lee, R.E.B.2    Barker, K.S.3    Lee, R.E.4    Wei, L.5    Homayouni, R.6
  • 55
    • 77950215343 scopus 로고    scopus 로고
    • Candidosis, a new challenge
    • López-Martínez R (2010) Candidosis, a new challenge. Clin Dermatol 28:178-184
    • (2010) Clin Dermatol , vol.28 , pp. 178-184
    • López-Martínez, R.1
  • 57
    • 17744410925 scopus 로고    scopus 로고
    • Rustmicin, a potent antifungal agent, inhibits sphingolipid synthesis at inositol phosphoceramide synthase
    • Mandala SM, Thornton RA,Milligan J, Rosenbach M, Garcia-Calvo M, Bull HG et al (1998) Rustmicin, a potent antifungal agent, inhibits sphingolipid synthesis at inositol phosphoceramide synthase. J Biol Chem 273:14942-14949
    • (1998) J Biol Chem , vol.273 , pp. 14942-14949
    • Mandala, S.M.1    Thornton, R.A.2    Milligan, J.3    Rosenbach, M.4    Garcia-Calvo, M.5    Bull, H.G.6
  • 58
    • 78149321014 scopus 로고    scopus 로고
    • Azole drugs are imported by facilitated diffusion in Candida albicans and other pathogenic fungi
    • Mansfield BE, Oltean HN, Oliver BG, Hoot SJ, Leyde SE, Hedstrom L et al (2010) Azole drugs are imported by facilitated diffusion in Candida albicans and other pathogenic fungi. PLoS Pathog 6(9):e1001126
    • (2010) PLoS Pathog , vol.6 , Issue.9
    • Mansfield, B.E.1    Oltean, H.N.2    Oliver, B.G.3    Hoot, S.J.4    Leyde, S.E.5    Hedstrom, L.6
  • 59
    • 0032826408 scopus 로고    scopus 로고
    • Contribution of mutations in the cytochrome P450 14alpha-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans
    • Marichal P, Koymans L, Willemsens S, Bellens D, Verhasselt P, Luyten W et al (1999) Contribution of mutations in the cytochrome P450 14alpha-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans. Microbiology 145:2701-2713
    • (1999) Microbiology , vol.145 , pp. 2701-2713
    • Marichal, P.1    Koymans, L.2    Willemsens, S.3    Bellens, D.4    Verhasselt, P.5    Luyten, W.6
  • 60
    • 77956101405 scopus 로고    scopus 로고
    • A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B
    • Martel CM, Parker JE, Bader O, Weig M, Gross U, Warrilow AG et al (2010) A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B. Antimicrob Agents Chemother 54:3578-3583
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 3578-3583
    • Martel, C.M.1    Parker, J.E.2    Bader, O.3    Weig, M.4    Gross, U.5    Warrilow, A.G.6
  • 61
    • 67651214054 scopus 로고    scopus 로고
    • In vitro analyses of the combination of high-dose doxycycline and antifungal agents against Candida albicans biofilms
    • Miceli MH, Bernardo SM, Lee SA (2009) In vitro analyses of the combination of high-dose doxycycline and antifungal agents against Candida albicans biofilms. Int J Antimicrob Agents 34:326-332
    • (2009) Int J Antimicrob Agents , vol.34 , pp. 326-332
    • Miceli, M.H.1    Bernardo, S.M.2    Lee, S.A.3
  • 63
    • 0031807604 scopus 로고    scopus 로고
    • Fluconazole resistance associated with drug efflux and increased transcription of a drug transporter gene, PDH1, in Candida glabrata
    • Miyazaki H, Miyazaki Y, Geber A, Parkinson T, Hitchcock C et al (1998) Fluconazole resistance associated with drug efflux and increased transcription of a drug transporter gene, PDH1, in Candida glabrata. Antimicrob Agents Chemother 42:1695-1701
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 1695-1701
    • Miyazaki, H.1    Miyazaki, Y.2    Geber, A.3    Parkinson, T.4    Hitchcock, C.5
  • 65
    • 77749291956 scopus 로고    scopus 로고
    • Screening for amino acid substitutions in the Candida albicans Erg11 protein of azole-susceptible and azole-resistant clinical isolates: New substitutions and a review of the literature
    • Morio F, Loge C, Besse B, Hennequin C, Le Pape P (2010) Screening for amino acid substitutions in the Candida albicans Erg11 protein of azole-susceptible and azole-resistant clinical isolates: new substitutions and a review of the literature. Diagn Microbiol Infect Dis 66:373-384
    • (2010) Diagn Microbiol Infect Dis , vol.66 , pp. 373-384
    • Morio, F.1    Loge, C.2    Besse, B.3    Hennequin, C.4    Le Pape, P.5
  • 66
    • 0035100252 scopus 로고    scopus 로고
    • Chs1 of Candida albicans is an essential chitin synthase required for synthesis of the septum and for cell integrity
    • Munro CA, Winter K, Buchan A, Henry K, Becker JM, Brown AJ et al (2001) Chs1 of Candida albicans is an essential chitin synthase required for synthesis of the septum and for cell integrity. Mol Microbiol 39:1414-1426
    • (2001) Mol Microbiol , vol.39 , pp. 1414-1426
    • Munro, C.A.1    Winter, K.2    Buchan, A.3    Henry, K.4    Becker, J.M.5    Brown, A.J.6
  • 67
    • 0030970048 scopus 로고    scopus 로고
    • Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene
    • Nagiec MM, Nagiec EE, Baltisberger JA, Wells GB, Lester RL, Dickson RC (1997) Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene. J Biol Chem 272:9809-9817
    • (1997) J Biol Chem , vol.272 , pp. 9809-9817
    • Nagiec, M.M.1    Nagiec, E.E.2    Baltisberger, J.A.3    Wells, G.B.4    Lester, R.L.5    Dickson, R.C.6
  • 68
    • 62449205550 scopus 로고    scopus 로고
    • In vitro antifungal combination effects of micafungin with fluconazole, voriconazole, amphotericin B, and flucytosine against clinical isolates of Candida species
    • Nishi I, Sunada A, Toyokawa M, Asari S, Iwatani Y (2009) In vitro antifungal combination effects of micafungin with fluconazole, voriconazole, amphotericin B, and flucytosine against clinical isolates of Candida species. J Infect Chemother 15:1-5
    • (2009) J Infect Chemother , vol.15 , pp. 1-5
    • Nishi, I.1    Sunada, A.2    Toyokawa, M.3    Asari, S.4    Iwatani, Y.5
  • 70
    • 0032424148 scopus 로고    scopus 로고
    • BE-31405, a new antifungal antibiotic produced by Penicillium minioluteum. I. Description of producing organism, fermentation, isolation, physico-chemical and biological properties
    • Okada H, Kamiya S, Shiina Y, Suwa H, Nagashima M, Nakajima S et al (1998) BE-31405, a new antifungal antibiotic produced by Penicillium minioluteum. I. Description of producing organism, fermentation, isolation, physico-chemical and biological properties. J Antibiot (Tokyo) 51:1081-1086
    • (1998) J Antibiot (Tokyo) , vol.51 , pp. 1081-1086
    • Okada, H.1    Kamiya, S.2    Shiina, Y.3    Suwa, H.4    Nagashima, M.5    Nakajima, S.6
  • 71
    • 28844452426 scopus 로고    scopus 로고
    • Treatment of Candida glabrata infection in immunosuppressed mice by using a combination of liposomal amphotericin B with caspofungin or micafungin
    • Olson JA, Adler-Moore JP, Smith PJ, Proffitt RT (2005) Treatment of Candida glabrata infection in immunosuppressed mice by using a combination of liposomal amphotericin B with caspofungin or micafungin. Antimicrob Agents Chemother 49:4895-4902
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 4895-4902
    • Olson, J.A.1    Adler-Moore, J.P.2    Smith, P.J.3    Proffitt, R.T.4
  • 72
    • 78449252630 scopus 로고    scopus 로고
    • Intragenic suppressing mutations correct the folding and intracellular traffic of misfolded mutants of Yor1p, a eukaryotic drug transporter
    • Pagant S, Halliday JJ, Kougentakis C, Miller EA (2010) Intragenic suppressing mutations correct the folding and intracellular traffic of misfolded mutants of Yor1p, a eukaryotic drug transporter. J Biol Chem 285:36304-36314
    • (2010) J Biol Chem , vol.285 , pp. 36304-36314
    • Pagant, S.1    Halliday, J.J.2    Kougentakis, C.3    Miller, E.A.4
  • 73
    • 46249131625 scopus 로고    scopus 로고
    • Activities and ultrastructural effects of antifungal combinations against simulated Candida endocardial vegetations
    • Pai MP, Samples ML, Mercier RC, Spilde MN (2008) Activities and ultrastructural effects of antifungal combinations against simulated Candida endocardial vegetations. Antimicrob Agents Chemother 52:2367-2376
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 2367-2376
    • Pai, M.P.1    Samples, M.L.2    Mercier, R.C.3    Spilde, M.N.4
  • 74
    • 44449114759 scopus 로고    scopus 로고
    • Isolation and structure elucidation of parnafungins, antifungal natural products that inhibit mRNA polyadenylation
    • Parish CA, Smith SK, Calati K, Zink D, Wilson K, Roemer T et al (2008) Isolation and structure elucidation of parnafungins, antifungal natural products that inhibit mRNA polyadenylation. J Am Chem Soc 130:7060-7066
    • (2008) J Am Chem Soc , vol.130 , pp. 7060-7066
    • Parish, C.A.1    Smith, S.K.2    Calati, K.3    Zink, D.4    Wilson, K.5    Roemer, T.6
  • 75
    • 23044471740 scopus 로고    scopus 로고
    • Specific substitutions in the echinocandin target Fks1p account for reduced susceptibility of rare laboratory and clinical Candida sp. isolates
    • Park S, Kelly R, Kahn JN, Robles J, Hsu MJ, Register E et al (2005) Specific substitutions in the echinocandin target Fks1p account for reduced susceptibility of rare laboratory and clinical Candida sp. isolates. Antimicrob Agents Chemother 49:3264-3273
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 3264-3273
    • Park, S.1    Kelly, R.2    Kahn, J.N.3    Robles, J.4    Hsu, M.J.5    Register, E.6
  • 76
    • 33947672774 scopus 로고    scopus 로고
    • Structure and function analysis of CaMdr1p, a major facilitator superfamily antifungal efflux transporter protein of Candida albicans: Identification of amino acid residues critical for drug/HC transport
    • Pasrija R, Banerjee D, Prasad R (2007) Structure and function analysis of CaMdr1p, a major facilitator superfamily antifungal efflux transporter protein of Candida albicans: identification of amino acid residues critical for drug/HC transport. Eukaryot Cell 6:443-453
    • (2007) Eukaryot Cell , vol.6 , pp. 443-453
    • Pasrija, R.1    Banerjee, D.2    Prasad, R.3
  • 77
    • 34447105864 scopus 로고    scopus 로고
    • Resistance to echinocandin-class antifungal drugs
    • Perlin DS (2007) Resistance to echinocandin-class antifungal drugs. Drug Resist Updat 10:121- 130
    • (2007) Drug Resist Updat , vol.10 , pp. 121-130
    • Perlin, D.S.1
  • 78
    • 79955625171 scopus 로고    scopus 로고
    • Current perspectives on echinocandin class drugs
    • Perlin DS (2011) Current perspectives on echinocandin class drugs. Future Microbiol 6:441-457
    • (2011) Future Microbiol , vol.6 , pp. 441-457
    • Perlin, D.S.1
  • 79
    • 4644234808 scopus 로고    scopus 로고
    • Efficacy of PLD-118, a novel inhibitor of candida isoleucyl-tRNA synthetase, against experimental oropharyngeal and esophageal candidiasis caused by fluconazole-resistant C. albicans
    • Petraitis V, Petraitiene R, Kelaher AM, Sarafandi AA, Sein T, Mickiene D et al (2004) Efficacy of PLD-118, a novel inhibitor of candida isoleucyl-tRNA synthetase, against experimental oropharyngeal and esophageal candidiasis caused by fluconazole-resistant C. albicans. Antimicrob Agents Chemother 48:3959-3967
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 3959-3967
    • Petraitis, V.1    Petraitiene, R.2    Kelaher, A.M.3    Sarafandi, A.A.4    Sein, T.5    Mickiene, D.6
  • 80
    • 84858704434 scopus 로고    scopus 로고
    • Yeast ATP-binding cassette transporters conferring multidrug resistance
    • Prasad R, Goffeau A (2012) Yeast ATP-binding cassette transporters conferring multidrug resistance. Annu Rev Microbiol 66:39-63
    • (2012) Annu Rev Microbiol , vol.66 , pp. 39-63
    • Prasad, R.1    Goffeau, A.2
  • 81
    • 10444285332 scopus 로고    scopus 로고
    • Multidrug resistance in yeast Candida
    • Prasad R, Kapoor K (2005) Multidrug resistance in yeast Candida. Int Rev Cytol 242:215-248
    • (2005) Int Rev Cytol , vol.242 , pp. 215-248
    • Prasad, R.1    Kapoor, K.2
  • 82
    • 0028928549 scopus 로고
    • Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals
    • Prasad R, DeWergifosse P, Goffeau A, Balzi E (1995) Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals. Curr Genet 27:320-329
    • (1995) Curr Genet , vol.27 , pp. 320-329
    • Prasad, R.1    DeWergifosse, P.2    Goffeau, A.3    Balzi, E.4
  • 85
    • 84922217054 scopus 로고    scopus 로고
    • Antifungal drug development: Challenges, unmet clinical needs, and new approaches
    • pii:a019703
    • Roemer T, Krysan DJ (2014) Antifungal drug development: challenges, unmet clinical needs, and new approaches. Cold Spring Harb Perspect Med 4 pii:a019703
    • (2014) Cold Spring Harb Perspect Med , pp. 4
    • Roemer, T.1    Krysan, D.J.2
  • 87
    • 0032734512 scopus 로고    scopus 로고
    • The ATP binding cassette transporter gene CgCDR1 from Candida glabrata is involved in the resistance of clinical isolates to azole antifungal agents
    • Sanglard D, Ischer F, Calabrese D, Majcherczyk PA, Bille J (1999) The ATP binding cassette transporter gene CgCDR1 from Candida glabrata is involved in the resistance of clinical isolates to azole antifungal agents. Antimicrob Agents Chemother 43:2753-2765
    • (1999) Antimicrob Agents Chemother , vol.43 , pp. 2753-2765
    • Sanglard, D.1    Ischer, F.2    Calabrese, D.3    Majcherczyk, P.A.4    Bille, J.5
  • 88
    • 0043270593 scopus 로고    scopus 로고
    • Candida albicans mutations in the ergosterol biosynthetic pathway and resistance to several antifungal agents
    • Sanglard D, Ischer F, Parkinson T, Falconer D, Bille J (2003) Candida albicans mutations in the ergosterol biosynthetic pathway and resistance to several antifungal agents. Antimicrob Agents Chemother 47:2404-2412
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 2404-2412
    • Sanglard, D.1    Ischer, F.2    Parkinson, T.3    Falconer, D.4    Bille, J.5
  • 89
    • 70350026151 scopus 로고    scopus 로고
    • Antifungal drug resistance mechanisms in fungal pathogens from the perspective of transcriptional gene regulation
    • Sanglard D, Coste A, Ferrari S (2009) Antifungal drug resistance mechanisms in fungal pathogens from the perspective of transcriptional gene regulation. FEMS Yeast Res 9:1029-1050
    • (2009) FEMS Yeast Res , vol.9 , pp. 1029-1050
    • Sanglard, D.1    Coste, A.2    Ferrari, S.3
  • 90
    • 31844440045 scopus 로고    scopus 로고
    • Role of AFR1, an ABC transporter-encoding gene, in the in vivo response to fluconazole and virulence of Cryptococcus neoformans
    • Sanguinetti M, Posteraro B, La Sorda M, Torelli R, Fiori B, Santangelo R et al (2006) Role of AFR1, an ABC transporter-encoding gene, in the in vivo response to fluconazole and virulence of Cryptococcus neoformans. Infect Immun 74:1352-1359
    • (2006) Infect Immun , vol.74 , pp. 1352-1359
    • Sanguinetti, M.1    Posteraro, B.2    La Sorda, M.3    Torelli, R.4    Fiori, B.5    Santangelo, R.6
  • 91
    • 84864387155 scopus 로고    scopus 로고
    • Inducible and constitutive activation of two polymorphic promoter alleles of the Candida albicans multidrug efflux pump MDR1
    • Sasse C, Schillig R, Reimund A, Merk J, Morschhäuser J (2012) Inducible and constitutive activation of two polymorphic promoter alleles of the Candida albicans multidrug efflux pump MDR1. Antimicrob Agents Chemother 56:4490-4494
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 4490-4494
    • Sasse, C.1    Schillig, R.2    Reimund, A.3    Merk, J.4    Morschhäuser, J.5
  • 92
  • 93
    • 79958060479 scopus 로고    scopus 로고
    • Regulatory circuitry governing fungal development, drug resistance, and disease
    • Shapiro RS, Robbins N, Cowen LE (2011) Regulatory circuitry governing fungal development, drug resistance, and disease. Microbiol Mol Biol Rev 75:213-267
    • (2011) Microbiol Mol Biol Rev , vol.75 , pp. 213-267
    • Shapiro, R.S.1    Robbins, N.2    Cowen, L.E.3
  • 94
    • 67749099622 scopus 로고    scopus 로고
    • Curcumin modulates efflux mediated by yeast ABC multidrug transporters and is synergistic with antifungals
    • Sharma M, Manoharlal R, Shukla S, Puri N, Prasad T, Ambudkar SV et al (2009) Curcumin modulates efflux mediated by yeast ABC multidrug transporters and is synergistic with antifungals. Antimicrob Agents Chemother 53:3256-3265
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 3256-3265
    • Sharma, M.1    Manoharlal, R.2    Shukla, S.3    Puri, N.4    Prasad, T.5    Ambudkar, S.V.6
  • 95
    • 78650862876 scopus 로고    scopus 로고
    • Antifungal curcumin induces reactive oxygen species and triggers an early apoptosis but prevents hyphae development by targeting the global repressor TUP1 in Candida albicans
    • Sharma M, Manoharlal R, Puri N, Prasad R (2010) Antifungal curcumin induces reactive oxygen species and triggers an early apoptosis but prevents hyphae development by targeting the global repressor TUP1 in Candida albicans. Biosci Rep 30:391-404
    • (2010) Biosci Rep , vol.30 , pp. 391-404
    • Sharma, M.1    Manoharlal, R.2    Puri, N.3    Prasad, R.4
  • 96
    • 78650424102 scopus 로고    scopus 로고
    • The combination of minocycline and fluconazole causes synergistic growth inhibition against Candida albicans: An in vitro interaction of antifungal and antibacterial agents
    • Shi W, Chen Z, Chen X, Cao L, Liu P, Sun S (2010) The combination of minocycline and fluconazole causes synergistic growth inhibition against Candida albicans: an in vitro interaction of antifungal and antibacterial agents. FEMS Yeast Res 10:885-893
    • (2010) FEMS Yeast Res , vol.10 , pp. 885-893
    • Shi, W.1    Chen, Z.2    Chen, X.3    Cao, L.4    Liu, P.5    Sun, S.6
  • 98
    • 0034329375 scopus 로고    scopus 로고
    • Membrane transporters and antifungal drug resistance
    • St Georgiev V (2000) Membrane transporters and antifungal drug resistance. Curr Drug Targets 1:261-284
    • (2000) Curr Drug Targets , vol.1 , pp. 261-284
    • St Georgiev, V.1
  • 100
    • 0030781143 scopus 로고    scopus 로고
    • Cloning and characterization of CneMDR1: A Cryptococcus neoformans gene encoding a protein related to multidrug resistance proteins
    • Thornewell SJ, Peery RB, Skatrud PL (1997) Cloning and characterization of CneMDR1: a Cryptococcus neoformans gene encoding a protein related to multidrug resistance proteins. Gene 201:21-29
    • (1997) Gene , vol.201 , pp. 21-29
    • Thornewell, S.J.1    Peery, R.B.2    Skatrud, P.L.3
  • 102
    • 77950809214 scopus 로고    scopus 로고
    • Antifungal activity of amphotericin B, caspofungin and posaconazole on Candida albicans biofilms in intermediate and mature development phases
    • Tobudic S, Lassnigg A, Kratzer C, Graninger W, Presterl E (2010b) Antifungal activity of amphotericin B, caspofungin and posaconazole on Candida albicans biofilms in intermediate and mature development phases. Mycoses 53:208-214
    • (2010) Mycoses , vol.53 , pp. 208-214
    • Tobudic, S.1    Lassnigg, A.2    Kratzer, C.3    Graninger, W.4    Presterl, E.5
  • 103
    • 40549126935 scopus 로고    scopus 로고
    • The ATP-binding cassette transporter-encoding gene CgSNQ2 is contributing to the CgPDR1-dependent azole resistance of Candida glabrata
    • Torelli R, Posteraro B, Ferrari S, La Sorda M, Fadda G, Sanglard D et al (2008) The ATP-binding cassette transporter-encoding gene CgSNQ2 is contributing to the CgPDR1-dependent azole resistance of Candida glabrata. Mol Microbiol 68:186-201
    • (2008) Mol Microbiol , vol.68 , pp. 186-201
    • Torelli, R.1    Posteraro, B.2    Ferrari, S.3    La Sorda, M.4    Fadda, G.5    Sanglard, D.6
  • 104
    • 40549140735 scopus 로고    scopus 로고
    • Synergistic effect of calcineurin inhibitors and fluconazole against Candida albicans biofilms
    • Uppuluri P, Nett J, Heitman J, Andes D (2008) Synergistic effect of calcineurin inhibitors and fluconazole against Candida albicans biofilms. Antimicrob Agents Chemother 52:1127-1132
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 1127-1132
    • Uppuluri, P.1    Nett, J.2    Heitman, J.3    Andes, D.4
  • 105
    • 0027441959 scopus 로고
    • Effects of itraconazole on cytochrome P-450-dependent sterol 14 alpha-demethylation and reduction of 3-ketosteroids in Cryptococcus neoformans
    • Vanden Bossche H, Marichal P, Le Jeune L, Coene MC, Gorrens J, Cools W (1993) Effects of itraconazole on cytochrome P-450-dependent sterol 14 alpha-demethylation and reduction of 3-ketosteroids in Cryptococcus neoformans. Antimicrob Agents Chemother 37:2101-2105
    • (1993) Antimicrob Agents Chemother , vol.37 , pp. 2101-2105
    • Vanden Bossche, H.1    Marichal, P.2    Le Jeune, L.3    Coene, M.C.4    Gorrens, J.5    Cools, W.6
  • 106
    • 33847611100 scopus 로고    scopus 로고
    • Reduced susceptibility to polyenes associated with a missense mutation in the ERG6 gene in a clinical isolate of Candida glabrata with pseudohyphal growth
    • Vandeputte P, Tronchin G, Berge's T, Hennequin C, Chabasse D, Bouchara JP (2007) Reduced susceptibility to polyenes associated with a missense mutation in the ERG6 gene in a clinical isolate of Candida glabrata with pseudohyphal growth. Antimicrob Agents Chemother 51:982-990
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 982-990
    • Vandeputte, P.1    Tronchin, G.2    Berge's, T.3    Hennequin, C.4    Chabasse, D.5    Bouchara, J.P.6
  • 107
    • 84855683118 scopus 로고    scopus 로고
    • Antifungal resistance and new strategies to control fungal infections
    • Vandeputte P, Ferrari S, Coste AT (2012) Antifungal resistance and new strategies to control fungal infections. Int J Microbiol 2012:713687
    • (2012) Int J Microbiol , vol.2012
    • Vandeputte, P.1    Ferrari, S.2    Coste, A.T.3
  • 109
    • 69549122668 scopus 로고    scopus 로고
    • Rapid detection of ERG11 gene mutations in clinical Candida albicans isolates with reduced susceptibility to fluconazole by rolling circle amplification and DNA sequencing
    • Wang H, Kong F, Sorrell TC, Wang B, McNicholas P, Pantarat N et al (2009) Rapid detection of ERG11 gene mutations in clinical Candida albicans isolates with reduced susceptibility to fluconazole by rolling circle amplification and DNA sequencing. BMC Microbiol 14:167
    • (2009) BMC Microbiol , vol.14 , pp. 167
    • Wang, H.1    Kong, F.2    Sorrell, T.C.3    Wang, B.4    McNicholas, P.5    Pantarat, N.6
  • 110
    • 27844588529 scopus 로고    scopus 로고
    • Regulation of sterol metabolism in Candida albicans by the UPC2 gene
    • White TC, Silver PM (2005) Regulation of sterol metabolism in Candida albicans by the UPC2 gene. Biochem Soc Trans 33:1215-1218
    • (2005) Biochem Soc Trans , vol.33 , pp. 1215-1218
    • White, T.C.1    Silver, P.M.2
  • 111
    • 0031969879 scopus 로고    scopus 로고
    • Clinical, cellular, and molecular factors that contribute to antifungal drug resistance
    • White TC, Marr KA, Bowden RA (1998) Clinical, cellular, and molecular factors that contribute to antifungal drug resistance. Clin Microbiol Rev 11:382-402
    • (1998) Clin Microbiol Rev , vol.11 , pp. 382-402
    • White, T.C.1    Marr, K.A.2    Bowden, R.A.3
  • 114
    • 0042424651 scopus 로고    scopus 로고
    • Disruption of ergosterol biosynthesis confers resistance to amphotericin B in Candida lusitaniae
    • Young LY, Hull CM, Heitman J (2003) Disruption of ergosterol biosynthesis confers resistance to amphotericin B in Candida lusitaniae. Antimicrob Agents Chemother 47:2717-2724
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 2717-2724
    • Young, L.Y.1    Hull, C.M.2    Heitman, J.3
  • 115
    • 77954685203 scopus 로고    scopus 로고
    • Requirement for ergosterol in V-ATPase function underlies antifungal activity of azole drugs
    • Zhang YQ, Gamarra S, Garcia-Effron G, Park S, Perlin DS, Rao R (2010) Requirement for ergosterol in V-ATPase function underlies antifungal activity of azole drugs. PLoS Pathog 6:e1000939
    • (2010) PLoS Pathog , vol.6
    • Zhang, Y.Q.1    Gamarra, S.2    Garcia-Effron, G.3    Park, S.4    Perlin, D.S.5    Rao, R.6


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