메뉴 건너뛰기




Volumn 271, Issue 5, 2004, Pages 554-565

A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains

Author keywords

Gene regulation; Multidrug efflux pumps; Proteomics; Regulatory networks; Two dimensional gel electrophoresis

Indexed keywords

FLUCONAZOLE; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2;

EID: 3142672919     PISSN: 16174615     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00438-004-0984-x     Document Type: Article
Times cited : (42)

References (38)
  • 1
    • 0032891070 scopus 로고    scopus 로고
    • The bZip transcription factor Cap1p is involved in multidrug resistance and oxidative stress response in Candida albicans
    • Alarco AM, Raymond M (1999) The bZip transcription factor Cap1p is involved in multidrug resistance and oxidative stress response in Candida albicans. J Bacteriol 181:700-708
    • (1999) J Bacteriol , vol.181 , pp. 700-708
    • Alarco, A.M.1    Raymond, M.2
  • 3
    • 0344329881 scopus 로고    scopus 로고
    • Dual channel imaging of two-dimensional electropherograms in Bacillus subtilis
    • Bernhardt J, Büttner K, Scharf C, Hecker M (1999) Dual channel imaging of two-dimensional electropherograms in Bacillus subtilis. Electrophoresis 20:2225-2240
    • (1999) Electrophoresis , vol.20 , pp. 2225-2240
    • Bernhardt, J.1    Büttner, K.2    Scharf, C.3    Hecker, M.4
  • 4
    • 84988074679 scopus 로고
    • Improved silver staining of plant proteins, RNA and DNA in polyacrylamide gels
    • Blum H, Beier H, Gross HJ (1987) Improved silver staining of plant proteins, RNA and DNA in polyacrylamide gels. Electrophoresis 8:93-99
    • (1987) Electrophoresis , vol.8 , pp. 93-99
    • Blum, H.1    Beier, H.2    Gross, H.J.3
  • 7
    • 0036223414 scopus 로고    scopus 로고
    • A common drug-responsive element mediates the upregulation of the C andida albicans ABC transporters CDR1 and CDR2, two genes involved in antifungal drug resistance
    • De Micheli M, Bille J, Schueller C, Sanglard D (2002) A common drug-responsive element mediates the upregulation of the C andida albicans ABC transporters CDR1 and CDR2, two genes involved in antifungal drug resistance. Mol Microbiol 43:1197-1214
    • (2002) Mol Microbiol , vol.43 , pp. 1197-1214
    • De Micheli, M.1    Bille, J.2    Schueller, C.3    Sanglard, D.4
  • 8
    • 0025774660 scopus 로고
    • Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methotrexate
    • Fling ME, Kopf J, Tamarkin A, Gorman JA, Smith HA, Koltin Y (1991) Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methotrexate. Mol Gen Genet 227:318-329
    • (1991) Mol Gen Genet , vol.227 , pp. 318-329
    • Fling, M.E.1    Kopf, J.2    Tamarkin, A.3    Gorman, J.A.4    Smith, H.A.5    Koltin, Y.6
  • 9
    • 0027192868 scopus 로고
    • Isogenic strain construction and gene mapping in Candida albicans
    • Fonzi WA, Irwin MY (1993) Isogenic strain construction and gene mapping in Candida albicans. Genetics 134:717-728
    • (1993) Genetics , vol.134 , pp. 717-728
    • Fonzi, W.A.1    Irwin, M.Y.2
  • 10
    • 0031759244 scopus 로고    scopus 로고
    • Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains
    • Franz R, Kelly SL, Lamb DC, Kelly DE, Ruhnke M, Morschhäuser J (1998) Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains. Antimicrob Agents Chemother 42:3065-3072
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 3065-3072
    • Franz, R.1    Kelly, S.L.2    Lamb, D.C.3    Kelly, D.E.4    Ruhnke, M.5    Morschhäuser, J.6
  • 11
    • 0032888237 scopus 로고    scopus 로고
    • Molecular aspects of fluconazole resistance development in Candida albicans
    • Franz R, Ruhnke M, Morschhäuser J (1999) Molecular aspects of fluconazole resistance development in Candida albicans. Mycoses 42:453-458
    • (1999) Mycoses , vol.42 , pp. 453-458
    • Franz, R.1    Ruhnke, M.2    Morschhäuser, J.3
  • 13
    • 0021742042 scopus 로고
    • Isolation of the Candida albicans gene for orotidine-5′-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations
    • Gillum AM, Tsay EY, Kirsch DR (1984) Isolation of the Candida albicans gene for orotidine-5′-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations. Mol Gen Genet 198:179-182
    • (1984) Mol Gen Genet , vol.198 , pp. 179-182
    • Gillum, A.M.1    Tsay, E.Y.2    Kirsch, D.R.3
  • 14
    • 0030938651 scopus 로고    scopus 로고
    • Overexpression of a cloned IMP dehydrogenase gene of Candida albicans confers resistance to the specific inhibitor mycophenolic acid
    • Köhler GA, White TC, Agabian N (1997) Overexpression of a cloned IMP dehydrogenase gene of Candida albicans confers resistance to the specific inhibitor mycophenolic acid. J Bacteriol 179:2331-2338
    • (1997) J Bacteriol , vol.179 , pp. 2331-2338
    • Köhler, G.A.1    White, T.C.2    Agabian, N.3
  • 15
    • 0031755686 scopus 로고    scopus 로고
    • Distinct patterns of gene expression associated with development of fluconazole resistance in serial Candida albicans isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis
    • Lopez-Ribot JL, McAtee RK, Lee LN, Kirkpatrick WR, White TC, Sanglard D, Patterson TF (1998) Distinct patterns of gene expression associated with development of fluconazole resistance in serial Candida albicans isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis. Antimicrob Agents Chemother 42:2932-2937
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 2932-2937
    • Lopez-Ribot, J.L.1    McAtee, R.K.2    Lee, L.N.3    Kirkpatrick, W.R.4    White, T.C.5    Sanglard, D.6    Patterson, T.F.7
  • 16
    • 0028324030 scopus 로고
    • Fluconazole-resistant recurrent oral candidiasis in human immunodeficiency virus-positive patients: Persistence of Candida albicans strains with the same genotype
    • Millon L, Manteaux A, Reboux G, Drobacheff C, Monod M, Barale T, Michel-Briand Y (1994) Fluconazole-resistant recurrent oral candidiasis in human immunodeficiency virus-positive patients: persistence of Candida albicans strains with the same genotype. J Clin Microbiol 32:1115-1118
    • (1994) J Clin Microbiol , vol.32 , pp. 1115-1118
    • Millon, L.1    Manteaux, A.2    Reboux, G.3    Drobacheff, C.4    Monod, M.5    Barale, T.6    Michel-Briand, Y.7
  • 17
    • 0037130284 scopus 로고    scopus 로고
    • The genetic basis of fluconazole resistance development in Candida albicans
    • Morschhäuser J (2002) The genetic basis of fluconazole resistance development in Candida albicans. Biochim Biophys Acta 1587:240-248
    • (2002) Biochim Biophys Acta , vol.1587 , pp. 240-248
    • Morschhäuser, J.1
  • 18
    • 0031952147 scopus 로고    scopus 로고
    • Expression of a chromosomally integrated, single-copy GFP gene in Candida albicans, and its use as a reporter of gene regulation
    • Morschhäuser J, Michel S, Hacker J (1998) Expression of a chromosomally integrated, single-copy GFP gene in Candida albicans, and its use as a reporter of gene regulation. Mol Gen Genet 257:412-420
    • (1998) Mol Gen Genet , vol.257 , pp. 412-420
    • Morschhäuser, J.1    Michel, S.2    Hacker, J.3
  • 19
    • 0032903245 scopus 로고    scopus 로고
    • Sequential gene disruption in Candida albicans by FLP-mediated site-specific recombination
    • Morschhäuser J, Michel S, Staib P (1999) Sequential gene disruption in Candida albicans by FLP-mediated site-specific recombination. Mol Microbiol 32:547-556
    • (1999) Mol Microbiol , vol.32 , pp. 547-556
    • Morschhäuser, J.1    Michel, S.2    Staib, P.3
  • 20
    • 0035846932 scopus 로고    scopus 로고
    • Multiple Yap1p-binding sites mediate the induction of the yeast major facilitator FLR1 gene in response to drugs, oxidants, and alkylating agents
    • Nguyen D-T, Alarco AM, Raymond M (2000) Multiple Yap1p-binding sites mediate the induction of the yeast major facilitator FLR1 gene in response to drugs, oxidants, and alkylating agents. J Biol Chem 276:1138-1145
    • (2000) J Biol Chem , vol.276 , pp. 1138-1145
    • Nguyen, D.-T.1    Alarco, A.M.2    Raymond, M.3
  • 22
    • 0034812585 scopus 로고    scopus 로고
    • Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients
    • Perea S, Lopez-Ribot JL, Kirkpatrick WR, McAtee RK, Santillan RA, Martinez M, Calabrese D, Sanglard D, Patterson TF (2001) Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients. Antimicrob Agents Chemother 45:2676-2684
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 2676-2684
    • Perea, S.1    Lopez-Ribot, J.L.2    Kirkpatrick, W.R.3    McAtee, R.K.4    Santillan, R.A.5    Martinez, M.6    Calabrese, D.7    Sanglard, D.8    Patterson, T.F.9
  • 23
    • 0028928549 scopus 로고
    • Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals
    • Prasad R, De Wergifosse P, Goffeau A, Balzi E (1995) Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals. Curr Genet 27:320-329
    • (1995) Curr Genet , vol.27 , pp. 320-329
    • Prasad, R.1    De Wergifosse, P.2    Goffeau, A.3    Balzi, E.4
  • 24
    • 0036839691 scopus 로고    scopus 로고
    • Evaluation of differential gene expression in fluconazole-susceptible and -resistant isolates of Candida albicans by cDNA microarray analysis
    • Rogers PD, Barker KS (2002) Evaluation of differential gene expression in fluconazole-susceptible and -resistant isolates of Candida albicans by cDNA microarray analysis. Antimicrob Agents Chemother 46:3412-3417
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 3412-3417
    • Rogers, P.D.1    Barker, K.S.2
  • 25
    • 0037378017 scopus 로고    scopus 로고
    • Genome-wide expression profile analysis reveals coordinately regulated genes associated with stepwise acquisition of azole resistance in Candida albicans clinical isolates
    • Rogers PD, Barker KS (2003) Genome-wide expression profile analysis reveals coordinately regulated genes associated with stepwise acquisition of azole resistance in Candida albicans clinical isolates. Antimicrob Agents Chemother 47:1220-1227
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 1220-1227
    • Rogers, P.D.1    Barker, K.S.2
  • 26
    • 0028001183 scopus 로고
    • Emergence of fluconazole-resistant strains of Candida albicans in patients with recurrent oropharyngeal candidosis and human immunodeficiency virus infection
    • Ruhnke M, Eigler A, Tennagen I, Geiseler B, Engelmann E, Trautmann M (1994) Emergence of fluconazole-resistant strains of Candida albicans in patients with recurrent oropharyngeal candidosis and human immunodeficiency virus infection. J Clin Microbiol 32:2092-2098
    • (1994) J Clin Microbiol , vol.32 , pp. 2092-2098
    • Ruhnke, M.1    Eigler, A.2    Tennagen, I.3    Geiseler, B.4    Engelmann, E.5    Trautmann, M.6
  • 27
    • 0028793725 scopus 로고
    • Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters
    • Sanglard D, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J (1995) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. Antimicrob Agents Chemother 39:2378-2386
    • (1995) Antimicrob Agents Chemother , vol.39 , pp. 2378-2386
    • Sanglard, D.1    Kuchler, K.2    Ischer, F.3    Pagani, J.L.4    Monod, M.5    Bille, J.6
  • 28
    • 0029820482 scopus 로고    scopus 로고
    • Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors
    • Sanglard D, Ischer F, Monod M, Bille J (1996) Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors. Antimicrob Agents Chemother 40:2300-2305
    • (1996) Antimicrob Agents Chemother , vol.40 , pp. 2300-2305
    • Sanglard, D.1    Ischer, F.2    Monod, M.3    Bille, J.4
  • 29
    • 0031047670 scopus 로고    scopus 로고
    • Cloning of Candida albicans genes conferring resistance to azole antifungal agents: Characterization of CDR2, a new multidrug ABC transporter gene
    • Sanglard D, Ischer F, Monod M, Bille J (1997) Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene. Microbiology 143:405-416
    • (1997) Microbiology , vol.143 , pp. 405-416
    • Sanglard, D.1    Ischer, F.2    Monod, M.3    Bille, J.4
  • 30
    • 0031938057 scopus 로고    scopus 로고
    • Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents
    • Sanglard D, Ischer F, Koymans L, Bille J (1998) Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents. Antimicrob Agents Chemother 42:241-253
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 241-253
    • Sanglard, D.1    Ischer, F.2    Koymans, L.3    Bille, J.4
  • 31
    • 0034989952 scopus 로고    scopus 로고
    • Cloning and analysis of a Candida albicans gene that affects cell surface hydrophobicity
    • Singleton DR, Masuoka J, Hazen KC (2001) Cloning and analysis of a Candida albicans gene that affects cell surface hydrophobicity. J Bacteriol 183:3582-3588
    • (2001) J Bacteriol , vol.183 , pp. 3582-3588
    • Singleton, D.R.1    Masuoka, J.2    Hazen, K.C.3
  • 32
    • 0030757227 scopus 로고    scopus 로고
    • Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus
    • White TC (1997a) Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus. Antimicrob Agents Chemother 41:1482-1487
    • (1997) Antimicrob Agents Chemother , vol.41 , pp. 1482-1487
    • White, T.C.1
  • 33
    • 0030792602 scopus 로고    scopus 로고
    • The presence of an R467K amino acid substitution and loss of allelic variation correlate with an azole-resistant lanosterol 14α demethylase in Candida albicans
    • White TC (1997b) The presence of an R467K amino acid substitution and loss of allelic variation correlate with an azole-resistant lanosterol 14α demethylase in Candida albicans. Antimicrob Agents Chemother 41:1488-1494
    • (1997) Antimicrob Agents Chemother , vol.41 , pp. 1488-1494
    • White, T.C.1
  • 34
    • 0031969879 scopus 로고    scopus 로고
    • Clinical, cellular, and molecular factors that contribute to antifungal drug resistance
    • White TC, Marr KA, Bowden RA (1998) Clinical, cellular, and molecular factors that contribute to antifungal drug resistance. Clin Microbiol Rev 11:382-402
    • (1998) Clin Microbiol Rev , vol.11 , pp. 382-402
    • White, T.C.1    Marr, K.A.2    Bowden, R.A.3
  • 35
    • 0033989179 scopus 로고    scopus 로고
    • Activation of the multiple drug resistance gene MDR1 in fluconazole-resistant, clinical Candida albicans strains is caused by mutations in a trans-regulatory factor
    • Wirsching S, Michel S, Köhler G, Morschhäuser J (2000a) Activation of the multiple drug resistance gene MDR1 in fluconazole-resistant, clinical Candida albicans strains is caused by mutations in a trans-regulatory factor. J Bacteriol 182:400-404
    • (2000) J Bacteriol , vol.182 , pp. 400-404
    • Wirsching, S.1    Michel, S.2    Köhler, G.3    Morschhäuser, J.4
  • 36
    • 0034081664 scopus 로고    scopus 로고
    • Targeted gene disruption in Candida albicans wild-type strains: The role of the MDR1 gene in fluconazole resistance of clinical Candida albicans isolates
    • Wirsching S, Michel S, Morschhäuser J (2000b) Targeted gene disruption in Candida albicans wild-type strains: the role of the MDR1 gene in fluconazole resistance of clinical Candida albicans isolates. Mol Microbiol 36:856-865
    • (2000) Mol Microbiol , vol.36 , pp. 856-865
    • Wirsching, S.1    Michel, S.2    Morschhäuser, J.3
  • 38
    • 0034100845 scopus 로고    scopus 로고
    • Analysis of the oxidative stress regulation of the C andida albicans transcription factor Cap1p
    • Zhang X, de Micheli M, Coleman ST, Sanglard D, Moye-Rowley WS (2000) Analysis of the oxidative stress regulation of the C andida albicans transcription factor Cap1p. Mol Microbiol 36:618-629
    • (2000) Mol Microbiol , vol.36 , pp. 618-629
    • Zhang, X.1    De Micheli, M.2    Coleman, S.T.3    Sanglard, D.4    Moye-Rowley, W.S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.