In vitro and in vivo antifungal activities of T-2307, a novel arylamidine

Antimicrobial Agents and Chemotherapy

Volumn 52, Issue 4, 2008, Pages 1318-1324

  Mitsuyama, Junichi ^a   Nomura, Nobuhiko ^a   Hashimoto, Kyoko ^a   Yamada, Eio ^a   Nishikawa, Hiroshi ^a   Kaeriyama, Makoto ^a   Kimura, Akiko ^a   Todo, Yozo ^a   Narita, Hirokazu ^a  

^a TOYAMA CHEMICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDINE; AMPHOTERICIN B; FLUCONAZOLE; MICAFUNGIN; T 2307; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLOSIS; ASPERGILLUS; CANDIDA ALBICANS; CANDIDIASIS; CONTROLLED STUDY; CRYPTOCOCCOSIS; CRYPTOCOCCUS NEOFORMANS; DOSE RESPONSE; FUNGAL STRAIN; IN VITRO STUDY; IN VIVO STUDY; MALE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIFUNGAL AGENTS; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; BENZAMIDINES; CANDIDA ALBICANS; CANDIDIASIS; CRYPTOCOCCOSIS; CRYPTOCOCCUS NEOFORMANS; MALE; MICE; MICE, INBRED ICR; MICROBIAL SENSITIVITY TESTS; MYCOSES; SPECIFIC PATHOGEN-FREE ORGANISMS; TREATMENT OUTCOME;

EID: 42049087374     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.01159-07     Document Type: Article

References (35)

1. Abi-Said, D., E. Anaissie, O. Uzun, I. Raad, H. Pinzcowski, and S. Vartivarian. 1997. The epidemiology of hematogenous candidiasis caused by different Candida species. Clin. Infect. Dis. 24:1122-1128.
2. Cappelletty, D., and K. Eiselstein-McKitrick. 2007. The echinocandins. Pharmacotherapy 27:369-388.
3. Denning, D. W. 2003. Echinocandin antifungal drugs. Lancet 362:1142-1151.
4. Dykstra, C. C., and R. R. Tidwell. 1991. Inhibition of topoisomerases from Pneumocystis carinii by aromatic dicationic molecules. J. Protozool. 38:78S-81S.
5. Edwards, K. J., T. C. Jenkins, and S. Neidle. 1992. Crystal structure of a pentamidine-oligonucleotide complex: implications for DNA-binding properties. Biochemistry 31:7104-7109.
6. Grady, R. W., S. H. Blobstein, S. R. Meshnick, P. C. Ulrich, A. Cerami, J. Amirmoazzami, and E. M. Hodnett. 1984. The in vitro trypanocidal activity of N-substituted p-benzoquinone imines: assessment of biochemical structure-activity relationships using the Hansch approach. J. Cell. Biochem. 25:15-29.
7. Hashimoto, K., E. Yamada, H. Nishikawa, N. Oogake, Y. Ito, N. Nomura, K. Hayashi, J. Mitsuyama, and N. Terashima. 2005. Abstr. 45th Intersci. Conf. Antimicrob. Agents Chemother., abstr. F-486.
8. Ikeda, F., Y. Wakai, S. S. Matsumoto, K. Maki, E. Watabe, S. Tawara, T. Goto, Y. Watanabe, F. Matsumoto, and S. Kuwahara. 2000. Efficacy of FK463, a new lipopeptide antifungal agent, in mouse models of disseminated candidiasis and aspergillosis. Antimicrob. Agents Chemother. 44: 614-618.
9. Ikeda, F., K. Otomo, T. Nakai, Y. Morishita, K. Maki, S. Tawara, S. Mutoh, F. Matsumoto, and S. Kuwahara. 2002. In vitro activity of a new lipopeptide antifungal agent, micafungin, against a variety of clinically important fungi. Jpn. J. Chemother. 50:8-19.
10. Iwen, P. C., D. M. Kelly, E. C. Reed, and S. H. Hinrichs. 1995. Invasive infection due to Candida krusei in immunocompromised patients not treated with fluconazole. Clin. Infect. Dis. 20:342-347.
11. Jenkins, T. C., and A. N. Lane. 1997. AT selectivity and DNA minor groove binding: modelling, NMR and structural studies of the interactions of propamidine and pentamidine with d(CGCGAATTCGCG)2. Biochim. Biophys. Acta 1350:189-204.
12. Kaneko, T., K. Makimura, M. Onozaki, K. Ueda, Y. Yamada, Y. Nishiyama, and H. Yamaguchi. 2005. Vital growth factors of Malassezia species on modified CHROMagar Candida. Med. Mycol. 43:699-704.
13. Lanteri, C. A., B. L. Trumpower, R. R. Tidwell, and S. R. Meshnick. 2004. DB75, a novel trypanocidal agent, disrupts mitochondrial function in Saccharomyces cerevisiae. Antimicrob. Agents Chemother. 48:3968-3974.
14. Liu, Y., and M. J. Leibowitz. 1993. Variation and in vitro splicing of group I introns in rRNA genes of Pneumocystis carinii. Nucleic Acids Res. 21:2415-2421.
15. Liu, Y., R. R. Tidwell, and M. J. Leibowitz. 1994. Inhibition of in vitro splicing of a group I intron of Pneumocystis carinii. J. Eukaryot. Microbiol. 41:31-38.
16. Miletti, K. E., and M. J. Leibowitz. 2000. Pentamidine inhibition of group I intron splicing in Candida albicans correlates with growth inhibition. Antimicrob. Agents Chemother. 44:958-966.
17. National Committee for Clinical Laboratory Standards. 2002. Reference method for broth dilution testing of yeasts. Approved standard, 2nd ed. M27-A2. National Committee for Clinical Laboratory Standards, Wayne, PA.
18. National Committee for Clinical Laboratory Standards. 2002. Reference method for broth dilution antifungal susceptibility testing of filamentous fungi. Approved standard. M38-A. National Committee for Clinical Laboratory Standards, Wayne, PA.
19. Nishikawa, H., K. Hashimoto, N. Oogake, E. Yamada, Y. Ito, N. Nomura, K. Hayashi, J. Mitsuyama, and N. Terashima. 2005. Abstr. 45th Intersci. Conf. Antimicrob. Agents Chemother., abstr. F1-487.
20. Nunn, C. M., T. C. Jenkins, and S. Neidle. 1993. Crystal structure of d(CGCGAATTCGCG) complexed with propamidine, a short-chain homologue of the drug pentamidine. Biochemistry 32:13838-13843.
21. Pfaller, M. A., D. J. Diekema, R. N. Jones, H. S. Sader, A. C. Fluit, R. J. Hollis, and S. A. Messer. 2001. International surveillance of bloodstream infections due to Candida species: frequency of occurrence and in vitro susceptibilities to fluconazole, ravuconazole, and voriconazole of isolates collected from 1997 through 1999 in the SENTRY antimicrobial surveillance program. J. Clin. Microbiol. 36:1886-1889.
22. Pfaller, M. A., S. A. Messer, L. Boyken, C. Rice, S. Tendolkar, R. J. Hollis, and D. J. Diekema. 2004. Further standardization of broth microdilution methodology for in vitro susceptibility testing of caspofungin against Candida species by use of an international collection of more than 3,000 clinical isolates. J. Clin. Microbiol. 42:3117-3119.
23. Shapiro, T. A., and P. T. Englund. 1990. Selective cleavage of kinetoplast DNA minicircles promoted by antitrypanosomal drugs. Proc. Natl. Acad. Sci. USA 87:950-954.
24. Shapiro, T. A. 1993. Inhibition of topoisomerases in African trypanosomes. Acta Trop. 54:251-260.
25. Shibata, T., T. Takahashi, E. Yamada, H. Nishikawa, H. Hayakawa, N. Nomura, and J. Mitsuyama. 2007. Abstr. 47th Intersci. Conf. Antimicrob. Agents Chemother., abstr F1-943.
26. Sturk, L. M., J. L. Brock, C. R. Bagnell, J. E. Hall, and R. R. Tidwell. 2004. Distribution and quantitation of the anti-trypanosomal diamidine 2,5-bis(4-amidinophenyl)furan (DB75) and its N-methoxy prodrug DB289 in murine brain tissue. Acta Trop. 91:131-143.
27. Thomas, A. H. 1986. Suggested mechanisms for the antimycotic activity of the polyene antibiotics and the N-substituted imidazoles. J. Antimicrob. Chemother. 17:269-279.
28. Tidwell, R. R., S. K. Jones, J. D. Geratz, K. A. Ohemeng, M. Cory, and J. E. Hall. 1990. Analogues of 1,5-bis(4-amidiniumphenoxy)pentane (pentamidine) in the treatment of experimental Pneumocystis carinii pneumonia. J. Med. Chem. 33:1252-1257.
29. Velegraki, A., E. C. Alexopoulos, S. Kritikou, and G. Gaitanis. 2004. Use of fatty acid RPMI 1640 media for testing susceptibilities of eight Malassezia species to the new triazole posaconazole and to six established antifungal agents by a modified NCCLS M27-A2 microdilution method and Etest. J. Clin. Microbiol. 42:3589-3593. (Erratum, 43:1014, 2005.)
30. Viscoli, C., C. Girmenia, A. Marinus, L. Collette, P. Martino, B. Vandercam, C. Doyen, B. Lebeau, D. Spence, V. Krcmary, B. De Pauw, and F. Meunier. 1999. Candidemia in cancer patients: a prospective, multicenter surveillance study by the Invasive Fungal Infection Group (IFIG) of the European Organization for Research and Treatment of Cancer (EORTC). Clin. Infect. Dis. 28:1071-1979.
31. Wingard, J. R., W. G. Merz, M. G. Rinaldi, T. R. Johnson, J. E. Karp, and R. Saral. 1991. Increase in Candida krusei infection among patients with bone marrow transplantation and neutropenia treated prophylactically with fluconazole. N. Engl. J. Med. 325:1274-1277.
32. Wingard, J. R., W. G. Merz, M. G. Rinaldi, C. B. Miller, J. E. Karp, and R. Saral. 1993. Association of Torulopsis glabrata infections with fluconazole prophylaxis in neutropenic bone marrow transplant patients. Antimicrob. Agents Chemother. 37:1847-1849.
33. Yamada, E., H. Nishikawa, T. Shibata, N. Fujino, K. Hashimoto, N. Nomura, and J. Mitsuyama. 2006. Abstr. 46th Intersci. Conf. Antimicrob. Agents Chemother., abstr. F1-1369.
34. Yeates, C. 2003. DB-289 Immtech International. IDrugs 6:1086-1093.
35. Zhang, Y., A. Bell, P. S. Perlman, and M. J. Leibowitz. 2000. Pentamidine inhibits mitochondrial intron splicing and translation in Saccharomyces cerevisiae. RNA 6:937-951.