Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene

Journal of Biological Chemistry

Volumn 272, Issue 15, 1997, Pages 9809-9817

  Nagiec, M Marek ^a   Nagiec, Elzbieta E ^a   Baltisberger, Julie A ^a   Wells, Gerald B ^a   Lester, Robert L ^a   Dickson, Robert C ^a  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; AUREOBASIDIN A; INOSITOL PHOSPHORYLCERAMIDE SYNTHASE; MYOINOSITOL 1 PHOSPHATE SYNTHASE; SPHINGOLIPID; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; BIOACCUMULATION; BIOSYNTHESIS; DRUG MECHANISM; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANTIBIOTICS, ANTIFUNGAL; CERAMIDES; DEPSIPEPTIDES; DRUG RESISTANCE, MICROBIAL; FUNGAL PROTEINS; HEXOSYLTRANSFERASES; MOLECULAR SEQUENCE DATA; PEPTIDES, CYCLIC; SACCHAROMYCES CEREVISIAE; SPHINGOLIPIDS; SPHINGOSINE;

SACCHAROMYCES CEREVISIAE;

EID: 0030970048     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.15.9809     Document Type: Article

References (40)

1. Lester, R. L., and Dickson, R. C. (1993) Adv. Lipid. Res. 26, 253-272
2. Wells, G. B., Dickson, R. C., and Lester, R. L. (1996) J. Bacteriol. 178, 6223-6226
3. Smith, S. W., and Lester, R. L. (1974) J. Biol. Chem. 249, 3395-3405
4. Steiner, S., Smith, S., Waechter, C. J., and Lester, R. L. (1969) Proc. Natl. Acad. Sci. U. S. A. 64, 1042-1048
5. Becker, G. W., and Lester, R. L. (1980) J. Bacteriol. 142, 474-754
6. Wells, G. B., and Lester, R. L. (1983) J. Biol. Chem. 258, 10200-10203
7. Pinto, W. J., Srinivasan, B., Shepherd, S., Schmidt, A., Dickson, R. C., and Lester, R. L. (1992) J. Bacteriol. 174, 2565-2574
8. Nagiec, M. M., Baltisberger, J. A., Wells, G. B., Lester, R. L., and Dickson, R. C. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 7899-7902
9. Fishbein, J. D., Dobrowsky, R. T., Bielawska, A., Garrett, S., and Hannun, Y. A. (1993) J. Biol. Chem. 268, 9255-9261
10. Nickels, J. T., and Broach, J. R. (1996) Genes Dev. 10, 382-394
11. Dickson, R. C., Wells, G. B., Schmidt, A., and Lester, R. L. (1990) Mol. Cell. Biol. 10, 2176-2181
12. Nagiec, M. M., Wells, G. B., Lester, R. L., and Dickson, R. C. (1993) J. Biol. Chem. 268, 22156-22163
13. Lester, R. L., Wells, G. B., Oxford, G., and Dickson, R. C. (1993) J. Biol. Chem. 268, 845-856
14. Heidler, S. A., and Radding, J. A. (1995) Antimicrob. Agents Chemother. 39, 2765-2769
15. Hashida-Okado, T., Ogawa, A., Endo, M., Yasumoto, R., Takesako, K., and Kato, I. (1996) Mol. Gen. Genet. 251, 236-244
16. Sikorski, R. S., and Hieter, P. (1989) Genetics 122, 19-27
17. Russell, D. W., Jensen, R., Zoller, M. J., Burke, J., Errede, B., Smith, M., and Herskowitz, I. (1986) Mol. Cell. Biol. 6, 4281-4294
18. Herskowitz, I., and Jensen, R. E. (1991) Methods Enzymol. 194, 132-145
19. Buede, R., Rinker-Schaffer, C., Pinto, W. J., Lester, R. L., and Dickson, R. C. (1991) J. Bacteriol. 173, 4325-4332
20. Patton, J. L., Srinivasan, B., Dickson, R. C., and Lester, R. L. (1992) J. Bacteriol. 174, 7180-7184
21. Hanson, B. A., and Lester, R. L. (1880) J. Lipid Res. 21, 309-315
22. Clarke, N. G., and Dawson, R. M. C. (1981) Biochemical J. 195, 301-306
23. Steiner, M. R., and Lester, R. L. (1972) Biochem. Biophys. Acta 260, 222-243
24. Ko, J., Cheah, S., and Fischl, A. S. (1994) J. Bacteriol. 176, 5181-5183
25. Pinto, W. J., Wells, G. W., and Lester, R. L. (1992) J. Bacteriol. 174, 2575-2581
26. Gaver, R. C., and Sweeley, C. C. (1966) J. Am. Chem. Soc. 88, 3643-3647
27. Gietz, R. D., St. Jean, A., Woods, R. A., and Schiestl, R. H. (1992) Nucleic Acids Res. 8, 1425
28. Zweerink, M. M., Edison, A. M., Wells, G. B., Pinto, W., and Lester, R. L. (1992) J. Biol. Chem. 267, 25032-25038
29. Hanson, B. A., and Lester, R. L. (1980) J. Bacteriol. 142, 79-89
30. Rothstein, R. (1991) Methods Enzymol. 194, 281-301
31. Rao, M. J. K., and Argos, P. (1986) Biochim. Biophys. Acta 869, 197-214
32. Klein, P., Kanehisa, M., and DeLisi, C. (1985) Biochim. Biophys. Acta 815, 468-476
33. Eisenberg, D., Schwarz, E., Komaromy, M., and Wall, R. (1984) J. Mol. Biol. 179, 125-142
34. Altschul, S. F., Gish, W., Miller, W., Myers, E. W., and Lipman, D. J. (1990) J. Mol. Biol. 215, 403-410
35. Hobohm, U., and Sander, C. (1995) J. Mol. Biol. 251, 390-399
36. Kolesnick, R., and Fuks, Z. (1995) J. Exp. Med. 181, 1949-1952
37. Pushkareva, M., Obeid, L. M., and Hannun, Y. A. (1995) Immunol. Today 16, 294-297
38. Bose, R., Verheij, M., Haimovitz-Friedman, A., Scotto, K., Fuks, Z., and Kolesnick, R. (1995) Cell 82, 405-414
39. Takesaka, K., Ikae, K., Haruna, F., Endo, M., Shimanaka, K., Sono, E., Hakamura, T., Kato, I., and Yamaguchi, H. (1991) J. Antibiot. 44, 919-924
40. Myers, E. W., and Miller, W. (1988) Comput. Appl. Biosci. 4, 11-17