Rustmicin, a potent antifungal agent, inhibits sphingolipid synthesis at inositol phosphoceramide synthase

Journal of Biological Chemistry

Volumn 273, Issue 24, 1998, Pages 14942-14949

  Mandala, Suzanne M ^a   Thornton, Rosemary A ^a   Milligan, James ^a   Rosenbach, Mark ^a   Garcia Calvo, Margarita ^a   Bull, Herbert G ^a   Harris, Guy ^a   Abruzzo, George K ^a   Flattery, Amy M ^a   Gill, Charles J ^a   Bartizal, Kenneth ^a   Dreikorn, Sarah ^a   Kurtz, Myra B ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; GALBONOLIDE A; INOSITOL PHOSPHOCERAMIDE SYNTHASE; MACROLIDE; SPHINGOLIPID; SYNTHETASE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; CRYPTOCOCCOSIS; CRYPTOCOCCUS NEOFORMANS; DRUG MECHANISM; DRUG POTENCY; DRUG STABILITY; DRUG STRUCTURE; DRUG TRANSPORT; ENZYME INHIBITION; GROWTH INHIBITION; MULTIDRUG RESISTANCE; NONHUMAN; PHOSPHOLIPID SYNTHESIS; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIBIOTICS, ANTIFUNGAL; CELL DIVISION; CRYPTOCOCCOSIS; CRYPTOCOCCUS NEOFORMANS; ENZYME INHIBITORS; FUNGAL PROTEINS; FUNGI; GLYCOSPHINGOLIPIDS; HEXOSYLTRANSFERASES; INOSITOL; LACTONES; MEMBRANE PROTEINS; MICE; MICE, INBRED STRAINS; MOLECULAR STRUCTURE; SACCHAROMYCES CEREVISIAE; SPHINGOLIPIDS;

FILOBASIDIELLA NEOFORMANS; FUNGI; SACCHAROMYCES CEREVISIAE;

EID: 17744410925     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.24.14942     Document Type: Article

References (27)

1. Mundy, L. M., and Powderly, W. G. (1997) Semin. Respir. Crit. Care Med. 18, 249-257
2. Graybill, J. R. (1996) Clin. Infect. Diseases 22, (suppl.) S166-S178
3. Zweerink, M. M., Edison, A. M., Wells, G. B., Pinto, W., and Lester, R. L. (1992) J. Biol. Chem. 267, 25032-25038
4. Horn, W. S., Smith, J. L., Bills, G. F., Raghoobar, S. L., Helms, G. H., Kurtz, M. B., Marrinan, J. A., Frommer, B. R., Thornton, R. A., and Mandala, S. M. (1992) J. Antibiot. (Tokyo) 47, 376-379
5. Miyake, Y., Kozutsumi, Y., Nakamura, S., Fujita, T., and Kawasaki, T. (1995) Biochem. Biophys. Res. Commun. 211, 396-403
6. Mandala, S. M., Frommer, B. R., Thornton, R. A., Kurtz, M. B., Young, N. M., Cabello, M. A., Genilloud, O., Liesch, J. M., Smith, J. L., and Horn, W. S. (1994) J. Antibiot. (Tokyo) 47, 376-379
7. Mandala, S. M., Thornton, R. A., Frommer, B. R., Dreikorn, S., and Kurtz, M. B. (1997) J. Antibiot. (Tokyo) 50, 339-343
8. Michel, C., van Echten-Deckert, G., Rother, J., Sandhoff, K., Wang, E., and Merrill, A. H., Jr. (1997) J. Biol. Chem. 272, 22432-22437
9. Mandala, S. M., Thornton, R. A., Frommer, B. R., Curotto, J. E., Rozdilsky, W., Kurtz, M. B., Giacobbe, R. A., Bills, G. F., Cabello, M. A., Martin, I., Pelaez, F., and Harris, G. H. (1995) J. Antibiot. (Tokyo) 48, 349-356
10. Oh, C.-S., Toke, D. A., Mandala, S., and Martin, C. E. (1997) J. Biol. Chem 272, 17376-17384
11. Wang, E., Norred, W. P., Bacon, C. W., Riley, R. T., and Merrill, A. H., Jr. (1991) J. Biol. Chem. 266, 14486-14490
12. Gelderblom, W. C. A., Jaskiewicz, K., Marasas, W. F. O., Thiel, P. G., Horak, R. M., Vleggaar, R., and Kriek, N. P. J. (1988) Appl. Environ. Microbiol. 54, 1806-1811
13. Riley, R. T., Voss, K. A., Yoo, H.-S., Gelderblom, W. C. A., and Merrill, A. H., Jr. (1994) J. Food Prot. 57, 638-645
14. Mandala, S. M., Thornton, R. A., Rosenbach, M., Milligan, J., Garcia-Calvo, M., Bull, H. G., and Kurtz, M. B. (1997) J. Biol. Chem. 272, 32709-32714
15. Lester, R. L., and Dickson, R. C. (1993) Adv. Lipid Res. 26, 253-274
16. Boas, M. H. S. V., Egge, H., Pohlentz, G., Hartmann, R., and Bergter, E. B. (1994) Chem. Phys. Lipids 70, 11-19
17. Vincent, V. L., and Klig, L. S. (1995) Microbiology 141, 1829-1837
18. Nagiec, M. M., Nagiec, E. E., Baltisberger, J. A., Wells, G. B., Lester, R. L., and Dickson, R. C. (1997) J. Biol. Chem. 272, 9809-9817
19. Takatsu, T., Nakayama, H., Shimazu, A., Furihata, K., Ikeda, K., Furihata, K., Seto, H., and Otake, N. (1985) J. Antibiot. (Tokyo) 38, 1806-1809
20. Achenbach, H., Muhlenfeld, A., Fauth, U., and Zahner, H. (1985) Tet. Lett. 26, 6167-6170
21. Fauth, U., Zahner, H., Muhlenfeld, A., and Achenbach, H. (1986) J. Antibiot. (Tokyo) 39, 1760-1764
22. Achenbach, H., Muhlenfeld, A., Fauth, U., and Zahner, H. (1988) Ann. N.Y. Acad. Sci. 544, 128-140
23. Thomas, B. J., and Rothstein, R. (1989) Cell 56, 619-630
24. Meyers, S., Schauer, W., Balzi, E., Wagner, M., Goffeau, A., and Golin, J. (1992) Curr. Genet. 21, 431-436
25. Abruzzo, G. K., Flattery, A. M., Gill, C. J., Kong, L., Smith, J. G., Krupa, D., Pikounis, V. B., Kropp, H., and Bartizal, K. (1995) Antimicrob. Agents Chemother. 39, 1077-1081
26. Gaber, R. F., Copple, D. M., Kennedy, B. K., Vidal, M., and Bard, M. (1989) Mol. Cell. Biol. 9, 3447-3456
27. Tse, B., Blazey, C. M., Tu, B., and Balkovec, J. (1997) J. Org. Chem. 62, 3236-3241