Antifungal curcumin induces reactive oxygen species and triggers an early apoptosis but prevents hyphae development by targeting the global repressor TUP1 in Candida albicans

Bioscience Reports

Volumn 30, Issue 6, 2010, Pages 391-404

  Sharma, Monika ^a   Manoharlal, Raman ^a   Puri, Nidhi ^a   Prasad, Rajendra ^a  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

Antioxidant; Candida albicans; Curcumin; Hypha; Multidrug resistance; Oxidative stress

Indexed keywords

ABC TRANSPORTER; CATALASE; CATALASE 1; CELL PROTEIN; CURCUMIN; FLUCONAZOLE; FLUORESCEIN ISOTHIOCYANATE; FUNGAL ENZYME; LIPOCORTIN 5; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; NADPH DEPENDENT METHYL GLYOXAL REDUCTASE; PIPERINE; PUTATIVE NADH DEPENDENT FLAVIN OXIDOREDUCTASE; REACTIVE OXYGEN METABOLITE; THYMIDINE UPTAKE 1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIFUNGAL ACTIVITY; ANTIFUNGAL SUSCEPTIBILITY; APOPTOSIS; ARTICLE; CANDIDA ALBICANS; CANDIDIASIS; COLONY FORMING UNIT; CONTROLLED STUDY; FEMALE; FUNGAL CELL; FUNGAL DEVELOPMENT; FUNGAL STRAIN; FUNGUS GROWTH; FUNGUS HYPHAE; GROWTH INHIBITION; MALE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; NULL ALLELE; OXIDATIVE STRESS; PATHOGEN LOAD; QUORUM SENSING; SPECIES DIFFERENCE; WILD TYPE;

ANIMALS; ANTIFUNGAL AGENTS; APOPTOSIS; CANDIDA; CANDIDA ALBICANS; CANDIDIASIS; CURCUMIN; FUNGAL PROTEINS; HUMANS; HYPHAE; MICE; MICROBIAL SENSITIVITY TESTS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; REPRESSOR PROTEINS;

CANDIDA; CANDIDA ALBICANS; MURINAE; MUS;

EID: 78650862876     PISSN: 01448463     EISSN: None     Source Type: Journal    
DOI: 10.1042/BSR20090151     Document Type: Article

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