MiR-192-Mediated Positive Feedback Loop Controls the Robustness of Stress-Induced p53 Oscillations in Breast Cancer Cells

PLoS Computational Biology

Volumn 11, Issue 12, 2015, Pages

  Moore, Richard ^a,b   Ooi, Hsu Kiang ^a   Kang, Taek ^a,b   Bleris, Leonidas ^a,b   Ma, Lan ^a  

^a The University of Texas at Dallas   (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIFURCATION (MATHEMATICS); BIOINFORMATICS; CANCER CELLS; CELL CULTURE; CELL PROLIFERATION; DISEASES; RNA; ROBUSTNESS (CONTROL SYSTEMS);

BREAST CANCER CELLS; CANCER PREVENTION; CELLULAR STRESS; FEEDBACK LOOPS; LOOP CONTROL; POSITIVE FEEDBACK LOOP; SINGLE CELLS; STRESS PREVENTIONS; STRESS-INDUCED; TUMOR SUPPRESSOR PROTEINS;

FEEDBACK;

MICRORNA 192; PROTEIN MDM2; PROTEIN P53; MICRORNA; MIRN192 MICRORNA, HUMAN;

ARTICLE; BREAST CANCER; CELL DISRUPTION; CELL INTERACTION; CELL POPULATION; CELL STRESS; CONTROLLED STUDY; DNA DAMAGE; DOUBLE STRANDED DNA BREAK; IMAGE ANALYSIS; MATHEMATICAL MODEL; MCF 7 CELL LINE; MICROSCOPY; NOISE; OSCILLATION; PHENOTYPE; POSITIVE FEEDBACK; PREDICTION; PROCESS DEVELOPMENT; PROTEIN RNA BINDING; QUANTITATIVE ANALYSIS; RNA ANALYSIS; SIMULATION; WILD TYPE; BIOLOGICAL MODEL; BIOLOGICAL RHYTHM; BREAST TUMOR; COMPUTER SIMULATION; GENE EXPRESSION REGULATION; HUMAN; MCF-7 CELL LINE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGICAL FEEDBACK; PHYSIOLOGICAL STRESS;

BIOLOGICAL CLOCKS; BREAST NEOPLASMS; COMPUTER SIMULATION; DNA DAMAGE; FEEDBACK, PHYSIOLOGICAL; GENE EXPRESSION REGULATION; HUMANS; MCF-7 CELLS; MICRORNAS; MODELS, BIOLOGICAL; STRESS, PHYSIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84953290465     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1004653     Document Type: Article

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