A plausible model for the digital response of p53 to DNA damage

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 40, 2005, Pages 14266-14271

  Ma, Lan ^a   Wagner, John ^a   Rice, John Jeremy ^a   Hu, Wenwei ^b   Levine, Arnold J ^b,c   Stolovitzky, Gustavo A ^a  

^a IBM T J WATSON RESEARCH CENTER   (United States)

^b RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^c INSTITUTE FOR ADVANCED STUDY   (United States)

Author keywords

DNA damage response; Mathematical model of p53; p53 pathway; p53 regulation

Indexed keywords

ATM PROTEIN; DNA; PROTEIN MDM2; PROTEIN P53;

ANIMAL CELL; ARTICLE; COMPLEX FORMATION; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; FEEDBACK SYSTEM; IONIZING RADIATION; MATHEMATICAL MODEL; NONHUMAN; OSCILLATION; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN PHOSPHORYLATION; RADIATION DOSE;

CELL CYCLE PROTEINS; COMPUTER SIMULATION; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; FEEDBACK, BIOCHEMICAL; MODELS, BIOLOGICAL; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-MDM2; RADIATION, IONIZING; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

ATAXIA TELANGIECTASIA;

EID: 26444583906     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0501352102     Document Type: Article

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