p53-Mdm2 loop controlled by a balance of its feedback strength and effective dampening using ATM and delayed feedback

IEE Proceedings Systems Biology

Volumn 152, Issue 3, 2005, Pages 109-117

  Wagner, J ^a   Ma, L ^a   Rice, J J ^a   Hu, W ^b   Levine, A J ^b,c   Stolovitzky, G A ^a  

^a IBM   (United States)

^b ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c INSTITUTE FOR ADVANCED STUDY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCONTROL; BIOTECHNOLOGY; DAMPING; DNA; FEEDBACK CONTROL; MATHEMATICAL MODELS; PERTURBATION TECHNIQUES; PROTEINS; TUMORS;

GENOMIC INTEGRITY; LIMIT CYCLE BEHAVIOUR; NEGATIVE FEEDBACK LOOP; TUMOUR SUPPRESSOR PROTEIN;

CYTOLOGY;

ATM PROTEIN; PROTEIN MDM2; PROTEIN P53;

ARTICLE; DEGRADATION KINETICS; DNA DAMAGE; MATHEMATICAL MODEL; NEGATIVE FEEDBACK; OSCILLATION; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TRANSACTIVATION;

ANIMALS; BIOLOGICAL CLOCKS; CELL CYCLE PROTEINS; CELL PHYSIOLOGY; COMPUTER SIMULATION; DNA-BINDING PROTEINS; FEEDBACK; GENE EXPRESSION REGULATION; HUMANS; MODELS, BIOLOGICAL; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 27244451471     PISSN: 17412471     EISSN: None     Source Type: Journal    
DOI: 10.1049/ip-syb:20050025     Document Type: Article

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