Dual Delayed Feedback Provides Sensitivity and Robustness to the NF-κB Signaling Module

PLoS Computational Biology

Volumn 9, Issue 6, 2013, Pages

  Longo, Diane M ^a   Selimkhanov, Jangir ^a,b   Kearns, Jeffrey D ^c   Hasty, Jeff ^a,b,d,e   Hoffmann, Alexander ^b,c,e   Tsimring, Lev S ^b,e  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b University of California San Diego   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FEEDBACK CONTROL; LINEAR STABILITY ANALYSIS; ROBUST CONTROL; SIGNALING; STOCHASTIC SYSTEMS;

CELLULAR STRESS; COMPUTATIONAL MODELLING; CONTROL MODULE; DELAYED FEEDBACK; DYNAMIC BEHAVIORS; FUNCTIONAL REQUIREMENT; NEGATIVE FEEDBACK LOOP; OSCILLATORY BEHAVIORS; SIGNALING SYSTEMS; TRANSCRIPTION FACTOR NF-ΚB;

FREQUENCY MODULATION;

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ARTICLE; CALIBRATION; CELLULAR STRESS RESPONSE; COMPUTER MODEL; CONTROLLED STUDY; FREQUENCY MODULATION; MOLECULAR DYNAMICS; NEGATIVE FEEDBACK; OSCILLATION; QUANTITATIVE STUDY; SENSITIVITY ANALYSIS; SIGNAL NOISE RATIO; SIGNAL TRANSDUCTION; STOCHASTIC MODEL; TRANSCRIPTION REGULATION;

EID: 84879531246     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003112     Document Type: Article

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