메뉴 건너뛰기




Volumn 7, Issue , 2013, Pages

Modeling heterogeneous responsiveness of intrinsic apoptosis pathway

Author keywords

Extrinsic noise; Intrinsic apoptosis pathway; Intrinsic noise; Stochastic model

Indexed keywords

APOPTOSIS; ARTICLE; BIOLOGICAL MODEL; SIGNAL TRANSDUCTION; STATISTICS;

EID: 84880334589     PISSN: None     EISSN: 17520509     Source Type: Journal    
DOI: 10.1186/1752-0509-7-65     Document Type: Article
Times cited : (20)

References (82)
  • 1
    • 0036674617 scopus 로고    scopus 로고
    • Live or Let Die: The Cell's Response to p53
    • 10.1038/nrc864, 12154352
    • Vousden K, Lu X. Live or Let Die: The Cell's Response to p53. Nat Rev Cancer 2002, 2:594-604. 10.1038/nrc864, 12154352.
    • (2002) Nat Rev Cancer , vol.2 , pp. 594-604
    • Vousden, K.1    Lu, X.2
  • 2
    • 39749182234 scopus 로고    scopus 로고
    • Apoptosis: controlled demolition at the cellular level
    • Taylor R, Cullen S, Martin S. Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol 2008,, 9:231-41.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 231-241
    • Taylor, R.1    Cullen, S.2    Martin, S.3
  • 3
    • 79952635820 scopus 로고    scopus 로고
    • Measuring and Modeling Apoptosis in Single Cells
    • 10.1016/j.cell.2011.03.002, 3087303, 21414484
    • Spencer S, Sorger P. Measuring and Modeling Apoptosis in Single Cells. Cell 2011, 144:926-939. 10.1016/j.cell.2011.03.002, 3087303, 21414484.
    • (2011) Cell , vol.144 , pp. 926-939
    • Spencer, S.1    Sorger, P.2
  • 4
    • 34548686289 scopus 로고    scopus 로고
    • Apoptosis signaling pathways and lymphocyte homeostasis
    • 10.1038/cr.2007.52, 17576411
    • Xu G, Shi Y. Apoptosis signaling pathways and lymphocyte homeostasis. Cell Res 2007, 17:759-771. 10.1038/cr.2007.52, 17576411.
    • (2007) Cell Res , vol.17 , pp. 759-771
    • Xu, G.1    Shi, Y.2
  • 5
    • 81055125652 scopus 로고    scopus 로고
    • Programmed cell death in animal development and disease
    • 10.1016/j.cell.2011.10.033, 22078876
    • Fuchs Y, Steller H. Programmed cell death in animal development and disease. Cell 2011, 147(4):742-758. 10.1016/j.cell.2011.10.033, 22078876.
    • (2011) Cell , vol.147 , Issue.4 , pp. 742-758
    • Fuchs, Y.1    Steller, H.2
  • 6
    • 34250308322 scopus 로고    scopus 로고
    • Apoptosis: a review of programmed cell death
    • 10.1080/01926230701320337, 2117903, 17562483
    • Elmore S. Apoptosis: a review of programmed cell death. Toxicol Pathol 2007, 35(4):495-516. 10.1080/01926230701320337, 2117903, 17562483.
    • (2007) Toxicol Pathol , vol.35 , Issue.4 , pp. 495-516
    • Elmore, S.1
  • 7
    • 0033538475 scopus 로고    scopus 로고
    • Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II
    • 10.1016/S0092-8674(00)80605-4, 10412980
    • Wang J, Zheng L, Lobito A, Chan F, Dale J. Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II. Cell 1999, 98:47-48. 10.1016/S0092-8674(00)80605-4, 10412980.
    • (1999) Cell , vol.98 , pp. 47-48
    • Wang, J.1    Zheng, L.2    Lobito, A.3    Chan, F.4    Dale, J.5
  • 8
    • 0036463405 scopus 로고    scopus 로고
    • A matter of life and death
    • 10.1016/S1535-6108(02)00024-7, 12086884, Green D
    • Green D A matter of life and death. Cancer Cell 2002, 1:19-30. 10.1016/S1535-6108(02)00024-7, 12086884, Green D.
    • (2002) Cancer Cell , vol.1 , pp. 19-30
  • 9
  • 10
    • 34247345833 scopus 로고    scopus 로고
    • The apoptosome: signaling platform of cell death
    • Riedl S, Salvesen G. The apoptosome: signaling platform of cell death. Nat Rev Mol Cell Biol 2007, 8:405-413.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 405-413
    • Riedl, S.1    Salvesen, G.2
  • 11
    • 10644282148 scopus 로고    scopus 로고
    • The protein structures that shape caspase activity, specificity, activation and inhibition
    • 10.1042/BJ20041142, 1134104, 15450003
    • Fuentes-Prior P, Salvesen G. The protein structures that shape caspase activity, specificity, activation and inhibition. Biochem J 2004, 384:201-232. 10.1042/BJ20041142, 1134104, 15450003.
    • (2004) Biochem J , vol.384 , pp. 201-232
    • Fuentes-Prior, P.1    Salvesen, G.2
  • 12
    • 0028180546 scopus 로고
    • Intracellular Ca2+ signals activate apoptosis in thymocytes: studies using the Ca2+-ATPase inhibitor thapsigargin
    • 10.1006/excr.1994.1121, 8174645
    • Jiang S, Chow S, Nicotera P, Orrenius S. Intracellular Ca2+ signals activate apoptosis in thymocytes: studies using the Ca2+-ATPase inhibitor thapsigargin. Exp Cell Res 1994, 212:84-92. 10.1006/excr.1994.1121, 8174645.
    • (1994) Exp Cell Res , vol.212 , pp. 84-92
    • Jiang, S.1    Chow, S.2    Nicotera, P.3    Orrenius, S.4
  • 13
    • 0037025346 scopus 로고    scopus 로고
    • Single-cell fluorescence resonance energy transfer analysis demonstrates that caspase activation during apoptosis is a rapid process. Role of caspase-3
    • 10.1074/jbc.M110789200, 11964393
    • Rehm M, Dussmann H, Janicke R, Tavare J, Kogel D, Prehn J. Single-cell fluorescence resonance energy transfer analysis demonstrates that caspase activation during apoptosis is a rapid process. Role of caspase-3. J Biol Chem 2002, 277(27):24506-24514. 10.1074/jbc.M110789200, 11964393.
    • (2002) J Biol Chem , vol.277 , Issue.27 , pp. 24506-24514
    • Rehm, M.1    Dussmann, H.2    Janicke, R.3    Tavare, J.4    Kogel, D.5    Prehn, J.6
  • 14
    • 41549132691 scopus 로고    scopus 로고
    • Quantitative analysis of pathways controlling extrinsic apoptosis in single cells
    • 10.1016/j.molcel.2008.02.012, 2858979, 18406323
    • Albeck J, Burke J, Aldridge B, Zhang M, Lauffenburger D, Sorger P. Quantitative analysis of pathways controlling extrinsic apoptosis in single cells. Mol Cell 2008, 30:11-25. 10.1016/j.molcel.2008.02.012, 2858979, 18406323.
    • (2008) Mol Cell , vol.30 , pp. 11-25
    • Albeck, J.1    Burke, J.2    Aldridge, B.3    Zhang, M.4    Lauffenburger, D.5    Sorger, P.6
  • 15
    • 84883829346 scopus 로고    scopus 로고
    • Modeling a snap-action, variable-delay switch controlling extrinsic cell death
    • 2592357, 19053173
    • Albeck J, Burke J, Spencer S, Lauffenburger D, Sorger P. Modeling a snap-action, variable-delay switch controlling extrinsic cell death. PLoS Biol 2008, 6(12):2831-2852. 2592357, 19053173.
    • (2008) PLoS Biol , vol.6 , Issue.12 , pp. 2831-2852
    • Albeck, J.1    Burke, J.2    Spencer, S.3    Lauffenburger, D.4    Sorger, P.5
  • 16
    • 66249136447 scopus 로고    scopus 로고
    • Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis
    • 10.1038/nature08012, 2858974, 19363473
    • Spencer S, Gaudet S, Albeck J, Burke J, Sorger P. Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature 2009, 459:428-433. 10.1038/nature08012, 2858974, 19363473.
    • (2009) Nature , vol.459 , pp. 428-433
    • Spencer, S.1    Gaudet, S.2    Albeck, J.3    Burke, J.4    Sorger, P.5
  • 17
    • 4544246088 scopus 로고    scopus 로고
    • Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis
    • 10.1083/jcb.200404158, 2172102, 15364960
    • Bentele M, Lavrik I, Ulrich M, Stober S, Heermann D, Kalthoff H, Krammer P, Eils R. Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis. J Cell Biol 2004, 166:839-851. 10.1083/jcb.200404158, 2172102, 15364960.
    • (2004) J Cell Biol , vol.166 , pp. 839-851
    • Bentele, M.1    Lavrik, I.2    Ulrich, M.3    Stober, S.4    Heermann, D.5    Kalthoff, H.6    Krammer, P.7    Eils, R.8
  • 18
    • 4344674786 scopus 로고    scopus 로고
    • Bistability analyses of a caspase activation model for receptor-induced apoptosis
    • 10.1074/jbc.M404893200, 15208304
    • Eissing T, Conzelmann H, Gilles E, Allogowert F, Bullinger E, Scheurich P. Bistability analyses of a caspase activation model for receptor-induced apoptosis. J Biol Chem 2004, 279(35):36892-36897. 10.1074/jbc.M404893200, 15208304.
    • (2004) J Biol Chem , vol.279 , Issue.35 , pp. 36892-36897
    • Eissing, T.1    Conzelmann, H.2    Gilles, E.3    Allogowert, F.4    Bullinger, E.5    Scheurich, P.6
  • 19
    • 79952697535 scopus 로고    scopus 로고
    • Mathematical modelling of the mitochondrial apoptosis pathway
    • 10.1016/j.bbamcr.2010.10.004, 20950651
    • Huber H, Duessmann H, Wenus J, Kilbride S, Prehn J. Mathematical modelling of the mitochondrial apoptosis pathway. Biochimica et Biophysica Acta 2011, 1813(4):608-615. 10.1016/j.bbamcr.2010.10.004, 20950651.
    • (2011) Biochimica et Biophysica Acta , vol.1813 , Issue.4 , pp. 608-615
    • Huber, H.1    Duessmann, H.2    Wenus, J.3    Kilbride, S.4    Prehn, J.5
  • 20
    • 0033925842 scopus 로고    scopus 로고
    • A mathematical model of caspase function in apoptosis
    • 10.1038/77589, 10888847
    • Fussenegger M, Bailey J, Varner J. A mathematical model of caspase function in apoptosis. Nat Biotechnol 2000, 18:768-774. 10.1038/77589, 10888847.
    • (2000) Nat Biotechnol , vol.18 , pp. 768-774
    • Fussenegger, M.1    Bailey, J.2    Varner, J.3
  • 21
    • 3042591342 scopus 로고    scopus 로고
    • Early single cell bifurcation of pro- and antiapoptotic states during oxidative stress
    • 10.1074/jbc.M312135200, 15078887
    • Nair V, Yuen T, Olanow C, Sealfon S. Early single cell bifurcation of pro- and antiapoptotic states during oxidative stress. J Biol Chem 2004, 279(26):27494-27501. 10.1074/jbc.M312135200, 15078887.
    • (2004) J Biol Chem , vol.279 , Issue.26 , pp. 27494-27501
    • Nair, V.1    Yuen, T.2    Olanow, C.3    Sealfon, S.4
  • 22
    • 78650048538 scopus 로고    scopus 로고
    • Bcl-2 inhibits apoptosis by increasing the time-to-death and intrinsic cell-to-cell variations in the mitochondrial pathway of cell death
    • 10.1007/s10495-010-0515-7, 2948171, 20563668
    • Skommer J, Brittain T, Raychaudhuri S. Bcl-2 inhibits apoptosis by increasing the time-to-death and intrinsic cell-to-cell variations in the mitochondrial pathway of cell death. Apoptosis 2010, 15:1223-1233. 10.1007/s10495-010-0515-7, 2948171, 20563668.
    • (2010) Apoptosis , vol.15 , pp. 1223-1233
    • Skommer, J.1    Brittain, T.2    Raychaudhuri, S.3
  • 23
    • 77957817719 scopus 로고    scopus 로고
    • A minimal model of signaling network elucidates cell-to-cell stochastic variability in apoptosis
    • Raychaudhuri S. A minimal model of signaling network elucidates cell-to-cell stochastic variability in apoptosis. PLoS ONE 2010, 5(8):1-7.
    • (2010) PLoS ONE , vol.5 , Issue.8 , pp. 1-7
    • Raychaudhuri, S.1
  • 24
    • 31144431501 scopus 로고    scopus 로고
    • Robustness properties of apoptosis models with respect to parameter variations and intrinsic noise
    • Eissing T, Allogowert F, Bullinger E. Robustness properties of apoptosis models with respect to parameter variations and intrinsic noise. IEEE Proc Syst Biol 2005, 152(4):221-228.
    • (2005) IEEE Proc Syst Biol , vol.152 , Issue.4 , pp. 221-228
    • Eissing, T.1    Allogowert, F.2    Bullinger, E.3
  • 25
    • 77958507226 scopus 로고    scopus 로고
    • System biology approaches to the study of apoptosis
    • New York: Humana Press, Yin XM, Dong Z
    • Huber H, Bullinger E, Rehm M. System biology approaches to the study of apoptosis. Essentials of Apoptosis, 2009, 283-297. New York: Humana Press, Yin XM, Dong Z.
    • (2009) Essentials of Apoptosis, , pp. 283-297
    • Huber, H.1    Bullinger, E.2    Rehm, M.3
  • 26
    • 33750809764 scopus 로고    scopus 로고
    • Direct Lyapunov exponent analysis enables parametric study of transient signalling governing cell behaviour
    • Aldridge B, Haller G, Sorger P, Lauffenburger D. Direct Lyapunov exponent analysis enables parametric study of transient signalling governing cell behaviour. Syst Biol (Stevenage) 2006, 153(6):425-432.
    • (2006) Syst Biol (Stevenage) , vol.153 , Issue.6 , pp. 425-432
    • Aldridge, B.1    Haller, G.2    Sorger, P.3    Lauffenburger, D.4
  • 27
    • 23244462491 scopus 로고    scopus 로고
    • Effects of Bcl-2 levels on Fas signaling-induced caspase-3 activation: molecular genetic tests of computational model predictions
    • Hua F, Cornejo M, Cardone M, Stokes C, Lauffenburger D. Effects of Bcl-2 levels on Fas signaling-induced caspase-3 activation: molecular genetic tests of computational model predictions. J Immunol 2005, 175:985-995.
    • (2005) J Immunol , vol.175 , pp. 985-995
    • Hua, F.1    Cornejo, M.2    Cardone, M.3    Stokes, C.4    Lauffenburger, D.5
  • 28
    • 33749370199 scopus 로고    scopus 로고
    • Mathematical modeling identifies inhibitors of apoptosis as mediators of positive feedback and bistability
    • Legewie S, Bluthgen N, Herzel H. Mathematical modeling identifies inhibitors of apoptosis as mediators of positive feedback and bistability. PLoS Comput Biol 2006, 2(9):1061-1073.
    • (2006) PLoS Comput Biol , vol.2 , Issue.9 , pp. 1061-1073
    • Legewie, S.1    Bluthgen, N.2    Herzel, H.3
  • 29
    • 68949136900 scopus 로고    scopus 로고
    • Computational analysis of dynamical responses to the intrinsic pathway of programmed cell death
    • 10.1016/j.bpj.2009.04.053, 2711321, 19619456
    • Zhang T, Brazhnik P, Tyson J. Computational analysis of dynamical responses to the intrinsic pathway of programmed cell death. Biophys J 2009, 97:415-434. 10.1016/j.bpj.2009.04.053, 2711321, 19619456.
    • (2009) Biophys J , vol.97 , pp. 415-434
    • Zhang, T.1    Brazhnik, P.2    Tyson, J.3
  • 30
    • 33646124974 scopus 로고    scopus 로고
    • Bistability in apoptosis: Roles of Bax, Bcl-2, and mitochondrial permeability transition pores
    • 10.1529/biophysj.105.068122, 1367306, 16339882
    • Bagci E, Vodovotz Y, Billiar T, Ermentrout G, Bahar I. Bistability in apoptosis: Roles of Bax, Bcl-2, and mitochondrial permeability transition pores. Biophys J 2006, 90(5):1546-1559. 10.1529/biophysj.105.068122, 1367306, 16339882.
    • (2006) Biophys J , vol.90 , Issue.5 , pp. 1546-1559
    • Bagci, E.1    Vodovotz, Y.2    Billiar, T.3    Ermentrout, G.4    Bahar, I.5
  • 31
    • 13844253728 scopus 로고    scopus 로고
    • Mathematical modeling of the regulation of caspase-3 activation and degradation
    • 10.1016/j.jtbi.2004.11.011, 15721041
    • Stucki J, Simon H. Mathematical modeling of the regulation of caspase-3 activation and degradation. J Theor Biol 2005, 234:123-131. 10.1016/j.jtbi.2004.11.011, 15721041.
    • (2005) J Theor Biol , vol.234 , pp. 123-131
    • Stucki, J.1    Simon, H.2
  • 32
    • 33747184514 scopus 로고    scopus 로고
    • A mathematical model for apoptosome assembly: the optimal cytochrome c / Apaf-1 ratio
    • 10.1016/j.jtbi.2006.02.022, 16650876
    • Nakabayashi J, Sasaki A. A mathematical model for apoptosome assembly: the optimal cytochrome c / Apaf-1 ratio. J Theor Biol 2006, 242(2):280-287. 10.1016/j.jtbi.2006.02.022, 16650876.
    • (2006) J Theor Biol , vol.242 , Issue.2 , pp. 280-287
    • Nakabayashi, J.1    Sasaki, A.2
  • 33
    • 65349119888 scopus 로고    scopus 로고
    • Construction and analysis of a modular model of caspase activation in apoptosis
    • 2249573, 18182112
    • Harrington H, Ho K, Ghosh S, Tung K. Construction and analysis of a modular model of caspase activation in apoptosis. Theor Biol Med Model 2008, 5(26):1-15. 2249573, 18182112.
    • (2008) Theor Biol Med Model , vol.5 , Issue.26 , pp. 1-15
    • Harrington, H.1    Ho, K.2    Ghosh, S.3    Tung, K.4
  • 34
    • 84873718181 scopus 로고    scopus 로고
    • Modeling composition through model reduction: a combined model of CD95 and NF-kB signaling pathways
    • 10.1186/1752-0509-7-13, 3626841, 23409788
    • Kutumova E, Zinovyev A, Sharipov R, Kolpakov F. Modeling composition through model reduction: a combined model of CD95 and NF-kB signaling pathways. BMC Syst Biol 2013, 7:13. 10.1186/1752-0509-7-13, 3626841, 23409788.
    • (2013) BMC Syst Biol , vol.7 , pp. 13
    • Kutumova, E.1    Zinovyev, A.2    Sharipov, R.3    Kolpakov, F.4
  • 35
    • 0037119587 scopus 로고    scopus 로고
    • Stochastic gene expression in a single cell
    • 10.1126/science.1070919, 12183631
    • Elowitz M, Levine A, Siggia E, Swain P. Stochastic gene expression in a single cell. Science 2002, 297:1183-1186. 10.1126/science.1070919, 12183631.
    • (2002) Science , vol.297 , pp. 1183-1186
    • Elowitz, M.1    Levine, A.2    Siggia, E.3    Swain, P.4
  • 36
    • 0036790975 scopus 로고    scopus 로고
    • Intrinsic and extrinsic contributions to stochasticity in gene expression
    • 10.1073/pnas.162041399, 130539, 12237400
    • Swain P, Elowitz M, Siggia E. Intrinsic and extrinsic contributions to stochasticity in gene expression. Proc Natl Acad Sci USA 2002, 99:12795-12800. 10.1073/pnas.162041399, 130539, 12237400.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 12795-12800
    • Swain, P.1    Elowitz, M.2    Siggia, E.3
  • 37
    • 33749842033 scopus 로고    scopus 로고
    • Deviant effects in molecular reaction pathways
    • Samoilov M, Arkin A. Deviant effects in molecular reaction pathways. Nat Biotech 2006, 24:1235-1240.
    • (2006) Nat Biotech , vol.24 , pp. 1235-1240
    • Samoilov, M.1    Arkin, A.2
  • 38
    • 2942718723 scopus 로고    scopus 로고
    • Control of stochasticity in eukaryotic gene expression
    • 10.1126/science.1098641, 1410811, 15166317
    • Raser J, O'Shea E. Control of stochasticity in eukaryotic gene expression. Science 2004, 304:1811-1814. 10.1126/science.1098641, 1410811, 15166317.
    • (2004) Science , vol.304 , pp. 1811-1814
    • Raser, J.1    O'Shea, E.2
  • 39
    • 84861161954 scopus 로고    scopus 로고
    • Mitochondrial variability as a source of extrinsic cellular noise
    • 3355070, 22629235
    • Johnston I. Mitochondrial variability as a source of extrinsic cellular noise. PLoS Comput Biol 2012, 8(3):1-14. 3355070, 22629235.
    • (2012) PLoS Comput Biol , vol.8 , Issue.3 , pp. 1-14
    • Johnston, I.1
  • 40
    • 0842285841 scopus 로고    scopus 로고
    • Summing up the noise in gene networks
    • 10.1038/nature02257, 14749823
    • J P. Summing up the noise in gene networks. Nature 2004, 427(6973):415-418. 10.1038/nature02257, 14749823.
    • (2004) Nature , vol.427 , Issue.6973 , pp. 415-418
    • J, P.1
  • 41
    • 20344389483 scopus 로고    scopus 로고
    • Models of stochastic gene expression
    • J P. Models of stochastic gene expression. Physics Life Rev 2005, 2:157-175.
    • (2005) Physics Life Rev , vol.2 , pp. 157-175
    • J, P.1
  • 42
    • 84860257802 scopus 로고    scopus 로고
    • Interplay between gene expression noise and regulatory network architecture
    • 10.1016/j.tig.2012.01.006, 3340541, 22365642
    • Chalancon G, Ravarani C, Balaji S, Martinez-Arias A, Aravind L, Jothi R, Babu M. Interplay between gene expression noise and regulatory network architecture. Trends Genet 2012, 28(5):221-232. 10.1016/j.tig.2012.01.006, 3340541, 22365642.
    • (2012) Trends Genet , vol.28 , Issue.5 , pp. 221-232
    • Chalancon, G.1    Ravarani, C.2    Balaji, S.3    Martinez-Arias, A.4    Aravind, L.5    Jothi, R.6    Babu, M.7
  • 43
    • 57849096104 scopus 로고    scopus 로고
    • Determining biological noise via single cell analysis
    • 10.1007/s00216-008-2431-z, 3035192, 18958456
    • EA A. Determining biological noise via single cell analysis. Anal Bioanal Chem 2009, 393:73-80. 10.1007/s00216-008-2431-z, 3035192, 18958456.
    • (2009) Anal Bioanal Chem , vol.393 , pp. 73-80
    • EA, A.1
  • 44
    • 0035902599 scopus 로고    scopus 로고
    • Intrinsic noise in gene regulatory networks
    • 10.1073/pnas.151588598, 37484, 11438714
    • Thattai M, Oudenaarden A. Intrinsic noise in gene regulatory networks. Proc Natl Acad Sci U S A 2001, 98(15):8614-8619. 10.1073/pnas.151588598, 37484, 11438714.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.15 , pp. 8614-8619
    • Thattai, M.1    Oudenaarden, A.2
  • 45
    • 0036578645 scopus 로고    scopus 로고
    • Regulation of noise in the expression of a single gene
    • 10.1038/ng869, 11967532
    • Ozbudak E, Thattai M, Kurtser I, Grossman A, van Oudenaarden A. Regulation of noise in the expression of a single gene. Nat Genet 2002, 31:69-73. 10.1038/ng869, 11967532.
    • (2002) Nat Genet , vol.31 , pp. 69-73
    • Ozbudak, E.1    Thattai, M.2    Kurtser, I.3    Grossman, A.4    van Oudenaarden, A.5
  • 46
    • 2942657194 scopus 로고    scopus 로고
    • Intrinsic and external noise in an auto-regulatory genetic network
    • 10.1016/j.jtbi.2004.03.011, 15207470
    • Tao Y. Intrinsic and external noise in an auto-regulatory genetic network. J Theor Biol 2004, 229(2):147-156. 10.1016/j.jtbi.2004.03.011, 15207470.
    • (2004) J Theor Biol , vol.229 , Issue.2 , pp. 147-156
    • Tao, Y.1
  • 47
    • 15544371346 scopus 로고    scopus 로고
    • Gene Regulation at the Single-Cell Level
    • 10.1126/science.1106914, 15790856
    • Rosenfeld N, Young J, Alon U, Swain P, Elowitz M. Gene Regulation at the Single-Cell Level. Science 2005, 307(5717):1962-1965. 10.1126/science.1106914, 15790856.
    • (2005) Science , vol.307 , Issue.5717 , pp. 1962-1965
    • Rosenfeld, N.1    Young, J.2    Alon, U.3    Swain, P.4    Elowitz, M.5
  • 48
    • 33745220278 scopus 로고    scopus 로고
    • Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise
    • 10.1038/nature04785, 16699522
    • Newman J, Ghaemmaghami S, Ihmels J, Breslow D, Noble M, DeRisi J, Weissman J. Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise. Nature 2006, 441(7095):840-846. 10.1038/nature04785, 16699522.
    • (2006) Nature , vol.441 , Issue.7095 , pp. 840-846
    • Newman, J.1    Ghaemmaghami, S.2    Ihmels, J.3    Breslow, D.4    Noble, M.5    DeRisi, J.6    Weissman, J.7
  • 49
    • 43249118966 scopus 로고    scopus 로고
    • Colored extrinsic fluctuations and stochastic gene expression
    • Shahrezaei V, Ollivier J, Swain P. Colored extrinsic fluctuations and stochastic gene expression. Mol Syst Biol 2008, 4(196).
    • (2008) Mol Syst Biol , vol.4 , Issue.196
    • Shahrezaei, V.1    Ollivier, J.2    Swain, P.3
  • 50
    • 40649083597 scopus 로고    scopus 로고
    • Strong negative self regulation of prokaryotic transcription factors increases the intrinsic noise of protein expression
    • 10.1186/1752-0509-2-6, 2263017, 18205926
    • Stekel D, Jenkins D. Strong negative self regulation of prokaryotic transcription factors increases the intrinsic noise of protein expression. BMC Syst Biol 2008, 2:6. 10.1186/1752-0509-2-6, 2263017, 18205926.
    • (2008) BMC Syst Biol , vol.2 , pp. 6
    • Stekel, D.1    Jenkins, D.2
  • 51
    • 66149084052 scopus 로고    scopus 로고
    • Exploring the roles of noise in the eukaryotic cell cycle
    • 10.1073/pnas.0810034106, 2672517, 19246388
    • Kar S, Baumann W, Paul M, Tyson J. Exploring the roles of noise in the eukaryotic cell cycle. Proc Natl Acad Sci U S A 2009, 106(16):6471-6476. 10.1073/pnas.0810034106, 2672517, 19246388.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.16 , pp. 6471-6476
    • Kar, S.1    Baumann, W.2    Paul, M.3    Tyson, J.4
  • 52
    • 84862174236 scopus 로고    scopus 로고
    • Intrinsic intrinsic noise analyzer: a software package for the exploration of stochastic biochemical kinetics using the system size expansion
    • 10.1371/journal.pone.0038518, 3373587, 22723865
    • Thomas P, Matuschek H, Grima R. Intrinsic intrinsic noise analyzer: a software package for the exploration of stochastic biochemical kinetics using the system size expansion. PLoS ONE 2012, 7(6):e38518. 10.1371/journal.pone.0038518, 3373587, 22723865.
    • (2012) PLoS ONE , vol.7 , Issue.6
    • Thomas, P.1    Matuschek, H.2    Grima, R.3
  • 53
    • 84866083176 scopus 로고    scopus 로고
    • Dynamics of protein noise can distinguish between alternate sources of gene-expression variability
    • 3435505, 22929617
    • Singh A, Razooky B, Dar R, Weinberger L. Dynamics of protein noise can distinguish between alternate sources of gene-expression variability. Mol Syst Biol 2012, 8:607. 3435505, 22929617.
    • (2012) Mol Syst Biol , vol.8 , pp. 607
    • Singh, A.1    Razooky, B.2    Dar, R.3    Weinberger, L.4
  • 54
    • 56049121209 scopus 로고    scopus 로고
    • Monte Carlo simulation of cell death signaling predicts large cell-to-cell stochastic fluctuations through the type 2 pathway of apoptosis
    • 10.1529/biophysj.108.135483, 2553141, 18641073
    • Raychaudhuri S, Willgohs E, Nguyen T, Khan E, Goldkorn T. Monte Carlo simulation of cell death signaling predicts large cell-to-cell stochastic fluctuations through the type 2 pathway of apoptosis. Biophys J 2008, 95:3559-3562. 10.1529/biophysj.108.135483, 2553141, 18641073.
    • (2008) Biophys J , vol.95 , pp. 3559-3562
    • Raychaudhuri, S.1    Willgohs, E.2    Nguyen, T.3    Khan, E.4    Goldkorn, T.5
  • 55
    • 84874829147 scopus 로고    scopus 로고
    • How can we kill cancer cells: Insights from the computational models of apoptosis
    • 10.5306/wjco.v1.i1.24, 3095455, 21603307
    • Raychaudhuri S. How can we kill cancer cells: Insights from the computational models of apoptosis. World J Clin Oncol 2010, 1:24-28. 10.5306/wjco.v1.i1.24, 3095455, 21603307.
    • (2010) World J Clin Oncol , vol.1 , pp. 24-28
    • Raychaudhuri, S.1
  • 56
    • 38849133420 scopus 로고    scopus 로고
    • Selective control of the apoptosis signaling network in heterogeneous cell populations
    • 10.1371/journal.pone.0000547, 1890306, 17579719
    • Calzolari D, Paternostro G, Harrington PJ, Piermarocchi C, Duxbury P. Selective control of the apoptosis signaling network in heterogeneous cell populations. PLoS ONE 2007, 2(6):e547. 10.1371/journal.pone.0000547, 1890306, 17579719.
    • (2007) PLoS ONE , vol.2 , Issue.6
    • Calzolari, D.1    Paternostro, G.2    Harrington, P.J.3    Piermarocchi, C.4    Duxbury, P.5
  • 57
    • 0001424903 scopus 로고
    • An amplified sensitivity arising from covalent modification in biological systems
    • 10.1073/pnas.78.11.6840, 349147, 6947258
    • Goldbeter A, Koshland D. An amplified sensitivity arising from covalent modification in biological systems. Proc Natl Acad Sci U S A 1981, 78:6840-6844. 10.1073/pnas.78.11.6840, 349147, 6947258.
    • (1981) Proc Natl Acad Sci U S A , vol.78 , pp. 6840-6844
    • Goldbeter, A.1    Koshland, D.2
  • 58
    • 79959859399 scopus 로고    scopus 로고
    • Robust network topologies for generating switch-like cellular responses
    • 10.1371/journal.pcbi.1002085, 3121696, 21731481
    • Shah N, Sarkar C. Robust network topologies for generating switch-like cellular responses. PLoS Comput Biol 2011, 7(6):e1002085. 10.1371/journal.pcbi.1002085, 3121696, 21731481.
    • (2011) PLoS Comput Biol , vol.7 , Issue.6
    • Shah, N.1    Sarkar, C.2
  • 59
    • 0032085941 scopus 로고    scopus 로고
    • Autoactivation of Procaspase-9 by Apaf-1-Mediated Oligomerization
    • 10.1016/S1097-2765(00)80095-7, 9651578
    • Srinivasula S, Ahmad M, Fernandes-Alnemri T, Alnemri E. Autoactivation of Procaspase-9 by Apaf-1-Mediated Oligomerization. Mol Cell 1998, 1:949-957. 10.1016/S1097-2765(00)80095-7, 9651578.
    • (1998) Mol Cell , vol.1 , pp. 949-957
    • Srinivasula, S.1    Ahmad, M.2    Fernandes-Alnemri, T.3    Alnemri, E.4
  • 60
    • 0035213498 scopus 로고    scopus 로고
    • Caspase: cellular demolition experts
    • 10.1042/BST0290696, 11709057
    • Creagh E, Martin S. Caspase: cellular demolition experts. Biochem Soc Trans 2001, 29(6):696-702. 10.1042/BST0290696, 11709057.
    • (2001) Biochem Soc Trans , vol.29 , Issue.6 , pp. 696-702
    • Creagh, E.1    Martin, S.2
  • 61
    • 0033280669 scopus 로고    scopus 로고
    • Biochemical pathways of caspase activation during apoptosis
    • 10.1146/annurev.cellbio.15.1.269, 10611963
    • Budihardjo I, Oliver H, Lutter M, Luo X, Wang X. Biochemical pathways of caspase activation during apoptosis. Annu Rev Cell Dev Biol 1999, 15:269-290. 10.1146/annurev.cellbio.15.1.269, 10611963.
    • (1999) Annu Rev Cell Dev Biol , vol.15 , pp. 269-290
    • Budihardjo, I.1    Oliver, H.2    Lutter, M.3    Luo, X.4    Wang, X.5
  • 63
    • 2942532135 scopus 로고    scopus 로고
    • Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes
    • Hill M, Adrain C, Duriez P, Creagh E, Martin S. Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes. Eur Mol Biol Organ J 2004, 23:2134-2145.
    • (2004) Eur Mol Biol Organ J , vol.23 , pp. 2134-2145
    • Hill, M.1    Adrain, C.2    Duriez, P.3    Creagh, E.4    Martin, S.5
  • 64
    • 33645429016 scopus 로고
    • Exact stochastic simulation of coupled chemical reactions
    • Gillespie D. Exact stochastic simulation of coupled chemical reactions. J Phys Chem 1977, 81:2340-61.
    • (1977) J Phys Chem , vol.81 , pp. 2340-2361
    • Gillespie, D.1
  • 65
    • 34249950625 scopus 로고    scopus 로고
    • Stochastic simulation of chemical kinetics
    • 10.1146/annurev.physchem.58.032806.104637, 17037977
    • Gillespie D. Stochastic simulation of chemical kinetics. Annu Rev Phys Chem 2007, 58:35-55. 10.1146/annurev.physchem.58.032806.104637, 17037977.
    • (2007) Annu Rev Phys Chem , vol.58 , pp. 35-55
    • Gillespie, D.1
  • 67
    • 77950853375 scopus 로고    scopus 로고
    • Estimating the stochastic bifurcation structure of cellular networks
    • 10.1371/journal.pcbi.1000699, 2832680, 20221261
    • Song C, Phenix H, Abedi V, Scott M, Ingalls B, Kaern M, Perkins T. Estimating the stochastic bifurcation structure of cellular networks. PLoS Comput Biol 2010, 6(3):e1000699. 10.1371/journal.pcbi.1000699, 2832680, 20221261.
    • (2010) PLoS Comput Biol , vol.6 , Issue.3
    • Song, C.1    Phenix, H.2    Abedi, V.3    Scott, M.4    Ingalls, B.5    Kaern, M.6    Perkins, T.7
  • 68
    • 36949034670 scopus 로고    scopus 로고
    • Stochastic noise and synchronisation during dictyostelium aggregation make cAMP oscillations robust
    • 10.1371/journal.pcbi.0030218, 2065893, 17997595
    • Kim J, Heslop-Harrison P, Postlethwaite I, Bates D. Stochastic noise and synchronisation during dictyostelium aggregation make cAMP oscillations robust. PLoS Comput Biol 2007, 3(11):e218. 10.1371/journal.pcbi.0030218, 2065893, 17997595.
    • (2007) PLoS Comput Biol , vol.3 , Issue.11
    • Kim, J.1    Heslop-Harrison, P.2    Postlethwaite, I.3    Bates, D.4
  • 69
    • 33846435732 scopus 로고    scopus 로고
    • Spectral methods for parametric sensitivity in stochastic dynamical systems
    • 10.1529/biophysj.106.085084, 1751386, 17085489
    • Kim D, Debusschere B, Najm H. Spectral methods for parametric sensitivity in stochastic dynamical systems. Biophys J 2007, 92(2):379-393. 10.1529/biophysj.106.085084, 1751386, 17085489.
    • (2007) Biophys J , vol.92 , Issue.2 , pp. 379-393
    • Kim, D.1    Debusschere, B.2    Najm, H.3
  • 70
    • 70549093092 scopus 로고    scopus 로고
    • Non-genetic cell-to-cell variability and the consequences for pharmacology
    • 2975492, 19833543
    • Niepel M, Spencer S, Sorger P. Non-genetic cell-to-cell variability and the consequences for pharmacology. Curr Opin Chem Biol 2009, 13(5-6):556-561. 2975492, 19833543.
    • (2009) Curr Opin Chem Biol , vol.13 , Issue.5-6 , pp. 556-561
    • Niepel, M.1    Spencer, S.2    Sorger, P.3
  • 72
    • 0344304552 scopus 로고    scopus 로고
    • Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis
    • 10.1083/jcb.200307130, 2173693, 14623868
    • Potts P, Singh S, Knezek M, Thompson C, Deshmukh M. Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis. J Cell Biol 2003, 163:789-799. 10.1083/jcb.200307130, 2173693, 14623868.
    • (2003) J Cell Biol , vol.163 , pp. 789-799
    • Potts, P.1    Singh, S.2    Knezek, M.3    Thompson, C.4    Deshmukh, M.5
  • 73
    • 0037478904 scopus 로고    scopus 로고
    • Antisense oligonucleotides targeting XIAP induce apoptosis and enhance chemotherapeutic activity against human lung cancer cells in vitro and in vivo
    • Hu Y, Cherton-Horvat G, Dragowska V, Baird S, Korneluk R. Antisense oligonucleotides targeting XIAP induce apoptosis and enhance chemotherapeutic activity against human lung cancer cells in vitro and in vivo. Clin Cancer Res 2003, 9:2826-2836.
    • (2003) Clin Cancer Res , vol.9 , pp. 2826-2836
    • Hu, Y.1    Cherton-Horvat, G.2    Dragowska, V.3    Baird, S.4    Korneluk, R.5
  • 74
    • 84856495152 scopus 로고    scopus 로고
    • Targeting IAP proteins for therapeutic intervention in cancer
    • 10.1038/nrd3627, 22293567
    • Fulda S, Vucic D. Targeting IAP proteins for therapeutic intervention in cancer. Nat Rev Drug Discov 2012, 11(2):109-124. 10.1038/nrd3627, 22293567.
    • (2012) Nat Rev Drug Discov , vol.11 , Issue.2 , pp. 109-124
    • Fulda, S.1    Vucic, D.2
  • 75
    • 84875884456 scopus 로고    scopus 로고
    • Cellular heterogeneity and molecular evolution in cancer
    • Almendro V, Marusyk A, Polyak K. Cellular heterogeneity and molecular evolution in cancer. Annu Rev Pathol Mech Dis 2012, 8:277-302.
    • (2012) Annu Rev Pathol Mech Dis , vol.8 , pp. 277-302
    • Almendro, V.1    Marusyk, A.2    Polyak, K.3
  • 76
    • 84879552009 scopus 로고    scopus 로고
    • Analysis of a mathematical model of apoptosis: individual differences and malfunction in programmed cell death
    • 10.1007/s10877-013-9468-z, 23604638
    • Bagci E, Sen S, Camurdan M. Analysis of a mathematical model of apoptosis: individual differences and malfunction in programmed cell death. J Clin Monit Comput 2013, 27(4):465-479. 10.1007/s10877-013-9468-z, 23604638.
    • (2013) J Clin Monit Comput , vol.27 , Issue.4 , pp. 465-479
    • Bagci, E.1    Sen, S.2    Camurdan, M.3
  • 78
    • 0036957459 scopus 로고    scopus 로고
    • Deterministic versus stochastic models for circadian rhythms
    • 10.1023/A:1021286607354, 3456469, 23345804
    • Gonze D, Halloy J, Goldbeter A. Deterministic versus stochastic models for circadian rhythms. J Biol Phys 2002, 28:637-653. 10.1023/A:1021286607354, 3456469, 23345804.
    • (2002) J Biol Phys , vol.28 , pp. 637-653
    • Gonze, D.1    Halloy, J.2    Goldbeter, A.3
  • 79
    • 0012599475 scopus 로고    scopus 로고
    • Stochastic models for circadian rhythms: effect of molecular noise on periodic and chaotic behaviour
    • Gonze D, Halloy J, Jean-Christophe L, Goldbeter A. Stochastic models for circadian rhythms: effect of molecular noise on periodic and chaotic behaviour. C R Biol 2003, 326:189-203.
    • (2003) C R Biol , vol.326 , pp. 189-203
    • Gonze, D.1    Halloy, J.2    Jean-Christophe, L.3    Goldbeter, A.4
  • 80
    • 84861511440 scopus 로고    scopus 로고
    • Stochastic gene expression modeling with hill function for switch-like gene responses
    • Kim H, Gelenbe E. Stochastic gene expression modeling with hill function for switch-like gene responses. IEEE/ACM Trans Comput Biol Bioinformatics 2012, 9:973-979.
    • (2012) IEEE/ACM Trans Comput Biol Bioinformatics , vol.9 , pp. 973-979
    • Kim, H.1    Gelenbe, E.2
  • 81
    • 63249118904 scopus 로고    scopus 로고
    • Interlinked dual-time feedback loops can enhance robustness to stochasticity and persistence of memory
    • 031902-1-11
    • Smolen P, Baxter D, Byrne J. Interlinked dual-time feedback loops can enhance robustness to stochasticity and persistence of memory. Phys Rev 2009, 79:031902-1-11.
    • (2009) Phys Rev , vol.79
    • Smolen, P.1    Baxter, D.2    Byrne, J.3
  • 82
    • 0042237031 scopus 로고    scopus 로고
    • Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization
    • 10.1093/emboj/cdg423, 202365, 12941691
    • Arnoult D, Gaume B, Karbowski M, Sharpe J, Cecconi F, Youle R. Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization. EMBO J 2003, 22(17):4385-4399. 10.1093/emboj/cdg423, 202365, 12941691.
    • (2003) EMBO J , vol.22 , Issue.17 , pp. 4385-4399
    • Arnoult, D.1    Gaume, B.2    Karbowski, M.3    Sharpe, J.4    Cecconi, F.5    Youle, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.