Control of stochasticity in eukaryotic gene expression

Science

Volumn 304, Issue 5678, 2004, Pages 1811-1814

  Raser, Jonathan M ^a   O'Shea, Erin K ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; CELLS; MATHEMATICAL MODELS; MUTAGENESIS; OPTIMIZATION; RNA;

GENE EXPRESSIONS; RANDOM FLUCTUATIONS; REGULATORY PATHWAY;

GENES;

CIS ACTING ELEMENT; TRANS ACTING FACTOR;

BIOLOGY;

ALLELE; ARTICLE; CELL FUNCTION; DIPLOIDY; EUKARYOTE; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENE MUTATION; GENETIC TRAIT; GENETIC TRANSCRIPTION; NOISE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; STOCHASTIC MODEL;

ALLELES; BACTERIAL PROTEINS; CARRIER PROTEINS; CELL CYCLE; CHROMATIN; FLOW CYTOMETRY; FLUORESCENCE; GENE EXPRESSION; GENES, FUNGAL; GREEN FLUORESCENT PROTEINS; LUMINESCENT PROTEINS; MODELS, GENETIC; MUTATION; PROMOTER REGIONS (GENETICS); PROTON-PHOSPHATE SYMPORTERS; RNA, MESSENGER; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; STOCHASTIC PROCESSES; TATA BOX; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC;

EUKARYOTA;

EID: 2942718723     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1098641     Document Type: Article

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25. We thank J. Paulsson, D. Wykoff, J. Weissman, H. Li, R. Kishony, D. Schaffer, H. Madhani, W. Marshall, and members of the O'Shea lab for discussion and critical commentary. Supported by the Howard Hughes Medical Institute, NIH grant no. GM51377, and the David and Lucile Packard Foundation (E.K.O.) and by an American Diabetes Association Medical Scholars fellowship and the UCSF Medical Scientist Training Program (J.M.R.).