Cell fate decision mediated by p53 pulses

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 30, 2009, Pages 12245-12250

  Zhang, Xiao Peng ^a   Liu, Feng ^a   Cheng, Zhang ^a   Wang, Wei ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Apoptosis; DNA repair; p53 network; Variability

Indexed keywords

ATM PROTEIN; PROTEIN P53;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL DEATH; CELL FATE; CELL SURVIVAL; DNA DAMAGE; DNA REPAIR; GENOMICS; HUMAN; IONIZING RADIATION; NONHUMAN; OSCILLATOR; PRIORITY JOURNAL;

ALGORITHMS; APOPTOSIS; CASPASE 3; CELL CYCLE PROTEINS; CELL SURVIVAL; CYTOCHROMES C; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA-BINDING PROTEINS; HUMANS; MODELS, BIOLOGICAL; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-MDM2; RADIATION, IONIZING; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

ATAXIA TELANGIECTASIA;

EID: 68149084889     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0813088106     Document Type: Article

References (45)

1. Vousden KH, Lane DP (2007) p53 in health and disease. Nat Rev Mol Cell Biol 8:275-283.
2. Harris SL, Levine AJ (2005) The p53 pathway: positive and negative feedback loops. Oncogene 24:2899-2908.
3. Lev Bar-Or R, et al. (2000) Generation of oscillations by the p53-Mdm2 feedback loop: A theoretical and experimental study. Proc Natl Acad Sci USA 97:11250-11255.
4. Hu W, et al. (2007) A single nucleotide polymorphism in the Mdm2 gene disrupts the oscillation of p53 and Mdm2 levels in cells. Cancer Res 67:2757-2765.
5. Ramalingam S, et al. (2007) Quantitative assessment of the p53-Mdm2 feedback loop using protein lysate microarrays. Cancer Res 67:6247-6252.
6. Hamstra DA, et al. (2006) Real-time evaluation of p53 oscillatory behavior in vivo using bioluminescent imaging. Cancer Res 66:7482-7489.
7. Lahav G, et al. (2004) Dynamics of the p53-Mdm2 feedback loop in individual cells. Nat Genet 36:147-150.
8. Geva-Zatorsky N, et al. (2006) Oscillations and variability in the p53 system. Mol Syst Biol 2:2006.0033
9. Blanc C, et al. (2000) Caspase-3 is essential for procaspase-9 processing and cisplatin-induced apoptosis of MCF-7 breast cancer cells. Cancer Res 60:4386-4390.
10. Tyson JJ (2006) Another turn for p53. Mol Syst Biol 2:2006.0032.
11. Francisco DC, et al. (2008) Induction and processing of complex DNA damage in human breast cancer cells MCF-7 and nonmalignant MCF-10A cells. Free Radic Biol Med 44:558-569.
12. Ma L, et al. (2005) A plausible model for the digital response of p53 to DNA damage. Proc Natl Acad Sci USA 102:14266-14271.
13. Tiana G, Jensen MH, Sneppen K (2002) Time delay as a key to apoptosis induction in the p53 network. Eur Phys J B 29:135-140.
14. Ciliberto A, Novak B, Tyson JJ (2005) Steady states and oscillations in the p53/Mdm2 network. Cell Cycle 4:488-493.
15. Zhang T, Brazhnik P, Tyson JJ (2007) Exploring mechanisms of the DNA-damage response: p53 pulses and their possible relevance to apoptosis. Cell Cycle 6:85-94.
16. Batchelor E, Mock CS, Bhan I, Loewer A, Lahav G (2008) Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage. Mol Cell 30:277-289.
17. Sengupta S, Harris CC (2005) p53: traffic cop at the crossroads of DNA repair and recombination. Nat Rev Mol Cell Biol 6:44-55.
18. Rothkamm K, Lobrich M (2003) Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses. Proc Natl Acad Sci USA 100:5057-5062.
19. Stewart RD (2001) Two-lesion kinetic model of double-strand break rejoining and cell killing. Radiat Res 156:365-378.
20. Burma S, Chen BPC, Chen DJ (2006) Role of non-homologous end joining (NHEJ) in maintaining genomic integrity. DNA Repair 5:1042-1048.
21. Yang T, et al. (1997) p53 induced by ionizing radiation mediates DNA end-joining activity, but not apoptosis of thyroid cells. Oncogene 14:1511-1519.
22. Tang W, Willers H, Powell SN (1999) p53 directly enhances rejoining of DNA double-strand breaks with cohesive ends in gamma-irradiated mouse fibroblasts. Cancer Res 59:2562-2565.
23. Bill CA, Yu Y, Miselis NR, Little JB, Nickoloff JA (1997) A role for p53 in DNA end rejoining by human cell extracts. Mutat Res 385:21-29.
24. Akyuz N, et al. (2002) DNA substrate dependence of p53-mediated regulation of double-strand break repair. Mol Cell Biol 22:6306-6317.
25. Jeggo PA (2002) The fidelity of repair of radiation damage. Radiat Prot Dosimetry 99:117-122.
26. Brady N, Gaymes TJ, Cheung M, Mufti GJ, Rassool FV (2003) Increased error-prone NHEJ activity in myeloid leukemias is associated with DNA damage at sites that recruit key nonhomologous end-joining proteins. Cancer Res 63:1798-1805.
27. Bakkenist CJ, Kastan MB (2003) DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421:499-506.
28. Prives C (1998) Signaling to p53: breaking the Mdm2-p53 circuit. Cell 95:5-8.
29. Stommel JM, Wahl GM (2004) Accelerated Mdm2 auto-degradation induced by DNA-damage kinases is required for p53 activation. EMBO J 23:1547-1556.
30. Yin Y, Stephen CW, Luciani MG, Fahraeus R (2002) p53 stability and activity is regulated by Mdm2-mediated induction of alternative p53 translation products. Nat Cell Biol 4:462-467
31. Zhang XP, Cheng Z, Liu F, Wang W (2007) Linking fast and slow positive feedback loops creates an optimal bistable switch in cell signaling. Phys Rev E 76:031924.
32. Pomerening JR, Kim SY, Ferrell JE Jr (2005) Systems-level dissection of the cell-cycle oscillator: bypassing positive feedback produces damped oscillations. Cell 122:565-578.
33. Oda K, et al. (2000) p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell 102:849-862.
34. Okamura S, et al. (2001) p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis. Mol Cell 8:85-94.
35. Fiscella M, et al. (1997) Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner. Proc Natl Acad Sci USA 94:6048-6053.
36. Kirsch DG, et al. (1999) Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c. J Biol Chem 274:21155-21161.
37. Bagci EZ, Vodovotz Y, Billiar TR, Ermentrout GB, Bahar I (2006) Bistability in apoptosis: roles of Bax, Bcl-2, and mitochondrial permeability transition pores. Biophys J 90:1546-1559.
38. Geske FJ, Lieberman R, Srtange R, Gerschenson LE (2001) Early stages of p53-induced apoptosis are reversible. Cell Death Differ 8:182-191.
39. Kitano H (2004) Cancer as a robust system: implications for anticancer therapy. Nat Rev Cancer 4:227-235.
40. Cory S, Adams JM (2002) The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2:647-656.
41. Schultz D, Ben Jacob E, Onuchic JN, Wolynes PG (2007) Molecular level stochastic model for competence cycles in Bacillus subtilis. Proc Natl Acad Sci USA 104:17582-17587.
42. Schultz D, Walczak AM, Onuchic JN, Wolynes PG (2008) Extinction and resurrection in gene networks. Proc Natl Acad Sci USA 105:19165-19170.
43. Lapidus S, Han B, Wang J (2008) Intrinsic noise, dissipation cost, and robustness of cellular networks: The underlying energy landscape of MAPK signal transduction. Proc Natl Acad Sci USA 105:6039-6044.
44. Lepzelter D, Kim KY, Wang J (2007) Dynamics and intrinsic statistical fluctuations of a gene switch. J Phys Chem B 111:10239-10247.
45. Kim KY, Wang J (2007) Potential energy landscape and robustness of a gene regulatory network: toggle switch. PLoS Comput Biol 3:e60.