Cytotoxicity of some edible mushrooms extracts over liver hepatocellular carcinoma cells in conjunction with their antioxidant and antibacterial properties

Pharmacognosy Magazine

Volumn 11, Issue 42, 2015, Pages S6-S18

  Sadi, Gökhan ^a   Emsen, Buǧrahan ^a   Kaya, Abdullah ^a   Kocaba, Aytaç ^a   Çinar, Seval ^a   Kartal, Deniz Irtem ^b  

^a KARAMANOGLU MEHMETBEY UNIVERSITY   (Turkey)

^b MIDDLE EAST TECHNICAL UNIVERSITY   (Turkey)

Author keywords

Cancer cells; Cell toxicity; Edible macrofungi; Radical scavenging

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ANTINEOPLASTIC AGENT; BETA CAROTENE; COPRINUS COMATUS EXTRACT; FLAVONOID; FUNGAL EXTRACT; LENTINUS TIGRINUS EXTRACT; LYCOPENE; PHENOL DERIVATIVE; RHIZOPOGON LUTEOLUS EXTRACT; TRICHOLOMA FRACTICUM EXTRACT; UNCLASSIFIED DRUG;

AGROBACTERIUM TUMEFACIENS; ANTIBACTERIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BACILLUS LICHENIFORMIS; BACILLUS SUBTILIS; CANCER INHIBITION; CONTROLLED STUDY; COPRINUS COMATUS; DRUG DETERMINATION; DRUG EFFECT; DRUG MECHANISM; DRUG SYNTHESIS; EDIBLE MUSHROOM; ESCHERICHIA COLI; HEPATOCELLULAR CARCINOMA CELL LINE; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; LENTINUS TIGRINUS; NONHUMAN; RHIZOPOGON LUTEOLUS; STAPHYLOCOCCUS AUREUS; TRICHOLOMA FRACTICUM;

EID: 84952922089     PISSN: 09731296     EISSN: 09764062     Source Type: Journal    
DOI: 10.4103/0973-1296.157665     Document Type: Article

References (70)

1. Cheung LM, Cheung PC, Ooi VE. Antioxidant activity and total phenolics of edible mushroom extracts. Food Chem 2003;81:249-55.
2. Cheung PC. The nutritional and health benefits of mushrooms. Nutr Bull 2010;35:292-9.
3. Beluhan S, Ranogajec A. Chemical composition and non. volatile components of croatian wild edible mushrooms. Food Chem 2011;124:1076-82.
4. Barros L, Baptista P, Correia D, Casal S, Oliveira B, Ferreira I. Fatty acid and sugar compositions, and nutritional value of five wild edible mushrooms from Northeast Portugal. Food Chem 2007;105:140-5.
5. Reis FS, Barros L, Martins A, Ferreira IC. Chemical composition and nutritional value of the most widely appreciated cultivated mushrooms: An inter.species comparative study. Food Chem Toxicol 2012;50:191-7.
6. Barros L, Cruz T, Baptista P, Estevinho LM, Ferreira IC. Wild and commercial mushrooms as source of nutrients and nutraceuticals. Food Chem Toxicol 2008;46:2742-7.
7. Kala P. Chemical composition and nutritional value of European species of wild growing mushrooms: A review. Food Chem 2009;113:9-16.
8. Espin JC, Garcia. Conesa MT, Tomas. Barberan FA. Nutraceuticals: Facts and fiction. Phytochemistry 2007;68:2986-3008.
9. Fan L, Pan H, Soccol AT, Pandey A, Soccol CR. Advances in mushroom research in the last decade. Food Technol Biotechnol 2006;44:303-11.
10. Palacios I, Lozano M, Moro C, D'Arrigo M, Rostagno MA, Martinez JA, et al. Antioxidant properties of phenolic compounds occurring in edible mushrooms. Food Chem 2011;128:674-8.
11. Ramesh Ch, Pattar MG. Antimicrobial properties, antioxidant activity and bioactive compounds from six wild edible mushrooms of western ghats of Karnataka, India. Pharmacognosy Res 2010;2:107-12.
12. Wong JY, Chye FY. Antioxidant properties of selected tropical wild edible mushrooms. J Food Compost Anal 2009;22:269-77.
13. Kotan E, Alpsoy L, Anar M, Aslan A, Agar G. Protective role of methanol extract of Cetraria islandica (L.) against oxidative stress and genotoxic effects of AFB1 in human lymphocytes in vitro. Toxicol Ind Health 2011;27:599-605.
14. Ceker S, Agar G, Nardemir G, Anar M, Kizil HE, Alpsoy L. Investigation of anti.oxidative and anti.genotoxic effects of Origanum vulgare L. essential oil on human lymphocytes in vitro. J Essent Oil Bear Plants 2012;15:997-1005.
15. Turkez H, Togar B. Olive (Olea europaea L.) leaf extract counteracts genotoxicity and oxidative stress of permethrin in human lymphocytes. J Toxicol Sci 2011;36:531-7.
16. Turkez H, Togar B, Polat E. Olive leaf extract modulates permethrin induced genetic and oxidative damage in rats. Cytotechnology 2012;64:459-64.
17. Turkez H, Togar B. Aluminium phosphide.induced genetic and oxidative damages in vitro: Attenuation by Laurus nobilis L. leaf extract. Indian J Pharmacol 2013;45:71-5.
18. Breitenbach J, Kranzlin F. Fungi of Switzerland. Vol. 1-5. Lucerne: Verlag Mykologia; 1984-2000.
19. Abe K, Matsuki N. Measurement of cellular 3. (4, 5.dimethylthiazol.2.yl).2, 5.diphenyltetrazolium bromide (MTT) reduction activity and lactate dehydrogenase release using MTT. Neurosci Res 2000;38:325-9.
20. Taga MS, Miller EE, Pratt DE. Chia seeds as a source of natural lipid antioxidants. J Am Oil Chem Soc 1984;61:928-31.
21. Pal J, Ganguly S, Tahsin KS, Acharya K. In vitro free radical scavenging activity of wild edible mushroom, Pleurotus squarrosulus (Mont.) Singer. Indian J Exp Biol 2010;48:1210-8.
22. Turkoglu A, Duru ME, Mercan N, Kivrak I, Gezer K. Antioxidant and antimicrobial activities of Laetiporus sulphureus (Bull.) Murrill. Food Chem 2007;101:267-73.
23. Oyetayo VO, Dong CH, Yao YJ. Antioxidant and antimicrobial properties of aqueous extract from Dictyophora indusiata. Open Mycol J 2009;3:20-6.
24. Karamac M, Amarowicz R, Weidner S, Abe S, Shahidi F. Antioxidant activity of rye caryopses and embryos extracts. Czech J Food Sci 2000;20:209-14.
25. Bauer AW, Kirby WM, Sherris JC, Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol 1966;45:493-6.
26. Costantini S, Colonna G, Castello G. A holistic approach to study the effects of natural antioxidants on inflammation and liver cancer. Cancer Treat Res 2014;159:311-23.
27. Fernandes A, Barreira JC, Antonio AL, Oliveira MB, Martins A, Ferreira IC. Effects of gamma irradiation on chemical composition and antioxidant potential of processed samples of the wild mushroom Macrolepiota procera. Food Chem 2014;149:91-8.
28. Ito T, Urushima H, Sakaue M, Yukawa S, Honda H, Hirai K, et al. Reduction of adverse effects by a mushroom product, active hexose correlated compound (AHCC) in patients with advanced cancer during chemotherapy. The significance of the levels of HHV.6 DNA in saliva as a surrogate biomarker during chemotherapy. Nutr Cancer 2014;66:377-82.
29. Kim SP, Nam SH, Friedman M. Hericium erinaceus (Lion's Mane) mushroom extracts inhibit metastasis of cancer cells to the lung in CT.26 colon cancer.tansplanted mice. J Agric Food Chem 2013;61:4898-904.
30. Wang S, Zhu F, Meckling KA, Marcone MF. Antioxidant capacity of food mixtures is not correlated with their antiproliferative activity against MCF.7 breast cancer cells. J Med Food 2013;16:1138-45.
31. Fontes Vieira PA, Gontijo DC, Vieira BC, Fontes EA, De Assuncao LS, Leite JP, et al. Antioxidant activities, total phenolics and metal contents in Pleurotus ostreatus mushrooms enriched with iron, zinc or lithium. LWT Food Sci Technol 2013;54:421-5.
32. Alves MJ, Froufe HJ, Costa AF, Santos AF, Oliveira LG, Osorio SR, et al. Docking studies in target proteins involved in antibacterial action mechanisms: Extending the knowledge on standard antibiotics to antimicrobial mushroom compounds. Molecules 2014;19:1672-84.
33. Petrovic J, Glamoclija J, Stojkovic DS, Ciric A, Nikolic M, Bukvicki D, et al. Laetiporus sulphureus, edible mushroom from Serbia: Investigation on volatile compounds, in vitro antimicrobial activity and in situ control of Aspergillus flavus in tomato paste. Food Chem Toxicol 2013;59:297-302.
34. Vazquez. Velasco M, Gonzalez. Torres L, Lopez. Gasco P, Bastida S, Benedi J, Sanchez. Reus MI, et al. Liver oxidation and inflammation in Fa/Fa rats fed glucomannan/spirulina.surimi. Food Chem 2014;159:215-21.
35. Tavakol HS, Farzad K, Fariba M, Abdolkarim C, Hassan G, Seyed. Mostafa HZ, et al. Hepatoprotective effect of Matricaria chamomilla. L in paraquat induced rat liver injury. Drug Res (Stuttg) 2015;65:61-4.
36. Nichols JA, Katiyar SK. Skin photoprotection by natural polyphenols: Anti.inflammatory, antioxidant and DNA repair mechanisms. Arch Dermatol Res 2010;302:71-83.
37. Christhudas IV, Kumar PP, Sunil C, Vajravijayan S, Sundaram RL, Siril SJ, et al. In vitro studies on a.glucosidase inhibition, antioxidant and free radical scavenging activities of Hedyotis biflora L. Food Chem 2013;138:1689-95.
38. Dasgupta A, Rai M, Acharya K. Chemical composition and antioxidant activity of a wild edible mushroom Pleurotus flabellatus. Int J PharmTech Res 2013;5:1655-63.
39. Dulay RM, Arenas MC, Kalaw SP, Reyes RG, Cabrera EC. Proximate composition and functionality of the culinary.medicinal tiger sawgill mushroom, Lentinus tigrinus (higher basidiomycetes), from the Philippines. Int J Med Mushrooms 2014;16:85-94.
40. Lung MY, Huang WZ. Antioxidant potential and antioxidant compounds of extracts from the medicinal sulphur polypore, Laetiporus sulphureus (Higher basidiomycetes) in submerged cultures. Int J Med Mushrooms 2013;15:569-82.
41. Ejelonu OC, Akinmoladun AC, Elekofehinti OO, Olaleye MT. Antioxidant profile of four selected wild edible mushrooms in Nigeria. J Chem Pharm Res 2013;5:286-95.
42. Lee MR, Hou JG, Begum S, Xue JJ, Wang YB, Sung CK. Comparison of constituents, antioxidant potency, and acetylcholinesterase inhibition in Lentinus edodes, Sparassis crispa, and Mycoleptodonoides aitchisonii. Food Sci Biotechnol 2013;22:1747-51.
43. Kim MJ, Chu WM, Park EJ. Antioxidant and antigenotoxic effects of shiitake mushrooms affected by different drying methods. J Korean Soc Food Sci Nutr 2012;41:1041-8.
44. Lee J, Hong JH, Kim JD, Ahn BJ, Kim BS, Kim GH, et al. The antioxidant properties of solid.culture extracts of basidiomycetous fungi. J Gen Appl Microbiol 2013;59:279-85.
45. Hasnat MA, Pervin M, Debnath T, Lim BO. DNA protection, Total phenolics and antioxidant potential of the mushroom Russula virescens. J Food Biochem 2014;38:6-17.
46. Yildirim NC, Turkoglu S, Yildirim N, Ince OK. Antioxidant properties of wild edible mushroom Pleurotus eryngii collected from Tunceli province of Turkey. Dig J Nanomater Biostruct 2012;7:1647-54.
47. Fernandes A, Barros L, Barreira JC, Antonio AL, Oliveira MB, Martins A, et al. Effects of different processing technologies on chemical and antioxidant parameters of Macrolepiota procera wild mushroom. LWT Food Sci Technol 2013;54:493-9.
48. Khatua S, Roy T, Acharya K. Antioxidant and free radical scavenging capacity of phenolic extract from Russula laurocerasi. Asian J Pharm Clin Res 2013;6:156-60.
49. Pereira E, Oliveira I, Baptista P. Guttation droplets of the edible mushroom Suillus bovinus as a new source of natural antioxidants. Sci Hortic (Amsterdam) 2012;148:89-92.
50. Ayala. Zavala JF, Perez. Carlon JJ, Esqueda M, Gonzalez. Aguilar GA, Leyva JM, Cruz. Valenzuela MR, et al. Polar fractionation affects the antioxidant properties of methanolic extracts from species of genus Phellinus quel. (higher Basidiomycetes). Int J Med Mushrooms 2012;14:563-73.
51. Liu K, Wang JL, Gong WZ, Xiao X, Wang Q. Antioxidant activities in vitro of ethanol extract and fractions from mushroom, Lenzites betulina. J Food Biochem 2013;37:687-93.
52. Barros L, Baptista P, Ferreira IC. Effect of Lactarius piperatus fruiting body maturity stage on antioxidant activity measured by several biochemical assays. Food Chem Toxicol 2007;45:1731-7.
53. Reis FS, Barros L, Calhelha RC, Ciric A, Van Griensven LJ, Sokovic M, et al. The methanolic extract of Cordyceps militaris (L.) Link fruiting body shows antioxidant, antibacterial, antifungal and antihuman tumor cell lines properties. Food Chem Toxicol 2013;62:91-8.
54. Ferreira IC, Baptista P, Vilašboas M, Barros L. Free-radical scavenging capacity and reducing power of wild edible mushrooms from northeast Portugal: Individual cap and stipe activity. Food Chem 2007;100:1511-6.
55. Zhang Y, Liu Z, Ng TB, Chen Z, Qiao W, Liu F. Purification and characterization of a novel antitumor protein with antioxidant and deoxyribonuclease activity from edible mushroom Pholiota nameko. Biochimie 2014;99:28-37.
56. Soltaninejad K, Kebriaeezadeh A, Minaiee B, Ostad SN, Hosseini R, Azizi E, et al. Biochemical and ultrastructural evidences for toxicity of lead through free radicals in rat brain. Hum Exp Toxicol 2003;22:417-23.
57. Wong SP, Leong LP, Hoe J, Koh W. Antioxidant activities of aqueous extracts of selected plants. Food Chem 2006;99:775-83.
58. Liu Y, Du YQ, Wang JH, Zha XQ, Zhang JB. Structural analysis and antioxidant activities of polysaccharide isolated from Jinqian mushroom. Int J Biol Macromol 2014;64:63-8.
59. Nandi AK, Samanta S, Maity S, Sen IK, Khatua S, Devi KS, et al. Antioxidant and immunostimulant s.glucan from edible mushroom Russula albonigra (Krombh.) Fr. Carbohydr Polym 2014;99:774-82.
60. Elmastas M, Isildak O, Turkekul I, Temur N. Determination of antioxidant activity and antioxidant compounds in wild edible mushrooms. J Food Compost Anal 2014;20:337-45.
61. Yeh JY, Hsieh LH, Wu KT, Tsai CF. Antioxidant properties and antioxidant compounds of various extracts from the edible basidiomycete Grifola frondosa (Maitake). Molecules 2011;16:3197-211.
62. Ji H, Du A, Zhang L, Li S, Yang M, Li B. Effects of drying methods on antioxidant properties and phenolic content in white button mushroom. Int J Food Eng 2012;8.
63. Meir S, Kanner J, Akiri B, Philosoph. Hadas S. Determination and involvement of aqueous reducing compounds in oxidative defense systems of various senescing leaves. J Agric Food Chem 1995;43:1813-9.
64. Barros L, Falcao S, Baptista P, Freire C, Vilašboas M, Ferreira IC. Antioxidant activity of Agaricus sp. mushrooms by chemical, biochemical and electrochemical assays. Food Chem 2008;111:61-6.
65. Sulkowska. Ziaja K, Muszynska B, Motyl P, Pasko P, Ekiert H. Phenolic compounds and antioxidant activity in some species of polyporoid mushrooms from Poland. Int J Med Mushrooms 2012;14:385-93.
66. Paloi S, Acharya K. Antioxidant activities and bioactive compounds of polyphenol rich extract from Amanita vaginata (Bull.) Lam. Int J PharmTech Res 2013;5:1645-54.
67. Barros L, Calhelha RC, Vaz JA, Ferreira IC, Baptista P, Estevinho LM. Antimicrobial activity and bioactive compounds of Portuguese wild edible mushrooms methanolic extracts. Eur Food Res Technol 2006;225:151-6.
68. Yamac M, Bilgili F. Antimicrobial activities of fruit bodies and/or mycelial cultures of some mushroom isolates. Pharm Biol 2006;44:660-7.
69. Ranadive KR, Belsare MH, Deokule SS, Jagtap NV, Jadhav HK, Vaidya JG. Glimpses of antimicrobial activity of fungi from World. J New Biol Rep 2013;2:142-62.
70. Dyakov MY, Kamzolkina OV, Shtaer OV, Bisko NA, Poedinok NL, Mikhailova OB, et al. Morphological characteristics of natural strains of certain species of basidiomycetes and biological analysis of antimicrobial activity under submerged cultural conditions. Microbiology 2011;80:274-85.