Synthesis of isoxazole moiety containing thieno[2,3-d]pyrimidine derivatives and preliminarily in vitro anticancer activity (Part II)

Anti-Cancer Agents in Medicinal Chemistry

Volumn 15, Issue 9, 2015, Pages 1148-1155

  Yong, Jianping ^a   Lu, Canzhong ^a,b   Wu, Xiaoyuan ^b  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^b FUJIAN INSTITUTE OF RESEARCH ON THE STRUCTURE OF MATTER   (China)

Author keywords

Anticancer activity; Isoxazole moiety; Synthesis; Thieno 2,3 d pyrimidine derivatives

Indexed keywords

2,5 DIPHENYL 4 [(3 P TOLYL ISOXAZOL 5 YL ) METHOXY ] THIENO[2,3 D]PYRIMIDINE; 2,5 DIPHENYL 4 [(3 PHENYL ISOXAZOL 5 YL ) METHOXY ] THIENO[2,3 D]PYRIMIDINE; 2,5 DIPHENYL 4 [[3 (2 CHLORO PHENYL) ISOXAZOL 5 YL ] METHOXY] THIENO[2,3 D]PYRIMIDINE; 2,5 DIPHENYL 4 [[3 (2,4 DICHLORO PHENYL) ISOXAZOL 5 YL ] METHOXY] THIENO[2,3 D]PYRIMIDINE; 2,5 DIPHENYL 4 [[3 (4 BROMO PHENYL) ISOXAZOL 5 YL ] METHOXY] THIENO[2,3 D]PYRIMIDINE; 2,5 DIPHENYL 4 [[3 (4 CHLORO PHENYL) ISOXAZOL 5 YL ] METHOXY] THIENO[2,3 D]PYRIMIDINE; 2,5 DIPHENYL 4 [[3 (4 METHOXY PHENYL) ISOXAZOL 5 YL ] METHOXY ] THIENO[2,3 D]PYRIMIDINE; 5 METHYL 4 [(3 P TOLYL ISOXAZOL 5 YL )METHOXY] THIENO[2,3 D]PYRIMIDINE; 5 METHYL 4 [(3 PHENYL ISOXAZOL 5 YL )METHOXY] THIENO[2,3 D]PYRIMIDINE; 5 METHYL 4 [[3 (2 CHLORO PHENYL) ISOXAZOL 5 YL ] METHOXY ]THIENO[2,3 D]PYRIMIDINE; 5 METHYL 4 [[3 (2,4 DICHLORO PHENYL) ISOXAZOL 5 YL ] METHOXY ] THIENO[2,3 D]PYRIMIDINE; 5 METHYL 4 [[3 (4 BROMO PHENYL) ISOXAZOL 5 YL ] METHOXY ] THIENO[2,3 D]PYRIMIDINE; 5 METHYL 4 [[3 (4 CHLORO PHENYL) ISOXAZOL 5 YL ] METHOXY ] THIENO[2,3 D]PYRIMIDINE; 5 METHYL 4 [[3 (4 METHOXY PHENYL) ISOXAZOL 5 YL ] METHOXY ] THIENO[2,3 D]PYRIMIDINE; 5,6 DIMETHYL 4 [(3 P TOLYL ISOXAZOL 5 YL ) METHOXY ] THIENO[2,3 D]PYRIMIDINE; 5,6 DIMETHYL 4 [(3 PHENYL ISOXAZOL 5 YL ) METHOXY ] THIENO[2,3 D]PYRIMIDINE; 5,6 DIMETHYL 4 [[3 (2 CHLORO PHENYL) ISOXAZOL 5 YL ] METHOXY ] THIENO[2,3 D]PYRIMIDINE; 5,6 DIMETHYL 4 [[3 (2,4 DICHLORO PHENYL) ISOXAZOL 5 YL ] METHOXY ] THIENO[2,3 D]PYRIMIDINE; 5,6 DIMETHYL 4 [[3 (4 BROMO PHENYL) ISOXAZOL 5 YL ] METHOXY ] THIENO[2,3 D]PYRIMIDINE; 5,6 DIMETHYL 4 [[3 (4 CHLORO PHENYL) ISOXAZOL 5 YL ] METHOXY ] THIENO[2,3 D]PYRIMIDINE; 5,6 DIMETHYL 4 [[3 (4 METHOXY PHENYL) ISOXAZOL 5 YL ] METHOXY ] THIENO[2,3 D]PYRIMIDINE; GEFITINIB; THIENO[2,3 D]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; ISOXAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HUMAN CELL; MTT ASSAY; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; CHEMISTRY; DRUG SCREENING; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; ISOXAZOLES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84952917251     PISSN: 18715206     EISSN: 18755992     Source Type: Journal    
DOI: 10.2174/1871520615666150305103122     Document Type: Article

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