SCOPUS 정보 검색 플랫폼

Volumn 46, Issue 1, 2011, Pages 71-76

The highly potent and selective dipeptidyl peptidase IV inhibitors bearing a thienopyrimidine scaffold effectively treat type 2 diabetes

(14) Deng, Jifeng a Peng, Li a Zhang, Guicheng a Lan, Xiaobing a Li, Chufang a Chen, Fuxin a Zhou, Yayao a Lin, Zuoxian a Chen, Ling a Dai, Renke a Xu, Hongjiang b Yang, Ling b Zhang, Xiquan b Hu, Wenhui a

a GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH (China)

b Jiangsu Chia Tai Tianqing Pharmaceutical Co Ltd (China)

Author keywords

DPP IV inhibitor; Scaffold hopping; Type 2 diabetes

Indexed keywords

2 [[2 (3 AMINOPIPERIDIN 1 YL) 4 OXO 5 (TRIFLUOROMETHYL) [2,3 D] PYRIMIDIN 3(4H) YL]METHYL] BENZONITRILE; 2 [[2 (3 AMINOPIPERIDIN 1 YL) 4 OXOTHIENO [2,3 D] PYRIMIDIN 3(4H) YL]METHYL] BENZONITRILE; 2 [[2 (3 AMINOPIPERIDIN 1 YL) 4 OXOTHIENO [3,2 D] PYRIMIDIN 3(4H) YL]METHYL] BENZONITRILE; 2 [[2 (3 AMINOPIPERIDIN 1 YL) 5 METHYL 4 OXOTHIENO [2,3 D] PYRIMIDIN 3(4H) YL]METHYL] BENZONITRILE; 2 [[2 (3 AMINOPIPERIDIN 1 YL) 7 METHYL 4 OXOTHIOENOL [3,2 D] PYRIMIDIN 3(4H) YL]METHYL] BENZONITRILE; ALOGLIPTIN; DIPEPTIDYL PEPTIDASE IV INHIBITOR; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; RAT;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DIPEPTIDYL PEPTIDASE 4; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; DOGS; DRUG DISCOVERY; HEK293 CELLS; HUMANS; MALE; PIPERIDINES; PYRIMIDINES; RATS; URACIL;

EID: 78650513267 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2010.10.016 Document Type: Article

Times cited : (58)

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