Synthesis, analgesic, anti-inflammatory, ulcerogenic index and antibacterial activities of novel 2-methylthio-3-substituted-5,6,7,8-tetrahydrobenzo (b) thieno[2,3-d]pyrimidin-4(3H)-ones

European Journal of Medicinal Chemistry

Volumn 41, Issue 11, 2006, Pages 1293-1300

  Alagarsamy, V ^a   Meena, S ^b   Ramseshu, K V ^b   Solomon, V R ^c   Thirumurugan, K ^b   Dhanabal, K ^a   Murugan, M ^a  

^a ARULMIGU KALASALINGAM COLLEGE OF PHARMACY   (India)

^b K M COLLEGE OF PHARMACY   (India)

^c CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Analgesic; Anti inflammatory; Pyrimidine; Thienopyrimidine; Thioureas

Indexed keywords

(2 METHYLTHIO 4 OXO 3H 5,6,7,8 TETRAHYDROBENZO (B) THIENO[2,3 D]PYRIMIDIN 3 YL)DITHIOCARBAMIC ACID METHYL ESTER; 1 (3 METHYLPHENYL) 3 (2 METHYLTHIO 4 OXO 3H 5,6,7,8 TETRAHYDROBENZO (B) THIENO[2,3 D]PYRIMIDIN 3 YL)THIOUREA; 1 (3 NITROLPHENYL) 3 (2 METHYLTHIO 4 OXO 3H 5,6,7,8 TETRAHYDROBENZO (B) THIENO[2,3 D]PYRIMIDIN 3 YL)THIOUREA; 1 (4 BROMOPHENYL) 3 (2 METHYLTHIO 4 OXO 3H 5,6,7,8 TETRAHYDROBENZO (B) THIENO[2,3 D]PYRIMIDIN 3 YL)THIOUREA; 1 (4 CHLOROPHENYL) 3 (2 METHYLTHIO 4 OXO 3H 5,6,7,8 TETRAHYDROBENZO (B) THIENO[2,3 D]PYRIMIDIN 3 YL)THIOUREA; 1 (4 METHOXYPHENYL) 3 (2 METHYLTHIO 4 OXO 3H 5,6,7,8 TETRAHYDROBENZO (B) THIENO[2,3 D]PYRIMIDIN 3 YL)THIOUREA; 1 (4 METHYLPHENYL) 3 (2 METHYLTHIO 4 OXO 3H 5,6,7,8 TETRAHYDROBENZO (B) THIENO[2,3 D]PYRIMIDIN 3 YL)THIOUREA; 1 (4 NITROPHENYL) 3 (2 METHYLTHIO 4 OXO 3H 5,6,7,8 TETRAHYDROBENZO (B) THIENO[2,3 D]PYRIMIDIN 3 YL)THIOUREA; 1 (DIPHENYL) 3 (2 METHYLTHIO 4 OXO 3H 5,6,7,8 TETRAHYDROBENZO (B) THIENO[2,3 D]PYRIMIDIN 3 YL)THIOUREA; 1 DIETHYL 3 (2 METHYLTHIO 4 OXO 3H 5,6,7,8 TETRAHYDROBENZO (B) THIENO[2,3 D]PYRIMIDIN 3 YL)THIOUREA; 1 DIMETHYL 3 (2 METHYLTHIO 4 OXO 3H 5,6,7,8 TETRAHYDROBENZO (B) THIENO[2,3 D]PYRIMIDIN 3 YL)THIOUREA; 1 METHYL 3 (2 METHYLTHIO 4 OXO 3H 5,6,7,8 TETRAHYDROBENZO (B) THIENO [2,3 D]PYRIMIDIN 3 YL)THIOUREA; 1 MORPHOLINYL 3 (2 METHYLTHIO 4 OXO 3H 5,6,7,8 TETRAHYDROBENZO (B) THIENO[2,3 D]PYRIMIDIN 3 YL)THIOUREA; 1 PHENYL 3 (2 METHYLTHIO 4 OXO 3H 5,6,7,8 TETRAHYDROBENZO (B) THIENO[2,3 D]PYRIMIDIN 3 YL)THIOUREA; 1 PIPERAZINYL 3 (2 METHYLTHIO 4 OXO 3H 5,6,7,8 TETRAHYDRO (B) THIENO[2,3 D]PYRIMIDIN 3 YL)THIOUREA; 1 PYRROLIDINYL 3 (2 METHYLTHIO 4 OXO 3H 5,6,7,8 TETRAHYDROBENZO (B) THIENO[2,3 D]PYRIMIDIN 3 YL)THIOUREA; 2 AMINO 3 CARBETHOXY 4,5,6,7 TETRAHYDROBENZO (B) THIOPHENE; ACETYLSALICYLIC ACID; AMINE; ANALGESIC AGENT; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; ANTIULCER AGENT; DICLOFENAC; DITHIOCARBAMIC ACID; ESTER DERIVATIVE; NORFLOXACIN; PYRIMIDINONE DERIVATIVE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIULCER ACTIVITY; ARTICLE; BACTERIUM CULTURE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; EDEMA; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PAIN; RAT; ULCER; ULCEROGENESIS;

ANALGESICS; ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; EDEMA; FEMALE; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; MICE; MICROBIAL SENSITIVITY TESTS; PYRIMIDINONES; RATS; RATS, WISTAR; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STOMACH ULCER;

EID: 33750517493     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2006.06.005     Document Type: Article

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