Anticancer activities of some newly synthesized pyridine, pyrane, and pyrimidine derivatives

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 16, 2006, Pages 5481-5488

  Amr, Abdel Galil E ^a   Mohamed, Ashraf M ^a   Mohamed, Salwa F ^a   Abdel Hafez, Nagla A ^a   Hammam, Abu El Fotooh G ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Anticancer activity; Nitrobenzosuberone; Pyranes; Pyrazoles; Pyrimidinethiones

Indexed keywords

10 MERCAPTO 2 NITRO 11 PHENYL 5,6,7,11 TETRAHYDRO 12H BENZO[6',7'] CYCLOHEPTA[1',2':4,5]THIENO[2,3 B]PYRIDIN 12 ONE; 10 NITRO 2 OXO 4 (3',4',5' TRIMETHOXYPHENYL) 6,7 DIHYDRO 1H,5H BENZO[6,7]CYCLOHEPTA[1,2 B]PYRIDINE 3 CARBONITRILE; 10 NITRO 2 OXO 4 PHENYL 6,7 DIHYDRO 1H,5H BENZO[6,7]CYCLOHEPTA[1,2 B]PYRIDINE 3 CARBONITRILE; 10 NITRO 4 (3',4',5' TRIMETHOXYPHENYL) 1,3,4,5,6,7 HEXAHYDRO 2H BENZO[6,7]CYCLOPHEPTA[1,2 D]PYRIMIDINE 2 THIONE; 10 NITRO 4 (4 NITROPHENYL) 1,3,4,5,6,7 HEXAHYDRO 2H BENZO[6,7] CYCLOPHEPTA[1,2 D]PYRIMIDINE 2 THIONE; 10 NITRO 4 (4 NITROPHENYL) 2 OXO 6,7 DIHYDRO 1H,5H BENZO[6,7]CYCLOHEPTA[1,2 B]PYRIDINE 3 CARBONITRILE; 2 AMINO 10 NITRO 4 (4 NITROPHENYL) 4,5,6,7 TETRAHYDROBENZO[6,7] CYCLOPHEPTA[1,2 B]PYRAN 3 CARBONITRILE; 2 AMINO 4 (4 CHLOROPHENYL) 10 NITRO 4,5,6,7 TETRAHYDROBENZO[6,7] CYCLOPHEPTA[1,2 B]PYRAN 3 CARBONITRILE; 2 AMINO 4 (4 CHLOROPHENYL) 10 NITRO 6,7 DIHYDRO 5H BENZO[3,4]CYCLOHEPTA[1,2 C]PYRIDINE 1 CARBONITRILE; 2 AMINO 4 (4 CHLOROPHENYL) 10 NITRO 6,7 DIHYDRO 5H DIBENZO[A,C]CYCLOHEPTEN 1,3 DICARBONITRILE; 2 AMINO 5 NITRO 8,9 DIHYDRO 5H BENZO[3,4]CYCLOHEPTA[1,2 B]THIOPHEN 3 ETHYL CARBOXYLATE; 3 (4 BROMOPHENYL) 9 NITRO 2 PHENYL 2,3,3A,4,5,6 HEXAHYDROBENZO[6,7] CYCLOHEPTA[1,2 C]PYRAZOLE; 3 NITRO 6 (3',4',5' TRIMETHOXYBENZYLIDENE) 6,7,8,9 TETRAHYDRO 5H BENZOCYCLOHEPTEN 5 ONE; 3 NITRO 6,7,8,9 TETRAHYDRO 5H BENZOCYCLOHEPTEN 5 YLIDENE MALONONITRILE; 4 (4 CHLOROPHENYL) 10 NITRO 2 OXO 6,7 DIHYDRO 1H,5H BENZO[6,7]CYCLOHEPTA[1, 2 B]PYRIDINE 3 CARBONITRILE; 6 (4 BROMOBENZYLIDENE) 3 NITRO 6,7,8,9 TETRAHYDRO 5H BENZOCYCLOHEPTEN 5 ONE; 6 (4 CHLOROBENZYLIDENE) 3 NITRO 6,7,8,9 TETRAHYDRO 5H BENZOCYCLOHEPTEN 5 ONE; 6 (4 NITROBENZYLIDENE) 3 NITRO 6,7,8,9 TETRAHYDRO 5H BENZOCYCLOHEPTEN 5 ONE; FLOXURIDINE; NITROBENZENE DERIVATIVE; PYRAN DERIVATIVE; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BRAIN CANCER; BREAST CANCER; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SELECTIVITY; DRUG SYNTHESIS; EVALUATION; HUMAN; HUMAN CELL; IN VITRO STUDY; KIDNEY CANCER; LEUKEMIA; LUNG CANCER; MELANOMA; OVARY CANCER; PROSTATE CANCER; SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; HUMANS; INHIBITORY CONCENTRATION 50; PYRANS; PYRIDINES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33745604932     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.04.045     Document Type: Article

References (23)

1. Amr A.E., Hegab M.I., Ibrahim A.A., and Abdalah M.M. Monatsch. Chem. 134 (2003) 1395
2. Abou-Ghalia M.H., and Amr A.E. Amino Acids 26 (2004) 283
3. Hammam A.G., Fahmy A.F.M., Amr A.E., and Mohamed A.M. Indian J. Chem. 42B (2003) 1985
4. Hammam A.G., Sharaf M.A., and Abdel Hafez N.A. Indian J. Chem. 40B (2001) 213
5. Amr A.E., Mohamed A.M., and Ibrahim A.A. Z. Naturforsch. 58b (2003) 861
6. Amr A.E., Abdel-Salam O.I., Attia A., and Stibor I. Collect. Czech. Commun. 64 (1999) 288
7. Attia A., Abdel-Salam O.I., Amr A.E., Stibor I., and Budesinsky M. Egypt. J. Chem. 43 (2000) 187
8. Amr A.E., and Abdulla M.M. Indian J. Heterocycl. Chem. 12 (2002) 129
9. Abou-Ghalia M.H., Amr A.E., and Abdalah M.M. Z. Naturforsch. 58b (2003) 903
10. Fylaktakidou C.K., Hadjipavlou J.D.L., Litinas E.K., and Nicolaides N.D. Curr. Pharm. Des. 10 (2004) 3813
11. Jung J.C., Watkins E.B., and Avery M.A. Heterocycles 65 (2005) 77
12. Amr A.E. Indian J. Heterocycl. Chem. 10 (2000) 49
13. Hammam A.G., and Ali M.I. J. Chem. Eng. Data 26 (1981) 99
14. Hammam A.G., Abdel Hafez N.A., Midura W.H., and Mikolajczyk M. Z. Naturforsch. 55b (2000) 417
15. Hassan S.S.M., Abou-Ghalia M.H., Amr A.E., and Mohamed A.H.K. Talanta 60 (2003) 81
16. Hassan S.S.M., Abou-Ghalia M.H., Amr A.E., and Mohamed A.H.K. Anal. Chem. Acta 482 (2003) 9
17. Smith P.A., and Berry W.L. J. Org. Chem. 26 (1961) 27
18. Schneller S.W., and Moore D.R. J. Org. Chem. 39 (1977) 1433
19. Yousif N.M., Gad F.A., Fahmy A.F., Amine M.S., and Sayed H.H. Phosphorus, Sulfur Silicon Relat. Elem. 117 (1996) 11
20. Ally M.C., Scudiero D.A., Monks P.A., Hursey M.L., Czerwinski M.J., Fine D.A., Abbott B.J., Mayo J.G., Shoemaker R.H., and Boyd M.R. Cancer Res. 48 (1988) 589
21. Grever M.R., Schepartz S.A., and Chabner B.A. Semin. Oncol. 19 (1992) 622
22. Boyd M.R., and Paull K.D. Drug Dev. Res. 34 (1995) 91
23. Chemical structure of interest to the division Nancita R. Lomox and Dr. V.L. Naryanan, Drug Synthesis and Chemistry Branch Development Therapeutic Program, Vol. III, 1983.