Design, synthesis and biological evaluation of novel thieno[3,2-d] pyrimidine derivatives containing diaryl urea moiety as potent antitumor agents

European Journal of Medicinal Chemistry

Volumn 85, Issue , 2014, Pages 215-227

  Liu, Zijian ^a   Wang, Yu ^a   Lin, Huafang ^a   Zuo, Dazhuang ^a   Wang, Lihui ^a   Zhao, Yanfang ^a   Gong, Ping ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Antiproliferative activity; Diaryl urea moiety; Synthesis; Thieno 3,2 d pyrimidine derivatives

Indexed keywords

1 (2 CHLOROPHENYL) 3 [4 [4 [[2 (DIETHYLAMINO)ETHYL] AMINO]THIENO[3,2 DEXTRO]PYRIMIDIN 2 YL]PHENYL]UREA; 1 (2 CHLOROPHENYL) 3 [4 [4 [[2 (DIMETHYLAMINO)ETHYL] AMINO]THIENO[3,2 DEXTRO]PYRIMIDIN 2 YL]PHENYL]UREA; 1 (2 CHLOROPHENYL) 3 [4 [4 [[3 (DIETHYLAMINO)PROPYL] AMINO]THIENO[3,2 DEXTRO]PYRIMIDIN 2 YL]PHENYL]UREA; 1 (2 CHLOROPHENYL) 3 [4 [4 [[3 (DIMETHYLAMINO)PROPYL] AMINO]THIENO[3,2 DEXTRO]PYRIMID 2 YL]PHENYL]UREA; 1 (2 CHLOROPHENYL) 3 [4 [6,7 DICHLORO 4 [[3 (DIETHYLAMINO)PROPYL]AMINO]THIENO[3,2 DEXTRO]PYRIMIDIN 2 YL]PHENYL]UREA; 1 (2,4 DICHLOROPHENYL) 3 [4 [4 [[2 (DIETHYLAMINO)ETHYL] AMINO]THIENO[3,2 DEXTRO]PYRIMIDIN 2 YL]PHENYL]UREA; 1 (2,4 DICHLOROPHENYL) 3 [4 [4 [[2 (DIMETHYLAMINO)ETHYL] AMINO]THIENO[3,2 DEXTRO]PYRIMIDIN 2 YL]PHENYL]UREA; 1 (2,4 DICHLOROPHENYL) 3 [4 [4 [[3 (DIMETHYLAMINO)PROPYL] AMINO]THIENO[3,2 DEXTRO]PYRIMID 2 YL]PHENYL]UREA; 1 (4 (4 [[3 (DIMETHYLAMINO)PROPYL]AMINO]THIENO[3,2 DEXTRO]PYRIMIDIN 2 YL)PHENYL) 3 (2 FLUOROPHENYL)UREA; 1 (4 CHLOROPHENYL) 3 [4 [4 [[2 (DIETHYLAMINO)ETHYL] AMINO]THIENO[3,2 DEXTRO]PYRIMIDIN 2 YL]PHENYL]UREA; 1 (4 CHLOROPHENYL) 3 [4 [4 [[2 (DIMETHYLAMINO)ETHYL] AMINO]THIENO[3,2 DEXTRO]PYRIMIDIN 2 YL]PHENYL]UREA; 1 (4 CHLOROPHENYL) 3 [4 [4 [[3 (DIETHYLAMINO)PROPYL] AMINO]THIENO[3,2 DEXTRO]PYRIMIDIN 2 YL]PHENYL]UREA; 1 (4 CHLOROPHENYL) 3 [4 [6,7 DICHLORO 4 [[3 (DIETHYLAMINO)PROPYL]AMINO]THIENO[3,2 DEXTRO]PYRIMIDIN 2 YL]PHENYL]UREA; 1 [4 [4 [[2 (DIETHYLAMINO)ETHYL]AMINO]THIENO[3,2 DEXTRO]PYRIMIDIN 2 YL]PHENYL]3 (2 FLUOROPHENYL)UREA; 1 [4 [4 [[2 (DIMETHYLAMINO)ETHYL]AMINO]THIENO[3,2 DEXTRO] PYRIMIDIN 2 YL]PHENYL]3 (2 FLUOROPHENYL)UREA; 1 [4 [4 [[2 (DIMETHYLAMINO)ETHYL]AMINO]THIENO[3,2 DEXTRO]PYRIMIDIN 2 YL]PHENYL] 3 (4 FLUOROPHENYL)UREA; 1 [4 [4 [[2 (DIMETHYLAMINO)ETHYL]AMINO]THIENO[3,2 DEXTRO]PYRIMIDIN 2 YL]PHENYL] 3 (P TOLYL)UREA; 1 [4 [4 [[2 (DIMETHYLAMINO)ETHYL]AMINO]THIENO[3,2 DEXTRO]PYRIMIDIN 2 YL]PHENYL] 3 PHENYLUREA; 1 [4 [4 [[3 (DIETHYLAMINO)PROPYL]AMINO]THIENO[3,2 DEXTRO]PYRIMIDIN 2 YL]PHENYL] 3 (4 FLUOROPHENYL)UREA; 1 [4 [4 [[3 (DIETHYLAMINO)PROPYL]AMINO]THIENO[3,2 DEXTRO]PYRIMIDIN 2 YL]PHENYL] 3 (P TOLYL)UREA; 1 [4 [4 [[3 (DIETHYLAMINO)PROPYL]AMINO]THIENO[3,2 DEXTRO]PYRIMIDIN 2 YL]PHENYL] 3 PHENYLUREA; 1 [4 [4 [[3 (DIETHYLAMINO)PROPYL]AMINO]THIENO[3,2 DEXTRO]PYRIMIDIN 2 YL]PHENYL]3 (2 FLUOROPHENYL)UREA; 1 [4 [6,7 DICHLORO 4 [[2 (DIETHYLAMINO)ETHYL]AMINO]THIENO[3,2 DEXTRO]PYRIMIDIN 2 YL]PHENYL] 3 (4 FLUOROPHENYL)UREA; 1 [4 [6,7 DICHLORO 4 [[3 (DIETHYLAMINO)PROPYL]AMINO]THIENO[3,2 DEXTRO]PYRIMIDIN 2 YL]PHENYL] 3 (2,4 DICHLOROPHENYL)UREA; 1 [4 [6,7 DICHLORO 4 [[3 (DIETHYLAMINO)PROPYL]AMINO]THIENO[3,2 DEXTRO]PYRIMIDIN 2 YL]PHENYL] 3 (P TOLYL)UREA; ANTINEOPLASTIC AGENT; PICTILISIB; SORAFENIB; THIENO[3,2 D]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; PYRIMIDINE; PYRIMIDINE DERIVATIVE; UREA;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; ATOM; CANCER CELL LINE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYMATIC ASSAY; HUMAN; HUMAN CELL; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 84905194648     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.07.099     Document Type: Article

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