Isoxazolo(aza)naphthoquinones: A new class of cytotoxic Hsp90 inhibitors

European Journal of Medicinal Chemistry

Volumn 53, Issue , 2012, Pages 64-75

  Bargiotti, Alberto ^a   Musso, Loana ^a   Dallavalle, Sabrina ^a   Merlini, Lucio ^a   Gallo, Grazia ^b   Ciacci, Andrea ^b   Giannini, Giuseppe ^b   Cabri, Walter ^b   Penco, Sergio ^b   Vesci, Loredana ^b   Castorina, Massimo ^b   Milazzo, Ferdinando Maria ^b   Cervoni, Maria Luisa ^b   Barbarino, Marcella ^b   Pisano, Claudio ^b   Giommarelli, Chiara ^c   Zuco, Valentina ^c   De Cesare, Michelandrea ^c   Zunino, Franco ^c  

^a UNIVERSITY OF MILAN   (Italy)

^b Sigma Tau SpA   (Italy)

^c NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Antiproliferative activity; Antitumour; Hsp90 inhibitors; Isoxazolonaphthoquinones; QSAR; Synthesis

Indexed keywords

3 (1H INDOL 5 YL) NAPHTHO[2,3 D]ISOXAZOLE 4,9 DIONE; 3 (2 HYDROXYPHENYL)NAPHTHO[2,3 D]ISOXAZOLE 4,9 DIONE; 3 (2 METHOXYPHENYL)NAPHTHO[2,3 D]ISOXAZOLE 4,9 DIONE; 3 (4 FLUOROPHENYL) 1 OXA 2,6 DIAZACYCLOPENTA[B]NAPHTHALENE 4,9 DIONE; 3 (4 FLUOROPHENYL) 5 HYDROXYNAPHTHO[2,3ED]ISOXAZOLE 4,9 DIONE; 3 (4 FLUOROPHENYL)NAPHTHO[2,3 D]ISOXAZOLE 4,9 DIONE; 3 (4 HYDROXYPHENYL)NAPHTHO[2,3 D]ISOXAZOLE 4,9 DIONE; 3 (4 METHOXYPHENYL)NAPHTHO[2,3 D]ISOXAZOLE 4,9 DIONE; 3 (5 CHLORO 2 HYDROXY 4 METHOXYPHENYL)NAPHTHO[2,3 D]ISOXAZOLE 4,9 DIONE; 3 (5 CHLORO 2,4 DIHYDROXYPHENYL)NAPHTHO[2,3 D]ISOXAZOLE 4,9 DIONE; 3 (5 CHLORO 2,4 DIMETHOXYPHENYL)NAPHTHO[2,3 D]ISOXAZOLE 4,9 DIONE; 3 PHENYL NAPHTHO[2,3 D]ISOXAZOLE 4,9 DIONE; 3 PYRIDIN 2 YL NAPHTHO[2,3 D]ISOXAZOLE 4,9 DIONE; 3 PYRIDIN 4 YL NAPHTHO[2,3 D]ISOXAZOLE 4,9 DIONE; 3 STYRYL NAPHTHO[2,3 D]ISOXAZOLE 4,9 DIONE; 4 [2 [4 (4,9 DIOXO 4,9 DIHYDRONAPTHO[2,3 D]ISOXAZOL 3YL) PHENOXY]ETHYL]MORPHOLIN 4 IUM CHLORIDE; 5 HYDROXY 3 PYRIDIN 4 YL NAPHTHO[2,3 D]ISOXAZOLE 4,9 DIONE; 5 METHOXY 3 PYRIDIN 4 YL NAPHTHO[2,3 D]ISOXAZOLE 4,9 DIONE; ACETIC ACID 3 (4 FLUOROPHENYL) 4,9 DIOXO 4,9 DIHYDRONAPHTHO[2,3 D]ISOXAZOL 5 YL ESTER; ACETIC ACID 4,9 DIOXO 3 PYRIDIN 4 YL 4,9 DIHYDRONAPHTHO[2,3 D]ISOXAZOL 5 YL ESTER; CYCLIN DEPENDENT KINASE 4; EPIDERMAL GROWTH FACTOR RECEPTOR; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; NAPHTHOQUINONE; PROTEIN KINASE B; RAF PROTEIN; SURVIVIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CONTROLLED STUDY; CYCLOADDITION; CYTOTOXICITY; DOWN REGULATION; DRUG PROTEIN BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VIVO STUDY; MOLECULAR MODEL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; TUMOR CELL CULTURE; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; FEMALE; HSP90 HEAT-SHOCK PROTEINS; HUMANS; INHIBITORY CONCENTRATION 50; ISOXAZOLES; MICE; MODELS, MOLECULAR; NAPHTHOQUINONES; PROTEIN CONFORMATION; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84861644786     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.03.036     Document Type: Article

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