Antiarrhythmic, serotonin antagonist and antianxiety activities of novel substituted thiophene derivatives synthesized from 2-amino-4,5,6,7-tetrahydro-N- phenylbenzo[b]thiophene-3-carboxamide

European Journal of Medicinal Chemistry

Volumn 45, Issue 12, 2010, Pages 5935-5942

  Amr, Abd El Galil E ^a   Sherif, Mohamed H ^b   Assy, Mohamed G ^b   Al Omar, Mohamed A ^a   Ragab, Islam ^b  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b Zagazig University   (Egypt)

Author keywords

Antiarrhythmic; Oxazinones; Serotonin antagonist and antianxiety activities; Thiazoles; Thiophenes

Indexed keywords

(4 IMINO 2 MERCAPTO 4,5,6,7 TERAHYDROBENZO[B]THIENO[2,3 D]PYRIMIDIN 3(4H) YL)(PHENYL)METHANONE; 2 (BENZYLIDENEAMINO) 4,5,6,7 TETRAHYDROBENZO[B]THIOPHENE 3 CARBONITRILE; 2 (CINNAMOYL) 3 (3 METHOXYPHENYL) 4,5,6,7 TETRAHYDROBENZO[B]THIENO[2,3 D]PYRIMIDIN 4(3H) ONE; 2 (PHENYL) 3 (3 METHOXYPHENYL) 4,5,6,7 TETRAHYDROBENZO[B]THIENO[2,3 D]PYRIMIDIN 4(3H) ONE; 2 AMINO 4,5,6,7 TETRAHYDRO N PHENYLBENZO[B]THIOPHENE 3 CARBOXAMIDE; 2 BENZAMIDO N (3 METHOXYPHENYL) 4,5,6,7 TETRAHYDROBENZO[B]THIOPHENE 3 CARBOXAMIDE; 2 CHLORO N (3 CYANO 4,5,6,7 TETRAHYDROBENZO[B]THIOPHEN 2 YL)ACETAMIDE; 2 CINNAMAMIDO N (3 METHOXYPHENYL) 4,5,6,7 TETRAHYDROBENZO[B]THIOPHENE 3 CARBOXAMIDE; 2 CINNAMOYL 4,5,6,7 TETRAHYDROBENZO[B] 4H THIENO[2,3 D][1,3]OXAZIN 4 IMINE; 2 PHENYL 4,5,6,7 TETRAHYDROBENZO[B] 4H THIENO[2,3 D][1,3]OXAZIN 4 IMINE; 3 (3 METHOXYPHENYL) 2 THIO 5,6,7,8 TETRAHYDROBENZO[B]THIENO[2,3 D][1,2,3]TRIAZIN 4(3H) ONE; 3 (3 METHOXYPHENYL) 4,5,6,7 TETRAHYDROBENZO[B]THIENO[2,3 D][1,2,3]TRIAZIN 4(3H) ONE; 4 (3 CYANO 4,5,6,7 TETRAHYDROBENZO[B]THIOPHEN 2 YLCARBAMOYL) 2 OXOBUT 3 ENOIC ACID; 4,5,6,7 TETRAHYDRO 2 (2,5 DIOXO 2H PYRROL 1(5H) YL)BENZO[B]THIOPHENE 3 CARBONITRILE; 4,5,6,7 TETRAHYDRO 2 (2,6 DIPHENYL 4 THIOXO 2H 1,3,5 OXADIAZIN 3(4H) YL)BENZO[B]THIOPHENE 3 CARBONITRILE; 4,5,6,7 TETRAHYDRO 2 (4 HYDROXY 2 IMINOTHIAZOL 3(2H) YL) BENZO[B]THIOPHENE 3 CARBONITRILE; ANTIARRHYTHMIC AGENT; BUSPIRONE; DIAZEPAM; LIDOCAINE; N (3 CYANO 4,5,6,7 TETRAHYDROBENZO[B]THIOPHEN 2 YL)BENZAMIDE; N (3 CYANO 4,5,6,7 TETRAHYDROBENZO[B]THIOPHEN 2 YL)BENZOYLTHIOUREA; N (3 CYANO 4,5,6,7 TETRAHYDROBENZO[B]THIOPHEN 2 YL)CINNAMAMIDE; PROCAINAMIDE; SEROTONIN 1A RECEPTOR; SEROTONIN ANTAGONIST; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ACYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYCLIZATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; MALE; MOUSE; NITROSATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; RAT; SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; ANTI-ARRHYTHMIA AGENTS; MALE; MICE; MOLECULAR STRUCTURE; MOTOR ACTIVITY; RATS; RATS, WISTAR; SEROTONIN ANTAGONISTS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 78649325966     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.09.059     Document Type: Article

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