Thieno[2,3-d]pyrimidines in the synthesis of antitumor and antioxidant agents

Archiv der Pharmazie

Volumn 343, Issue 5, 2010, Pages 301-309

  Aly, Ashraf A ^a   Brown, Alan B ^b   Ramadan, Mohamed ^c   Gamal Eldeen, Amira M ^d   Abdel Aziz, Mohamed ^c   Abuo Rahma, Gamal El Din A A ^c   Radwan, Mohamed F ^c  

^a El Minia University ^*  (Egypt)

^b Florida Institute of Technology   (United States)

^c Minia University   (Egypt)

^d NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Antitumor activity; Cyclization; Dimethyl acetylenedicarboxylate; E dibenzoylethylene; Thienopyrimidines

Indexed keywords

2 BENZOYL 4 HYDROXY 4 PHENYL 2,3,6,7,8,9 HEXAHYDROBENZO[4,5][1,3]THIAZINO[3,2 A]THIENO[2,3 D] PYRIMIDINE 5(4H)ONE; 2 BENZOYL 4 HYDROXY 4 PHENYL 2,3,7,8 TETRAHYDRO 6H CYCLOPENTA[4,5][1,3]THIAZINO[3,2 A]THIENO [2,3 D]PYRIMIDINE 5(4H)ONE; 2 BENZOYL 4 HYDROXY 4 PHENYL 2,3,7,8,9,10 HEXAHYDRO 6H CYCLOHEPTA[4,5][1,3]THIAZINO[3,2 A] THIENO[2,3 D]PYRIMIDINE 5(4H)ONE; ANTINEOPLASTIC AGENT; ANTIOXIDANT; ETHYL 3' [(4 OXO 5,6,7,8 TETRAHYDRO 3H BENZO4,5]THIENO[2,3 D]PYRIMIDIN 2 YL)THIO]ACRYLIC ACID; ETHYL 3' [(4 OXO 6,7 DIHYDRO 3H,5H CYCLOPENTA[4,5]2,3 D]PYRIMIDIN 2 YL)THIO]ACRYLIC ACID; ETHYL 3' [(4 OXO 6,7,8,9 TETRAHYDRO 3H,5H CYCLOHEPTA[4,5]THIENO[2,3 D]PYRIMIDIN 2 YL)THIO] ACRYLIC ACID; METHYL (3,4 DIOXO 5,6,7,8 TETRAHYDROBENZO[4,5][1,3]THIAZOLO[3,2 A]THIENO[2,3 D]PYRIMIDIN 2 YLIDENE)ACETIC ACID; METHYL (3,4 DIOXO 6,7 DIHYDRO 5H CYCLOPENTA[4,5][1,3]THIAZOLO[3,2 A]THIENO[2,3 D]PYRIMIDIN 2 YLIDENE)ACETIC ACID; METHYL (3,4 DIOXO 6,7,8,9 TETRAHYDRO 5H CYCLOHEPTA[4,5][1,3]THIAZOLO[3,2 A]THIENO [2,3 D]PYRIMIDIN 2 YLIDENE)ACETIC ACID; THIAZOLO[3,2 A]THIENO [2,3 D]PYRIMIDIN 2 YLIDENE) ACETIC ACID DERIVATIVE; THIENO[2',3':4,5]PYRIMIDO[2,1 B][1,3] THIAZIN 6 ONE DERIVATIVE; THIENO[2,3 D]PYRIMIDIN 2 YLTHIOACRYLIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL GROWTH; CELL STRAIN HCT116; CELL STRAIN HEPG2; CONTROLLED STUDY; CYCLIZATION; CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LYMPHATIC LEUKEMIA; LYMPHOCYTE PROLIFERATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; BIPHENYL COMPOUNDS; CELL PROLIFERATION; CELLS, CULTURED; CYCLIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; DRUG SCREENING ASSAYS, ANTITUMOR; HCT116 CELLS; HEP G2 CELLS; HUMANS; PICRATES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77951609138     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200900245     Document Type: Article

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