Synthesis and biological evaluation of thieno [2′,3′:4,5] pyrimido[1,2-b][1,2,4]triazines and thieno[2,3-d][1,2,4]triazolo[1,5-a] pyrimidines as anti-inflammatory and analgesic agents

European Journal of Medicinal Chemistry

Volumn 62, Issue , 2013, Pages 341-351

  Ashour, Hayam M ^a   Shaaban, Omaima G ^a   Rizk, Ola H ^a   El Ashmawy, Ibrahim M ^a  

^a Alexandria University Faculty of Pharmacy   (Egypt)

Author keywords

Analgesic activity; Anti inflammatory activity; Thienopyrimidotriazines; Thienotriazolopyrimidines; Ulcerogenic effect

Indexed keywords

2 [6,7 DIMETHYL 8 OXO 3,8 DIHYDROTHIENO(2,3 D)(1,2,4)TRIAZOLO(1,5 A) PYRIMIDIN 2 YL] N PHENYL ACETAMIDE; 2,6,7 TRIMETHYLTHIENO[2,3 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 8(3H) ONE; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; DICLOFENAC; ETHYL [6,7 DIMETHYL 8 OXO 3,8 DIHYDROTHIENO(2,3 D)(1,2,4) TRIAZOLO(1,5 A)PYRIMID 2 YL]ACETATE; PYRIMIDINE DERIVATIVE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SAFETY; DRUG SYNTHESIS; MALE; MOUSE; NONHUMAN; PAW EDEMA; ULCEROGENESIS;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; FORMALDEHYDE; MALE; MOLECULAR STRUCTURE; PYRIMIDINES; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES; TRIAZINES; TRIAZOLES;

EID: 84873034000     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.12.003     Document Type: Article

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