Trypanoside, anti-tuberculosis, leishmanicidal, and cytotoxic activities of tetrahydrobenzothienopyrimidines

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 8, 2010, Pages 2880-2886

  Aponte, José C ^a   Vaisberg, Abraham J ^b   Castillo, Denis ^c   Gonzalez, German ^c   Estevez, Yannick ^c,h   Arevalo, Jorge ^c   Quiliano, Miguel ^d   Zimic, Mirko ^d   Verástegui, Manuela ^b   Málaga, Edith ^b   Gilman, Robert H ^e   Bustamante, Juan M ^f   Tarleton, Rick L ^f   Wang, Yuehong ^g   Franzblau, Scott G ^g   Pauli, Guido F ^g   Sauvain, Michel ^b,h   Hammond, Gerald B ^a  

^a UNIVERSITY OF LOUISVILLE   (United States)

^b Laboratorio de Transporte de Oxígeno   (Peru)

^c INSTITUTO DE MEDICINA TROPICAL ALEXANDER VON HUMBOLDT   (Peru)

^d Bioinformatics Unit Drug Design Group   (Peru)

^e JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^f UNIVERSITY OF GEORGIA   (United States)

^g UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^h Hôpital Purpan   (France)

Author keywords

Anticancer; Leishmania amazonensis; Mycobacterium tuberculosis; Tetrahydrobenzothienopyrimidine; Trypanosoma cruzi

Indexed keywords

2 (5,6,7,8 TETRAHYDRO[1]BENZOTHIENO[2,3 D]PYRIMIDIN 4 YL)HYDRAZONE DERIVATIVE; AMPHOTERICIN B; ANTINEOPLASTIC AGENT; ANTITRYPANOSOMAL AGENT; BENZNIDAZOLE; HYDRAZONE DERIVATIVE; MEGLUMINE ANTIMONATE; NIFURTIMOX; PYRIMIDINE DERIVATIVE; RIFAMPICIN; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBACTERIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LEISHMANIA; LEISHMANIASIS; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA CRUZI;

ANTIPROTOZOAL AGENTS; ANTITUBERCULAR AGENTS; CELL LINE, TUMOR; HUMANS; MYCOBACTERIUM TUBERCULOSIS; PARASITIC SENSITIVITY TESTS; PYRIMIDINES; TRYPANOSOMA CRUZI;

LEISHMANIA AMAZONENSIS; MYCOBACTERIUM TUBERCULOSIS; TRYPANOSOMA CRUZI;

EID: 77950520679     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.03.018     Document Type: Article

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