Synthesis and study of antiproliferative activity of novel thienopyrimidines on glioblastoma cells

European Journal of Medicinal Chemistry

Volumn 45, Issue 6, 2010, Pages 2473-2479

  Pédeboscq, Stéphane ^a,c   Gravier, Denis ^b   Casadebaig, Françoise ^b   Hou, Geneviève ^b   Gissot, Arnaud ^b   De Giorgi, Francesca ^c   Ichas, François ^c   Cambar, Jean ^b   Pometan, Jean Paul ^a,b  

^a HÔPITAL SAINT ANDRÉ   (France)

^b UNIVERSITÉ DE BORDEAUX   (France)

^c INSERM   (France)

Author keywords

Apoptosis; Cytotoxicity; Epidermal growth factor receptor; Thienopyrimidine; Tyrosine kinase

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 4 (2 METHOXYANILINO)BENZO[B]THIENO[2,3 D]PYRIMIDINE; 4 (2 METHYLANILINO)BENZO[B]THIENO[2,3 D]PYRIMIDINE; ANTINEOPLASTIC AGENT; BORTEZOMIB; CARBOPLATIN; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB; IMATINIB; PYRROLOPYRIMIDINE DERIVATIVE; SCAFFOLD PROTEIN; SORAFENIB; SUNITINIB; TEMOZOLOMIDE; THIENO[2,3 D]PYRIMIDIN 4 ONE DERIVATIVE; UNCLASSIFIED DRUG; VASCULOTROPIN; VERAPAMIL;

ANGIOGENESIS; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER SURVIVAL; CANCER THERAPY; CELL PROLIFERATION; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; FLOW CYTOMETRY; GLIOBLASTOMA; HUMAN; HUMAN CELL; IC 50; METASTASIS; PROTEIN BINDING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HUMANS; INHIBITORY CONCENTRATION 50; PYRIMIDINES; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 77950960624     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.02.032     Document Type: Article

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