Isoxazole derivatives as potent transient receptor potential melastatin type 8 (TRPM8) agonists

European Journal of Medicinal Chemistry

Volumn 69, Issue , 2013, Pages 659-669

  Ostacolo, Carmine ^a   Ambrosino, Paolo ^b   Russo, Roberto ^a   Lo Monte, Matteo ^c   Soldovieri, Maria Virginia ^b   Laneri, Sonia ^a   Sacchi, Antonia ^a   Vistoli, Giulio ^c   Taglialatela, Maurizio ^a,b   Calignano, Antonio ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF MOLISE   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

Calcium imaging; Chronic constriction injury; Isoxazolylamine derivatives; Structure activity relationship; Transient receptor potential melastatin type 8 channels

Indexed keywords

ANALGESIC AGENT; CALCIUM; ISOXAZOLE DERIVATIVE; MENTHOL; N (2 METHYL)PROPYL N (3 ISOXAZOLYL)AMINE; N (2 METHYL)PROPYL N (3 METHYL 5 ISOXAZOLYL)AMINE; N (2 METHYL)PROPYL N (5 METHYL 3 ISOXAZOLYL)AMINE; N (2' NITRO)BENZYL N (5 METHYL 3 ISOXAZOLYL)AMINE; N (3 METHYL)BUTYL N (5 METHYL 3 ISOXAZOLYL)AMINE; N (4' NITRO)BENZYL N (5 METHYL 3 ISOXAZOLYL)AMINE; N (BUTYL) N (3 METHYL 5 ISOXAZOLYL)AMINE; N (METHYL)ETHYL N (5 METHYL 3 ISOXAZOLYL)AMINE; N BUTYL N (3 ISOXAZOLYL)AMINE; N BUTYL N (5 METHYL 3 ISOXAZOLYL)AMINE; N CYCLOHEXYLMETHYL N (5 METHYL 3 ISOXAZOLYL)AMINE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8; UNCLASSIFIED DRUG;

ALLODYNIA; ANALGESIA; ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG EFFICACY; DRUG POTENCY; IN VITRO STUDY; MALE; MOLECULAR DOCKING; MOUSE; NONHUMAN; SCIATIC NERVE INJURY; SENSORY NERVE CELL; STRUCTURE ACTIVITY RELATION;

CA(2+); CALCIUM; CALCIUM IMAGING; CCI; CHRONIC CONSTRICTION INJURY; DIFFERENTIATION MEDIUM; DM; DMEM; DULBECCO'S MODIFIED EAGLE'S MEDIUM; FBS; FETAL BOVINE SERUM; GM; GROWTH MEDIUM; ISOXAZOLYLAMINE DERIVATIVES; REVERSE-TRANSCRIPTION PCR; ROOM TEMPERATURE; RT; RT-PCR; SAR; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSIENT RECEPTOR POTENTIAL MELASTATIN TYPE-8 CHANNELS; TRPM8 CHANNELS;

ANIMALS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; ISOXAZOLES; MALE; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MONTE CARLO METHOD; STRUCTURE-ACTIVITY RELATIONSHIP; TRPM CATION CHANNELS;

EID: 84884768588     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.08.056     Document Type: Article

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