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Volumn 46, Issue , 2015, Pages 68-77

Revisiting cardiovascular calcification: A multifaceted disease requiring a multidisciplinary approach

Author keywords

Aortic valve disease; Atherosclerosis; Cardiovascular calcification; Chronic renal disease; Microcalcification

Indexed keywords

CALCIUM; CALCIUM PHOSPHATE; COLLAGEN;

EID: 84952639267     PISSN: 10849521     EISSN: 10963634     Source Type: Journal    
DOI: 10.1016/j.semcdb.2015.09.004     Document Type: Review
Times cited : (42)

References (119)
  • 1
    • 23044460500 scopus 로고    scopus 로고
    • Coronary calcification improves cardiovascular risk prediction in the elderly
    • Vliegenthart R., et al. Coronary calcification improves cardiovascular risk prediction in the elderly. Circulation 2005, 112(4):572-577.
    • (2005) Circulation , vol.112 , Issue.4 , pp. 572-577
    • Vliegenthart, R.1
  • 2
    • 84893651437 scopus 로고    scopus 로고
    • Heart disease and stroke statistics - 2014 update: a report from the American Heart Association
    • Go A.S., et al. Heart disease and stroke statistics - 2014 update: a report from the American Heart Association. Circulation 2014, 129(3):e28-e292.
    • (2014) Circulation , vol.129 , Issue.3 , pp. e28-e292
    • Go, A.S.1
  • 3
    • 33750904801 scopus 로고    scopus 로고
    • Vascular calcification: pathobiological mechanisms and clinical implications
    • Johnson R.C., Leopold J.A., Loscalzo J. Vascular calcification: pathobiological mechanisms and clinical implications. Circ. Res. 2006, 99(10):1044-1059.
    • (2006) Circ. Res. , vol.99 , Issue.10 , pp. 1044-1059
    • Johnson, R.C.1    Leopold, J.A.2    Loscalzo, J.3
  • 5
    • 84886100299 scopus 로고    scopus 로고
    • Vascular calcification: an update on mechanisms and challenges in treatment
    • Wu M., Rementer C., Giachelli C.M. Vascular calcification: an update on mechanisms and challenges in treatment. Calcif. Tissue Int. 2013, 93(4):365-373.
    • (2013) Calcif. Tissue Int. , vol.93 , Issue.4 , pp. 365-373
    • Wu, M.1    Rementer, C.2    Giachelli, C.M.3
  • 6
    • 67650105636 scopus 로고    scopus 로고
    • A computational model of aging and calcification in the aortic heart valve
    • Weinberg E.J., Schoen F.J., Mofrad M.R. A computational model of aging and calcification in the aortic heart valve. PLoS ONE 2009, 4(6):e5960.
    • (2009) PLoS ONE , vol.4 , Issue.6 , pp. e5960
    • Weinberg, E.J.1    Schoen, F.J.2    Mofrad, M.R.3
  • 7
    • 84894645158 scopus 로고    scopus 로고
    • Effect of tissue properties, shape and orientation of microcalcifications on vulnerable cap stability using different hyperelastic constitutive models
    • Cardoso L., et al. Effect of tissue properties, shape and orientation of microcalcifications on vulnerable cap stability using different hyperelastic constitutive models. J. Biomech. 2014, 47(4):870-877.
    • (2014) J. Biomech. , vol.47 , Issue.4 , pp. 870-877
    • Cardoso, L.1
  • 8
    • 84930923746 scopus 로고    scopus 로고
    • Cardiovascular calcification: current controversies and novel concepts
    • Ruiz J.L., Hutcheson J.D., Aikawa E. Cardiovascular calcification: current controversies and novel concepts. Cardiovasc. Pathol. 2015.
    • (2015) Cardiovasc. Pathol.
    • Ruiz, J.L.1    Hutcheson, J.D.2    Aikawa, E.3
  • 9
    • 79958147911 scopus 로고    scopus 로고
    • Calcific aortic valve stenosis: methods, models, and mechanisms
    • Miller J.D., Weiss R.M., Heistad D.D. Calcific aortic valve stenosis: methods, models, and mechanisms. Circ. Res. 2011, 108(11):1392-1412.
    • (2011) Circ. Res. , vol.108 , Issue.11 , pp. 1392-1412
    • Miller, J.D.1    Weiss, R.M.2    Heistad, D.D.3
  • 10
    • 20844451175 scopus 로고    scopus 로고
    • Spotty calcification typifies the culprit plaque in patients with acute myocardial infarction: an intravascular ultrasound study
    • Ehara S., et al. Spotty calcification typifies the culprit plaque in patients with acute myocardial infarction: an intravascular ultrasound study. Circulation 2004, 110(22):3424-3429.
    • (2004) Circulation , vol.110 , Issue.22 , pp. 3424-3429
    • Ehara, S.1
  • 11
    • 84892638663 scopus 로고    scopus 로고
    • Calcium density of coronary artery plaque and risk of incident cardiovascular events
    • Criqui M.H., et al. Calcium density of coronary artery plaque and risk of incident cardiovascular events. JAMA 2014, 311(3):271-278.
    • (2014) JAMA , vol.311 , Issue.3 , pp. 271-278
    • Criqui, M.H.1
  • 12
    • 84879509846 scopus 로고    scopus 로고
    • Revised microcalcification hypothesis for fibrous cap rupture in human coronary arteries
    • Kelly-Arnold A., et al. Revised microcalcification hypothesis for fibrous cap rupture in human coronary arteries. Proc. Natl. Acad. Sci. U. S. A. 2013, 110(26):10741-10746.
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , Issue.26 , pp. 10741-10746
    • Kelly-Arnold, A.1
  • 13
    • 84872601671 scopus 로고    scopus 로고
    • The explosive growth of small voids in vulnerable cap rupture; cavitation and interfacial debonding
    • Maldonado N., et al. The explosive growth of small voids in vulnerable cap rupture; cavitation and interfacial debonding. J. Biomech. 2013, 46(2):396-401.
    • (2013) J. Biomech. , vol.46 , Issue.2 , pp. 396-401
    • Maldonado, N.1
  • 14
    • 84865749355 scopus 로고    scopus 로고
    • A mechanistic analysis of the role of microcalcifications in atherosclerotic plaque stability: potential implications for plaque rupture
    • Maldonado N., et al. A mechanistic analysis of the role of microcalcifications in atherosclerotic plaque stability: potential implications for plaque rupture. Am. J. Physiol. Heart Circ. Physiol. 2012, 303(5):H619-H628.
    • (2012) Am. J. Physiol. Heart Circ. Physiol. , vol.303 , Issue.5 , pp. H619-H628
    • Maldonado, N.1
  • 15
    • 0142053972 scopus 로고    scopus 로고
    • From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II
    • Naghavi M., et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II. Circulation 2003, 108(15):1772-1778.
    • (2003) Circulation , vol.108 , Issue.15 , pp. 1772-1778
    • Naghavi, M.1
  • 16
    • 0141885294 scopus 로고    scopus 로고
    • From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I
    • Naghavi M., et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I. Circulation 2003, 108(14):1664-1672.
    • (2003) Circulation , vol.108 , Issue.14 , pp. 1664-1672
    • Naghavi, M.1
  • 17
    • 84894662076 scopus 로고    scopus 로고
    • Computational approaches for analyzing the mechanics of atherosclerotic plaques: a review
    • Holzapfel G.A., et al. Computational approaches for analyzing the mechanics of atherosclerotic plaques: a review. J. Biomech. 2014, 47(4):859-869.
    • (2014) J. Biomech. , vol.47 , Issue.4 , pp. 859-869
    • Holzapfel, G.A.1
  • 18
    • 84881223424 scopus 로고    scopus 로고
    • Collagenases and cracks in the plaque
    • Libby P. Collagenases and cracks in the plaque. J. Clin. Invest. 2013, 123(8):3201-3203.
    • (2013) J. Clin. Invest. , vol.123 , Issue.8 , pp. 3201-3203
    • Libby, P.1
  • 19
    • 33646056999 scopus 로고    scopus 로고
    • Pathology of the vulnerable plaque
    • Virmani R., et al. Pathology of the vulnerable plaque. J. Am. Coll. Cardiol. 2006, 47(8 Suppl.):C13-C18.
    • (2006) J. Am. Coll. Cardiol. , vol.47 , Issue.8 , pp. C13-C18
    • Virmani, R.1
  • 20
    • 0038201864 scopus 로고    scopus 로고
    • Pathology of the thin-cap fibroatheroma: a type of vulnerable plaque
    • Virmani R., et al. Pathology of the thin-cap fibroatheroma: a type of vulnerable plaque. J. Interv. Cardiol. 2003, 16(3):267-272.
    • (2003) J. Interv. Cardiol. , vol.16 , Issue.3 , pp. 267-272
    • Virmani, R.1
  • 21
    • 0036892838 scopus 로고    scopus 로고
    • Vulnerable plaque: the pathology of unstable coronary lesions
    • Virmani R., et al. Vulnerable plaque: the pathology of unstable coronary lesions. J. Interv. Cardiol. 2002, 15(6):439-446.
    • (2002) J. Interv. Cardiol. , vol.15 , Issue.6 , pp. 439-446
    • Virmani, R.1
  • 22
    • 0027516690 scopus 로고
    • Distribution of circumferential stress in ruptured and stable atherosclerotic lesions. A structural analysis with histopathological correlation
    • Cheng G.C., et al. Distribution of circumferential stress in ruptured and stable atherosclerotic lesions. A structural analysis with histopathological correlation. Circulation 1993, 87(4):1179-1187.
    • (1993) Circulation , vol.87 , Issue.4 , pp. 1179-1187
    • Cheng, G.C.1
  • 23
    • 0024330373 scopus 로고
    • Influence of plaque configuration and stress distribution on fissuring of coronary atherosclerotic plaques
    • Richardson P.D., Davies M.J., Born G.V. Influence of plaque configuration and stress distribution on fissuring of coronary atherosclerotic plaques. Lancet 1989, 2(8669):941-944.
    • (1989) Lancet , vol.2 , Issue.8669 , pp. 941-944
    • Richardson, P.D.1    Davies, M.J.2    Born, G.V.3
  • 24
    • 84899438165 scopus 로고    scopus 로고
    • Changing views of the biomechanics of vulnerable plaque rupture: a review
    • Cardoso L., Weinbaum S. Changing views of the biomechanics of vulnerable plaque rupture: a review. Ann. Biomed. Eng. 2014, 42(2):415-431.
    • (2014) Ann. Biomed. Eng. , vol.42 , Issue.2 , pp. 415-431
    • Cardoso, L.1    Weinbaum, S.2
  • 25
    • 44849109250 scopus 로고    scopus 로고
    • Micro-CT based analysis of a new paradigm for vulnerable plaque rupture: cellular microcalcifications in fibrous caps
    • Vengrenyuk Y., Cardoso L., Weinbaum S. Micro-CT based analysis of a new paradigm for vulnerable plaque rupture: cellular microcalcifications in fibrous caps. Mol. Cell. Biomech. 2008, 5(1):37-47.
    • (2008) Mol. Cell. Biomech. , vol.5 , Issue.1 , pp. 37-47
    • Vengrenyuk, Y.1    Cardoso, L.2    Weinbaum, S.3
  • 26
    • 33749514279 scopus 로고    scopus 로고
    • A hypothesis for vulnerable plaque rupture due to stress-induced debonding around cellular microcalcifications in thin fibrous caps
    • Vengrenyuk Y., et al. A hypothesis for vulnerable plaque rupture due to stress-induced debonding around cellular microcalcifications in thin fibrous caps. Proc. Natl. Acad. Sci. U. S. A. 2006, 103(40):14678-14683.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , Issue.40 , pp. 14678-14683
    • Vengrenyuk, Y.1
  • 27
    • 84864538017 scopus 로고    scopus 로고
    • Microcalcifications increase coronary vulnerable plaque rupture potential: a patient-based micro-CT fluid-structure interaction study
    • Rambhia S.H., et al. Microcalcifications increase coronary vulnerable plaque rupture potential: a patient-based micro-CT fluid-structure interaction study. Ann. Biomed. Eng. 2012, 40(7):1443-1454.
    • (2012) Ann. Biomed. Eng. , vol.40 , Issue.7 , pp. 1443-1454
    • Rambhia, S.H.1
  • 28
    • 84897395443 scopus 로고    scopus 로고
    • Has our understanding of calcification in human coronary atherosclerosis progressed?
    • Otsuka F., et al. Has our understanding of calcification in human coronary atherosclerosis progressed?. Arterioscler. Thromb. Vasc. Biol. 2014, 34(4):724-736.
    • (2014) Arterioscler. Thromb. Vasc. Biol. , vol.34 , Issue.4 , pp. 724-736
    • Otsuka, F.1
  • 29
    • 38049127755 scopus 로고    scopus 로고
    • Mechanical response of a calcified plaque model to fluid shear force
    • Lin T.C., et al. Mechanical response of a calcified plaque model to fluid shear force. Ann. Biomed. Eng. 2006, 34(10):1535-1541.
    • (2006) Ann. Biomed. Eng. , vol.34 , Issue.10 , pp. 1535-1541
    • Lin, T.C.1
  • 30
    • 26844562077 scopus 로고    scopus 로고
    • Longitudinal structural determinants of atherosclerotic plaque vulnerability: a computational analysis of stress distribution using vessel models and three-dimensional intravascular ultrasound imaging
    • Imoto K., et al. Longitudinal structural determinants of atherosclerotic plaque vulnerability: a computational analysis of stress distribution using vessel models and three-dimensional intravascular ultrasound imaging. J. Am. Coll. Cardiol. 2005, 46(8):1507-1515.
    • (2005) J. Am. Coll. Cardiol. , vol.46 , Issue.8 , pp. 1507-1515
    • Imoto, K.1
  • 31
    • 84856988081 scopus 로고    scopus 로고
    • Effect of calcification on the mechanical stability of plaque based on a three-dimensional carotid bifurcation model
    • Wong K.K., et al. Effect of calcification on the mechanical stability of plaque based on a three-dimensional carotid bifurcation model. BMC Cardiovasc. Disord. 2012, 12:7.
    • (2012) BMC Cardiovasc. Disord. , vol.12 , pp. 7
    • Wong, K.K.1
  • 32
    • 84870894431 scopus 로고    scopus 로고
    • Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis
    • Gimbrone M.A., Garcia-Cardena G. Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis. Cardiovasc. Pathol. 2013, 22(1):9-15.
    • (2013) Cardiovasc. Pathol. , vol.22 , Issue.1 , pp. 9-15
    • Gimbrone, M.A.1    Garcia-Cardena, G.2
  • 33
    • 84897102793 scopus 로고    scopus 로고
    • Potential drug targets for calcific aortic valve disease
    • Hutcheson J.D., Aikawa E., Merryman W.D. Potential drug targets for calcific aortic valve disease. Nat. Rev. Cardiol. 2014, 11(4):218-231.
    • (2014) Nat. Rev. Cardiol. , vol.11 , Issue.4 , pp. 218-231
    • Hutcheson, J.D.1    Aikawa, E.2    Merryman, W.D.3
  • 34
    • 1542347890 scopus 로고    scopus 로고
    • Vascular calcification in chronic kidney disease
    • Goodman W.G., et al. Vascular calcification in chronic kidney disease. Am. J. Kidney Dis. 2004, 43(3):572-579.
    • (2004) Am. J. Kidney Dis. , vol.43 , Issue.3 , pp. 572-579
    • Goodman, W.G.1
  • 35
    • 84941127989 scopus 로고    scopus 로고
    • Diagnosis and management of valvular aortic stenosis
    • Czarny M.J., Resar J.R. Diagnosis and management of valvular aortic stenosis. Clin. Med. Insights Cardiol. 2014, 8(Suppl. 1):15-24.
    • (2014) Clin. Med. Insights Cardiol. , vol.8 , pp. 15-24
    • Czarny, M.J.1    Resar, J.R.2
  • 36
    • 37349065459 scopus 로고    scopus 로고
    • Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo
    • Aikawa E., et al. Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo. Circulation 2007, 116(24):2841-2850.
    • (2007) Circulation , vol.116 , Issue.24 , pp. 2841-2850
    • Aikawa, E.1
  • 37
    • 79961222817 scopus 로고    scopus 로고
    • Prevalence and characteristics of unoperated patients with severe aortic stenosis
    • Bach D.S. Prevalence and characteristics of unoperated patients with severe aortic stenosis. J. Heart Valve Dis. 2011, 20(3):284-291.
    • (2011) J. Heart Valve Dis. , vol.20 , Issue.3 , pp. 284-291
    • Bach, D.S.1
  • 38
    • 84855393451 scopus 로고    scopus 로고
    • Look more closely at the valve: imaging calcific aortic valve disease
    • Aikawa E., Otto C.M. Look more closely at the valve: imaging calcific aortic valve disease. Circulation 2012, 125(1):9-11.
    • (2012) Circulation , vol.125 , Issue.1 , pp. 9-11
    • Aikawa, E.1    Otto, C.M.2
  • 39
    • 84927581434 scopus 로고    scopus 로고
    • Relation of aortic valve calcium to chronic kidney disease (from the chronic renal insufficiency cohort study)
    • Guerraty M.A., et al. Relation of aortic valve calcium to chronic kidney disease (from the chronic renal insufficiency cohort study). Am. J. Cardiol. 2015, 115(9):1281-1286.
    • (2015) Am. J. Cardiol. , vol.115 , Issue.9 , pp. 1281-1286
    • Guerraty, M.A.1
  • 40
    • 84890025510 scopus 로고    scopus 로고
    • Aortic valve calcification in chronic kidney disease
    • Rattazzi M., et al. Aortic valve calcification in chronic kidney disease. Nephrol. Dial. Transplant. 2013, 28(12):2968-2976.
    • (2013) Nephrol. Dial. Transplant. , vol.28 , Issue.12 , pp. 2968-2976
    • Rattazzi, M.1
  • 41
    • 55449118235 scopus 로고    scopus 로고
    • Mineral surface in calcified plaque is like that of bone: further evidence for regulated mineralization
    • Duer M.J., et al. Mineral surface in calcified plaque is like that of bone: further evidence for regulated mineralization. Arterioscler. Thromb. Vasc. Biol. 2008, 28(11):2030-2034.
    • (2008) Arterioscler. Thromb. Vasc. Biol. , vol.28 , Issue.11 , pp. 2030-2034
    • Duer, M.J.1
  • 42
    • 84878255608 scopus 로고    scopus 로고
    • Nano-analytical electron microscopy reveals fundamental insights into human cardiovascular tissue calcification
    • Bertazzo S., et al. Nano-analytical electron microscopy reveals fundamental insights into human cardiovascular tissue calcification. Nat. Mater. 2013, 12(6):576-583.
    • (2013) Nat. Mater. , vol.12 , Issue.6 , pp. 576-583
    • Bertazzo, S.1
  • 43
    • 84880314624 scopus 로고    scopus 로고
    • Macrophage-derived matrix vesicles: an alternative novel mechanism for microcalcification in atherosclerotic plaques
    • New S.E., et al. Macrophage-derived matrix vesicles: an alternative novel mechanism for microcalcification in atherosclerotic plaques. Circ. Res. 2013, 113(1):72-77.
    • (2013) Circ. Res. , vol.113 , Issue.1 , pp. 72-77
    • New, S.E.1
  • 44
    • 79959954425 scopus 로고    scopus 로고
    • Calcium regulates key components of vascular smooth muscle cell-derived matrix vesicles to enhance mineralization
    • Kapustin A.N., et al. Calcium regulates key components of vascular smooth muscle cell-derived matrix vesicles to enhance mineralization. Circ. Res. 2011, 109(1):e1-e12.
    • (2011) Circ. Res. , vol.109 , Issue.1 , pp. e1-e12
    • Kapustin, A.N.1
  • 45
    • 0141560730 scopus 로고    scopus 로고
    • Matrix vesicles and calcification
    • Anderson H.C. Matrix vesicles and calcification. Curr. Rheumatol. Rep. 2003, 5(3):222-226.
    • (2003) Curr. Rheumatol. Rep. , vol.5 , Issue.3 , pp. 222-226
    • Anderson, H.C.1
  • 46
    • 1242316272 scopus 로고    scopus 로고
    • Impaired calcification around matrix vesicles of growth plate and bone in alkaline phosphatase-deficient mice
    • Anderson H.C., et al. Impaired calcification around matrix vesicles of growth plate and bone in alkaline phosphatase-deficient mice. Am. J. Pathol. 2004, 164(3):841-847.
    • (2004) Am. J. Pathol. , vol.164 , Issue.3 , pp. 841-847
    • Anderson, H.C.1
  • 47
    • 19544379935 scopus 로고    scopus 로고
    • The role of matrix vesicles in growth plate development and biomineralization
    • Anderson H.C., Garimella R., Tague S.E. The role of matrix vesicles in growth plate development and biomineralization. Front. Biosci. 2005, 10:822-837.
    • (2005) Front. Biosci. , vol.10 , pp. 822-837
    • Anderson, H.C.1    Garimella, R.2    Tague, S.E.3
  • 48
    • 80052640889 scopus 로고    scopus 로고
    • Matrix vesicles isolated from mineralization-competent Saos-2 cells are selectively enriched with annexins and S100 proteins
    • Cmoch A., et al. Matrix vesicles isolated from mineralization-competent Saos-2 cells are selectively enriched with annexins and S100 proteins. Biochem. Biophys. Res. Commun. 2011, 412(4):683-687.
    • (2011) Biochem. Biophys. Res. Commun. , vol.412 , Issue.4 , pp. 683-687
    • Cmoch, A.1
  • 49
    • 0035916929 scopus 로고    scopus 로고
    • Bone formation and inflammation in cardiac valves
    • Mohler E.R., et al. Bone formation and inflammation in cardiac valves. Circulation 2001, 103(11):1522-1528.
    • (2001) Circulation , vol.103 , Issue.11 , pp. 1522-1528
    • Mohler, E.R.1
  • 50
    • 0038711036 scopus 로고    scopus 로고
    • Human aortic valve calcification is associated with an osteoblast phenotype
    • Rajamannan N.M., et al. Human aortic valve calcification is associated with an osteoblast phenotype. Circulation 2003, 107(17):2181-2184.
    • (2003) Circulation , vol.107 , Issue.17 , pp. 2181-2184
    • Rajamannan, N.M.1
  • 51
    • 33646456644 scopus 로고    scopus 로고
    • Optical imaging of hydroxyapatite in the calcified vasculature of transgenic animals
    • Zaheer A., et al. Optical imaging of hydroxyapatite in the calcified vasculature of transgenic animals. Arterioscler. Thromb. Vasc. Biol. 2006, 26(5):1132-1136.
    • (2006) Arterioscler. Thromb. Vasc. Biol. , vol.26 , Issue.5 , pp. 1132-1136
    • Zaheer, A.1
  • 52
    • 0036148405 scopus 로고    scopus 로고
    • Development of bisphosphonates
    • Fleisch H. Development of bisphosphonates. Breast Cancer Res. 2002, 4(1):30-34.
    • (2002) Breast Cancer Res. , vol.4 , Issue.1 , pp. 30-34
    • Fleisch, H.1
  • 53
    • 77955736518 scopus 로고    scopus 로고
    • Near-infrared fluorescent probe traces bisphosphonate delivery and retention in vivo
    • Kozloff K.M., et al. Near-infrared fluorescent probe traces bisphosphonate delivery and retention in vivo. J. Bone Miner. Res. 2010, 25(8):1748-1758.
    • (2010) J. Bone Miner. Res. , vol.25 , Issue.8 , pp. 1748-1758
    • Kozloff, K.M.1
  • 54
    • 80054937214 scopus 로고    scopus 로고
    • Calcific aortic valve disease: not simply a degenerative process: a review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update
    • Rajamannan N.M., et al. Calcific aortic valve disease: not simply a degenerative process: a review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update. Circulation 2011, 124(16):1783-1791.
    • (2011) Circulation , vol.124 , Issue.16 , pp. 1783-1791
    • Rajamannan, N.M.1
  • 55
    • 84881024473 scopus 로고    scopus 로고
    • Role of extracellular vesicles in de novo mineralization: an additional novel mechanism of cardiovascular calcification
    • New S.E., Aikawa E. Role of extracellular vesicles in de novo mineralization: an additional novel mechanism of cardiovascular calcification. Arterioscler. Thromb. Vasc. Biol. 2013, 33(8):1753-1758.
    • (2013) Arterioscler. Thromb. Vasc. Biol. , vol.33 , Issue.8 , pp. 1753-1758
    • New, S.E.1    Aikawa, E.2
  • 56
    • 84897066485 scopus 로고    scopus 로고
    • Inflammatory, metabolic, and genetic mechanisms of vascular calcification
    • Demer L.L., Tintut Y. Inflammatory, metabolic, and genetic mechanisms of vascular calcification. Arterioscler. Thromb. Vasc. Biol. 2014, 34(4):715-723.
    • (2014) Arterioscler. Thromb. Vasc. Biol. , vol.34 , Issue.4 , pp. 715-723
    • Demer, L.L.1    Tintut, Y.2
  • 57
    • 84876392367 scopus 로고    scopus 로고
    • MicroRNA in cardiovascular calcification: focus on targets and extracellular vesicle delivery mechanisms
    • Goettsch C., Hutcheson J.D., Aikawa E. MicroRNA in cardiovascular calcification: focus on targets and extracellular vesicle delivery mechanisms. Circ. Res. 2013, 112(7):1073-1084.
    • (2013) Circ. Res. , vol.112 , Issue.7 , pp. 1073-1084
    • Goettsch, C.1    Hutcheson, J.D.2    Aikawa, E.3
  • 58
    • 84908061325 scopus 로고    scopus 로고
    • A current understanding of vascular calcification in CKD
    • Paloian N.J., Giachelli C.M. A current understanding of vascular calcification in CKD. Am. J. Physiol. Renal Physiol. 2014, 307(8):F891-F900.
    • (2014) Am. J. Physiol. Renal Physiol. , vol.307 , Issue.8 , pp. F891-F900
    • Paloian, N.J.1    Giachelli, C.M.2
  • 59
    • 84930928356 scopus 로고    scopus 로고
    • Vascular calcification: mechanisms of vascular smooth muscle cell calcification
    • Leopold J.A. Vascular calcification: mechanisms of vascular smooth muscle cell calcification. Trends Cardiovasc. Med. 2014.
    • (2014) Trends Cardiovasc. Med.
    • Leopold, J.A.1
  • 60
    • 84905365228 scopus 로고    scopus 로고
    • Bone cell communication factors and semaphorins
    • Negishi-Koga T., Takayanagi H. Bone cell communication factors and semaphorins. Bonekey Rep. 2012, 1:183.
    • (2012) Bonekey Rep. , vol.1 , pp. 183
    • Negishi-Koga, T.1    Takayanagi, H.2
  • 61
    • 84865515845 scopus 로고    scopus 로고
    • Smooth muscle cell-specific runx2 deficiency inhibits vascular calcification
    • Sun Y., et al. Smooth muscle cell-specific runx2 deficiency inhibits vascular calcification. Circ. Res. 2012, 111(5):543-552.
    • (2012) Circ. Res. , vol.111 , Issue.5 , pp. 543-552
    • Sun, Y.1
  • 62
    • 77954105508 scopus 로고    scopus 로고
    • Runx2/Cbfa1, but not loss of myocardin, is required for smooth muscle cell lineage reprogramming toward osteochondrogenesis
    • Speer M.Y., et al. Runx2/Cbfa1, but not loss of myocardin, is required for smooth muscle cell lineage reprogramming toward osteochondrogenesis. J. Cell. Biochem. 2010, 110(4):935-947.
    • (2010) J. Cell. Biochem. , vol.110 , Issue.4 , pp. 935-947
    • Speer, M.Y.1
  • 63
    • 0141817707 scopus 로고    scopus 로고
    • Calcification in atherosclerosis: bone biology and chronic inflammation at the arterial crossroads
    • Doherty T.M., et al. Calcification in atherosclerosis: bone biology and chronic inflammation at the arterial crossroads. Proc. Natl. Acad. Sci. U. S. A. 2003, 100(20):11201-11206.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , Issue.20 , pp. 11201-11206
    • Doherty, T.M.1
  • 64
    • 44649133999 scopus 로고    scopus 로고
    • Vascular calcification: pathobiology of a multifaceted disease
    • Demer L.L., Tintut Y. Vascular calcification: pathobiology of a multifaceted disease. Circulation 2008, 117(22):2938-2948.
    • (2008) Circulation , vol.117 , Issue.22 , pp. 2938-2948
    • Demer, L.L.1    Tintut, Y.2
  • 65
    • 84861409058 scopus 로고    scopus 로고
    • Sources of cells that contribute to atherosclerotic intimal calcification: an in vivo genetic fate mapping study
    • Naik V., et al. Sources of cells that contribute to atherosclerotic intimal calcification: an in vivo genetic fate mapping study. Cardiovasc. Res. 2012, 94(3):545-554.
    • (2012) Cardiovasc. Res. , vol.94 , Issue.3 , pp. 545-554
    • Naik, V.1
  • 66
    • 0034730291 scopus 로고    scopus 로고
    • Phosphate regulation of vascular smooth muscle cell calcification
    • Jono S., et al. Phosphate regulation of vascular smooth muscle cell calcification. Circ. Res. 2000, 87(7):E10-E17.
    • (2000) Circ. Res. , vol.87 , Issue.7 , pp. E10-E17
    • Jono, S.1
  • 67
    • 14544283020 scopus 로고    scopus 로고
    • Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD
    • Reynolds J.L., et al. Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD. J. Am. Soc. Nephrol. 2004, 15(11):2857-2867.
    • (2004) J. Am. Soc. Nephrol. , vol.15 , Issue.11 , pp. 2857-2867
    • Reynolds, J.L.1
  • 68
    • 80052561697 scopus 로고    scopus 로고
    • Arterial calcification in chronic kidney disease: key roles for calcium and phosphate
    • Shanahan C.M., et al. Arterial calcification in chronic kidney disease: key roles for calcium and phosphate. Circ. Res. 2011, 109(6):697-711.
    • (2011) Circ. Res. , vol.109 , Issue.6 , pp. 697-711
    • Shanahan, C.M.1
  • 69
    • 0028874582 scopus 로고
    • Beta-glycerophosphate accelerates calcification in cultured bovine vascular smooth muscle cells
    • Shioi A., et al. Beta-glycerophosphate accelerates calcification in cultured bovine vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 1995, 15(11):2003-2009.
    • (1995) Arterioscler. Thromb. Vasc. Biol. , vol.15 , Issue.11 , pp. 2003-2009
    • Shioi, A.1
  • 70
    • 84879142499 scopus 로고    scopus 로고
    • The phosphate source influences gene expression and quality of mineralization during osteogenic differentiation of human mesenchymal stem cells
    • Schack L.M., et al. The phosphate source influences gene expression and quality of mineralization during osteogenic differentiation of human mesenchymal stem cells. PLoS ONE 2013, 8(6):e65943.
    • (2013) PLoS ONE , vol.8 , Issue.6
    • Schack, L.M.1
  • 71
    • 84952640434 scopus 로고    scopus 로고
    • Enrichment of calcifying extracellular vesicles using density-based ultracentrifugation protocol
    • Hutcheson J.D., et al. Enrichment of calcifying extracellular vesicles using density-based ultracentrifugation protocol. J. Extracell. Vesicles 2014, 3:25129.
    • (2014) J. Extracell. Vesicles , vol.3 , pp. 25129
    • Hutcheson, J.D.1
  • 72
    • 84930803061 scopus 로고    scopus 로고
    • Vascular smooth muscle cell calcification is mediated by regulated exosome secretion
    • Kapustin A.N., et al. Vascular smooth muscle cell calcification is mediated by regulated exosome secretion. Circ. Res. 2015.
    • (2015) Circ. Res.
    • Kapustin, A.N.1
  • 73
    • 84924294862 scopus 로고    scopus 로고
    • Calcifying vascular smooth muscle cells and osteoblasts: independent cell types exhibiting extracellular matrix and biomineralization-related mimicries
    • Alves R.D., et al. Calcifying vascular smooth muscle cells and osteoblasts: independent cell types exhibiting extracellular matrix and biomineralization-related mimicries. BMC Genomics 2014, 15:965.
    • (2014) BMC Genomics , vol.15 , pp. 965
    • Alves, R.D.1
  • 74
    • 0029978937 scopus 로고    scopus 로고
    • Modifications induced by atherogenic diet in the capacity of the arterial wall in rats to respond to surgical insult
    • Bujan J., et al. Modifications induced by atherogenic diet in the capacity of the arterial wall in rats to respond to surgical insult. Atherosclerosis 1996, 122(2):141-152.
    • (1996) Atherosclerosis , vol.122 , Issue.2 , pp. 141-152
    • Bujan, J.1
  • 75
    • 0032515059 scopus 로고    scopus 로고
    • Diet-induced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice
    • Towler D.A., et al. Diet-induced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice. J. Biol. Chem. 1998, 273(46):30427-30434.
    • (1998) J. Biol. Chem. , vol.273 , Issue.46 , pp. 30427-30434
    • Towler, D.A.1
  • 76
    • 84883458350 scopus 로고    scopus 로고
    • A role for the endothelium in vascular calcification
    • Yao Y., et al. A role for the endothelium in vascular calcification. Circ. Res. 2013, 113(5):495-504.
    • (2013) Circ. Res. , vol.113 , Issue.5 , pp. 495-504
    • Yao, Y.1
  • 77
    • 80052174320 scopus 로고    scopus 로고
    • The regulation of valvular and vascular sclerosis by osteogenic morphogens
    • Bostrom K.I., Rajamannan N.M., Towler D.A. The regulation of valvular and vascular sclerosis by osteogenic morphogens. Circ. Res. 2011, 109(5):564-577.
    • (2011) Circ. Res. , vol.109 , Issue.5 , pp. 564-577
    • Bostrom, K.I.1    Rajamannan, N.M.2    Towler, D.A.3
  • 78
    • 79952184991 scopus 로고    scopus 로고
    • Mitral valve endothelial cells with osteogenic differentiation potential
    • Wylie-Sears J., et al. Mitral valve endothelial cells with osteogenic differentiation potential. Arterioscler. Thromb. Vasc. Biol. 2011, 31(3):598-607.
    • (2011) Arterioscler. Thromb. Vasc. Biol. , vol.31 , Issue.3 , pp. 598-607
    • Wylie-Sears, J.1
  • 79
    • 84879123915 scopus 로고    scopus 로고
    • Dkk1 and MSX2-Wnt7b signaling reciprocally regulate the endothelial-mesenchymal transition in aortic endothelial cells
    • Cheng S.L., et al. Dkk1 and MSX2-Wnt7b signaling reciprocally regulate the endothelial-mesenchymal transition in aortic endothelial cells. Arterioscler. Thromb. Vasc. Biol. 2013, 33(7):1679-1689.
    • (2013) Arterioscler. Thromb. Vasc. Biol. , vol.33 , Issue.7 , pp. 1679-1689
    • Cheng, S.L.1
  • 80
    • 84920719155 scopus 로고    scopus 로고
    • In vitro models of aortic valve calcification: solidifying a system
    • Bowler M.A., Merryman W.D. In vitro models of aortic valve calcification: solidifying a system. Cardiovasc. Pathol. 2015, 24(1):1-10.
    • (2015) Cardiovasc. Pathol. , vol.24 , Issue.1 , pp. 1-10
    • Bowler, M.A.1    Merryman, W.D.2
  • 81
    • 0035923477 scopus 로고    scopus 로고
    • Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves
    • Rabkin E., et al. Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves. Circulation 2001, 104(21):2525-2532.
    • (2001) Circulation , vol.104 , Issue.21 , pp. 2525-2532
    • Rabkin, E.1
  • 82
    • 34548485827 scopus 로고    scopus 로고
    • Synergistic effects of cyclic tension and transforming growth factor-beta1 on the aortic valve myofibroblast
    • Merryman W.D., et al. Synergistic effects of cyclic tension and transforming growth factor-beta1 on the aortic valve myofibroblast. Cardiovasc. Pathol. 2007, 16(5):268-276.
    • (2007) Cardiovasc. Pathol. , vol.16 , Issue.5 , pp. 268-276
    • Merryman, W.D.1
  • 83
    • 33645739512 scopus 로고    scopus 로고
    • Human semilunar cardiac valve remodeling by activated cells from fetus to adult: implications for postnatal adaptation, pathology, and tissue engineering
    • Aikawa E., et al. Human semilunar cardiac valve remodeling by activated cells from fetus to adult: implications for postnatal adaptation, pathology, and tissue engineering. Circulation 2006, 113(10):1344-1352.
    • (2006) Circulation , vol.113 , Issue.10 , pp. 1344-1352
    • Aikawa, E.1
  • 84
    • 80052890196 scopus 로고    scopus 로고
    • Can valvular interstitial cells become true osteoblasts? A side-by-side comparison
    • Monzack E.L., Masters K.S. Can valvular interstitial cells become true osteoblasts? A side-by-side comparison. J. Heart Valve Dis. 2011, 20(4):449-463.
    • (2011) J. Heart Valve Dis. , vol.20 , Issue.4 , pp. 449-463
    • Monzack, E.L.1    Masters, K.S.2
  • 85
    • 64049113676 scopus 로고    scopus 로고
    • Calcification by valve interstitial cells is regulated by the stiffness of the extracellular matrix
    • Yip C.Y., et al. Calcification by valve interstitial cells is regulated by the stiffness of the extracellular matrix. Arterioscler. Thromb. Vasc. Biol. 2009, 29(6):936-942.
    • (2009) Arterioscler. Thromb. Vasc. Biol. , vol.29 , Issue.6 , pp. 936-942
    • Yip, C.Y.1
  • 86
    • 73949092806 scopus 로고    scopus 로고
    • Statins block calcific nodule formation of valvular interstitial cells by inhibiting alpha-smooth muscle actin expression
    • Benton J.A., et al. Statins block calcific nodule formation of valvular interstitial cells by inhibiting alpha-smooth muscle actin expression. Arterioscler. Thromb. Vasc. Biol. 2009, 29(11):1950-1957.
    • (2009) Arterioscler. Thromb. Vasc. Biol. , vol.29 , Issue.11 , pp. 1950-1957
    • Benton, J.A.1
  • 87
    • 84871778802 scopus 로고    scopus 로고
    • Cadherin-11 regulates cell-cell tension necessary for calcific nodule formation by valvular myofibroblasts
    • Hutcheson J.D., et al. Cadherin-11 regulates cell-cell tension necessary for calcific nodule formation by valvular myofibroblasts. Arterioscler. Thromb. Vasc. Biol. 2013, 33(1):114-120.
    • (2013) Arterioscler. Thromb. Vasc. Biol. , vol.33 , Issue.1 , pp. 114-120
    • Hutcheson, J.D.1
  • 88
    • 84857641156 scopus 로고    scopus 로고
    • Intracellular Ca(2+) accumulation is strain-dependent and correlates with apoptosis in aortic valve fibroblasts
    • Hutcheson J.D., et al. Intracellular Ca(2+) accumulation is strain-dependent and correlates with apoptosis in aortic valve fibroblasts. J. Biomech. 2012, 45(5):888-894.
    • (2012) J. Biomech. , vol.45 , Issue.5 , pp. 888-894
    • Hutcheson, J.D.1
  • 89
    • 79958828890 scopus 로고    scopus 로고
    • Cell-matrix interactions in the pathobiology of calcific aortic valve disease: critical roles for matricellular, matricrine, and matrix mechanics cues
    • Chen J.H., Simmons C.A. Cell-matrix interactions in the pathobiology of calcific aortic valve disease: critical roles for matricellular, matricrine, and matrix mechanics cues. Circ. Res. 2011, 108(12):1510-1524.
    • (2011) Circ. Res. , vol.108 , Issue.12 , pp. 1510-1524
    • Chen, J.H.1    Simmons, C.A.2
  • 90
    • 84940493805 scopus 로고    scopus 로고
    • Biophysical analysis of dystrophic and osteogenic models of valvular calcification
    • Chen J., et al. Biophysical analysis of dystrophic and osteogenic models of valvular calcification. J. Biomech. Eng. 2015, 137(2):020903.
    • (2015) J. Biomech. Eng. , vol.137 , Issue.2
    • Chen, J.1
  • 91
    • 84871897290 scopus 로고    scopus 로고
    • High expression of the Pi-transporter SLC20A1/Pit1 in calcific aortic valve disease promotes mineralization through regulation of Akt-1
    • El Husseini D., et al. High expression of the Pi-transporter SLC20A1/Pit1 in calcific aortic valve disease promotes mineralization through regulation of Akt-1. PLOS ONE 2013, 8(1):e53393.
    • (2013) PLOS ONE , vol.8 , Issue.1
    • El Husseini, D.1
  • 92
    • 84911913843 scopus 로고    scopus 로고
    • Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease
    • Yutzey K.E., et al. Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease. Arterioscler. Thromb. Vasc. Biol. 2014, 34(11):2387-2393.
    • (2014) Arterioscler. Thromb. Vasc. Biol. , vol.34 , Issue.11 , pp. 2387-2393
    • Yutzey, K.E.1
  • 93
    • 0019349284 scopus 로고
    • Presence of a smooth muscle system in aortic valve leaflets
    • Bairati A., DeBiasi S. Presence of a smooth muscle system in aortic valve leaflets. Anat. Embryol. (Berl.) 1981, 161(3):329-340.
    • (1981) Anat. Embryol. (Berl.) , vol.161 , Issue.3 , pp. 329-340
    • Bairati, A.1    DeBiasi, S.2
  • 94
    • 0242329683 scopus 로고    scopus 로고
    • Smoothelin-positive cells in human and porcine semilunar valves
    • Cimini M., Rogers K.A., Boughner D.R. Smoothelin-positive cells in human and porcine semilunar valves. Histochem. Cell Biol. 2003, 120(4):307-317.
    • (2003) Histochem. Cell Biol. , vol.120 , Issue.4 , pp. 307-317
    • Cimini, M.1    Rogers, K.A.2    Boughner, D.R.3
  • 95
    • 0033767042 scopus 로고    scopus 로고
    • Cell composition of the human pulmonary valve: a comparative study with the aortic valve - the VESALIO Project. Vitalitate Exornatum Succedaneum Aorticum labore Ingegnoso Obtinebitur
    • Della Rocca F., et al. Cell composition of the human pulmonary valve: a comparative study with the aortic valve - the VESALIO Project. Vitalitate Exornatum Succedaneum Aorticum labore Ingegnoso Obtinebitur. Ann. Thorac. Surg. 2000, 70(5):1594-1600.
    • (2000) Ann. Thorac. Surg. , vol.70 , Issue.5 , pp. 1594-1600
    • Della Rocca, F.1
  • 96
    • 84938097016 scopus 로고    scopus 로고
    • Expression of smooth muscle cell markers and co-activators in calcified aortic valves
    • Latif N., et al. Expression of smooth muscle cell markers and co-activators in calcified aortic valves. Eur. Heart J. 2015, 36(21):1335-1345.
    • (2015) Eur. Heart J. , vol.36 , Issue.21 , pp. 1335-1345
    • Latif, N.1
  • 97
    • 0034700234 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha promotes in vitro calcification of vascular cells via the cAMP pathway
    • Tintut Y., et al. Tumor necrosis factor-alpha promotes in vitro calcification of vascular cells via the cAMP pathway. Circulation 2000, 102(21):2636-2642.
    • (2000) Circulation , vol.102 , Issue.21 , pp. 2636-2642
    • Tintut, Y.1
  • 98
    • 84877732914 scopus 로고    scopus 로고
    • Inflammation is associated with the remodeling of calcific aortic valve disease
    • Cote N., et al. Inflammation is associated with the remodeling of calcific aortic valve disease. Inflammation 2013, 36(3):573-581.
    • (2013) Inflammation , vol.36 , Issue.3 , pp. 573-581
    • Cote, N.1
  • 99
    • 65349154635 scopus 로고    scopus 로고
    • Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease
    • Aikawa E., et al. Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease. Circulation 2009, 119(13):1785-1794.
    • (2009) Circulation , vol.119 , Issue.13 , pp. 1785-1794
    • Aikawa, E.1
  • 100
    • 79957674758 scopus 로고    scopus 로고
    • Molecular imaging insights into early inflammatory stages of arterial and aortic valve calcification
    • New S.E., Aikawa E. Molecular imaging insights into early inflammatory stages of arterial and aortic valve calcification. Circ. Res. 2011, 108(11):1381-1391.
    • (2011) Circ. Res. , vol.108 , Issue.11 , pp. 1381-1391
    • New, S.E.1    Aikawa, E.2
  • 101
    • 79957463868 scopus 로고    scopus 로고
    • Runx2-upregulated receptor activator of nuclear factor kappaB ligand in calcifying smooth muscle cells promotes migration and osteoclastic differentiation of macrophages
    • Byon C.H., et al. Runx2-upregulated receptor activator of nuclear factor kappaB ligand in calcifying smooth muscle cells promotes migration and osteoclastic differentiation of macrophages. Arterioscler. Thromb. Vasc. Biol. 2011, 31(6):1387-1396.
    • (2011) Arterioscler. Thromb. Vasc. Biol. , vol.31 , Issue.6 , pp. 1387-1396
    • Byon, C.H.1
  • 102
    • 84861911292 scopus 로고    scopus 로고
    • Emerging role of circulating calcifying cells in the bone-vascular axis
    • Fadini G.P., et al. Emerging role of circulating calcifying cells in the bone-vascular axis. Circulation 2012, 125(22):2772-2781.
    • (2012) Circulation , vol.125 , Issue.22 , pp. 2772-2781
    • Fadini, G.P.1
  • 103
    • 84868202254 scopus 로고    scopus 로고
    • Role of circulating osteogenic progenitor cells in calcific aortic stenosis
    • Gossl M., et al. Role of circulating osteogenic progenitor cells in calcific aortic stenosis. J. Am. Coll. Cardiol. 2012, 60(19):1945-1953.
    • (2012) J. Am. Coll. Cardiol. , vol.60 , Issue.19 , pp. 1945-1953
    • Gossl, M.1
  • 104
    • 79955576133 scopus 로고    scopus 로고
    • Widespread increase in myeloid calcifying cells contributes to ectopic vascular calcification in type 2 diabetes
    • Fadini G.P., et al. Widespread increase in myeloid calcifying cells contributes to ectopic vascular calcification in type 2 diabetes. Circ. Res. 2011, 108(9):1112-1121.
    • (2011) Circ. Res. , vol.108 , Issue.9 , pp. 1112-1121
    • Fadini, G.P.1
  • 105
    • 84947202950 scopus 로고    scopus 로고
    • Osteogenic monocytes within the coronary circulation and their association with plaque vulnerability in patients with early atherosclerosis
    • Collin J., et al. Osteogenic monocytes within the coronary circulation and their association with plaque vulnerability in patients with early atherosclerosis. Int. J. Cardiol. 2014, 181C:57-64.
    • (2014) Int. J. Cardiol. , vol.181C , pp. 57-64
    • Collin, J.1
  • 106
    • 33745725939 scopus 로고    scopus 로고
    • Possible role for mast cell-derived cathepsin G in the adverse remodelling of stenotic aortic valves
    • Helske S., et al. Possible role for mast cell-derived cathepsin G in the adverse remodelling of stenotic aortic valves. Eur. Heart J. 2006, 27(12):1495-1504.
    • (2006) Eur. Heart J. , vol.27 , Issue.12 , pp. 1495-1504
    • Helske, S.1
  • 107
    • 7044237097 scopus 로고    scopus 로고
    • Induction of local angiotensin II-producing systems in stenotic aortic valves
    • Helske S., et al. Induction of local angiotensin II-producing systems in stenotic aortic valves. J. Am. Coll. Cardiol. 2004, 44(9):1859-1866.
    • (2004) J. Am. Coll. Cardiol. , vol.44 , Issue.9 , pp. 1859-1866
    • Helske, S.1
  • 108
    • 84879497909 scopus 로고    scopus 로고
    • Mast cells in human stenotic aortic valves are associated with the severity of stenosis
    • Wypasek E., et al. Mast cells in human stenotic aortic valves are associated with the severity of stenosis. Inflammation 2013, 36(2):449-456.
    • (2013) Inflammation , vol.36 , Issue.2 , pp. 449-456
    • Wypasek, E.1
  • 109
    • 84857708170 scopus 로고    scopus 로고
    • Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs
    • Hergenreider E., et al. Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. Nat. Cell Biol. 2012, 14(3):249-256.
    • (2012) Nat. Cell Biol. , vol.14 , Issue.3 , pp. 249-256
    • Hergenreider, E.1
  • 110
    • 84878635008 scopus 로고    scopus 로고
    • A 3D microfluidic platform incorporating methacrylated gelatin hydrogels to study physiological cardiovascular cell-cell interactions
    • Chen M.B., et al. A 3D microfluidic platform incorporating methacrylated gelatin hydrogels to study physiological cardiovascular cell-cell interactions. Lab Chip 2013, 13(13):2591-2598.
    • (2013) Lab Chip , vol.13 , Issue.13 , pp. 2591-2598
    • Chen, M.B.1
  • 111
    • 84928212735 scopus 로고    scopus 로고
    • Directing valvular interstitial cell myofibroblast-like differentiation in a hybrid hydrogel platform
    • Hjortnaes J., et al. Directing valvular interstitial cell myofibroblast-like differentiation in a hybrid hydrogel platform. Adv. Healthc. Mater. 2014.
    • (2014) Adv. Healthc. Mater.
    • Hjortnaes, J.1
  • 112
    • 33646564670 scopus 로고    scopus 로고
    • Valvular endothelial cells regulate the phenotype of interstitial cells in co-culture: effects of steady shear stress
    • Butcher J.T., Nerem R.M. Valvular endothelial cells regulate the phenotype of interstitial cells in co-culture: effects of steady shear stress. Tissue Eng. 2006, 12(4):905-915.
    • (2006) Tissue Eng. , vol.12 , Issue.4 , pp. 905-915
    • Butcher, J.T.1    Nerem, R.M.2
  • 113
    • 84856264839 scopus 로고    scopus 로고
    • Porcine small diameter arterial extracellular matrix supports endothelium formation and media remodeling forming a promising vascular engineered biograft
    • Dahan N., et al. Porcine small diameter arterial extracellular matrix supports endothelium formation and media remodeling forming a promising vascular engineered biograft. Tissue Eng. Part A 2012, 18(3-4):411-422.
    • (2012) Tissue Eng. Part A , vol.18 , Issue.3-4 , pp. 411-422
    • Dahan, N.1
  • 114
    • 84895070548 scopus 로고    scopus 로고
    • Monocyte/macrophage cytokine activity regulates vascular smooth muscle cell function within a degradable polyurethane scaffold
    • Battiston K.G., et al. Monocyte/macrophage cytokine activity regulates vascular smooth muscle cell function within a degradable polyurethane scaffold. Acta Biomater. 2014, 10(3):1146-1155.
    • (2014) Acta Biomater. , vol.10 , Issue.3 , pp. 1146-1155
    • Battiston, K.G.1
  • 115
    • 84910098848 scopus 로고    scopus 로고
    • Design and utilization of macrophage and vascular smooth muscle cell co-culture systems in atherosclerotic cardiovascular disease investigation
    • Zuniga M.C., White S.L., Zhou W. Design and utilization of macrophage and vascular smooth muscle cell co-culture systems in atherosclerotic cardiovascular disease investigation. Vasc. Med. 2014, 19(5):394-406.
    • (2014) Vasc. Med. , vol.19 , Issue.5 , pp. 394-406
    • Zuniga, M.C.1    White, S.L.2    Zhou, W.3
  • 116
    • 0035824898 scopus 로고    scopus 로고
    • Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfa1 and downregulation of smooth muscle lineage markers
    • Steitz S.A., et al. Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfa1 and downregulation of smooth muscle lineage markers. Circ. Res. 2001, 89(12):1147-1154.
    • (2001) Circ. Res. , vol.89 , Issue.12 , pp. 1147-1154
    • Steitz, S.A.1
  • 117
    • 0034711505 scopus 로고    scopus 로고
    • Apoptosis regulates human vascular calcification in vitro: evidence for initiation of vascular calcification by apoptotic bodies
    • Proudfoot D., et al. Apoptosis regulates human vascular calcification in vitro: evidence for initiation of vascular calcification by apoptotic bodies. Circ. Res. 2000, 87(11):1055-1062.
    • (2000) Circ. Res. , vol.87 , Issue.11 , pp. 1055-1062
    • Proudfoot, D.1
  • 118
    • 84894564729 scopus 로고    scopus 로고
    • Cystathionine gamma-lyase accelerates osteoclast differentiation: identification of a novel regulator of osteoclastogenesis by proteomic analysis
    • Itou T., et al. Cystathionine gamma-lyase accelerates osteoclast differentiation: identification of a novel regulator of osteoclastogenesis by proteomic analysis. Arterioscler. Thromb. Vasc. Biol. 2014, 34(3):626-634.
    • (2014) Arterioscler. Thromb. Vasc. Biol. , vol.34 , Issue.3 , pp. 626-634
    • Itou, T.1
  • 119
    • 84938125109 scopus 로고    scopus 로고
    • Valvular interstitial cells suppress calcification of valvular endothelial cells
    • Hjortnaes J., et al. Valvular interstitial cells suppress calcification of valvular endothelial cells. Atherosclerosis 2015, 242(1):251-260.
    • (2015) Atherosclerosis , vol.242 , Issue.1 , pp. 251-260
    • Hjortnaes, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.