Cystathionine γ-lyase accelerates osteoclast differentiation: Identification of a novel regulator of osteoclastogenesis by proteomic analysis

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 34, Issue 3, 2014, Pages 626-634

  Itou, Takahiro ^a,d   Maldonado, Natalia ^a,b   Yamada, Iwao ^a,d   Goettsch, Claudia ^a   Matsumoto, Jiro ^a,d   Aikawa, Masanori ^a   Singh, Sasha ^a   Aikawa, Elena ^a,c  

^a Center for Interdisciplinary Cardiovascular Sciences   (United States)

^b CHANNING LABORATORY   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d KOWA COMPANY LTD   (Japan)

Author keywords

Macrophages; Osteoclast; Proteomics; RANKL protein; Vascular calcification

Indexed keywords

MACROPHAGES; OSTEOCLAST; PROTEOMICS; RANKL PROTEIN; VASCULAR CALCIFICATION;

ALKYNES; ANIMALS; AORTA, THORACIC; APOLIPOPROTEINS E; BIOLOGICAL MARKERS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CYSTATHIONINE GAMMA-LYASE; DIETARY FATS; GENE EXPRESSION PROFILING; GLYCINE; MACROPHAGE COLONY-STIMULATING FACTOR; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; NF-KAPPA B; OSTEOCLASTS; PROTEOMICS; RANK LIGAND; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TRANSCRIPTION, GENETIC;

EID: 84894564729     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.113.302576     Document Type: Article

References (32)

1. Demer LL, Tintut Y. Vascular calcification: Pathobiology of a multifaceted disease. Circulation. 2008;117:2938-2948
2. Towler DA. Vascular calcification: A perspective on an imminent disease epidemic. IBMS BoneKEy. 2008;5:41-58
3. Aikawa E, Aikawa M, Libby P, Figueiredo JL, Rusanescu G, Iwamoto Y, Fukuda D, Kohler RH, Shi GP, Jaffer FA, Weissleder R. Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease. Circulation. 2009;119:1785-1794
4. Huang H, Virmani R, Younis H, Burke AP, Kamm RD, Lee RT. The impact of calcification on the biomechanical stability of atherosclerotic plaques. Circulation. 2001;103:1051-1056
5. Kelly-Arnold A, Maldonado N, Laudier D, Aikawa E, Cardoso L, Weinbaum S. Revised microcalcification hypothesis for fibrous cap rupture in human coronary arteries. Proc Natl Acad Sci U S A. 2013;110:10741-10746
6. Aikawa E, Nahrendorf M, Figueiredo JL, Swirski FK, Shtatland T, Kohler RH, Jaffer FA, Aikawa M, Weissleder R. Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo. Circulation. 2007;116:2841-2850
7. Aikawa E, Nahrendorf M, Sosnovik D, Lok VM, Jaffer FA, Aikawa M, Weissleder R. Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation. 2007;115:377-386
8. Doherty TM, Asotra K, Fitzpatrick LA, Qiao JH, Wilkin DJ, Detrano RC, Dunstan CR, Shah PK, Rajavashisth TB. Calcification in atherosclerosis: Bone biology and chronic inflammation at the arterial crossroads. Proc Natl Acad Sci U S A. 2003;100:11201-11206
9. Massy ZA, Mentaverri R, Mozar A, Brazier M, Kamel S. The pathophysiology of vascular calcification: Are osteoclast-like cells the missing link? Diabetes Metab. 2008;34 Suppl 1:S16-S20
10. Dayon L, Sanchez JC. Relative protein quantification by MS/MS using the tandem mass tag technology. Methods Mol Biol. 2012;893:115-127
11. Lee SK, Chung JH, Choi SC, Auh QS, Lee YM, Lee SI, Kim EC. Sodium hydrogen sulfide inhibits nicotine and lipopolysaccharide-induced osteoclastic differentiation and reversed osteoblastic differentiation in human periodontal ligament cells. J Cell Biochem. 2013;114:1183-1193
12. Aebersold R, Burlingame AL, Bradshaw RA. Western Blots vs. SRM Assays: Time to turn the tables? Mol Cell Proteomics. 2013 (in press
13. Park EK, Kim MS, Lee SH, Kim KH, Park JY, Kim TH, Lee IS, Woo JT, Jung JC, Shin HI, Choi JY, Kim SY. Furosin, an ellagitannin, suppresses RANKL-induced osteoclast differentiation and function through inhibition of MAP kinase activation and actin ring formation. Biochem Biophys Res Commun. 2004;325:1472-1480
14. Bucci M, Papapetropoulos A, Vellecco V, Zhou Z, Pyriochou A, Roussos C, Roviezzo F, Brancaleone V, Cirino G. Hydrogen sulfide is an endogenous inhibitor of phosphodiesterase activity. Arterioscler Thromb Vasc Biol. 2010;30:1998-2004
15. Khosla S. Minireview: The OPG/RANKL/RANK system. Endocrinology. 2001;142:5050-5055
16. Rajachar RM, Truong AQ, Giachelli CM. The influence of surface mineral and osteopontin on the formation and function of murine bone marrowderived osteoclasts. J Mater Sci Mater Med. 2008;19:3279-3285
17. Abedin M, Tintut Y, Demer LL. Vascular calcification: Mechanisms and clinical ramifications. Arterioscler Thromb Vasc Biol. 2004;24:1161-1170
18. Takahashi N, Udagawa N, Kobayashi Y, Suda T. Generation of osteoclasts in vitro, and assay of osteoclast activity. Methods Mol Med. 2007;135:285-301
19. Kubota K, Wakabayashi K, Matsuoka T. Proteome analysis of secreted proteins during osteoclast differentiation using two different methods: Two-dimensional electrophoresis and isotope-coded affinity tags analysis with two-dimensional chromatography. Proteomics. 2003;3:616-626
20. Ha BG, Hong JM, Park JY, Ha MH, Kim TH, Cho JY, Ryoo HM, Choi JY, Shin HI, Chun SY, Kim SY, Park EK. Proteomic profile of osteoclast membrane proteins: Identification of Na+/H+ exchanger domain containing 2 and its role in osteoclast fusion. Proteomics. 2008;8:2625-2639
21. Olsen JV, Schwartz JC, Griep-Raming J, Nielsen ML, Damoc E, Denisov E, Lange O, Remes P, Taylor D, Splendore M, Wouters ER, Senko M, Makarov A, Mann M, Horning S. A dual pressure linear ion trap Orbitrap instrument with very high sequencing speed. Mol Cell Proteomics. 2009;8:2759-2769
22. Hidai C, Zupancic T, Penta K, Mikhail A, Kawana M, Quertermous EE, Aoka Y, Fukagawa M, Matsui Y, Platika D, Auerbach R, Hogan BL, Snodgrass R, Quertermous T. Cloning and characterization of developmental endothelial locus-1: An embryonic endothelial cell protein that binds the alphavbeta3 integrin receptor. Genes Dev. 1998;12:21-33
23. Choi EY, Chavakis E, Czabanka MA, et al. Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment. Science. 2008;322:1101-1104
24. Eskan MA, Jotwani R, Abe T, et al. The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss. Nat Immunol. 2012;13:465-473
25. Gundry RL, Raginski K, Tarasova Y, Tchernyshyov I, Bausch-Fluck D, Elliott ST, Boheler KR, Van Eyk JE, Wollscheid B. The mouse C2C12 myoblast cell surface N-linked glycoproteome: Identification, glycosite occupancy, and membrane orientation. Mol Cell Proteomics. 2009;8:2555-2569
26. Wollscheid B, Bausch-Fluck D, Henderson C, O'Brien R, Bibel M, Schiess R, Aebersold R, Watts JD. Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. Nat Biotechnol. 2009;27:378-386
27. Silverman GA, Bird PI, Carrell RW, Church FC, Coughlin PB, Gettins PG, Irving JA, Lomas DA, Luke CJ, Moyer RW, Pemberton PA, Remold-O'Donnell E, Salvesen GS, Travis J, Whisstock JC. The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature. J Biol Chem. 2001;276:33293-33296
28. Khurana S, George SP. Regulation of cell structure and function by actin-binding proteins: Villin's perspective. FEBS Lett. 2008;582:2128-2139
29. Robbens J, Louahed J, De Pestel K, Van Colen I, Ampe C, Vandekerckhove J, Renauld JC. Murine adseverin (D5), a novel member of the gelsolin family, and murine adseverin are induced by interleukin-9 in T-helper lymphocytes. Mol Cell Biol. 1998;18:4589-4596
30. Yang G, Wu L, Jiang B, Yang W, Qi J, Cao K, Meng Q, Mustafa AK, Mu W, Zhang S, Snyder SH, Wang R. H2S as a physiologic vasorelaxant: Hypertension in mice with deletion of cystathionine gamma-lyase. Science. 2008;322:587-590
31. Zavaczki E, Jeney V, Agarwal A, Zarjou A, Oros M, Katkó M, Varga Z, Balla G, Balla J. Hydrogen sulfide inhibits the calcification and osteoblastic differentiation of vascular smooth muscle cells. Kidney Int. 2011;80:731-739
32. Rattazzi M, Bertacco E, Puato M, Faggin E, Pauletto P. Hypertension and vascular calcification: A vicious cycle? J Hypertens. 2012;30:1885-1893