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Volumn 109, Issue 5, 2011, Pages 564-577

The regulation of valvular and vascular sclerosis by osteogenic morphogens

Author keywords

BMP; inflammation; osteoblast differentiation; vascular calcification; Wnt

Indexed keywords

BETA CATENIN; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN 6; REACTIVE OXYGEN METABOLITE; WNT1 PROTEIN;

EID: 80052174320     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.110.234278     Document Type: Review
Times cited : (218)

References (178)
  • 1
    • 44649133999 scopus 로고    scopus 로고
    • Vascular calcification: Pathobiology of a multifaceted disease
    • DOI 10.1161/CIRCULATIONAHA.107.743161, PII 0000301720080603000015
    • Demer LL, Tintut Y. Vascular calcification: pathobiology of a multifaceted disease. Circulation. 2008;117:2938-2948. (Pubitemid 351787058)
    • (2008) Circulation , vol.117 , Issue.22 , pp. 2938-2948
    • Demer, L.L.1    Tintut, Y.2
  • 2
    • 0022730151 scopus 로고
    • Calcification in atherosclerosis, I: Human studies
    • Tanimura A, McGregor DH, Anderson HC. Calcification in atherosclerosis, I: human studies. J Exp Pathol. 1986;2:261-273.
    • (1986) J Exp Pathol , vol.2 , pp. 261-273
    • Tanimura, A.1    McGregor, D.H.2    Anderson, H.C.3
  • 4
    • 0014723599 scopus 로고
    • Bone formation in implants of partially and wholly demineralized bone matrix: Including observations on acetone-fixed intra and extracellular proteins
    • Urist MR, Strates BS. Bone formation in implants of partially and wholly demineralized bone matrix: including observations on acetone-fixed intra and extracellular proteins. Clin Orthop Relat Res. 1970;71:271-278.
    • (1970) Clin Orthop Relat Res , vol.71 , pp. 271-278
    • Urist, M.R.1    Strates, B.S.2
  • 7
    • 13444291335 scopus 로고    scopus 로고
    • BMP signaling in skeletal development
    • DOI 10.1016/j.bbrc.2004.11.067, Vertebrate Skeletal Biology
    • Wan M, Cao X. BMP signaling in skeletal development. Biochem Biophys Res Commun. 2005;328:651-657. (Pubitemid 40208302)
    • (2005) Biochemical and Biophysical Research Communications , vol.328 , Issue.3 , pp. 651-657
    • Wan, M.1    Cao, X.2
  • 8
    • 33751506452 scopus 로고    scopus 로고
    • BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing
    • DOI 10.1038/ng1916, PII NG1916
    • Tsuji K, Bandyopadhyay A, Harfe BD, Cox K, Kakar S, Gerstenfeld L, Einhorn T, Tabin CJ, Rosen V. BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Nat Genet. 2006;38:1424-1429. (Pubitemid 44837565)
    • (2006) Nature Genetics , vol.38 , Issue.12 , pp. 1424-1429
    • Tsuji, K.1    Bandyopadhyay, A.2    Harfe, B.D.3    Cox, K.4    Kakar, S.5    Gerstenfeld, L.6    Einhorn, T.7    Tabin, C.J.8    Rosen, V.9
  • 10
    • 58149107786 scopus 로고    scopus 로고
    • The osteogenic-angiogenic interface: Novel insights into the biology of bone formation and fracture repair
    • Towler DA. The osteogenic-angiogenic interface: novel insights into the biology of bone formation and fracture repair. Curr Osteoporos Rep. 2008;6:67-71.
    • (2008) Curr Osteoporos Rep , vol.6 , pp. 67-71
    • Towler, D.A.1
  • 12
    • 0033774832 scopus 로고    scopus 로고
    • Merging the old skeletal biology with the new, I: Intramembranous ossification, endochondral ossification, ectopic bone, secondary cartilage, and pathologic considerations
    • Cohen MM Jr. Merging the old skeletal biology with the new, I: Intramembranous ossification, endochondral ossification, ectopic bone, secondary cartilage, and pathologic considerations. J Craniofac Genet Dev Biol. 2000;20:84-93.
    • (2000) J Craniofac Genet Dev Biol , vol.20 , pp. 84-93
    • Cohen Jr., M.M.1
  • 13
    • 33644872519 scopus 로고    scopus 로고
    • The new bone biology: Pathologic, molecular, and clinical correlates
    • DOI 10.1002/ajmg.a.31368
    • Cohen MM Jr. The new bone biology: pathologic, molecular, and clinical correlates. Am J Med Genet A. 2006;140:2646-2706. (Pubitemid 44865095)
    • (2006) American Journal of Medical Genetics, Part A , vol.140 , Issue.23 , pp. 2646-2706
    • Cohen Jr., M.M.1
  • 15
    • 59849090189 scopus 로고    scopus 로고
    • Growth and patterning in the limb: Signaling gradients make the decision
    • Yang Y. Growth and patterning in the limb: signaling gradients make the decision. Sci Signal. 2009;2:pe3.
    • (2009) Sci Signal , vol.2
    • Yang, Y.1
  • 16
    • 70549110151 scopus 로고    scopus 로고
    • Vertebrate limb development: Moving from classical morphogen gradients to an integrated 4-dimensional patterning system
    • Benazet JD, Zeller R. Vertebrate limb development: moving from classical morphogen gradients to an integrated 4-dimensional patterning system. Cold Spring Harb Perspect Biol. 2009;1:a001339.
    • (2009) Cold Spring Harb Perspect Biol , vol.1
    • Benazet, J.D.1    Zeller, R.2
  • 17
    • 3042702989 scopus 로고    scopus 로고
    • En1 and Wnt7a interact with Dkk1 during limb development in the mouse
    • DOI 10.1016/j.ydbio.2004.04.026, PII S0012160604003161
    • Adamska M, MacDonald BT, Sarmast ZH, Oliver ER, Meisler MH. En1 and Wnt7a interact with Dkk1 during limb development in the mouse. Dev Biol. 2004;272:134-144. (Pubitemid 38887290)
    • (2004) Developmental Biology , vol.272 , Issue.1 , pp. 134-144
    • Adamska, M.1    MacDonald, B.T.2    Sarmast, Z.H.3    Oliver, E.R.4    Meisler, M.H.5
  • 18
    • 0038687536 scopus 로고    scopus 로고
    • Developmental regulation of the growth plate
    • DOI 10.1038/nature01657
    • Kronenberg HM. Developmental regulation of the growth plate. Nature. 2003;423:332-336. (Pubitemid 40852707)
    • (2003) Nature , vol.423 , Issue.6937 , pp. 332-336
    • Kronenberg, H.M.1
  • 19
    • 77951624097 scopus 로고    scopus 로고
    • Update in new anabolic therapies for osteoporosis
    • Canalis E. Update in new anabolic therapies for osteoporosis. J Clin Endocrinol Metab. 2010;95:1496-1504.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 1496-1504
    • Canalis, E.1
  • 22
    • 77955983359 scopus 로고    scopus 로고
    • Hypoxia HIFs and bone development
    • Araldi E, Schipani E. Hypoxia, HIFs and bone development. Bone. 2010;47:190-196.
    • (2010) Bone , vol.47 , pp. 190-196
    • Araldi, E.1    Schipani, E.2
  • 23
    • 13444302715 scopus 로고    scopus 로고
    • Sequential roles of Hedgehog and Wnt signaling in osteoblast development
    • DOI 10.1242/dev.01564
    • Hu H, Hilton MJ, Tu X, Yu K, Ornitz DM, Long F. Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development. 2005;132:49-60. (Pubitemid 40207966)
    • (2005) Development , vol.132 , Issue.1 , pp. 49-60
    • Hu, H.1    Hilton, M.J.2    Tu, X.3    Yu, K.4    Ornitz, D.M.5    Long, F.6
  • 26
    • 84860225643 scopus 로고    scopus 로고
    • The classic: Bone morphogenetic protein
    • Urist MR, Strates BS. The classic: bone morphogenetic protein. Clin Orthop Relat Res. 2009;467:3051-3062.
    • (2009) Clin Orthop Relat Res , vol.467 , pp. 3051-3062
    • Urist, M.R.1    Strates, B.S.2
  • 27
    • 70450170394 scopus 로고    scopus 로고
    • The extracellular regulation of bone morphogenetic protein signaling
    • Umulis D, O'Connor MB, Blair SS. The extracellular regulation of bone morphogenetic protein signaling. Development. 2009;136:3715-3728.
    • (2009) Development , vol.136 , pp. 3715-3728
    • Umulis, D.1    O'Connor, M.B.2    Blair, S.S.3
  • 28
    • 0036904895 scopus 로고    scopus 로고
    • Genetic analysis of the mammalian transforming growth factor-β superfamily
    • DOI 10.1210/er.2002-0003
    • Chang H, Brown CW, Matzuk MM. Genetic analysis of the mammalian transforming growth factor-beta superfamily. Endocr Rev. 2002;23: 787-823. (Pubitemid 35454589)
    • (2002) Endocrine Reviews , vol.23 , Issue.6 , pp. 787-823
    • Chang, H.1    Brown, C.W.2    Matzuk, M.M.3
  • 30
    • 67449146883 scopus 로고    scopus 로고
    • Emerging role of bone morphogenetic proteins in angiogenesis
    • David L, Feige JJ, Bailly S. Emerging role of bone morphogenetic proteins in angiogenesis. Cytokine Growth Factor Rev. 2009;20: 203-212.
    • (2009) Cytokine Growth Factor Rev , vol.20 , pp. 203-212
    • David, L.1    Feige, J.J.2    Bailly, S.3
  • 31
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-β signaling from cell membrane to the nucleus
    • DOI 10.1016/S0092-8674(03)00432-X
    • Shi Y, Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell. 2003;113:685-700. (Pubitemid 36724933)
    • (2003) Cell , vol.113 , Issue.6 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 32
    • 21344455768 scopus 로고    scopus 로고
    • BMP receptor signaling: Transcriptional targets, regulation of signals, and signaling cross-talk
    • DOI 10.1016/j.cytogfr.2005.01.009, PII S1359610105000390
    • Miyazono K, Maeda S, Imamura T. BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk. Cytokine Growth Factor Rev. 2005;16:251-263. (Pubitemid 40910315)
    • (2005) Cytokine and Growth Factor Reviews , vol.16 , Issue.3 SPEC. ISS. , pp. 251-263
    • Miyazono, K.1    Maeda, S.2    Imamura, T.3
  • 33
    • 0142241118 scopus 로고    scopus 로고
    • BMP-2 Controls Alkaline Phosphatase Expression and Osteoblast Mineralization by a Wnt Autocrine Loop
    • DOI 10.1359/jbmr.2003.18.10.1842
    • Rawadi G, Vayssiere B, Dunn F, Baron R, Roman-Roman S. BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop. J Bone Miner Res. 2003;18:1842-1853. (Pubitemid 37322562)
    • (2003) Journal of Bone and Mineral Research , vol.18 , Issue.10 , pp. 1842-1853
    • Rawadi, G.1    Vayssiere, B.2    Dunn, F.3    Baron, R.4    Roman-Roman, S.5
  • 34
    • 34250752682 scopus 로고    scopus 로고
    • Wnt signaling and the regulation of bone mass
    • Baron R, Rawadi G. Wnt signaling and the regulation of bone mass. Curr Osteoporos Rep. 2007;5:73-80. (Pubitemid 46954745)
    • (2007) Current Osteoporosis Reports , vol.5 , Issue.2 , pp. 73-80
    • Baron, R.1    Rawadi, G.2
  • 35
    • 33845352082 scopus 로고    scopus 로고
    • Wnts as ligands: Processing, secretion and reception
    • DOI 10.1038/sj.onc.1210053, PII 1210053
    • Mikels AJ, Nusse R. Wnts as ligands: processing, secretion and reception. Oncogene. 2006;25:7461-7468. (Pubitemid 44885745)
    • (2006) Oncogene , vol.25 , Issue.57 , pp. 7461-7468
    • Mikels, A.J.1    Nusse, R.2
  • 36
    • 70349932747 scopus 로고    scopus 로고
    • Towards an integrated view of Wnt signaling in development
    • van Amerongen R, Nusse R. Towards an integrated view of Wnt signaling in development. Development. 2009;136:3205-3214.
    • (2009) Development , vol.136 , pp. 3205-3214
    • Van Amerongen, R.1    Nusse, R.2
  • 37
    • 73949156925 scopus 로고    scopus 로고
    • Ror-family receptor tyrosine kinases in noncanonical Wnt signaling: Their implications in developmental morphogenesis and human diseases
    • Minami Y, Oishi I, Endo M, Nishita M. Ror-family receptor tyrosine kinases in noncanonical Wnt signaling: their implications in developmental morphogenesis and human diseases. Dev Dyn. 2010;239:1-15.
    • (2010) Dev Dyn , vol.239 , pp. 1-15
    • Minami, Y.1    Oishi, I.2    Endo, M.3    Nishita, M.4
  • 38
    • 41349091246 scopus 로고    scopus 로고
    • Wnt signaling inside the nucleus
    • DOI 10.1111/j.1349-7006.2007.00716.x
    • Shitashige M, Hirohashi S, Yamada T. Wnt signaling inside the nucleus. Cancer Sci. 2008;99:631-637. (Pubitemid 351448063)
    • (2008) Cancer Science , vol.99 , Issue.4 , pp. 631-637
    • Shitashige, M.1    Hirohashi, S.2    Yamada, T.3
  • 39
    • 63349111610 scopus 로고    scopus 로고
    • Transcriptional regulation of SM22alpha by Wnt3a: Convergence with TGFbeta(1)/Smad signaling at a novel regulatory element
    • Shafer SL, Towler DA. Transcriptional regulation of SM22alpha by Wnt3a: convergence with TGFbeta(1)/Smad signaling at a novel regulatory element. J Mol Cell Cardiol. 2009;46:621-635.
    • (2009) J Mol Cell Cardiol , vol.46 , pp. 621-635
    • Shafer, S.L.1    Towler, D.A.2
  • 40
    • 79952134815 scopus 로고    scopus 로고
    • Catenin mediates mechanically regulated, transforming growth factor-1-induced myofibroblast differentiation of aortic valve interstitial cells
    • Chen JH, Chen WL, Sider KL, Yip CY, Simmons CA. Catenin mediates mechanically regulated, transforming growth factor-1-induced myofibroblast differentiation of aortic valve interstitial cells. Arterioscler Thromb Vasc Biol. 2011;31:590-597.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 590-597
    • Chen, J.H.1    Chen, W.L.2    Sider, K.L.3    Yip, C.Y.4    Simmons, C.A.5
  • 41
    • 77954685213 scopus 로고    scopus 로고
    • Regulation of Lrp6 phosphorylation
    • Niehrs C, Shen J. Regulation of Lrp6 phosphorylation. Cell Mol Life Sci. 2010;67:2551-2562.
    • (2010) Cell Mol Life Sci , vol.67 , pp. 2551-2562
    • Niehrs, C.1    Shen, J.2
  • 43
    • 78549292104 scopus 로고    scopus 로고
    • WNT signaling in adult cardiac hypertrophy and remodeling: Lessons learned from cardiac development
    • Bergmann MW. WNT signaling in adult cardiac hypertrophy and remodeling: lessons learned from cardiac development. Circ Res. 2010; 107:1198-1208.
    • (2010) Circ Res , vol.107 , pp. 1198-1208
    • Bergmann, M.W.1
  • 46
    • 22844445934 scopus 로고    scopus 로고
    • SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor
    • DOI 10.1074/jbc.M504308200
    • Semenov M, Tamai K, He X. SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor. J Biol Chem. 2005;280:26770-26775. (Pubitemid 41040710)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.29 , pp. 26770-26775
    • Semenov, M.1    Tamai, K.2    He, X.3
  • 48
    • 2142759439 scopus 로고    scopus 로고
    • ICAT is a multipotent inhibitor of β-catenin. Focus on "Role for ICAT in β-catenin-dependent nuclear signaling and cadherin functions"
    • Stow JL. ICAT is a multipotent inhibitor of beta-catenin: focus on "role for ICAT in beta-catenin-dependent nuclear signaling and cadherin functions." Am J Physiol Cell Physiol. 2004;286:C745-C746. (Pubitemid 38543801)
    • (2004) American Journal of Physiology - Cell Physiology , vol.286 , Issue.4
    • Stow, J.L.1
  • 50
    • 0028944006 scopus 로고
    • Immunolocalization of BMP-6, a novel TGF-beta-related cytokine, in normal and atherosclerotic smooth muscle cells
    • Schluesener HJ, Meyermann R. Immunolocalization of BMP-6, a novel TGF-beta-related cytokine, in normal and atherosclerotic smooth muscle cells. Atherosclerosis. 1995;113:153-156.
    • (1995) Atherosclerosis , vol.113 , pp. 153-156
    • Schluesener, H.J.1    Meyermann, R.2
  • 51
    • 33745962708 scopus 로고    scopus 로고
    • Molecular mechanisms of vascular calcification: Lessons learned from the aorta
    • DOI 10.1161/01.ATV.0000220441.42041.20, PII 0004360520060700000005
    • Shao JS, Cai J, Towler DA. Molecular mechanisms of vascular calcification: lessons learned from the aorta. Arterioscler Thromb Vasc Biol. 2006;26:1423-1430. (Pubitemid 44288965)
    • (2006) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.26 , Issue.7 , pp. 1423-1430
    • Shao, J.-S.1    Cai, J.2    Towler, D.A.3
  • 52
    • 22744434737 scopus 로고    scopus 로고
    • Bone morphogenetic proteins in vascular calcification
    • DOI 10.1161/01.RES.00000175571.53833.6c
    • Hruska KA, Mathew S, Saab G. Bone morphogenetic proteins in vascular calcification. Circ Res. 2005;97:105-114. (Pubitemid 41033466)
    • (2005) Circulation Research , vol.97 , Issue.2 , pp. 105-114
    • Hruska, K.A.1    Mathew, S.2    Saab, G.3
  • 53
    • 79952071106 scopus 로고    scopus 로고
    • Activation of vascular bone morphogenetic protein signaling in diabetes mellitus
    • Bostrom KI, Jumabay M, Matveyenko A, Nicholas SB, Yao Y. Activation of vascular bone morphogenetic protein signaling in diabetes mellitus. Circ Res. 2011;108:446-457.
    • (2011) Circ Res , vol.108 , pp. 446-457
    • Bostrom, K.I.1    Jumabay, M.2    Matveyenko, A.3    Nicholas, S.B.4    Yao, Y.5
  • 55
    • 77956225591 scopus 로고    scopus 로고
    • Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcification
    • Yao Y, Bennett BJ, Wang X, Rosenfeld ME, Giachelli C, Lusis AJ, Bostrom KI. Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcification. Circ Res. 2010;107:485-494.
    • (2010) Circ Res , vol.107 , pp. 485-494
    • Yao, Y.1    Bennett, B.J.2    Wang, X.3    Rosenfeld, M.E.4    Giachelli, C.5    Lusis, A.J.6    Bostrom, K.I.7
  • 56
    • 67449152947 scopus 로고    scopus 로고
    • New insights into bone morphogenetic protein signaling: Focus on angiogenesis
    • Moreno-Miralles I, Schisler JC, Patterson C. New insights into bone morphogenetic protein signaling: focus on angiogenesis. Curr Opin Hematol. 2009;16:195-201.
    • (2009) Curr Opin Hematol , vol.16 , pp. 195-201
    • Moreno-Miralles, I.1    Schisler, J.C.2    Patterson, C.3
  • 57
    • 67649199928 scopus 로고    scopus 로고
    • Hereditary haemorrhagic telangiectasia: A clinical and scientific review
    • Govani FS, Shovlin CL. Hereditary haemorrhagic telangiectasia: a clinical and scientific review. Eur J Hum Genet. 2009;17:860-871.
    • (2009) Eur J Hum Genet , vol.17 , pp. 860-871
    • Govani, F.S.1    Shovlin, C.L.2
  • 58
    • 61349100681 scopus 로고    scopus 로고
    • Altered bone morphogenetic protein and transforming growth factor-beta signaling in rat models of pulmonary hypertension: Potential for activin receptor-like kinase-5 inhibition in prevention and progression of disease
    • Long L, Crosby A, Yang X, Southwood M, Upton PD, Kim DK, Morrell NW. Altered bone morphogenetic protein and transforming growth factor-beta signaling in rat models of pulmonary hypertension: potential for activin receptor-like kinase-5 inhibition in prevention and progression of disease. Circulation. 2009;119:566-576.
    • (2009) Circulation , vol.119 , pp. 566-576
    • Long, L.1    Crosby, A.2    Yang, X.3    Southwood, M.4    Upton, P.D.5    Kim, D.K.6    Morrell, N.W.7
  • 59
    • 45149132191 scopus 로고    scopus 로고
    • Mutations in bone morphogenetic protein type II receptor cause dysregulation of Id gene expression in pulmonary artery smooth muscle cells: Implications for familial pulmonary arterial hypertension
    • Yang J, Davies RJ, Southwood M, Long L, Yang X, Sobolewski A, Upton PD, Trembath RC, Morrell NW. Mutations in bone morphogenetic protein type II receptor cause dysregulation of Id gene expression in pulmonary artery smooth muscle cells: implications for familial pulmonary arterial hypertension. Circ Res. 2008;102: 1212-1221.
    • (2008) Circ Res , vol.102 , pp. 1212-1221
    • Yang, J.1    Davies, R.J.2    Southwood, M.3    Long, L.4    Yang, X.5    Sobolewski, A.6    Upton, P.D.7    Trembath, R.C.8    Morrell, N.W.9
  • 60
    • 0037040197 scopus 로고    scopus 로고
    • Matrix GLA protein, a regulatory protein for bone morphogenetic protein-2
    • DOI 10.1074/jbc.M109683200
    • Zebboudj AF, Imura M, Bostrom K. Matrix GLA protein, a regulatory protein for bone morphogenetic protein-2. J Biol Chem. 2002;277: 4388-4394. (Pubitemid 34968705)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.6 , pp. 4388-4394
    • Zebboudj, A.F.1    Imura, M.2    Bostrom, K.3
  • 61
    • 43449132997 scopus 로고    scopus 로고
    • Proline and γ-carboxylated glutamate residues in matrix Gla protein are critical for binding of bone morphogenetic protein-4
    • DOI 10.1161/CIRCRESAHA.107.166124, PII 0000301220080509000011
    • Yao Y, Shahbazian A, Bostrom KI. Proline and gamma-carboxylated glutamate residues in matrix Gla protein are critical for binding of bone morphogenetic protein-4. Circ Res. 2008;102:1065-1074. (Pubitemid 351667860)
    • (2008) Circulation Research , vol.102 , Issue.9 , pp. 1065-1074
    • Yao, Y.1    Shahbazian, A.2    Bostrom, K.I.3
  • 62
    • 33845921834 scopus 로고    scopus 로고
    • Regulation of bone morphogenetic protein-4 by matrix GLA protein in vascular endothelial cells involves activin-like kinase receptor 1
    • DOI 10.1074/jbc.M604239200
    • Yao Y, Zebboudj AF, Shao E, Perez M, Bostrom K. Regulation of bone morphogenetic protein-4 by matrix GLA protein in vascular endothelial cells involves activin-like kinase receptor 1. J Biol Chem. 2006;281: 33921-33930. (Pubitemid 46036604)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.45 , pp. 33921-33930
    • Yao, Y.1    Zebboudj, A.F.2    Shao, E.3    Perez, M.4    Bostrom, K.5
  • 63
    • 0030947025 scopus 로고    scopus 로고
    • Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protien
    • DOI 10.1038/386078a0
    • Luo G, Ducy P, McKee MD, Pinero GJ, Loyer E, Behringer RR, Karsenty G. Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature. 1997;386:78-81. (Pubitemid 27130923)
    • (1997) Nature , vol.386 , Issue.6620 , pp. 78-81
    • Luo, G.1    Ducy, P.2    McKee, M.D.3    Pinero, G.J.4    Loyer, E.5    Behringer, R.R.6    Karsenty, G.7
  • 66
    • 35649010993 scopus 로고    scopus 로고
    • Matrix GLA protein, an inhibitory morphogen in pulmonary vascular development
    • DOI 10.1074/jbc.M704297200
    • Yao Y, Nowak S, Yochelis A, Garfinkel A, Bostrom KI. Matrix GLA protein, an inhibitory morphogen in pulmonary vascular development. J Biol Chem. 2007;282:30131-30142. (Pubitemid 350035283)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.41 , pp. 30131-30142
    • Yao, Y.1    Nowak, S.2    Yochelis, A.3    Garfinkel, A.4    Bostrom, K.I.5
  • 67
    • 70349260659 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cells
    • Shao ES, Lin L, Yao Y, Bostrom KI. Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cells. Blood. 2009;114:2197-2206.
    • (2009) Blood , vol.114 , pp. 2197-2206
    • Shao, E.S.1    Lin, L.2    Yao, Y.3    Bostrom, K.I.4
  • 69
    • 0242443189 scopus 로고    scopus 로고
    • Matrix GLA protein and BMP-2 regulate osteoinduction in calcifying vascular cells
    • DOI 10.1002/jcb.10669
    • Zebboudj AF, Shin V, Bostrom K. Matrix GLA protein and BMP-2 regulate osteoinduction in calcifying vascular cells. J Cell Biochem. 2003;90:756-765. (Pubitemid 37392466)
    • (2003) Journal of Cellular Biochemistry , vol.90 , Issue.4 , pp. 756-765
    • Zebboudj, A.F.1    Shin, V.2    Bostrom, K.3
  • 70
    • 77955854944 scopus 로고    scopus 로고
    • Fine mapping of the hereditary haemorrhagic telangiectasia (HHT)3 locus on chromosome 5 excludes VE-Cadherin-2, Sprouty4 and other interval genes
    • Govani FS, Shovlin CL. Fine mapping of the hereditary haemorrhagic telangiectasia (HHT)3 locus on chromosome 5 excludes VE-Cadherin-2, Sprouty4 and other interval genes. J Angiogenes Res. 2010;2:15.
    • (2010) J Angiogenes Res , vol.2 , pp. 15
    • Govani, F.S.1    Shovlin, C.L.2
  • 72
    • 6344283050 scopus 로고    scopus 로고
    • Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a Nox1-based NADPH oxidase
    • DOI 10.1161/01.RES.0000145728.22878.45
    • Sorescu GP, Song H, Tressel SL, Hwang J, Dikalov S, Smith DA, Boyd NL, Platt MO, Lassegue B, Griendling KK, Jo H. Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxidase. Circ Res. 2004;95:773-779. (Pubitemid 39390579)
    • (2004) Circulation Research , vol.95 , Issue.8 , pp. 773-779
    • Sorescu, G.P.1    Song, H.2    Tressel, S.L.3    Hwang, J.4    Dikalov, S.5    Smith, D.A.6    Boyd, N.L.7    Platt, M.O.8    Lassegue, B.9    Griendling, K.K.10    Jo, H.11
  • 74
    • 18544384985 scopus 로고    scopus 로고
    • 2, and high intravascular pressure
    • DOI 10.1161/01.CIR.0000164201.40634.1D
    • Csiszar A, Smith KE, Koller A, Kaley G, Edwards JG, Ungvari Z. Regulation of bone morphogenetic protein-2 expression in endothelial cells: role of nuclear factor-kappaB activation by tumor necrosis factoralpha, H2O2, and high intravascular pressure. Circulation. 2005;111: 2364-2372. (Pubitemid 40655331)
    • (2005) Circulation , vol.111 , Issue.18 , pp. 2364-2372
    • Csiszar, A.1    Smith, K.E.2    Koller, A.3    Kaley, G.4    Edwards, J.G.5    Ungvari, Z.6
  • 76
    • 66749182718 scopus 로고    scopus 로고
    • Hemodynamic forces, vascular oxidative stress, and regulation of BMP-2/4 expression
    • Csiszar A, Lehouz S, Ungvari Z. Hemodynamic forces, vascular oxidative stress, and regulation of BMP-2/4 expression. Antioxid Redox Signal. 2009;11:683-697.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 683-697
    • Csiszar, A.1    Lehouz, S.2    Ungvari, Z.3
  • 77
    • 34948907257 scopus 로고    scopus 로고
    • Bone morphogenic protein antagonists are coexpressed with bone morphogenic protein 4 in endothelial cells exposed to unstable flow in vitro in mouse aortas and in human coronary arteries: Role of bone morphogenic protein antagonists in inflammation and atherosclerosis
    • DOI 10.1161/CIRCULATIONAHA.106.683227
    • Chang K, Weiss D, Suo J, Vega JD, Giddens D, Taylor WR, Jo H. Bone morphogenic protein antagonists are coexpressed with bone morphogenic protein 4 in endothelial cells exposed to unstable flow in vitro in mouse aortas and in human coronary arteries: role of bone morphogenic protein antagonists in inflammation and atherosclerosis. Circulation. 2007;116:1258-1266. (Pubitemid 47517537)
    • (2007) Circulation , vol.116 , Issue.11 , pp. 1258-1266
    • Chang, K.1    Weiss, D.2    Suo, J.3    Vega, J.D.4    Giddens, D.5    Taylor, W.R.6    Jo, H.7
  • 78
    • 57549104510 scopus 로고    scopus 로고
    • Highdensity lipoproteins affect endothelial BMP-signaling by modulating expression of the activin-like kinase receptor 1 and 2
    • Yao Y, Shao ES, Jumabay M, Shahbazian A, Ji S, Bostrom KI. Highdensity lipoproteins affect endothelial BMP-signaling by modulating expression of the activin-like kinase receptor 1 and 2. Arterioscler Thromb Vasc Biol. 2008;28:2266-2274.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 2266-2274
    • Yao, Y.1    Shao, E.S.2    Jumabay, M.3    Shahbazian, A.4    Ji, S.5    Bostrom, K.I.6
  • 81
    • 19044398689 scopus 로고    scopus 로고
    • Angiogenesis and pericytes in the initiation of ectopic calcification
    • DOI 10.1161/01.RES.0000163634.51301.0d
    • Collett GD, Canfield AE. Angiogenesis and pericytes in the initiation of ectopic calcification. Circ Res. 2005;96:930-938. (Pubitemid 40712792)
    • (2005) Circulation Research , vol.96 , Issue.9 , pp. 930-938
    • Collett, G.D.M.1    Canfield, A.E.2
  • 83
    • 79551529058 scopus 로고    scopus 로고
    • Hyperphosphatemia-induced nanocrystals upregulate the expression of bone morphogenetic protein-2 and osteopontin genes in mouse smooth muscle cells in vitro
    • Sage AP, Lu J, Tintut Y, Demer LL. Hyperphosphatemia-induced nanocrystals upregulate the expression of bone morphogenetic protein-2 and osteopontin genes in mouse smooth muscle cells in vitro. Kidney Int. 2011;79:414-422.
    • (2011) Kidney Int , vol.79 , pp. 414-422
    • Sage, A.P.1    Lu, J.2    Tintut, Y.3    Demer, L.L.4
  • 84
    • 33751417865 scopus 로고    scopus 로고
    • High glucose increases the expression of Cbfa1 and BMP-2 and enhances the calcification of vascular smooth muscle cells
    • DOI 10.1093/ndt/gfl429
    • Chen NX, Duan D, O'Neill KD, Moe SM. High glucose increases the expression of Cbfa1 and BMP-2 and enhances the calcification of vascular smooth muscle cells. Nephrol Dial Transplant. 2006;21: 3435-3442. (Pubitemid 44817092)
    • (2006) Nephrology Dialysis Transplantation , vol.21 , Issue.12 , pp. 3435-3442
    • Chen, N.X.1    Duan, D.2    O'Neill, K.D.3    Moe, S.M.4
  • 85
    • 33645213711 scopus 로고    scopus 로고
    • Transcriptional regulation of vascular bone morphogenetic protein by endothelin receptors in early autoimmune diabetes mellitus
    • Nett PC, Ortmann J, Celeiro J, Haas E, Hofmann-Lehmann R, Tornillo L, Terraciano LM, Barton M. Transcriptional regulation of vascular bone morphogenetic protein by endothelin receptors in early autoimmune diabetes mellitus. Life Sci. 2006;78:2213-2218.
    • (2006) Life Sci , vol.78 , pp. 2213-2218
    • Nett, P.C.1    Ortmann, J.2    Celeiro, J.3    Haas, E.4    Hofmann-Lehmann, R.5    Tornillo, L.6    Terraciano, L.M.7    Barton, M.8
  • 86
    • 79952071106 scopus 로고    scopus 로고
    • Activation of vascular bone morphogenetic protein signaling in diabetes mellitus
    • Bostrom KI, Jumabay M, Matveyenko A, Nicholas SB, Yao Y. Activation of vascular bone morphogenetic protein signaling in diabetes mellitus. Circ Res. 2011;108:446-457.
    • (2011) Circ Res , vol.108 , pp. 446-457
    • Bostrom, K.I.1    Jumabay, M.2    Matveyenko, A.3    Nicholas, S.B.4    Yao, Y.5
  • 87
    • 33646395697 scopus 로고    scopus 로고
    • Myofibroblast progenitor cells are increased in number in patients with type 1 diabetes and express less bone morphogenetic protein 6: A novel clue to adverse tissue remodelling?
    • Nguyen TQ, Chon H, van Nieuwenhoven FA, Braam B, Verhaar MC, Goldschmeding R. Myofibroblast progenitor cells are increased in number in patients with type 1 diabetes and express less bone morphogenetic protein 6: a novel clue to adverse tissue remodelling? Diabetologia. 2006;49:1039-1048.
    • (2006) Diabetologia , vol.49 , pp. 1039-1048
    • Nguyen, T.Q.1    Chon, H.2    Van Nieuwenhoven, F.A.3    Braam, B.4    Verhaar, M.C.5    Goldschmeding, R.6
  • 88
    • 0028180137 scopus 로고
    • TGF-beta 1 and 25-hydroxycholesterol stimulate osteoblast-like vascular cells to calcify
    • Watson KE, Bostrom K, Ravindranath R, Lam T, Norton B, Demer LL. TGF-beta 1 and 25-hydroxycholesterol stimulate osteoblast-like vascular cells to calcify. J Clin Invest. 1994;93:2106-2113.
    • (1994) J Clin Invest , vol.93 , pp. 2106-2113
    • Watson, K.E.1    Bostrom, K.2    Ravindranath, R.3    Lam, T.4    Norton, B.5    Demer, L.L.6
  • 91
    • 3543095147 scopus 로고    scopus 로고
    • β-catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse
    • DOI 10.1083/jcb.200403050
    • Liebner S, Cattelino A, Gallini R, Rudini N, Iurlaro M, Piccolo S, Dejana E. Beta-catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse. J Cell Biol. 2004;166:359-367. (Pubitemid 39031239)
    • (2004) Journal of Cell Biology , vol.166 , Issue.3 , pp. 359-367
    • Liebner, S.1    Cattelino, A.2    Gallini, R.3    Rudini, N.4    Iurlaro, M.5    Piccolo, S.6    Dejana, E.7
  • 92
    • 0033598796 scopus 로고    scopus 로고
    • Medial localization of mineralization-regulating proteins in association with Monckeberg's sclerosis: Evidence for smooth muscle cell-mediated vascular calcification
    • Shanahan CM, Cary NR, Salisbury JR, Proudfoot D, Weissberg PL, Edmonds ME. Medial localization of mineralization-regulating proteins in association with Monckeberg's sclerosis: evidence for smooth muscle cell-mediated vascular calcification. Circulation. 1999;100:2168-2176.
    • (1999) Circulation , vol.100 , pp. 2168-2176
    • Shanahan, C.M.1    Cary, N.R.2    Salisbury, J.R.3    Proudfoot, D.4    Weissberg, P.L.5    Edmonds, M.E.6
  • 93
    • 58149339930 scopus 로고    scopus 로고
    • Media calcification and intima calcification are distinct entities in chronic kidney disease
    • Amann K. Media calcification and intima calcification are distinct entities in chronic kidney disease. Clin J Am Soc Nephrol. 2008;3: 1599-1605.
    • (2008) Clin J Am Soc Nephrol , vol.3 , pp. 1599-1605
    • Amann, K.1
  • 94
    • 1642284407 scopus 로고    scopus 로고
    • Regulation of cardiovascular calcification
    • DOI 10.1016/S1054-8807(03)00130-3, PII S1054880703001303
    • Speer MY, Giachelli CM. Regulation of cardiovascular calcification. Cardiovasc Pathol. 2004;13:63-70. (Pubitemid 38366423)
    • (2004) Cardiovascular Pathology , vol.13 , Issue.2 , pp. 63-70
    • Speer, M.Y.1    Giachelli, C.M.2
  • 95
    • 40949158527 scopus 로고    scopus 로고
    • BMP-2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells
    • Li X, Yang HY, Giachelli CM. BMP-2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells. Atherosclerosis. 2008;199:271-277.
    • (2008) Atherosclerosis , vol.199 , pp. 271-277
    • Li, X.1    Yang, H.Y.2    Giachelli, C.M.3
  • 96
    • 34250613172 scopus 로고    scopus 로고
    • Sodium-dependent phosphate cotransporters and vascular calcification
    • DOI 10.1097/MNH.0b013e3281c55ef1, PII 0004155220070700000007
    • Li X, Giachelli CM. Sodium-dependent phosphate cotransporters and vascular calcification. Curr Opin Nephrol Hypertens. 2007;16:325-328. (Pubitemid 46944330)
    • (2007) Current Opinion in Nephrology and Hypertension , vol.16 , Issue.4 , pp. 325-328
    • Li, X.1    Giachelli, C.M.2
  • 97
    • 33646157733 scopus 로고    scopus 로고
    • Role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification
    • Li X, Yang HY, Giachelli CM. Role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification. Circ Res. 2006;98:905-912.
    • (2006) Circ Res , vol.98 , pp. 905-912
    • Li, X.1    Yang, H.Y.2    Giachelli, C.M.3
  • 98
    • 73849131053 scopus 로고    scopus 로고
    • Targeting bone morphogenetic protein signaling on renal and vascular diseases
    • Maciel TT, Kempf H, Campos AH. Targeting bone morphogenetic protein signaling on renal and vascular diseases. Curr Opin Nephrol Hypertens. 2010;19:26-31.
    • (2010) Curr Opin Nephrol Hypertens , vol.19 , pp. 26-31
    • MacIel, T.T.1    Kempf, H.2    Campos, A.H.3
  • 99
    • 34247485138 scopus 로고    scopus 로고
    • Sodium thiosulfate treatment for calcific uremic arteriolopathy in children and young adults
    • Araya CE, Fennell RS, Neiberger RE, Dharnidharka VR. Sodium thiosulfate treatment for calcific uremic arteriolopathy in children and young adults. Clin J Am Soc Nephrol. 2006;1:1161-1166.
    • (2006) Clin J Am Soc Nephrol , vol.1 , pp. 1161-1166
    • Araya, C.E.1    Fennell, R.S.2    Neiberger, R.E.3    Dharnidharka, V.R.4
  • 100
    • 77953723529 scopus 로고    scopus 로고
    • Calcific uremic arteriolopathy: Pathophysiology, reactive oxygen species and therapeutic approaches
    • Sowers KM, Hayden MR. Calcific uremic arteriolopathy: pathophysiology, reactive oxygen species and therapeutic approaches. Oxid Med Cell Longev. 2010;3:109-121.
    • (2010) Oxid Med Cell Longev , vol.3 , pp. 109-121
    • Sowers, K.M.1    Hayden, M.R.2
  • 101
    • 30144445850 scopus 로고    scopus 로고
    • Calcific uremic arteriolopathy (calciphylaxis)
    • Rifkin BS, Perazella MA. Calcific uremic arteriolopathy (calciphylaxis). Mayo Clin Proc. 2006;81:9. (Pubitemid 43054310)
    • (2006) Mayo Clinic Proceedings , vol.81 , Issue.1 , pp. 9
    • Rifkin, B.S.1    Perazella, M.A.2
  • 103
    • 14544283020 scopus 로고    scopus 로고
    • Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: A potential mechanism for accelerated vascular calcification in ESRD
    • DOI 10.1097/01.ASN.0000141960.01035.28
    • Reynolds JL, Joannides AJ, Skepper JN, McNair R, Schurgers LJ, Proudfoot D, Jahnen-Dechent W, Weissberg PL, Shanahan CM. Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD. J Am Soc Nephrol. 2004;15:2857-2867. (Pubitemid 41103395)
    • (2004) Journal of the American Society of Nephrology , vol.15 , Issue.11 , pp. 2857-2867
    • Reynolds, J.L.1    Joannides, A.J.2    Skepper, J.N.3    Mcnair, R.4    Schurgers, L.J.5    Proudfoot, D.6    Jahnen-Dechent, W.7    Weissberg, P.L.8    Shanahan, C.M.9
  • 107
    • 33646907966 scopus 로고    scopus 로고
    • Valvular aortic stenosis: Disease severity and timing of intervention
    • DOI 10.1016/j.jacc.2006.03.002, PII S0735109706006176
    • Otto CM. Valvular aortic stenosis: disease severity and timing of intervention. J Am Coll Cardiol. 2006;47:2141-2151. (Pubitemid 43795057)
    • (2006) Journal of the American College of Cardiology , vol.47 , Issue.11 , pp. 2141-2151
    • Otto, C.M.1
  • 110
    • 33746860419 scopus 로고    scopus 로고
    • Pathogenesis of calcific aortic valve disease: A disease process comes of age (and a good deal more)
    • DOI 10.1161/01.ATV.0000227513.13697.ac, PII 0004360520060800000008
    • O'Brien KD. Pathogenesis of calcific aortic valve disease: a disease process comes of age (and a good deal more). Arterioscler Thromb Vasc Biol. 2006;26:1721-1728. (Pubitemid 44305324)
    • (2006) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.26 , Issue.8 , pp. 1721-1728
    • O'Brien, K.D.1
  • 111
    • 79955714207 scopus 로고    scopus 로고
    • Bicuspid aortic valve disease: The role of oxidative stress in Lrp5 bone formation
    • Rajamannan NM. Bicuspid aortic valve disease: the role of oxidative stress in Lrp5 bone formation. Cardiovasc Pathol. 2011;20:168-176.
    • (2011) Cardiovasc Pathol , vol.20 , pp. 168-176
    • Rajamannan, N.M.1
  • 112
    • 0038545837 scopus 로고    scopus 로고
    • Calcific aortic stenosis: From bench to the bedside - Emerging clinical and cellular concepts
    • Rajamannan NM, Gersh B, Bonow RO. Calcific aortic stenosis: from bench to the bedside: emerging clinical and cellular concepts. Heart. 2003;89:801-805. (Pubitemid 36760652)
    • (2003) Heart , vol.89 , Issue.7 , pp. 801-805
    • Rajamannan, N.M.1    Gersh, B.2    Bonow, R.O.3
  • 115
    • 0027991976 scopus 로고
    • Characterization of the early lesion of 'degenerative' valvular aortic stenosis: Histological and immunohistochemical studies
    • Otto CM, Kuusisto J, Reichenbach DD, Gown AM, O'Brien KD. Characterization of the early lesion of 'degenerative' valvular aortic stenosis: histological and immunohistochemical studies. Circulation. 1994;90: 844-853. (Pubitemid 24242754)
    • (1994) Circulation , vol.90 , Issue.2 , pp. 844-853
    • Otto, C.M.1    Kuusisto, J.2    Reichenbach, D.D.3    Gown, A.M.4    O'Brien, K.D.5
  • 118
    • 49849089138 scopus 로고    scopus 로고
    • Dysregulation of antioxidant mechanisms contributes to increased oxidative stress in calcific aortic valvular stenosis in humans
    • Miller JD, Chu Y, Brooks RM, Richenbacher WE, Pena-Silva R, Heistad DD. Dysregulation of antioxidant mechanisms contributes to increased oxidative stress in calcific aortic valvular stenosis in humans. J Am Coll Cardiol. 2008;52:843-850.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 843-850
    • Miller, J.D.1    Chu, Y.2    Brooks, R.M.3    Richenbacher, W.E.4    Pena-Silva, R.5    Heistad, D.D.6
  • 119
    • 64049113676 scopus 로고    scopus 로고
    • Calcification by valve interstitial cells is regulated by the stiffness of the extracellular matrix
    • Yip CY, Chen JH, Zhao R, Simmons CA. Calcification by valve interstitial cells is regulated by the stiffness of the extracellular matrix. Arterioscler Thromb Vasc Biol. 2009;29:936-942.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 936-942
    • Yip, C.Y.1    Chen, J.H.2    Zhao, R.3    Simmons, C.A.4
  • 120
    • 62549151245 scopus 로고    scopus 로고
    • Identification and characterization of aortic valve mesenchymal progenitor cells with robust osteogenic calcification potential
    • Chen JH, Yip CY, Sone ED, Simmons CA. Identification and characterization of aortic valve mesenchymal progenitor cells with robust osteogenic calcification potential. Am J Pathol. 2009;174:1109-1119.
    • (2009) Am J Pathol , vol.174 , pp. 1109-1119
    • Chen, J.H.1    Yip, C.Y.2    Sone, E.D.3    Simmons, C.A.4
  • 122
    • 59449092756 scopus 로고    scopus 로고
    • Calcific aortic stenosis: Lessons learned from experimental and clinical studies
    • Rajamannan NM. Calcific aortic stenosis: lessons learned from experimental and clinical studies. Arterioscler Thromb Vasc Biol. 2009;29: 162-168.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 162-168
    • Rajamannan, N.M.1
  • 123
    • 33750973380 scopus 로고    scopus 로고
    • Cultured endothelial cells display endogenous activation of the canonical Wnt signaling pathway and express multiple ligands, receptors, and secreted modulators of Wnt signaling
    • DOI 10.1002/dvdy.20939
    • Goodwin AM, Sullivan KM, D'Amore PA. Cultured endothelial cells display endogenous activation of the canonical Wnt signaling pathway and express multiple ligands, receptors, and secreted modulators of Wnt signaling. Dev Dyn. 2006;235:3110-3120. (Pubitemid 44749701)
    • (2006) Developmental Dynamics , vol.235 , Issue.11 , pp. 3110-3120
    • Goodwin, A.M.1    Sullivan, K.M.2    D'Amore, P.A.3
  • 124
    • 0036937945 scopus 로고    scopus 로고
    • Wnt signaling in the vasculature
    • DOI 10.1023/A:1021563510866
    • Goodwin AM, D'Amore PA. Wnt signaling in the vasculature. Angiogenesis. 2002;5:1-9. (Pubitemid 36076918)
    • (2002) Angiogenesis , vol.5 , Issue.1-2 , pp. 1-9
    • Goodwin, A.M.1    D'Amore, P.A.2
  • 126
    • 33749676226 scopus 로고    scopus 로고
    • Human pulmonary valve progenitor cells exhibit endothelial/mesenchymal plasticity in response to vascular endothelial growth factor-A and transforming growth factor-β2
    • DOI 10.1161/01.RES.0000245188.41002.2c, PII 0000301220061013000012
    • Paruchuri S, Yang JH, Aikawa E, Melero-Martin JM, Khan ZA, Loukogeorgakis S, Schoen FJ, Bischoff J. Human pulmonary valve progenitor cells exhibit endothelial/mesenchymal plasticity in response to vascular endothelial growth factor-A and transforming growth factorbeta2. Circ Res. 2006;99:861-869. (Pubitemid 44556385)
    • (2006) Circulation Research , vol.99 , Issue.8 , pp. 861-869
    • Paruchuri, S.1    Yang, J.-H.2    Aikawa, E.3    Melero-Martin, J.M.4    Khan, Z.A.5    Loukogeorgakis, S.6    Schoen, F.J.7    Bischoff, J.8
  • 127
    • 53049103869 scopus 로고    scopus 로고
    • Osteocalcin expression by circulating endothelial progenitor cells in patients with coronary atherosclerosis
    • Gossl M, Modder UI, Atkinson EJ, Lerman A, Khosla S. Osteocalcin expression by circulating endothelial progenitor cells in patients with coronary atherosclerosis. J Am Coll Cardiol. 2008;52:1314-1325.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 1314-1325
    • Gossl, M.1    Modder, U.I.2    Atkinson, E.J.3    Lerman, A.4    Khosla, S.5
  • 128
    • 50149108009 scopus 로고    scopus 로고
    • Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium
    • Chen YH, Ishii M, Sucov HM, Maxson RE Jr. Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium. BMC Dev Biol. 2008;8:75.
    • (2008) BMC Dev Biol , vol.8 , pp. 75
    • Chen, Y.H.1    Ishii, M.2    Sucov, H.M.3    Maxson Jr., R.E.4
  • 129
    • 17644380642 scopus 로고    scopus 로고
    • Spatial heterogeneity of endothelial phenotypes correlates with side-specific vulnerability to calcification in normal porcine aortic valves
    • DOI 10.1161/01.RES.0000161998.92009.64
    • Simmons CA, Grant GR, Manduchi E, Davies PF. Spatial heterogeneity of endothelial phenotypes correlates with side-specific vulnerability to calcification in normal porcine aortic valves. Circ Res. 2005;96: 792-799. (Pubitemid 40559519)
    • (2005) Circulation Research , vol.96 , Issue.7 , pp. 792-799
    • Simmons, C.A.1    Grant, G.R.2    Manduchi, E.3    Davies, P.F.4
  • 131
    • 0032515059 scopus 로고    scopus 로고
    • Diet-induced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice
    • DOI 10.1074/jbc.273.46.30427
    • Towler DA, Bidder M, Latifi T, Coleman T, Semenkovich CF. Dietinduced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice. J Biol Chem. 1998;273:30427-30434. (Pubitemid 28545516)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.46 , pp. 30427-30434
    • Towler, D.A.1    Bidder, M.2    Latifi, T.3    Coleman, T.4    Semenkovich, C.F.5
  • 132
    • 77149122729 scopus 로고    scopus 로고
    • Inflammation and the osteogenic regulation of vascular calcification: A review and perspective
    • Shao JS, Cheng SL, Sadhu J, Towler DA. Inflammation and the osteogenic regulation of vascular calcification: a review and perspective. Hypertension. 2010;55:579-592.
    • (2010) Hypertension , vol.55 , pp. 579-592
    • Shao, J.S.1    Cheng, S.L.2    Sadhu, J.3    Towler, D.A.4
  • 133
    • 33646452759 scopus 로고    scopus 로고
    • Features of the metabolic syndrome and diabetes mellitus as predictors of aortic valve calcification in the Multi-Ethnic Study of Atherosclerosis
    • Katz R, Wong ND, Kronmal R, Takasu J, Shavelle DM, Probstfield JL, Bertoni AG, Budoff MJ, O'Brien KD. Features of the metabolic syndrome and diabetes mellitus as predictors of aortic valve calcification in the Multi-Ethnic Study of Atherosclerosis. Circulation. 2006;113: 2113-2119.
    • (2006) Circulation , vol.113 , pp. 2113-2119
    • Katz, R.1    Wong, N.D.2    Kronmal, R.3    Takasu, J.4    Shavelle, D.M.5    Probstfield, J.L.6    Bertoni, A.G.7    Budoff, M.J.8    O'Brien, K.D.9
  • 136
    • 77955173409 scopus 로고    scopus 로고
    • Activation of vascular smooth muscle parathyroid hormone receptor inhibits Wnt/beta-catenin signaling and aortic fibrosis in diabetic arteriosclerosis
    • Cheng SL, Shao JS, Halstead LR, Distelhorst K, Sierra O, Towler DA. Activation of vascular smooth muscle parathyroid hormone receptor inhibits Wnt/beta-catenin signaling and aortic fibrosis in diabetic arteriosclerosis. Circ Res. 2010;107:271-282.
    • (2010) Circ Res , vol.107 , pp. 271-282
    • Cheng, S.L.1    Shao, J.S.2    Halstead, L.R.3    Distelhorst, K.4    Sierra, O.5    Towler, D.A.6
  • 137
    • 0347379905 scopus 로고    scopus 로고
    • Teriparatide (Human Parathyroid Hormone (1-34)) Inhibits Osteogenic Vascular Calcification in Diabetic Low Density Lipoprotein Receptor-deficient Mice
    • DOI 10.1074/jbc.M308825200
    • Shao JS, Cheng SL, Charlton-Kachigian N, Loewy AP, Towler DA. Teriparatide (human parathyroid hormone (1-34)) inhibits osteogenic vascular calcification in diabetic low density lipoprotein receptordeficient mice. J Biol Chem. 2003;278:50195-50202. (Pubitemid 37548859)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.50 , pp. 50195-50202
    • Shao, J.-S.1    Cheng, S.-L.2    Charlton-Kachigian, N.3    Loewy, A.P.4    Towler, D.A.5
  • 139
    • 0034700234 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha promotes in vitro calcification of vascular cells via the cAMP pathway
    • Tintut Y, Patel J, Parhami F, Demer LL. Tumor necrosis factor-alpha promotes in vitro calcification of vascular cells via the cAMP pathway. Circulation. 2000;102:2636-2642.
    • (2000) Circulation , vol.102 , pp. 2636-2642
    • Tintut, Y.1    Patel, J.2    Parhami, F.3    Demer, L.L.4
  • 140
    • 70349256058 scopus 로고    scopus 로고
    • Heat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein
    • Yao Y, Watson AD, Ji S, Bostrom KI. Heat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein. Circ Res. 2009;105:575-584.
    • (2009) Circ Res , vol.105 , pp. 575-584
    • Yao, Y.1    Watson, A.D.2    Ji, S.3    Bostrom, K.I.4
  • 142
    • 79251630740 scopus 로고    scopus 로고
    • Oxidized low-density lipoprotein promotes osteoblast differentiation in primary cultures of vascular smooth muscle cells by up-regulating Osterix expression in an Msx2-dependent manner
    • Taylor J, Butcher M, Zeadin M, Politano A, Shaughnessy SG. Oxidized low-density lipoprotein promotes osteoblast differentiation in primary cultures of vascular smooth muscle cells by up-regulating Osterix expression in an Msx2-dependent manner. J Cell Biochem. 2011;112: 581-588.
    • (2011) J Cell Biochem , vol.112 , pp. 581-588
    • Taylor, J.1    Butcher, M.2    Zeadin, M.3    Politano, A.4    Shaughnessy, S.G.5
  • 144
    • 79953295363 scopus 로고    scopus 로고
    • Oxidized low-density lipoprotein induces bone morphogenetic protein-2 in coronary artery endothelial cells via Toll-like receptors 2 and 4
    • Su X, Ao L, Shi Y, Johnson TR, Fullerton DA, Meng X. Oxidized low-density lipoprotein induces bone morphogenetic protein-2 in coronary artery endothelial cells via Toll-like receptors 2 and 4. J Biol Chem. 2011;286;12213-12220.
    • (2011) J Biol Chem , vol.286 , pp. 12213-12220
    • Su, X.1    Ao, L.2    Shi, Y.3    Johnson, T.R.4    Fullerton, D.A.5    Meng, X.6
  • 145
    • 47249157776 scopus 로고    scopus 로고
    • Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling
    • Byon CH, Javed A, Dai Q, Kappes JC, Clemens TL, Darley-Usmar VM, McDonald JM, Chen Y. Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling. J Biol Chem. 2008;283:15319-15327.
    • (2008) J Biol Chem , vol.283 , pp. 15319-15327
    • Byon, C.H.1    Javed, A.2    Dai, Q.3    Kappes, J.C.4    Clemens, T.L.5    Darley-Usmar, V.M.6    McDonald, J.M.7    Chen, Y.8
  • 148
    • 79956333162 scopus 로고    scopus 로고
    • Notch enhances bone morphogenetic protein2 (BMP2) responsiveness of Msx2 gene to induce osteogenic differentiation and mineralization of vascular smooth muscle cells
    • Shimizu T, Tanaka T, Iso T, Matsui H, Ooyama Y, Kawai-Kowase K, Arai M, Kurabayashi M. Notch enhances bone morphogenetic protein2 (BMP2) responsiveness of Msx2 gene to induce osteogenic differentiation and mineralization of vascular smooth muscle cells. J Biol Chem. 2011;286:19138-19148.
    • (2011) J Biol Chem , vol.286 , pp. 19138-19148
    • Shimizu, T.1    Tanaka, T.2    Iso, T.3    Matsui, H.4    Ooyama, Y.5    Kawai-Kowase, K.6    Arai, M.7    Kurabayashi, M.8
  • 151
    • 70350580660 scopus 로고    scopus 로고
    • Notch1 represses osteogenic pathways in aortic valve cells
    • Nigam V, Srivastava D. Notch1 represses osteogenic pathways in aortic valve cells. J Mol Cell Cardiol. 2009;47:828-834.
    • (2009) J Mol Cell Cardiol , vol.47 , pp. 828-834
    • Nigam, V.1    Srivastava, D.2
  • 157
    • 4544369860 scopus 로고    scopus 로고
    • Vascular calcification in patients with end-stage renal disease
    • DOI 10.1093/ndt/gfh1058
    • Floege J, Ketteler M. Vascular calcification in patients with end-stage renal disease. Nephrol Dial Transplant. 2004;19(Suppl 5):V59-V66. (Pubitemid 39214202)
    • (2004) Nephrology Dialysis Transplantation , vol.19 , Issue.SUPPL. 5
    • Floege, J.1    Ketteler, M.2
  • 159
    • 78349266526 scopus 로고    scopus 로고
    • Decreased oxidative stress and greater bone anabolism in the aged, when compared to the young, murine skeleton with parathyroid hormone administration
    • Jilka RL, Almeida M, Ambrogini E, Han L, Roberson PK, Weinstein RS, Manolagas SC. Decreased oxidative stress and greater bone anabolism in the aged, when compared to the young, murine skeleton with parathyroid hormone administration. Aging Cell. 2010;9:851-867.
    • (2010) Aging Cell , vol.9 , pp. 851-867
    • Jilka, R.L.1    Almeida, M.2    Ambrogini, E.3    Han, L.4    Roberson, P.K.5    Weinstein, R.S.6    Manolagas, S.C.7
  • 160
    • 77954505723 scopus 로고    scopus 로고
    • Intermittent parathyroid hormone administration counteracts the adverse effects of glucocorticoids on osteoblast and osteocyte viability, bone formation, and strength in mice
    • Weinstein RS, Jilka RL, Almeida M, Roberson PK, Manolagas SC. Intermittent parathyroid hormone administration counteracts the adverse effects of glucocorticoids on osteoblast and osteocyte viability, bone formation, and strength in mice. Endocrinology. 2010;151:2641-2649.
    • (2010) Endocrinology , vol.151 , pp. 2641-2649
    • Weinstein, R.S.1    Jilka, R.L.2    Almeida, M.3    Roberson, P.K.4    Manolagas, S.C.5
  • 161
    • 39549103433 scopus 로고    scopus 로고
    • The effect of apolipoprotein mimetic peptides in inflammatory disorders other than atherosclerosis
    • DOI 10.1016/j.tcm.2007.12.006, PII S1050173808000029
    • Navab M, Anantharamaiah GM, Fogelman AM. The effect of apolipoprotein mimetic peptides in inflammatory disorders other than atherosclerosis. Trends Cardiovasc Med. 2008;18:61-66. (Pubitemid 351282495)
    • (2008) Trends in Cardiovascular Medicine , vol.18 , Issue.2 , pp. 61-66
    • Navab, M.1    Anantharamaiah, G.M.2    Fogelman, A.M.3
  • 163
    • 34247573373 scopus 로고    scopus 로고
    • Reassessment of statins to retard the progression of aortic stenosis
    • Rajamannan NM. Reassessment of statins to retard the progression of aortic stenosis. Curr Cardiol Rep. 2007;9:99-104. (Pubitemid 46681110)
    • (2007) Current Cardiology Reports , vol.9 , Issue.2 , pp. 99-104
    • Rajamannan, N.M.1
  • 164
    • 17644398457 scopus 로고    scopus 로고
    • Regulation of vascular calcification: Roles of phosphate and osteopontin
    • DOI 10.1161/01.RES.0000161997.24797.c0
    • Giachelli CM, Speer MY, Li X, Rajachar RM, Yang H. Regulation of vascular calcification: roles of phosphate and osteopontin. Circ Res. 2005;96:717-722. (Pubitemid 40559510)
    • (2005) Circulation Research , vol.96 , Issue.7 , pp. 717-722
    • Giachelli, C.M.1    Speer, M.Y.2    Li, X.3    Rajachar, R.M.4    Yang, H.5
  • 165
    • 55349109288 scopus 로고    scopus 로고
    • Hypoxic chondrogenic differentiation of human embryonic stem cells enhances cartilage protein synthesis and biomechanical functionality
    • Koay EJ, Athanasiou KA. Hypoxic chondrogenic differentiation of human embryonic stem cells enhances cartilage protein synthesis and biomechanical functionality. Osteoarthritis Cartilage. 2008;16: 1450-1456.
    • (2008) Osteoarthritis Cartilage , vol.16 , pp. 1450-1456
    • Koay, E.J.1    Athanasiou, K.A.2
  • 166
    • 48749086529 scopus 로고    scopus 로고
    • Hypoxia promotes chondrogenesis in rat mesenchymal stem cells: A role for AKT and hypoxia-inducible factor (HIF)-1alpha
    • Kanichai M, Ferguson D, Prendergast PJ, Campbell VA. Hypoxia promotes chondrogenesis in rat mesenchymal stem cells: a role for AKT and hypoxia-inducible factor (HIF)-1alpha. J Cell Physiol. 2008;216: 708-715.
    • (2008) J Cell Physiol , vol.216 , pp. 708-715
    • Kanichai, M.1    Ferguson, D.2    Prendergast, P.J.3    Campbell, V.A.4
  • 167
    • 46449124286 scopus 로고    scopus 로고
    • Hypoxic expansion promotes the chondrogenic potential of articular chondrocytes
    • Egli RJ, Bastian JD, Ganz R, Hofstetter W, Leunig M. Hypoxic expansion promotes the chondrogenic potential of articular chondrocytes. J Orthop Res. 2008;26:977-985.
    • (2008) J Orthop Res , vol.26 , pp. 977-985
    • Egli, R.J.1    Bastian, J.D.2    Ganz, R.3    Hofstetter, W.4    Leunig, M.5
  • 174
    • 33744964431 scopus 로고    scopus 로고
    • Mouse cristin/R-spondin family proteins are novel ligands for the frizzled 8 and LRP6 receptors and activate β-catenin-dependent gene expression
    • DOI 10.1074/jbc.M508324200
    • Nam JS, Turcotte TJ, Smith PF, Choi S, Yoon JK. Mouse cristin/Rspondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression. J Biol Chem. 2006;281:13247-13257. (Pubitemid 43855236)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.19 , pp. 13247-13257
    • Nam, J.-S.1    Turcotte, T.J.2    Smith, P.F.3    Choi, S.4    Jeong, K.Y.5
  • 176
    • 34447526784 scopus 로고    scopus 로고
    • R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and β-catenin signaling
    • DOI 10.1074/jbc.M701927200
    • Wei Q, Yokota C, Semenov MV, Doble B, Woodgett J, He X. R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling. J Biol Chem. 2007;282: 15903-15911. (Pubitemid 47093310)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.21 , pp. 15903-15911
    • Wei, Q.1    Yokota, C.2    Semenov, M.V.3    Doble, B.4    Woodgett, J.5    He, X.6
  • 178
    • 42049108832 scopus 로고    scopus 로고
    • Extracellular transglutaminase 2 activates beta-catenin signaling in calcifying vascular smooth muscle cells
    • Faverman L, Mikhaylova L, Malmquist J, Nurminskaya M. Extracellular transglutaminase 2 activates beta-catenin signaling in calcifying vascular smooth muscle cells. FEBS Lett. 2008;582:1552-1557.
    • (2008) FEBS Lett , vol.582 , pp. 1552-1557
    • Faverman, L.1    Mikhaylova, L.2    Malmquist, J.3    Nurminskaya, M.4


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