Mast cells in human stenotic aortic valves are associated with the severity of stenosis

Inflammation

Volumn 36, Issue 2, 2013, Pages 449-456

  Wypasek, E ^a,b   Natorska, J ^a,b   Grudzien G ^a,b   Filip, G ^a,b   Sadowski, J ^a,b   Undas, A ^a,b  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b Krakowski Szpital Specjalistyczny Im Jana Pawła II   (Poland)

Author keywords

aortic stenosis; mast cells; transvalvular gradients; valvular calcification

Indexed keywords

CHYMASE; TRYPTASE;

ADULT; AORTA VALVE; AORTA VALVE STENOSIS; ARTICLE; BIOACCUMULATION; CELL ASSAY; CELL FUNCTION; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; ENZYME ASSAY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; MAST CELL; OUTCOME ASSESSMENT; PRESSURE GRADIENT; SIGNAL TRANSDUCTION;

AGED; AORTIC VALVE; AORTIC VALVE STENOSIS; CHYMASES; FEMALE; FIBROSIS; HUMANS; INFLAMMATION; MACROPHAGES; MALE; MAST CELLS; MIDDLE AGED; TRYPTASES; VASCULAR CALCIFICATION;

EID: 84879497909     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-012-9565-z     Document Type: Article

References (25)

1. Olszowska, M. 2011. Pathogenesis and pathophysiology of aortic valve stenosis in adults. Polskie Archiwum Medycyny Wewnȩtrznej 121: 409-413.
2. Jian, B.; N. Narula, Q.Y. Li, E.R. Mohler 3rd, and R.J. Levy. 2003. Progression of aortic valve stenosis: TGF-beta1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis. The Annals of Thoracic Surgery 75: 457-465.
3. Otto, C.M.; J. Kuusisto, D.D. Reichenbach, A.M. Gown, and K.D. O'Brien. 1994. Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies. Circulation 90: 844-853.
4. Helske, S.; K.A. Lindstedt, M. Laine, M. Mäyränpää, K. Werkkala, J. Lommi, H. Turto, and M. Kupari. 2004. Induction of local angiotensin II-producing systems in stenotic aortic valves. Journal of the American College of Cardiology 44: 1859-1866.
5. Lindstedt, K.A.; Y. Wang, N. Shiota, J. Saarinen, M. Hyytiäinen, J.O. Kokkonen, J. Keski-Oja, and P.T. Kovanen. 2001. Activation of paracrine TGF-beta1 signaling upon stimulation and degranulation of rat serosal mast cells: a novel function for chymase. The FASEB Journal 15: 1377-1388.
6. Pejler, G.; E. Rönnberg, I. Waern, and S. Wernersson. 2010. Mast cell proteases: multifaceted regulators of inflammatory disease. Blood 17(115): 4981-4990.
7. Caughey, G.H. 2011. Mast cell proteases as protective and inflammatory mediators. Advances in Experimental Medicine and Biology 716: 212-234.
8. Zhang, W.; A.L. Chancey, H.P. Tzeng, Z. Zhou, K.J. Lavine, F. Gao, N. Sivasubramanian, P.M. Barger, and D.L. Mann. 2011. The development of myocardial fibrosis in transgenic mice with targeted overexpression of tumor necrosis factor requires mast cell-fibroblast interactions. Circulation 8: 2106-2116.
9. Helske, S.; S. Syväranta, M. Kupari, J. Lappalainen, M. Laine, J. Lommi, H. Turto, M. Mäyränpää, K. Werkkala, P.T. Kovanen, and K.A. Lindstedt. 2006. Possible role for mast cell-derived cathepsin G in the adverse remodelling of stenotic aortic valves. European Heart Journal 27: 1495-1504.
10. Syväranta, S.; S. Helske, M. Laine, J. Lappalainen, M. Kupari, M.I. Mäyränpää, K.A. Lindstedt, and P.T. Kovanen. 2010. Vascular endothelial growth factor-secreting mast cells and myofibroblasts: a novel self-perpetuating angiogenic pathway in aortic valve stenosis. Arteriosclerosis, Thrombosis, and Vascular Biology 30: 1220-1227.
11. Kovanen, P.T.; M. Kaartinen, and T. Paavonen. 1995. Infiltrates of activated mast cells at the site of coronary atheromatous erosion or rupture in myocardial infarction. Circulation 92: 1084-1088.
12. Teirstein, P.; M. Yeager, P.G. Yock, and R.L. Popp. 1986. Doppler echocardiographic measurement of aortic valve area in aortic stenosis: a noninvasive application of the Gorlin formula. Journal of the American College of Cardiology 8: 1059-1065.
13. Natorska, J.; G. Marek, M. Hlawaty, J. Sadowski, W. Tracz, and A. Undas. 2011. Fibrin presence within aortic valves in patients with aortic stenosis: association with in vivo thrombin generation and fibrin clot properties. Thrombosis and Haemostasis 105: 254-260.
14. Lamprecht, M.R.; D.M. Sabatini, and A.E. Carpenter. 2007. Cell Profiler: versatile software for automated biological image analysis. Biotechniques 42: 71-75.
15. Jeziorska, M.; C. McCollum, and D.E. Woolley. 1997. Mast cell distribution, activation, and phenotype in atherosclerotic lesions of human carotid arteries. The Journal of Pathology 182: 115-122.
16. Laine, P.; A. Naukkarinen, L. Heikkilä, A. Penttilä, and P.T. Kovanen. 2000. Adventitial mast cells connect with sensory nerve fibers in atherosclerotic coronary arteries. Circulation 101: 1665-1669.
17. Joghetaei, N.; P. Akhyari, B.H. Rauch, P. Cullen, A. Lichtenberg, M. Rudelius, J. Pelisek, and R. Schmidt. 2011. Extracellular matrix metalloproteinase inducer (CD147) and membrane type 1-matrix metalloproteinase are expressed on tissue macrophages in calcific aortic stenosis and induce transmigration in an artificial valve model. The Journal of Thoracic and Cardiovascular Surgery 142: 191-198.
18. Tani, K.; F. Ogushi, H. Kido, T. Kawano, Y. Kunori, T. Kamimura, P. Cui, and S. Sone. 2000. Chymase is a potent chemoattractant for human monocytes and neutrophils. Journal of Leukocyte Biology 67: 585-589.
19. Gordon, J.R. 2000. TGFbeta1 and TNFalpha secreted by mast cells stimulated via the FcepsilonRI activate fibroblasts for high-level production of monocyte chemoattractant protein-1 (MCP-1). Cellular Immunology 201: 42-49.
20. Galli, S.J.; and M. Tsai. 2010. Mast cells in allergy and infection: versatile effector and regulatory cells in innate and adaptive immunity. European Journal of Immunology 40: 1843-1851.
21. Bot, I.; S.C. de Jager, A. Zernecke, K.A. Lindstedt, T.J. van Berkel, C. Weber, and E.A. Biessen. 2007. Perivascular mast cells promote atherogenesis and induce plaque destabilization in apoE deficient mice. Circulation 115: 2516-2525.
22. Galante, A.; A. Pietroiusti, M. Vellini, P. Piccolo, G. Possati, M. De Bonis, R.L. Grillo, C. Fontana, and C. Favalli. 2001. C-reactive protein is increased in patients with degenerative aortic valvular stenosis. Journal of the American College of Cardiology 38: 1078-1082.
23. Helske, S.; R. Oksjoki, K.A. Lindstedt, J. Lommi, H. Turto, K. Werkkala, M. Kupari, and P.T. Kovanen. 2008. Complement system is activated in stenotic aortic valves. Atherosclerosis 196: 190-200.
24. Wojta, J.; C. Kaun, G. Zorn, M. Ghannadan, A.W. Hauswirth, W.R. Sperr, G. Fritsch, D. Printz, B.R. Binder, G. Schatzl, J. Zwirner, G. Maurer, K. Huber, and P. Valent. 2002. C5a stimulates production of plasminogen activator inhibitor-1 in human mast cells and basophils. Blood 100: 517-523.
25. Warrier, B.; R. Mallipeddi, P.K. Karla, and C.H. Lee. 2005. The functional role of C-reactive protein in aortic wall calcification. Cardiology 104: 57-64.