Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves

Circulation

Volumn 104, Issue 21, 2001, Pages 2525-2532

  Rabkin, Elena ^a   Aikawa, Masanori ^a   Stone, James R ^a   Fukumoto, Yoshihiro ^a   Libby, Peter ^a   Schoen, Frederick J ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Collagen; Metalloproteinases; Mitral valve; Remodeling

Indexed keywords

ALPHA ACTIN; CATHEPSIN K; CATHEPSIN S; COLLAGENASE; COLLAGENASE 3; DESMIN; ENZYME; GELATINASE A; GELATINASE B; INTERLEUKIN 1BETA; INTERSTITIAL COLLAGENASE; MYOSIN; PROCOLLAGEN; VIMENTIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FEMALE; HEART VENTRICLE REMODELING; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MITRAL VALVE REGURGITATION; MYOFIBROBLAST; MYXOMA; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; VALVULAR HEART DISEASE;

EID: 0035923477     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/hc4601.099489     Document Type: Article

References (26)

1. Pathology of the myxomatous mitral valve. Nature, secondary changes and complications
2. The floppy mitral valve: Study of incidence, pathology, and complications in surgical, necropsy, and forensic material
3. Abnormalities in elastic fibers and other connective-tissue components of floppy mitral valve
4. Aortic valve structure-function correlations: Role of elastic fibers no longer a stretch of the imagination
5. A modification of the Movat pentachrome stain
6. Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma
7. Evidence for increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques
8. Myofibroblasts, I: Paracrine cells important in health and disease
9. Lipid lowering promotes accumulation of mature smooth muscle cells expressing smooth muscle myosin heavy chain isoforms in atheroma of hypercholesterolemic rabbits
10. Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis
11. The myofibroblast: A quarter century after its discovery
12. Tissue heart valves: Current challenges and future research perspectives
13. Immunohistochemistry of matrix metalloproteinases and their inhibitors in thoracic aortic aneurysms and aortic valves of patients with Marfan's syndrome
14. Association of mitral valve prolapse and systemic abnormalities of connective tissue: A phenotypic continuum
15. Mechanical properties of myxomatous mitral valves
16. Dual structural and functional phenotypes of the porcine aortic valve interstitial population: Characteristics of the leaflet myofibroblast
17. Cell biology of valvular interstitial cells
18. Phenotypic and functional characterization of interstitial cells from human heart valves, pericardium and skin
19. Studies on the histogenesis of myxomatous tissue of human coronary lesions
20. Age-related collagen and elastin content of heart valves
21. Different collagenase gene products have different roles in degradation of type I collagen
22. Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells
23. Cardiac catabolic factors: The degradation of heart valve intercellular matrix
24. Production of a factor by cultured human heart valves that is immunologically related to interleukin-1
25. Cytokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion
26. Connective tissue abnormalities in spontaneous rupture of chordae tendineae