Smoothelin-positive cells in human and porcine semilunar valves

Histochemistry and Cell Biology

Volumn 120, Issue 4, 2003, Pages 307-317

  Cimini, Massimo ^b,c   Rogers, Kem A ^b   Boughner, Derek R ^a,c  

^a LONDON HEALTH SCIENCES CENTRE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c ROBARTS RESEARCH INSTITUTE   (Canada)

Author keywords

Semilunar heart valves; Smooth muscle actin; Smooth muscle cells; Smoothelin; Valvular interstitial cells

Indexed keywords

ALPHA ACTIN; PROTEIN; SMOOTHELIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; AORTA VALVE; AORTA VALVE STENOSIS; ARTICLE; CELL DIFFERENTIATION; CELL LABELING; CONTROLLED STUDY; ELECTROPHORESIS; EXTRACTION; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCHEMISTRY; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; MYOFIBROBLAST; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PULMONARY VALVE; SMOOTH MUSCLE FIBER; SWINE; TISSUE ENGINEERING; WESTERN BLOTTING;

ANIMALS; AORTIC VALVE; CYTOSKELETAL PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MUSCLE PROTEINS; MYOCYTES, SMOOTH MUSCLE; PULMONARY VALVE; SWINE;

ANIMALIA; SUIDAE; SUS SCROFA;

EID: 0242329683     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00418-003-0570-z     Document Type: Article

References (68)

1. Agmon Y, Khandheria BK, Meissner I, Sicks JR, O'Fallon WM, Wiebers DO, Whisnant JP, Seward JB, Tajik AJ (2000) Aortic valve sclerosis and aortic atherosclerosis: different manifestations of the same disease? Insights from a population-based study. J Am Coll Cardiol 38:827-834
2. Aronow WS, Ahn C (1994) Correlation of serum lipids with the presence or absence of coronary artery disease in 1,793 men and women aged ≥62 years. Am J Cardiol 73:702-703
3. Aronow WS, Schwartz KS, Koenigsberg M (1987) Correlation of serum lipids, calcium and phosphorus, diabetes mellitus, aortic valve stenosis and history of systemic hypertension with presence or absence of mitral anular calcium in persons older than 62 years in a long-term health care facility. Am J Cardiol 59:381-382
4. Bairati A, DeBiasi S (1981) Presence of a smooth muscle system in aortic valve leaflets. Anat Embryol (Berl) 161:329-340
5. Bar H, Wende P, Watson L, Denger S, van Eys G, Kreuzer J, Jahn L (2002) Smoothelin is an indicator of reversible phenotype modulation of smooth muscle cells in balloon-injured rat carotid arteries. Basic Res Cardiol 97:9-16
6. Christen T, Bochaton-Piallat ML, Neuville P, Rensen S, Redard M, van Eys G, Gabbiani G (1999) Cultured porcine coronary artery smooth muscle cells. A new model with advanced differentiation. Circ Res 85:99-107
7. Cimini M, Rogers KA, Boughner DR (2002) Aortic valve interstitial cells: an evaluation of cell viability and cell phenotype over time. J Heart Valve Dis 11:881-887
8. De Biasi S, Vitellaro-Zuccarello L (1982) Intrinsic innervation of porcine semilunar heart valves. Anat Embryol (Berl) 165:71-79
9. Della Rocca F, Sartore S, Guidolin D, Bertiplaglia B, Gerosa G, Casarotto D, Pauletto P (2000) Cell composition of the human pulmonary valve: a comparative study with the aortic valve: the VESALIO Project. Ann Thorac Surg 70:1594-1600
10. Durbin AD, Gotlieb AI (2002) Advances towards understanding heart valve response to injury. Cardiovasc Pathol 11:69-77
11. Edwards J (1963) Etiology of calcific aortic stenosis. Circulation 26:17-18
12. Eyden BP, Ponting J, Davies H, Bartley C, Torgersen E (1994) Defining the myofibroblast: normal tissues, with special reference to the stromal cells of Wharton's jelly in human umbilical cord. J Submicrosc Cytol Pathol 26:347-355
13. Filip DA, Radu A, Simionescu M (1986) Interstitial cells of the heart valves possess characteristics similar to smooth muscle cells. Circ Res 59:310-320
14. Filip DA, Nistor A, Bulla A, Radu A, Lupu F, Simionescu M (1987) Cellular events in the development of valvular atherosclerotic lesions induced by experimental hypercholesterolemia. Atherosclerosis 67:199-214
15. Gittenberger-de Groot AC, DeRuiter MC, Bergwerff M, Poelmann RE (1999) Smooth muscle cell origin and its relation to heterogeneity in development and disease. Arterioscler Thromb Vasc Biol 19:1589-1594
16. Gotoh T, Kuroda T, Yamasawa M, Nishinaga M, Mitsuhashi T, Seino Y, Nagoh N, Kayaba K, Yamada S, Matsuo H (1995) Correlation between lipoprotein(a) and aortic valve sclerosis assessed by echocardiography (the JMS Cardiac Echo and Cohort Study). Am J Cardiol 76:928-932
17. Gross L, Kugel M (1931) Topographic anatomy and histology of the valves in the human heart. Am J Pathol 7:445-473
18. Hinck L, Nathke IS, Papkoff J, Nelson WJ (1994) Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly. J Cell Biol 125:1327-1340
19. Hoagland PM, Cook EF, Flatley M, Walker C, Goldman L (1985) Case-control analysis of risk factors for presence of aortic stenosis in adults (age 50 years or older). Am J Cardiol 55:744-747
20. Hoerstrup SP, Sodian R, Daebritz S, Wang J, Bacha EA, Martin DP, Moran AM, Guleserian KJ, Sperling JS, Kaushal S, Vacanti JP, Schoen FJ, Mayer JEJ (2000) Functional living trileaflet heart valves grown in vitro. Circulation 102: III44-III49
21. Jester JV, Rodrigues MM, Herman IM (1987) Characterization of avascular corneal wound healing fibroblasts. New insights into the myofibroblast. Am J Pathol 127:140-148
22. Johansson B, Eriksson A, Ramaekers F, Thornell L (1999a) Smoothelin in adult and developing human arteries and myocardium. Histochem Cell Biol 112:291-299
23. Johansson B, Eriksson A, Ramaekers F, Thornell LE (1999b) Smoothelin and intermediate filament proteins in human aortocoronary saphenous vein by-pass grafts. Histochem J 31:723-727
24. Johnson CM, Hanson MN, Helgeson SC (1987) Porcine cardiac valvular subendothelial cells in culture: cell isolation and growth characteristics. J Mol Cell Cardiol 19:1185-1193
25. Kawano H, Shirai T, Kawano Y, Okada R (1996) Morphological study of vagal innervation in human semilunar valves using a histochemical method. Jpn Circ J 60:62-66
26. Kramer J, Aguirre-Artera AM, Thiel C, Gross CM, Dietz R, Cardoso MC, Leonhardt H (1999) A novel isoform of the smooth muscle cell differentiation merker smoothclin. J Mol Med 77:294-298
27. Kramer J, Quensel C, Meding J, Cardoso MC, Leonhardt H (2001) Identification and characterization of novel smoothelin isoforms in vascular smooth muscle. J Vasc Res 38:120-132
28. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685
29. Lindroos M, Kupari M, Heikkila J, Tilvis R (1993) Prevalence of aortic valve abnormalities in the elderly: an echocardiographic study of a random population sample. J Am Coll Cardiol 21:1220-1225
30. Marron K, Yacoub MH, Polak JM, Sheppard MN, Fagan D, Whitehead BF, de Leval MR, Anderson RH, Wharton J (1996) Innervation of human atrioventricular and arterial valves. Circulation 94:368-375
31. Messier RHJ, Bass BL, Aly HM, Jones JL, Domkowski PW, Wallace RB, Hopkins RA (1994) Dual structural and functional phenotypes of the porcine aortic valve interstitial population: characteristics of the leaflet myofibroblast. J Surg Res 57:1-21
32. Messier RHJ, Bass BL, Domkowski PW, Hopkins RA (1999) Interstitial cellular and matrix restoration of cardiac valves after cryopreservation. J Thorac Cardiovasc Surg 118:36-49
33. Mohler ER (2000) Are atherosclerotic processes involved in aortic-valve calcification? Lancet 356:524-525
34. Mohler ER, Adam LP, McClelland P, Graham L, Hathaway DR (1997) Detection of osteopontin in calcified human aortic valves. Arterioscler Thromb Vasc Biol 17:547-552
35. Mohler ER, Chawla MK, Chang AW, Vyavahare N, Levy RJ, Graham L, Gannon FH (1999) Identification and characterization of calcifying valve cells from human and canine aortic valves. J Heart Valve Dis 8:254-260
36. Mulholland DL, Gotlieb AI (1996) Cell biology of valvular interstitial cells. Can J Cardiol 12:231-236
37. Mulholland DL, Gotlieb AI (1997) Cardiac valve interstitial cells: regulator of valve structure and function. Cardiovasc Pathol 6:167-174
38. O'Brien KD, Kuusisto J, Reichenbach DD, Ferguson M, Giachelli C, Alpers CE, Otto CM (1995) Osteopontin is expressed in human aortic valvular lesions. Circulation 92:2163-2168
39. O'Brien KD, Reichenbach DD, Marcovina SM, Kuusisto J, Alpers CE, Otto CM (1996) Apolipoproteins B, (a), and E accumulate in the morphologically early lesion of 'degenerative' valvular aortic stenosis. Arterioscler Thromb Vasc Biol 16:523-532
40. O'Brien KD, Shavelle DM, Caulfield MT, McDonald TO, Olin-Lewis K, Otto CM, Probstfield JL (2002) Association of angiotensin-converting enzyme with low-density lipoprotein in aortic valvular lesions and in human plasma. Circulation 106:2224-2230
41. Otto CM, Kuusisto J, Reichenbach DD, Gown AM, O'Brien KD (1994) Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies. Circulation 90:844-853
42. Otto CM, Lind BK, Kitzman DW, Gersh BJ, Siscovick DS (1999) Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly. N Engl J Med 341:142-147
43. Palta S, Pai AM, Gill KS, Pai RG (2000) New insights into the progression of aortic stenosis: implications for secondary prevention. Circulation 101:2497-2502
44. Quensel C, Kramer J, Cardoso MC, Leonhardt H (2002) Smoothelin contains a novel actin cytoskeleton localization sequence with similarity to troponin T. J Cell Biochem 85:403-409
45. Rajamannan NM, Sangiorgi G, Springett M, Arnold K, Mohacsi T, Spagnoli LG, Edwards WD, Tajik AJ, Schwartz RS (2001) Experimental hypercholesterolemia induces apoptosis in the aortic valve. J Heart Valve Dis 10:371-374
46. Rajamannan NM, Subramaniam M, Springett M, Sebo TC, Niekrasz M, McConnell JP, Singh RJ, Stone NJ, Bonow RO, Spelsberg TC (2002) Atorvastatin inhibits hypercholesterolemia-induced cellular proliferation and bone matrix production in the rabbit aortic valve. Circulation 105:2660-2665
47. Russell HK (1972) A modification of Movat's pentachrome stain. Arch Pathol 94:187-191
48. Sarphie TG (1982) Surface topography of mitral valve endothelium from diet-induced, hypercholesterolemic rabbits. Atherosclerosis 45:203-220
49. Sarphie TG (1985) Surface responses of aortic valve endothelia from diet-induced, hypercholesterolemic rabbits. Atherosclerosis 54:283-299
50. Sartore S, Franch R, Roelofs M, Chiavegato A (1999) Molecular and cellular phenotypes and their regulation in smooth muscle. Rev Physiol Biochem Pharmacol 134:235-320
51. Shinoka T, Shum-Tim D, Ma PX, Tanel RE, Langer R, Vacanti JP, Mayer JEJ (1997) Tissue-engineered heart valve leaflets: does cell origin affect outcome? Circulation 96: II-7
52. Simionescu N, Vasile E, Lupu F, Popescu G, Simionescu M (1986) Prelesional events in atherogenesis. Accumulation of extracellular cholesterol-rich liposomes in the arterial intima and cardiac valves of the hyperlipidemic rabbit. Am J Pathol 123:109-125
53. Sodian R, Hoerstrup SP, Sperling JS, Daebritz S, Martin DP, Moran AM, Kim BS, Schoen FJ, Vacanti JP, Mayer JEJ (2000) Early in vivo experience with tissue-engineered trileaflet heart valves. Circulation 102: III22-III29
54. Steinhoff G, Stock U, Karim N, Mertsching H, Timke A, Meliss RR, Pethig K, Haverich A, Bader A (2000) Tissue engineering of pulmonary heart valves on allogenic acellular matrix conduits: in vivo restoration of valve tissue. Circulation 102:1150-1155
55. Tamura K, Jones M, Yamada I, Ferrans VJ (2000) Wound healing in the mitral valve. J Heart Valve Dis 9:53-63
56. Taylor PM, Allen SP, Yacoub MH (2000) Phenotypic and functional characterization of interstitial cells from human heart valves, pericardium and skin. J Heart Valve Dis 9:150-158
57. Taylor PM, Batten P, Brand NJ, Thomas PS, Yacoub MH (2003) The cardiac valve interstitial cell. Int J Biochem Cell Biol 35:113-118
58. van der Loop FT, Schaart G, Timmer ED, Ramaekers FC, van Eys GJ (1996) Smoothelin, a novel cytoskeletal protein specific for smooth muscle cells. J Cell Biol 134:401-411
59. van der Loop FT, Gabbiani G, Kohnen G, Ramaekers FC, van Eys GJ (1997) Differentiation of smooth muscle cells in human blood vessels as defined by smoothelin, a novel marker for the contractile phenotype. Arterioscler Thromb Vasc Biol 17:665-671
60. van Eys GJ, Voller MC, Timmer ED, Wehrens XH, Small JV, Schalken JA, Ramaekers FC, van der Loop FT (1997) Smoothelin expression characteristics: development of a smooth muscle cell in vitro system and identification of a vascular variant. Cell Struct Funct 22:65-72
61. Vesely I, Noseworthy R (1992) Micromechanics of the fibrosa and the ventricularis in aortic valve leaflets. J Biomech 25:101-113
62. Wassenaar C, Bax WA, van Suylen RJ, Vuzevski VD, Bos E (1997) Effects of cryopreservation on contractile properties of porcine isolated aortic valve leaflets and aortic wall. J Thorac Cardiovasc Surg 113:165-172
63. Wehrens XH, Mies B, Gimona M, Ramaekers FC, van Eys GJ, Small JV (1997) Localization of smoothelin in avian smooth muscle and identification of a vascular-specific isoform. FEBS Lett 405:315-320
64. Weind KL, Ellis CG, Boughner DR (2000) The aortic valve blood supply. J Heart Valve Dis 9:1-7
65. Weind KL, Boughner DR, Rigutto L, Ellis CG (2001) Oxygen diffusion and consumption of aortic valve cusps. Am J Physiol Heart Circ Physiol 281:H2604-H2611
66. Wierzbicki A, Shetty C (1999) Aortic stenosis: an atherosclerotic disease? J Heart Valve Dis 8:416-423
67. Zahor Z, Czabanova V (1977) Experimental atherosclerosis of the heart valves in rats following a long-term atherogenic regimen. Atherosclerosis 27:49-57
68. Zalewski A, Shi Y (1997) Vascular myofibroblasts. Lessons from coronary repair and remodeling. Arterioscler Thromb Vasc Biol 17:417-422