Development of bisphosphonates

Breast Cancer Research

Volumn 4, Issue 1, 2002, Pages 30-34

  Fleisch, H ^a  

^a NONE   (Switzerland)

Author keywords

Bisphosphonates; Bone; Bone resorption; Calcification; Inhibitors

Indexed keywords

ADENOSINE TRIPHOSPHATE DERIVATIVE; BISPHOSPHONIC ACID DERIVATIVE; CALCIUM PHOSPHATE; CARBON; CLODRONIC ACID; ETIDRONIC ACID; FARNESYL DIPHOSPHATE; GERANYLTRANSFERASE; GUANINE NUCLEOTIDE BINDING PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IBANDRONIC ACID; ISOPRENOID; MATRIX METALLOPROTEINASE; MEVALONIC ACID; NITROGEN DERIVATIVE; PAMIDRONIC ACID; PHOSPHORUS; PROTEIN TYROSINE KINASE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; PYROPHOSPHORIC ACID DERIVATIVE; RAS PROTEIN; RHO FACTOR; RISEDRONIC ACID; TECHNETIUM 99M; TILUDRONIC ACID; ZOLEDRONIC ACID;

ARTERY CALCIFICATION; BONE MINERALIZATION; BONE TUMOR; CELL ACTIVITY; CONTROLLED STUDY; CYTOSKELETON; DRUG MECHANISM; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; KIDNEY CALCIFICATION; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; OSTEOPOROSIS; PAGET BONE DISEASE; RAT; REVIEW; SKIN CALCIFICATION; SOFT TISSUE CALCIFICATION; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; BONE RESORPTION; BREAST NEOPLASMS; DIPHOSPHONATES; FEMALE; HUMANS; OSTEITIS DEFORMANS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036148405     PISSN: 14655411     EISSN: None     Source Type: Journal    
DOI: 10.1186/bcr414     Document Type: Review

References (30)

1. Ueber die Einwirkung des Chloracetyls auf phosphorige Säure
2. The influence of pyrophosphate analogues (diphosphonates) on the precipitation and dissolution of calcium phosphate in vitro and in vivo
3. Effect of pyrophosphate on hydroxyapatite and its implications in calcium homeostasis
4. Diphosphonates inhibit formation of calcium phosphate crystals in vitro and pathological calcification in vivo
5. Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo
6. The binding of pyrophosphate and two diphosphonates by hydroxyapatite crystals
7. Effect of ethane-1-hydroxy-1,1-diphosphonate (EHDP) and dichloromethylene diphosphonate (CI2MDP) on the calcification and resorption of cartilage and bone in the tibial epiphysis and metaphysis of rats
8. The influence of two diphosphonates on calcium metabolism in the rat
9. Inhibition by two diphosphonates of bone lysis in tumor conditioned media
10. The effects of dichloromethylene diphosphonate on hypercalcemia and other parameters of the humoral hypercalcemia of malignancy in the rat Leydig cell tumor
11. Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice
12. Facilitation and suppression of bone metastasis
13. Bisphosphonates inhibit the adhesion of breast cancer cells to bone matrices in vitro
14. Bisphosphonates inhibit prostate and breast carcinoma cell adhesion to unmineralized and mineralized bone extracellular matrices
15. The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway
16. 3H-etidronate in rat and mouse bones
17. Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo
18. Heterocycle-containing bisphosphonates cause apoptosis and inhibit bone resorption by preventing protein prenylation: Evidence from structure-activity relationships in J774 macrophages
19. Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of gtp-binding proteins, including ras
20. Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates
21. Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase
22. Alendronate mechanism of action: Gernylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro
23. The role of geranylgeranylation in bone resorption and its suppression by bisphosphonates in fetal bone explants in vitro: A clue to the mechanism of action of nitrogen-containing bisphosphonates
24. Structure-activity relationships for inhibition of farnesy diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates
25. Nitrogen-bisphosphonates block retinoblastoma phosphorylation and cell growth by inhibiting the cholesterol biosynthetic pathway in a keratinocyte model for esophageal irritation
26. Bisphosphonates are incorporated into adenine nucleotides by human aminoacyl-trna synthetase enzymes
27. Clodronate and liposome-encapsulated clodronate are metabolised to a toxic ATP analog, adenosine 5′(β,γ-dichloromethylene)triphosphate, by mammalian cells in vitro
28. Bisphosphonates: Mechanisms of action
29. Bisphosphonates: Pharmacology, mechanisms of action and clinical uses