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Volumn 47, Issue 7, 2015, Pages

Epigenetic modulation as a therapeutic approach for pulmonary arterial hypertension

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Indexed keywords

MICRORNA;

EID: 84949838007     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/EMM.2015.45     Document Type: Review
Times cited : (57)

References (121)
  • 1
    • 84901401598 scopus 로고    scopus 로고
    • Apelin-APJ signaling: A potential therapeutic target for pulmonary arterial hypertension
    • Kim J. Apelin-APJ signaling: a potential therapeutic target for pulmonary arterial hypertension. Mol Cell 2014; 37: 196–201.
    • (2014) Mol Cell , vol.37 , pp. 196-201
    • Kim, J.1
  • 3
    • 84899631957 scopus 로고    scopus 로고
    • The genetic basis of pulmonary arterial hypertension
    • Ma L, Chung WK. The genetic basis of pulmonary arterial hypertension. Hum Genet 2014; 133: 471–479.
    • (2014) Hum Genet , vol.133 , pp. 471-479
    • Ma, L.1    Chung, W.K.2
  • 4
    • 84903592110 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension in adults: Novel drugs and catheter ablation techniques show promise? Systematic review on pharmacotherapy and interventional strategies
    • Rosanio S, Pelliccia F, Gaudio C, Greco C, Keylani AM, D'Agostino DC. Pulmonary arterial hypertension in adults: novel drugs and catheter ablation techniques show promise? Systematic review on pharmacotherapy and interventional strategies. Biomed Res Int 2014; 2014: 743868.
    • (2014) Biomed Res Int , vol.2014
    • Rosanio, S.1    Pelliccia, F.2    Gaudio, C.3    Greco, C.4    Keylani, A.M.5    D'agostino, D.C.6
  • 5
    • 84863519076 scopus 로고    scopus 로고
    • An evaluation of long-term survival from time of diagnosis in pulmonary arterial hypertension from the REVEAL Registry
    • Benza RL, Miller DP, Barst RJ, Badesch DB, Frost AE, McGoon MD. An evaluation of long-term survival from time of diagnosis in pulmonary arterial hypertension from the REVEAL Registry. Chest 2012; 142: 448–456.
    • (2012) Chest , vol.142 , pp. 448-456
    • Benza, R.L.1    Miller, D.P.2    Barst, R.J.3    Badesch, D.B.4    Frost, A.E.5    McGoon, M.D.6
  • 7
    • 84864290214 scopus 로고    scopus 로고
    • Histone deacetylation inhibition in pulmonary hypertension: Therapeutic potential of valproic acid and suberoylanilide hydroxamic acid
    • Zhao L, Chen CN, Hajji N, Oliver E, Cotroneo E, Wharton J et al. Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. Circulation 2012; 126: 455–467.
    • (2012) Circulation , vol.126 , pp. 455-467
    • Zhao, L.1    Chen, C.N.2    Hajji, N.3    Oliver, E.4    Cotroneo, E.5    Wharton, J.6
  • 8
    • 77954083190 scopus 로고    scopus 로고
    • Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: A basis for excessive cell proliferation and a new therapeutic target
    • Archer SL, Marsboom G, Kim GH, Zhang HJ, Toth PT, Svensson EC et al. Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target. Circulation 2010; 121: 2661–2671.
    • (2010) Circulation , vol.121 , pp. 2661-2671
    • Archer, S.L.1    Marsboom, G.2    Kim, G.H.3    Zhang, H.J.4    Toth, P.T.5    Svensson, E.C.6
  • 9
    • 84961289965 scopus 로고    scopus 로고
    • Restoration of impaired endothelial myocyte enhancer factor 2 function rescues pulmonary arterial hypertension
    • Kim J, Hwangbo C, Hu X, Kang Y, Papangeli I, Mehrotra D et al. Restoration of impaired endothelial myocyte enhancer factor 2 function rescues pulmonary arterial hypertension. Circulation 2015; 131: 190–199.
    • (2015) Circulation , vol.131 , pp. 190-199
    • Kim, J.1    Hwangbo, C.2    Hu, X.3    Kang, Y.4    Papangeli, I.5    Mehrotra, D.6
  • 11
    • 84866028172 scopus 로고    scopus 로고
    • Epigenetic mechanisms of pulmonary hypertension
    • Kim GH, Ryan JJ, Marsboom G, Archer SL. Epigenetic mechanisms of pulmonary hypertension. Pulm Circ 2011; 1: 347–356.
    • (2011) Pulm Circ , vol.1 , pp. 347-356
    • Kim, G.H.1    Ryan, J.J.2    Marsboom, G.3    Archer, S.L.4
  • 12
    • 79951903268 scopus 로고    scopus 로고
    • Genome-wide DNA methylation in human heart failure
    • Movassagh M, Vujic A, Foo R. Genome-wide DNA methylation in human heart failure. Epigenomics 2011; 3: 103–109.
    • (2011) Epigenomics , vol.3 , pp. 103-109
    • Movassagh, M.1    Vujic, A.2    Foo, R.3
  • 14
    • 84892763878 scopus 로고    scopus 로고
    • Reversing DNA methylation: Mechanisms, genomics, and biological functions
    • Wu H, Zhang Y. Reversing DNA methylation: mechanisms, genomics, and biological functions. Cell 2014; 156: 45–68.
    • (2014) Cell , vol.156 , pp. 45-68
    • Wu, H.1    Zhang, Y.2
  • 15
    • 0030710153 scopus 로고    scopus 로고
    • How does DNA methylation repress transcription?
    • Kass SU, Pruss D, Wolffe AP. How does DNA methylation repress transcription? Trends Genet 1997; 13: 444–449.
    • (1997) Trends Genet , vol.13 , pp. 444-449
    • Kass, S.U.1    Pruss, D.2    Wolffe, A.P.3
  • 16
  • 17
    • 84861391922 scopus 로고    scopus 로고
    • DNA methylation screening identifies driver epigenetic events of cancer cell survival
    • De Carvalho DD, Sharma S, You JS, Su SF, Taberlay PC, Kelly TK et al. DNA methylation screening identifies driver epigenetic events of cancer cell survival. Cancer Cell 2012; 21: 655–667.
    • (2012) Cancer Cell , vol.21 , pp. 655-667
    • de Carvalho, D.D.1    Sharma, S.2    You, J.S.3    Su, S.F.4    Taberlay, P.C.5    Kelly, T.K.6
  • 19
    • 42649089780 scopus 로고    scopus 로고
    • The methylome: Approaches for global DNA methylation profiling
    • Beck S, Rakyan VK. The methylome: approaches for global DNA methylation profiling. Trends Genet 2008; 24: 231–237.
    • (2008) Trends Genet , vol.24 , pp. 231-237
    • Beck, S.1    Rakyan, V.K.2
  • 20
  • 21
    • 84891891996 scopus 로고    scopus 로고
    • Environmental epigenetics and its implication on disease risk and health outcomes
    • Ho SM, Johnson A, Tarapore P, Janakiram V, Zhang X, Leung YK. Environmental epigenetics and its implication on disease risk and health outcomes. ILAR J 2012; 53: 289–305.
    • (2012) ILAR J , vol.53 , pp. 289-305
    • Ho, S.M.1    Johnson, A.2    Tarapore, P.3    Janakiram, V.4    Zhang, X.5    Leung, Y.K.6
  • 22
    • 84867524010 scopus 로고    scopus 로고
    • Genomic impact of cigarette smoke, with application to three smokingrelated diseases
    • Talikka M, Sierro N, Ivanov NV, Chaudhary N, Peck MJ, Hoeng J et al. Genomic impact of cigarette smoke, with application to three smokingrelated diseases. Crit Rev Toxicol 2012; 42: 877–889.
    • (2012) Crit Rev Toxicol , vol.42 , pp. 877-889
    • Talikka, M.1    Sierro, N.2    Ivanov, N.V.3    Chaudhary, N.4    Peck, M.J.5    Hoeng, J.6
  • 23
    • 0034644473 scopus 로고    scopus 로고
    • Signaling to chromatin through histone modifications
    • Cheung P, Allis CD, Sassone-Corsi P. Signaling to chromatin through histone modifications. Cell 2000; 103: 263–271.
    • (2000) Cell , vol.103 , pp. 263-271
    • Cheung, P.1    Allis, C.D.2    Sassone-Corsi, P.3
  • 24
    • 78650304236 scopus 로고    scopus 로고
    • Charting histone modifications and the functional organization of mammalian genomes
    • Zhou VW, Goren A, Bernstein BE. Charting histone modifications and the functional organization of mammalian genomes. Nat Rev Genet 2011; 12: 7–18.
    • (2011) Nat Rev Genet , vol.12 , pp. 7-18
    • Zhou, V.W.1    Goren, A.2    Bernstein, B.E.3
  • 25
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modifications and their function
    • Kouzarides T. Chromatin modifications and their function. Cell 2007; 128: 693–705.
    • (2007) Cell , vol.128 , pp. 693-705
    • Kouzarides, T.1
  • 26
    • 79952534189 scopus 로고    scopus 로고
    • Regulation of chromatin by histone modifications
    • Bannister AJ, Kouzarides T. Regulation of chromatin by histone modifications. Cell Res 2011; 21: 381–395.
    • (2011) Cell Res , vol.21 , pp. 381-395
    • Bannister, A.J.1    Kouzarides, T.2
  • 27
    • 35848951163 scopus 로고    scopus 로고
    • Covalent modifications of histones during development and disease pathogenesis
    • Bhaumik SR, Smith E, Shilatifard A. Covalent modifications of histones during development and disease pathogenesis. Nat Struct Mol Biol 2007; 14: 1008–1016.
    • (2007) Nat Struct Mol Biol , vol.14 , pp. 1008-1016
    • Bhaumik, S.R.1    Smith, E.2    Shilatifard, A.3
  • 28
    • 0037188911 scopus 로고    scopus 로고
    • Histone methylation: Dynamic or static?
    • Bannister AJ, Schneider R, Kouzarides T. Histone methylation: dynamic or static? Cell 2002; 109: 801–806.
    • (2002) Cell , vol.109 , pp. 801-806
    • Bannister, A.J.1    Schneider, R.2    Kouzarides, T.3
  • 29
    • 84859893371 scopus 로고    scopus 로고
    • Histone methylation: A dynamic mark in health, disease and inheritance
    • Greer EL, Shi Y. Histone methylation: a dynamic mark in health, disease and inheritance. Nat Rev Genet 2012; 13: 343–357.
    • (2012) Nat Rev Genet , vol.13 , pp. 343-357
    • Greer, E.L.1    Shi, Y.2
  • 30
    • 84892814234 scopus 로고    scopus 로고
    • Chromatin modifiers and remodellers: Regulators of cellular differentiation
    • Chen T, Dent SY. Chromatin modifiers and remodellers: regulators of cellular differentiation. Nat Rev Genet 2014; 15: 93–106.
    • (2014) Nat Rev Genet , vol.15 , pp. 93-106
    • Chen, T.1    Dent, S.Y.2
  • 31
    • 84881166117 scopus 로고    scopus 로고
    • Mechanisms and functions of ATP-dependent chromatin-remodeling enzymes
    • Narlikar GJ, Sundaramoorthy R, Owen-Hughes T. Mechanisms and functions of ATP-dependent chromatin-remodeling enzymes. Cell 2013; 154: 490–503.
    • (2013) Cell , vol.154 , pp. 490-503
    • Narlikar, G.J.1    Sundaramoorthy, R.2    Owen-Hughes, T.3
  • 33
    • 84866618858 scopus 로고    scopus 로고
    • Immune and inflammatory mechanisms in pulmonary arterial hypertension
    • El Chami H, Hassoun PM. Immune and inflammatory mechanisms in pulmonary arterial hypertension. Prog Cardiovasc Dis 2012; 55: 218–228.
    • (2012) Prog Cardiovasc Dis , vol.55 , pp. 218-228
    • El Chami, H.1    Hassoun, P.M.2
  • 35
    • 84903603318 scopus 로고    scopus 로고
    • Therapeutic implications of microRNAs in pulmonary arterial hypertension
    • Lee A, McLean D, Choi J, Kang H, Chang W, Kim J. Therapeutic implications of microRNAs in pulmonary arterial hypertension. BMB Rep 2014; 47: 311–317.
    • (2014) BMB Rep , vol.47 , pp. 311-317
    • Lee, A.1    McLean, D.2    Choi, J.3    Kang, H.4    Chang, W.5    Kim, J.6
  • 36
    • 84892930632 scopus 로고    scopus 로고
    • MicroRNA-124 controls the proliferative, migratory, and inflammatory phenotype of pulmonary vascular fibroblasts
    • Wang D, Zhang H, Li M, Frid MG, Flockton AR, McKeon BA et al. MicroRNA-124 controls the proliferative, migratory, and inflammatory phenotype of pulmonary vascular fibroblasts. Circ Res 2014; 114: 67–78.
    • (2014) Circ Res , vol.114 , pp. 67-78
    • Wang, D.1    Zhang, H.2    Li, M.3    Frid, M.G.4    Flockton, A.R.5    McKeon, B.A.6
  • 37
    • 3943073829 scopus 로고    scopus 로고
    • Vascular protection: Superoxide dismutase isoforms in the vessel wall
    • Faraci FM, Didion SP. Vascular protection: superoxide dismutase isoforms in the vessel wall. Arterioscler Thromb Vasc Biol 2004; 24: 1367–1373.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1367-1373
    • Faraci, F.M.1    Didion, S.P.2
  • 38
  • 39
    • 14244264689 scopus 로고    scopus 로고
    • Mef2c is activated directly by Ets transcription factors through an evolutionarily conserved endothelial cell-specific enhancer
    • De Val S, Anderson JP, Heidt AB, Khiem D, Xu SM, Black BL. Mef2c is activated directly by Ets transcription factors through an evolutionarily conserved endothelial cell-specific enhancer. Dev Biol 2004; 275: 424–434.
    • (2004) Dev Biol , vol.275 , pp. 424-434
    • de Val, S.1    Anderson, J.P.2    Heidt, A.B.3    Khiem, D.4    Xu, S.M.5    Black, B.L.6
  • 40
    • 0029888320 scopus 로고    scopus 로고
    • Early expression of the different isoforms of the myocyte enhancer factor-2 (MEF2) protein in myogenic as well as non-myogenic cell lineages during mouse embryogenesis
    • Subramanian SV, Nadal-Ginard B. Early expression of the different isoforms of the myocyte enhancer factor-2 (MEF2) protein in myogenic as well as non-myogenic cell lineages during mouse embryogenesis. Mech Dev 1996; 57: 103–112.
    • (1996) Mech Dev , vol.57 , pp. 103-112
    • Subramanian, S.V.1    Nadal-Ginard, B.2
  • 41
    • 84861635499 scopus 로고    scopus 로고
    • MEF2C ablation in endothelial cells reduces retinal vessel loss and suppresses pathologic retinal neovascularization in oxygen-induced retinopathy
    • Xu Z, Gong J, Maiti D, Vong L, Wu L, Schwarz JJ et al. MEF2C ablation in endothelial cells reduces retinal vessel loss and suppresses pathologic retinal neovascularization in oxygen-induced retinopathy. Am J Pathol 2012; 180: 2548–2560.
    • (2012) Am J Pathol , vol.180 , pp. 2548-2560
    • Xu, Z.1    Gong, J.2    Maiti, D.3    Vong, L.4    Wu, L.5    Schwarz, J.J.6
  • 42
    • 84880299608 scopus 로고    scopus 로고
    • Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development
    • Kang Y, Kim J, Anderson JP, Wu J, Gleim SR, Kundu RK et al. Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development. Circ Res 2013; 113: 22–31.
    • (2013) Circ Res , vol.113 , pp. 22-31
    • Kang, Y.1    Kim, J.2    Anderson, J.P.3    Wu, J.4    Gleim, S.R.5    Kundu, R.K.6
  • 43
    • 84872078405 scopus 로고    scopus 로고
    • An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension
    • Kim J, Kang Y, Kojima Y, Lighthouse JK, Hu X, Aldred MA et al. An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension. Nat Med 2013; 19: 74–82.
    • (2013) Nat Med , vol.19 , pp. 74-82
    • Kim, J.1    Kang, Y.2    Kojima, Y.3    Lighthouse, J.K.4    Hu, X.5    Aldred, M.A.6
  • 44
    • 71549131914 scopus 로고    scopus 로고
    • Epigenetic profiles distinguish malignant pleural mesothelioma from lung adenocarcinoma
    • Goto Y, Shinjo K, Kondo Y, Shen L, Toyota M, Suzuki H et al. Epigenetic profiles distinguish malignant pleural mesothelioma from lung adenocarcinoma. Cancer Res 2009; 69: 9073–9082.
    • (2009) Cancer Res , vol.69 , pp. 9073-9082
    • Goto, Y.1    Shinjo, K.2    Kondo, Y.3    Shen, L.4    Toyota, M.5    Suzuki, H.6
  • 45
    • 84871887199 scopus 로고    scopus 로고
    • Apelin/APJ signaling is a critical regulator of statin effects in vascular endothelial cells–brief report
    • McLean DL, Kim J, Kang Y, Shi H, Atkins GB, Jain MK et al. Apelin/APJ signaling is a critical regulator of statin effects in vascular endothelial cells–brief report. Arterioscler Thromb Vasc Biol 2012; 32: 2640–2643.
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 2640-2643
    • McLean, D.L.1    Kim, J.2    Kang, Y.3    Shi, H.4    Atkins, G.B.5    Jain, M.K.6
  • 47
    • 79958768845 scopus 로고    scopus 로고
    • Homomeric and heteromeric complexes among TGF-β and BMP receptors and their roles in signaling
    • Ehrlich M, Horbelt D, Marom B, Knaus P, Henis YI. Homomeric and heteromeric complexes among TGF-β and BMP receptors and their roles in signaling. Cell Signal 2011; 23: 1424–1432.
    • (2011) Cell Signal , vol.23 , pp. 1424-1432
    • Ehrlich, M.1    Horbelt, D.2    Marom, B.3    Knaus, P.4    Henis, Y.I.5
  • 49
    • 84865066131 scopus 로고    scopus 로고
    • Context-dependent proangiogenic function of bone morphogenetic protein signaling is mediated by disabled homolog 2
    • Kim JD, Kang H, Larrivée B, Lee MY, Mettlen M, Schmid SL et al. Context-dependent proangiogenic function of bone morphogenetic protein signaling is mediated by disabled homolog 2. Dev Cell 2012; 23: 441–448.
    • (2012) Dev Cell , vol.23 , pp. 441-448
    • Kim, J.D.1    Kang, H.2    Larrivée, B.3    Lee, M.Y.4    Mettlen, M.5    Schmid, S.L.6
  • 50
    • 79957910125 scopus 로고    scopus 로고
    • Distinct signalling pathways regulate sprouting angiogenesis from the dorsal aorta and the axial vein
    • Wiley DM, Kim JD, Hao J, Hong CC, Bautch VL, Jin SW. Distinct signalling pathways regulate sprouting angiogenesis from the dorsal aorta and the axial vein. Nat Cell Biol 2011; 13: 686–692.
    • (2011) Nat Cell Biol , vol.13 , pp. 686-692
    • Wiley, D.M.1    Kim, J.D.2    Hao, J.3    Hong, C.C.4    Bautch, V.L.5    Jin, S.W.6
  • 51
    • 84906938281 scopus 로고    scopus 로고
    • Diversity is in my veins: Role of bone morphogenetic protein signaling during venous morphogenesis in zebrafish illustrates the heterogeneity within endothelial cells
    • Kim JD, Lee HW, Jin SW. Diversity is in my veins: role of bone morphogenetic protein signaling during venous morphogenesis in zebrafish illustrates the heterogeneity within endothelial cells. Arterioscler Thromb Vasc Biol 2014; 34: 1838–1845.
    • (2014) Arterioscler Thromb Vasc Biol , vol.34 , pp. 1838-1845
    • Kim, J.D.1    Lee, H.W.2    Jin, S.W.3
  • 52
    • 67449146883 scopus 로고    scopus 로고
    • Emerging role of bone morphogenetic proteins in angiogenesis
    • David L, Feige JJ, Bailly S. Emerging role of bone morphogenetic proteins in angiogenesis. Cytokine Growth Factor Rev 2009; 20: 203–212.
    • (2009) Cytokine Growth Factor Rev , vol.20 , pp. 203-212
    • David, L.1    Feige, J.J.2    Bailly, S.3
  • 54
    • 0031019091 scopus 로고    scopus 로고
    • Localization of the gene for familial primary pulmonary hypertension to chromosome 2q31-32
    • Nichols WC, Koller DL, Slovis B, Foroud T, Terry VH, Arnold ND et al. Localization of the gene for familial primary pulmonary hypertension to chromosome 2q31-32. Nat Genet 1997; 15: 277–280.
    • (1997) Nat Genet , vol.15 , pp. 277-280
    • Nichols, W.C.1    Koller, D.L.2    Slovis, B.3    Foroud, T.4    Terry, V.H.5    Arnold, N.D.6
  • 55
    • 0035683060 scopus 로고    scopus 로고
    • Genetic aspects of pulmonary arterial hypertension
    • Morse JH, Deng Z, Knowles JA. Genetic aspects of pulmonary arterial hypertension. Ann Med 2001; 33: 596–603.
    • (2001) Ann Med , vol.33 , pp. 596-603
    • Morse, J.H.1    Deng, Z.2    Knowles, J.A.3
  • 56
    • 84861581610 scopus 로고    scopus 로고
    • Missense mutations of the BMPR1B (ALK6) gene in childhood idiopathic pulmonary arterial hypertension
    • Chida A, Shintani M, Nakayama T, Furutani Y, Hayama E, Inai K et al. Missense mutations of the BMPR1B (ALK6) gene in childhood idiopathic pulmonary arterial hypertension. Circ J 2012; 76: 1501–1508.
    • (2012) Circ J , vol.76 , pp. 1501-1508
    • Chida, A.1    Shintani, M.2    Nakayama, T.3    Furutani, Y.4    Hayama, E.5    Inai, K.6
  • 58
    • 77953920377 scopus 로고    scopus 로고
    • Characterization of the human activin-A receptor type II-like kinase 1 (ACVRL1) promoter and its regulation by Sp1
    • Garrido-Martin EM, Blanco FJ, Fernandez L A, Langa C, Vary CP, Lee UE et al. Characterization of the human activin-A receptor type II-like kinase 1 (ACVRL1) promoter and its regulation by Sp1. BMC Mol Biol 2010; 11: 51.
    • (2010) BMC Mol Biol , vol.11 , pp. 51
    • Garrido-Martin, E.M.1    Blanco, F.J.2    Fernandez, L.A.3    Langa, C.4    Vary, C.P.5    Lee, U.E.6
  • 59
    • 84905700344 scopus 로고    scopus 로고
    • miR-656 inhibits glioma tumorigenesis through repression of BMPR1A
    • Guo M, Jiang Z, Zhang X, Lu D, Ha AD, Sun J et al. miR-656 inhibits glioma tumorigenesis through repression of BMPR1A. Carcinogenesis 2014; 35: 1698–1706.
    • (2014) Carcinogenesis , vol.35 , pp. 1698-1706
    • Guo, M.1    Jiang, Z.2    Zhang, X.3    Lu, D.4    Ha, A.D.5    Sun, J.6
  • 60
    • 37349067098 scopus 로고    scopus 로고
    • Epigeneticmediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells
    • Lee J, Son MJ, Woolard K, Donin NM, Li A, Cheng CH et al. Epigeneticmediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells. Cancer Cell 2008; 13: 69–80.
    • (2008) Cancer Cell , vol.13 , pp. 69-80
    • Lee, J.1    Son, M.J.2    Woolard, K.3    Donin, N.M.4    Li, A.5    Cheng, C.H.6
  • 61
    • 84890049738 scopus 로고    scopus 로고
    • Genetics and the molecular pathogenesis of pulmonary arterial hypertension
    • Liu D, Morrell NW. Genetics and the molecular pathogenesis of pulmonary arterial hypertension. Curr Hypertens Rep 2013; 15: 632–637.
    • (2013) Curr Hypertens Rep , vol.15 , pp. 632-637
    • Liu, D.1    Morrell, N.W.2
  • 62
    • 80051771345 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension: Insights from genetic studies
    • Loyd JE. Pulmonary arterial hypertension: insights from genetic studies. Proc Am Thorac Soc 2011; 8: 154–157.
    • (2011) Proc am Thorac Soc , vol.8 , pp. 154-157
    • Loyd, J.E.1
  • 63
    • 84902980316 scopus 로고    scopus 로고
    • The genetics of pulmonary arterial hypertension
    • Austin ED, Loyd JE. The genetics of pulmonary arterial hypertension. Circ Res 2014; 115: 189–202.
    • (2014) Circ Res , vol.115 , pp. 189-202
    • Austin, E.D.1    Loyd, J.E.2
  • 64
    • 66949118228 scopus 로고    scopus 로고
    • Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway
    • Brock M, Trenkmann M, Gay RE, Michel BA, Gay S, Fischler M et al. Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway. Circ Res 2009; 104: 1184–1191.
    • (2009) Circ Res , vol.104 , pp. 1184-1191
    • Brock, M.1    Trenkmann, M.2    Gay, R.E.3    Michel, B.A.4    Gay, S.5    Fischler, M.6
  • 65
    • 84922347131 scopus 로고    scopus 로고
    • AntagomiR directed against miR-20a restores functional BMPR2 signalling and prevents vascular remodelling in hypoxia-induced pulmonary hypertension
    • Brock M, Samillan VJ, Trenkmann M, Schwarzwald C, Ulrich S, Gay RE et al. AntagomiR directed against miR-20a restores functional BMPR2 signalling and prevents vascular remodelling in hypoxia-induced pulmonary hypertension. Eur Heart J 2014; 35: 3203–3211.
    • (2014) Eur Heart J , vol.35 , pp. 3203-3211
    • Brock, M.1    Samillan, V.J.2    Trenkmann, M.3    Schwarzwald, C.4    Ulrich, S.5    Gay, R.E.6
  • 66
    • 84888341033 scopus 로고    scopus 로고
    • Epigenetic repression of bone morphogenetic protein receptor II expression in scleroderma
    • Wang Y, Kahaleh B. Epigenetic repression of bone morphogenetic protein receptor II expression in scleroderma. J Cell Mol Med 2013; 17: 1291–1299.
    • (2013) J Cell Mol Med , vol.17 , pp. 1291-1299
    • Wang, Y.1    Kahaleh, B.2
  • 67
    • 41049094560 scopus 로고    scopus 로고
    • Endoglin in angiogenesis and vascular diseases
    • ten Dijke P, Goumans MJ, Pardali E. Endoglin in angiogenesis and vascular diseases. Angiogenesis 2008; 11: 79–89.
    • (2008) Angiogenesis , vol.11 , pp. 79-89
    • Ten Dijke, P.1    Goumans, M.J.2    Pardali, E.3
  • 68
    • 84885189346 scopus 로고    scopus 로고
    • Endoglin promoter hypermethylation identifies a field defect in human primary esophageal cancer
    • Jin Z, Zhao Z, Cheng Y, Dong M, Zhang X, Wang L et al. Endoglin promoter hypermethylation identifies a field defect in human primary esophageal cancer. Cancer 2013; 119: 3604–3609.
    • (2013) Cancer , vol.119 , pp. 3604-3609
    • Jin, Z.1    Zhao, Z.2    Cheng, Y.3    Dong, M.4    Zhang, X.5    Wang, L.6
  • 69
    • 84894252009 scopus 로고    scopus 로고
    • MicroRNA-208a increases myocardial fibrosis via endoglin in volume overloading heart
    • Wang BW, Wu GJ, Cheng WP, Shyu KG. MicroRNA-208a increases myocardial fibrosis via endoglin in volume overloading heart. PLoS ONE 2014; 9: e84188.
    • (2014) Plos ONE , vol.9
    • Wang, B.W.1    Wu, G.J.2    Cheng, W.P.3    Shyu, K.G.4
  • 70
    • 84907555365 scopus 로고    scopus 로고
    • MicroRNA-370 suppresses proliferation and promotes endometrioid ovarian cancer chemosensitivity to cDDP by negatively regulating ENG
    • Chen XP, Chen YG, Lan JY, Shen ZJ. MicroRNA-370 suppresses proliferation and promotes endometrioid ovarian cancer chemosensitivity to cDDP by negatively regulating ENG. Cancer Lett 2014; 353: 201–210.
    • (2014) Cancer Lett , vol.353 , pp. 201-210
    • Chen, X.P.1    Chen, Y.G.2    Lan, J.Y.3    Shen, Z.J.4
  • 71
    • 81255136932 scopus 로고    scopus 로고
    • Molecular genetic characterization of SMAD signaling molecules in pulmonary arterial hypertension
    • Nasim MT, Ogo T, Ahmed M, Randall R, Chowdhury HM, Snape KM et al. Molecular genetic characterization of SMAD signaling molecules in pulmonary arterial hypertension. Hum Mutat 2011; 32: 1385–1389.
    • (2011) Hum Mutat , vol.32 , pp. 1385-1389
    • Nasim, M.T.1    Ogo, T.2    Ahmed, M.3    Randall, R.4    Chowdhury, H.M.5    Snape, K.M.6
  • 72
    • 66249125359 scopus 로고    scopus 로고
    • A new nonsense mutation of SMAD8 associated with pulmonary arterial hypertension
    • Shintani M, Yagi H, Nakayama T, Saji T, Matsuoka R. A new nonsense mutation of SMAD8 associated with pulmonary arterial hypertension. J Med Genet 2009; 46: 331–337.
    • (2009) J Med Genet , vol.46 , pp. 331-337
    • Shintani, M.1    Yagi, H.2    Nakayama, T.3    Saji, T.4    Matsuoka, R.5
  • 73
    • 84904864177 scopus 로고    scopus 로고
    • Nanotopography directs mesenchymal stem cells to osteoblast lineage through regulation of microRNA-SMAD-BMP-2 circuit
    • Kato RB, Roy B, De Oliveira FS, Ferraz EP, De Oliveira PT, Kemper AG et al. Nanotopography directs mesenchymal stem cells to osteoblast lineage through regulation of microRNA-SMAD-BMP-2 circuit. J Cell Physiol 2014; 229: 1690–1696.
    • (2014) J Cell Physiol , vol.229 , pp. 1690-1696
    • Kato, R.B.1    Roy, B.2    de Oliveira, F.S.3    Ferraz, E.P.4    de Oliveira, P.T.5    Kemper, A.G.6
  • 74
    • 77956116784 scopus 로고    scopus 로고
    • Altered microRNAs in bicuspid aortic valve: A comparison between stenotic and insufficient valves
    • Nigam V, Sievers HH, Jensen BC, Sier HA, Simpson PC, Srivastava D et al. Altered microRNAs in bicuspid aortic valve: a comparison between stenotic and insufficient valves. J Heart Valve Dis 2010; 19: 459–465.
    • (2010) J Heart Valve Dis , vol.19 , pp. 459-465
    • Nigam, V.1    Sievers, H.H.2    Jensen, B.C.3    Sier, H.A.4    Simpson, P.C.5    Srivastava, D.6
  • 75
    • 84884821341 scopus 로고    scopus 로고
    • MiR-205 is downregulated in hereditary hemorrhagic telangiectasia and impairs TGF-beta signaling pathways in endothelial cells
    • Tabruyn SP, Hansen S, Ojeda-Fernández ML, Bovy N, Zarrabeitia R, Recio-Poveda L et al. MiR-205 is downregulated in hereditary hemorrhagic telangiectasia and impairs TGF-beta signaling pathways in endothelial cells. Angiogenesis 2013; 16: 877–887.
    • (2013) Angiogenesis , vol.16 , pp. 877-887
    • Tabruyn, S.P.1    Hansen, S.2    Ojeda-Fernández, M.L.3    Bovy, N.4    Zarrabeitia, R.5    Recio-Poveda, L.6
  • 76
    • 84902154205 scopus 로고    scopus 로고
    • The antifibrotic effects and mechanisms of microRNA-26a action in idiopathic pulmonary fibrosis
    • Liang H, Xu C, Pan Z, Zhang Y, Xu Z, Chen Y et al. The antifibrotic effects and mechanisms of microRNA-26a action in idiopathic pulmonary fibrosis. Mol Ther 2014; 22: 1122–1133.
    • (2014) Mol Ther , vol.22 , pp. 1122-1133
    • Liang, H.1    Xu, C.2    Pan, Z.3    Zhang, Y.4    Xu, Z.5    Chen, Y.6
  • 77
    • 77649242925 scopus 로고    scopus 로고
    • Targeting of SMAD5 links microRNA-155 to the TGF-beta pathway and lymphomagenesis
    • Rai D, Kim SW, McKeller MR, Dahia PL, Aguiar RC. Targeting of SMAD5 links microRNA-155 to the TGF-beta pathway and lymphomagenesis. Proc Natl Acad Sci USA 2010; 107: 3111–3116.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 3111-3116
    • Rai, D.1    Kim, S.W.2    McKeller, M.R.3    Dahia, P.L.4    Aguiar, R.C.5
  • 78
    • 84863128531 scopus 로고    scopus 로고
    • Kaposi’s sarcoma-associated herpesvirus-encoded microRNA miR-K12-11 attenuates transforming growth factor beta signaling through suppression of SMAD5
    • Liu Y, Sun R, Lin X, Liang D, Deng Q, Lan K. Kaposi’s sarcoma-associated herpesvirus-encoded microRNA miR-K12-11 attenuates transforming growth factor beta signaling through suppression of SMAD5. J Virol 2012; 86: 1372–1381.
    • (2012) J Virol , vol.86 , pp. 1372-1381
    • Liu, Y.1    Sun, R.2    Lin, X.3    Liang, D.4    Deng, Q.5    Lan, K.6
  • 79
    • 77955454919 scopus 로고    scopus 로고
    • X-linked inhibitor of apoptosis protein controls alpha5-integrin-mediated cell adhesion and migration
    • Kim J, Ahn S, Ko YG, Boo YC, Chi SG, Ni CW et al. X-linked inhibitor of apoptosis protein controls alpha5-integrin-mediated cell adhesion and migration. Am J Physiol Heart Circ Physiol 2010; 299: H300–H309.
    • (2010) Am J Physiol Heart Circ Physiol , vol.299 , pp. H300-H309
    • Kim, J.1    Ahn, S.2    Ko, Y.G.3    Boo, Y.C.4    Chi, S.G.5    Ni, C.W.6
  • 80
    • 84859799127 scopus 로고    scopus 로고
    • Regulation of eNOS in caveolae
    • Mineo C, Shaul PW. Regulation of eNOS in caveolae. Adv Exp Med Biol 2012; 729: 51–62.
    • (2012) Adv Exp Med Biol , vol.729 , pp. 51-62
    • Mineo, C.1    Shaul, P.W.2
  • 81
  • 82
    • 84899684802 scopus 로고    scopus 로고
    • Expression of Caveolin 1 is enhanced by DNA demethylation during adipocyte differentiation. status of insulin signaling
    • Palacios-Ortega S, Varela-Guruceaga M, Milagro FI, Martínez JA, de Miguel C. Expression of Caveolin 1 is enhanced by DNA demethylation during adipocyte differentiation. status of insulin signaling. PLoS ONE 2014; 9: e95100.
    • (2014) Plos ONE , vol.9
    • Palacios-Ortega, S.1    Varela-Guruceaga, M.2    Milagro, F.I.3    Martínez, J.A.4    de Miguel, C.5
  • 83
    • 78650825062 scopus 로고    scopus 로고
    • Caveolin-1 mediates tumor cell migration and invasion and its regulation by miR-133a in head and neck squamous cell carcinoma
    • Nohata N, Hanazawa T, Kikkawa N, Mutallip M, Fujimura L, Yoshino H et al. Caveolin-1 mediates tumor cell migration and invasion and its regulation by miR-133a in head and neck squamous cell carcinoma. Int J Oncol 2011; 38: 209–217.
    • (2011) Int J Oncol , vol.38 , pp. 209-217
    • Nohata, N.1    Hanazawa, T.2    Kikkawa, N.3    Mutallip, M.4    Fujimura, L.5    Yoshino, H.6
  • 84
    • 79957687792 scopus 로고    scopus 로고
    • MicroRNA 802 stimulates ROMK channels by suppressing caveolin-1
    • Lin DH, Yue P, Pan C, Sun P, Wang WH. MicroRNA 802 stimulates ROMK channels by suppressing caveolin-1. J Am Soc Nephrol 2011; 22: 1087–1098.
    • (2011) J am Soc Nephrol , vol.22 , pp. 1087-1098
    • Lin, D.H.1    Yue, P.2    Pan, C.3    Sun, P.4    Wang, W.H.5
  • 85
    • 84936743443 scopus 로고    scopus 로고
    • miR-103/107 modulates multidrug resistance in human gastric carcinoma by downregulating Cav-1
    • Zhang Y, Qu X, Li C, Fan Y, Che X, Wang X et al. miR-103/107 modulates multidrug resistance in human gastric carcinoma by downregulating Cav-1. Tumour Biol 2014; 36: 2277–2285.
    • (2014) . Tumour Biol , vol.36 , pp. 2277-2285
    • Zhang, Y.1    Qu, X.2    Li, C.3    Fan, Y.4    Che, X.5    Wang, X.6
  • 86
    • 84874779817 scopus 로고    scopus 로고
    • miR-199a-5p Is upregulated during fibrogenic response to tissue injury and mediates TGFbeta-induced lung fibroblast activation by targeting caveolin-1
    • Lino Cardenas CL, Henaoui IS, Courcot E, Roderburg C, Cauffiez C, Aubert S et al. miR-199a-5p Is upregulated during fibrogenic response to tissue injury and mediates TGFbeta-induced lung fibroblast activation by targeting caveolin-1. PLoS Genet 2013; 9: e1003291.
    • (2013) Plos Genet , vol.9
    • Lino Cardenas, C.L.1    Henaoui, I.S.2    Courcot, E.3    Roderburg, C.4    Cauffiez, C.5    Aubert, S.6
  • 87
    • 84860330710 scopus 로고    scopus 로고
    • MicroRNA-203 regulates caveolin-1 in breast tissue during caloric restriction
    • Ørom UA, Lim MK, Savage JE, Jin L, Saleh AD, Lisanti MP et al. MicroRNA-203 regulates caveolin-1 in breast tissue during caloric restriction. Cell Cycle 2012; 11: 1291–1295.
    • (2012) Cell Cycle , vol.11 , pp. 1291-1295
    • Ørom, U.A.1    Lim, M.K.2    Savage, J.E.3    Jin, L.4    Saleh, A.D.5    Lisanti, M.P.6
  • 88
    • 84925558991 scopus 로고    scopus 로고
    • A novel channelopathy in pulmonary arterial hypertension
    • Chung WK, Sampson KS, Kass RS. A novel channelopathy in pulmonary arterial hypertension. N Engl J Med 2013; 369: 2162.
    • (2013) N Engl J Med , vol.369 , pp. 2162
    • Chung, W.K.1    Sampson, K.S.2    Kass, R.S.3
  • 90
    • 84925843644 scopus 로고    scopus 로고
    • Treatment of pulmonary arterial hypertension in children
    • Latus H, Delhaas T, Schranz D, Apitz C. Treatment of pulmonary arterial hypertension in children. Nat Rev Cardiol 2015; 12: 244–254.
    • (2015) Nat Rev Cardiol , vol.12 , pp. 244-254
    • Latus, H.1    Delhaas, T.2    Schranz, D.3    Apitz, C.4
  • 92
    • 84937760097 scopus 로고    scopus 로고
    • The role of endothelin-1 in pulmonary arterial hypertension
    • Chester AH, Yacoub MH. The role of endothelin-1 in pulmonary arterial hypertension. Glob Cardiol Sci Pract 2014; 2014: 62–78.
    • (2014) Glob Cardiol Sci Pract , vol.2014 , pp. 62-78
    • Chester, A.H.1    Yacoub, M.H.2
  • 93
    • 84911459288 scopus 로고    scopus 로고
    • Current state of endothelin receptor antagonism in hypertension and pulmonary hypertension
    • Miyagawa K, Emoto N. Current state of endothelin receptor antagonism in hypertension and pulmonary hypertension. Ther Adv Cardiovasc Dis 2014; 8: 202–216.
    • (2014) Ther Adv Cardiovasc Dis , vol.8 , pp. 202-216
    • Miyagawa, K.1    Emoto, N.2
  • 95
    • 84922632326 scopus 로고    scopus 로고
    • PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer
    • Das A, Durrant D, Salloum FN, Xi L, Kukreja RC. PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer. Pharmacol Ther 2015; 147C: 12–21.
    • (2015) Pharmacol Ther , vol.147C , pp. 12-21
    • Das, A.1    Durrant, D.2    Salloum, F.N.3    Xi, L.4    Kukreja, R.C.5
  • 96
    • 84858232841 scopus 로고    scopus 로고
    • Current and future treatment of pulmonary hypertension
    • Pabani S, Mousa SA.. Current and future treatment of pulmonary hypertension. Drugs Today (Barc) 2012; 48: 133–147.
    • (2012) Drugs Today (Barc) , vol.48 , pp. 133-147
    • Pabani, S.1    Mousa, S.A.2
  • 97
    • 84893687227 scopus 로고    scopus 로고
    • Effectiveness and safety of phosphodiesterase 5 inhibitors in patients with cardiovascular disease and hypertension
    • Chrysant SG. Effectiveness and safety of phosphodiesterase 5 inhibitors in patients with cardiovascular disease and hypertension. Curr Hypertens Rep 2013; 15: 475–483.
    • (2013) Curr Hypertens Rep , vol.15 , pp. 475-483
    • Chrysant, S.G.1
  • 99
    • 84888817021 scopus 로고    scopus 로고
    • Emerging molecular targets for anti-proliferative strategies in pulmonary arterial hypertension
    • Tu L, Guignabert C. Emerging molecular targets for anti-proliferative strategies in pulmonary arterial hypertension. Handb Exp Pharmacol 2013; 218: 409–436.
    • (2013) Handb Exp Pharmacol , vol.218 , pp. 409-436
    • Tu, L.1    Guignabert, C.2
  • 100
    • 84863231352 scopus 로고    scopus 로고
    • Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism
    • Cavasin MA, Demos-Davies K, Horn TR, Walker LA, Lemon DD, Birdsey N et al. Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism. Circ Res 2012; 110: 739–748.
    • (2012) Circ Res , vol.110 , pp. 739-748
    • Cavasin, M.A.1    Demos-Davies, K.2    Horn, T.R.3    Walker, L.A.4    Lemon, D.D.5    Birdsey, N.6
  • 101
    • 79956200230 scopus 로고    scopus 로고
    • Suppression of histone deacetylases worsens right ventricular dysfunction after pulmonary artery banding in rats
    • Bogaard HJ, Mizuno S, Hussaini AA, Toldo S, Abbate A, Kraskauskas D et al. Suppression of histone deacetylases worsens right ventricular dysfunction after pulmonary artery banding in rats. Am J Respir Crit Care Med 2011; 183: 1402–1410.
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 1402-1410
    • Bogaard, H.J.1    Mizuno, S.2    Hussaini, A.A.3    Toldo, S.4    Abbate, A.5    Kraskauskas, D.6
  • 104
    • 84923934273 scopus 로고    scopus 로고
    • The hypoxia-induced microRNA-130a controls pulmonary smooth muscle cell proliferation by directly targeting CDKN1A
    • Brock M, Haider TJ, Vogel J, Gassmann M, Speich R, Trenkmann M et al. The hypoxia-induced microRNA-130a controls pulmonary smooth muscle cell proliferation by directly targeting CDKN1A. Int J Biochem Cell Biol 2015; 61: 129–137.
    • (2015) Int J Biochem Cell Biol , vol.61 , pp. 129-137
    • Brock, M.1    Haider, T.J.2    Vogel, J.3    Gassmann, M.4    Speich, R.5    Trenkmann, M.6
  • 105
    • 84924755766 scopus 로고    scopus 로고
    • Loss of microRNA-17 ∼ 92 in smooth muscle cells attenuates experimental pulmonary hypertension via induction of PDZ and LIM domain 5
    • Chen T, Zhou G, Zhou Q, Tang H, Ibe JC, Cheng H et al. Loss of microRNA-17 ∼ 92 in smooth muscle cells attenuates experimental pulmonary hypertension via induction of PDZ and LIM domain 5. Am J Respir Crit Care Med 2015; 191: 678–692.
    • (2015) Am J Respir Crit Care Med , vol.191 , pp. 678-692
    • Chen, T.1    Zhou, G.2    Zhou, Q.3    Tang, H.4    Ibe, J.C.5    Cheng, H.6
  • 107
    • 84961292069 scopus 로고    scopus 로고
    • The microRNA-130/301 family controls vasoconstriction in pulmonary hypertension
    • Bertero T, Cottrill K, Krauszman A, Lu Y, Annis S, Hale A et al. The microRNA-130/301 family controls vasoconstriction in pulmonary hypertension. J Biol Chem 2015; 290: 2069–2085.
    • (2015) J Biol Chem , vol.290 , pp. 2069-2085
    • Bertero, T.1    Cottrill, K.2    Krauszman, A.3    Lu, Y.4    Annis, S.5    Hale, A.6
  • 108
    • 84905454459 scopus 로고    scopus 로고
    • Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension
    • Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R et al. Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension. J Clin Invest 2014; 124: 3514–3528.
    • (2014) J Clin Invest , vol.124 , pp. 3514-3528
    • Bertero, T.1    Lu, Y.2    Annis, S.3    Hale, A.4    Bhat, B.5    Saggar, R.6
  • 109
    • 84921054050 scopus 로고    scopus 로고
    • MKP-1 is a target of miR-210 and mediate the negative regulation of miR-210 inhibitor on hypoxic hPASMC proliferation
    • Jin Y, Pang T, Nelin LD, Wang W, Wang Y, Yan J et al. MKP-1 is a target of miR-210 and mediate the negative regulation of miR-210 inhibitor on hypoxic hPASMC proliferation. Cell Biol Int 2015; 39: 113–120.
    • (2015) Cell Biol Int , vol.39 , pp. 113-120
    • Jin, Y.1    Pang, T.2    Nelin, L.D.3    Wang, W.4    Wang, Y.5    Yan, J.6
  • 110
  • 111
    • 84992747893 scopus 로고    scopus 로고
    • Transient but not genetic loss of miR-451 is protective in the development of pulmonary arterial hypertension
    • Grant JS, Morecroft I, Dempsie Y, van Rooij E, MacLean MR, Baker AH. Transient but not genetic loss of miR-451 is protective in the development of pulmonary arterial hypertension. Pulm Circ 2013; 3: 840–850.
    • (2013) Pulm Circ , vol.3 , pp. 840-850
    • Grant, J.S.1    Morecroft, I.2    Dempsie, Y.3    van Rooij, E.4    Maclean, M.R.5    Baker, A.H.6
  • 112
    • 84907376787 scopus 로고    scopus 로고
    • Apolipoprotein A-I mimetic peptide 4F rescues pulmonary hypertension by inducing microRNA-193-3p
    • Sharma S, Umar S, Potus F, Iorga A, Wong G, Meriwether D et al. Apolipoprotein A-I mimetic peptide 4F rescues pulmonary hypertension by inducing microRNA-193-3p. Circulation 2014; 130: 776–785.
    • (2014) Circulation , vol.130 , pp. 776-785
    • Sharma, S.1    Umar, S.2    Potus, F.3    Iorga, A.4    Wong, G.5    Meriwether, D.6
  • 113
    • 84902314338 scopus 로고    scopus 로고
    • HIF-1 alpha-induced up-regulation of miR-9 contributes to phenotypic modulation in pulmonary artery smooth muscle cells during hypoxia
    • Shan F, Li J, Huang QY. HIF-1 alpha-induced up-regulation of miR-9 contributes to phenotypic modulation in pulmonary artery smooth muscle cells during hypoxia. J Cell Physiol 2014; 229: 1511–1520.
    • (2014) J Cell Physiol , vol.229 , pp. 1511-1520
    • Shan, F.1    Li, J.2    Huang, Q.Y.3
  • 115
    • 84893826747 scopus 로고    scopus 로고
    • Hypoxia mediates mutual repression between microRNA-27a and PPARγ in the pulmonary vasculature
    • Kang BY, Park KK, Green DE, Bijli KM, Searles CD, Sutliff RL et al. Hypoxia mediates mutual repression between microRNA-27a and PPARγ in the pulmonary vasculature. PLoS ONE 2013; 8: e79503.
    • (2013) Plos ONE , vol.8
    • Kang, B.Y.1    Park, K.K.2    Green, D.E.3    Bijli, K.M.4    Searles, C.D.5    Sutliff, R.L.6
  • 116
    • 84883426400 scopus 로고    scopus 로고
    • MicroRNA-124 suppresses the transactivation of nuclear factor of activated T cells by targeting multiple genes and inhibits the proliferation of pulmonary artery smooth muscle cells
    • Kang K, Peng X, Zhang X, Wang Y, Zhang L, Gao L et al. MicroRNA-124 suppresses the transactivation of nuclear factor of activated T cells by targeting multiple genes and inhibits the proliferation of pulmonary artery smooth muscle cells. J Biol Chem 2013; 288: 25414–25427.
    • (2013) J Biol Chem , vol.288 , pp. 25414-25427
    • Kang, K.1    Peng, X.2    Zhang, X.3    Wang, Y.4    Zhang, L.5    Gao, L.6
  • 117
    • 84877783446 scopus 로고    scopus 로고
    • MicroRNA-138 plays a role in hypoxic pulmonary vascular remodelling by targeting Mst1
    • Li S, Ran Y, Zhang D, Chen J, Zhu D. MicroRNA-138 plays a role in hypoxic pulmonary vascular remodelling by targeting Mst1. Biochem J 2013; 452: 281–291.
    • (2013) Biochem J , vol.452 , pp. 281-291
    • Li, S.1    Ran, Y.2    Zhang, D.3    Chen, J.4    Zhu, D.5
  • 119
    • 84864229176 scopus 로고    scopus 로고
    • A role for miR-145 in pulmonary arterial hypertension: Evidence from mouse models and patient samples
    • Caruso P, Dempsie Y, Stevens HC, McDonald RA, Long L, Lu R et al. A role for miR-145 in pulmonary arterial hypertension: evidence from mouse models and patient samples. Circ Res 2012; 111: 290–300.
    • (2012) Circ Res , vol.111 , pp. 290-300
    • Caruso, P.1    Dempsie, Y.2    Stevens, H.C.3    McDonald, R.A.4    Long, L.5    Lu, R.6
  • 120
    • 84863419659 scopus 로고    scopus 로고
    • The microRNA-328 regulates hypoxic pulmonary hypertension by targeting at insulin growth factor 1 receptor and L-type calcium channel-α1C
    • Guo L, Qiu Z, Wei L, Yu X, Gao X, Jiang S et al. The microRNA-328 regulates hypoxic pulmonary hypertension by targeting at insulin growth factor 1 receptor and L-type calcium channel-α1C. Hypertension 2012; 59: 1006–1013.
    • (2012) Hypertension , vol.59 , pp. 1006-1013
    • Guo, L.1    Qiu, Z.2    Wei, L.3    Yu, X.4    Gao, X.5    Jiang, S.6


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