MKP-1 is a target of miR-210 and mediate the negative regulation of miR-210 inhibitor on hypoxic hPASMC proliferation

Cell Biology International

Volumn 39, Issue 1, 2015, Pages 113-120

  Jin, Youpeng ^a   Pang, Tingting ^a   Nelin, Leif D ^b   Wang, Wei ^a   Wang, Yulin ^a   Yan, Jinchun ^c   Zhao, Chun ^a  

^a SHANDONG UNIVERSITY   (China)

^b OHIO STATE UNIVERSITY   (United States)

^c UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

Author keywords

Hypoxia; MiR 210; MKP 1; Pulmonary hypertension

Indexed keywords

MESSENGER RNA; MICRORNA 210; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; OXYGEN; SMALL INTERFERING RNA; DUSP1 PROTEIN, HUMAN; MICRORNA; MIRN210 MICRORNA, HUMAN;

ARTICLE; CELL HYPOXIA; CELL PROLIFERATION; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION; GENE FUNCTION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MITOSIS INHIBITION; NEGATIVE FEEDBACK; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; PROTEIN RNA BINDING; PROTEIN TARGETING; PULMONARY ARTERY; PULMONARY HYPERTENSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; ANTAGONISTS AND INHIBITORS; CELL LINE; CYTOLOGY; GENETICS; METABOLISM; RNA INTERFERENCE; UPREGULATION;

MUS;

CELL HYPOXIA; CELL LINE; CELL PROLIFERATION; DUAL SPECIFICITY PHOSPHATASE 1; HUMANS; MICRORNAS; MYOCYTES, SMOOTH MUSCLE; PULMONARY ARTERY; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; UP-REGULATION;

EID: 84921054050     PISSN: 10656995     EISSN: 10958355     Source Type: Journal    
DOI: 10.1002/cbin.10339     Document Type: Article

References (35)

1. Bennett AM, Tonks NK (1997) Regulation of distinct stages of skeletal muscle differentiation by mitogen-activated protein kinases. Science 278: 1288-129.
2. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dyebinding. Anal Biochem 72: 248-54.
3. Camps C, Buffa FM, Colella S, Moore J, Sotiriou C, Sheldon H, Harris AL, Gleadle JM, Ragoussis J (2008) Hsa-miR-210 is induced by hypoxia and is an independent prognostic factor in breast cancer. Clin Cancer Res 14: 1340-8.
4. Chan SY, Zhang YY, Hemann C, Mahoney CE, Zweier JL, Loscalzo J (2009) MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. Cell Metab 10: 273-84.
5. Chan YC, Banerjee J, Choi SY, Sen CK (2012) MiR-210: the master hypoxamir. Microcirculation 19: 215-23.
6. Chen B, Calvert AE, Cui H, Nelin LD (2009) Hypoxia promotes human pulmonary artery smooth muscle cell proliferation though induction of arginase. Am J Physiol Lung Cell MolPhysiol 297: L1151-9.
7. Cordes KR, Srivastava D (2009) MicroRNA regulation of cardiovascular development. Circ Res 104: 724-32.
8. Crosby ME, Kulsheshtha R, Ivan M, GlazerPM(2009) MicroRNA regulation of DNA repair gene expression in hypoxic stress. Cancer Res 69: 1221-9.
9. Garzon R, Calin GA, Croce CM (2009) MicroRNAs in Cancer. Annu Rev Med 60: 167-79.
10. Gou D, Ramchandran R, Peng X, Yao L, Kang K, Sarkar J, Wang Z, Zhou G, Raj JU (2012) MiR-210 has an antiapoptotic effect in pulmonary artery smooth muscle cells during hypoxia. Am J Physiol Lung Cell Mol Physiol 303: L682-91.
11. Huang X, Ding L, Bennewith KL, Tong RT, Welford SM, Ang KK, Story M, Le QT Giaccia (2009) Hypoxia-inducible miR-210 regulates normoxic gene expression involved in tumor initiation. Molecular Cell 35: 856-67.
12. Huang X, Le QT Giaccia (2010) MiR-210-micromanager of the hypoxia pathway. Trends Mol Med 16: 230-7.
13. HumbertM,Morrell NW, Archer SL, Stenmark KR,MacLean MR, Lang IM, Chistman BW, Weir EK, Eickelberg O, Voelkel NF, Rabinovitch M (2004) Cellular and molecular pathobiology of pulmonary arterial hypertension. J AmColl Cardiol 43: 13S-24.
14. Jeffery TK, Morrell NW (2002) Molecular and cellular basis of pulmonary vascular remodeling in pulmonary hypertension. Prog Cardiovasc Dis 45: 173-202.
15. Jin Y, Calvert TJ, Chen B, Chicoine LG, Joshi M, Bauer JA, Liu Y, Nelin LD (2010) Mice deficient in MKP-1 develop more severe pulmonary hypertension and greater lung protein levels of arginase in response to chonic hypoxia. Am J Physiol Heart Circ Physiol 298: H1518-2.
16. Kassel O, Sancono A, Krätzschmar J, Kreft B, Stassen M, Cato AC (2001) Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1. EMBO J 20: 7108-16.
17. Keyse SM, Emslie EA (1992) Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase. Nature 359: 644-7.
18. Kim HW, Haider HK, Jiang S, Ashaf M (2009) Ischemic preconditioning augments survival of stem cells via miR-210 expression by targeting caspase-8-associated protein 2. J Biol Chem 284: 33161-8.
19. Laderoute KR, Mendonca HL, Calaoagan JM, Knapp AM, Giaccia AJ, Stork PJ (1999) Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments. A candidate MKP for the inactivation of hypoxia-inducible stress-activated protein kinase/c-Jun N-terminal protein kinase activity. J Biol Chem 274: 12890-7.
20. Li B, Yang L, Shen J, Wang C, Jiang Z (2007) The antiproliferative effect of sildenafil on pulmonary artery smooth muscle cells is mediated via upregulation of mitogen-activated protein kinase phosphatase-1 and degradation of extracellular signal-regulated kinase 1/2 phosphorylation. Anesth Analg 105: 1034-41.
21. Liu Y, Gorospe M, Yang C, Holbrook NJ (1995) Role of mitogenactivated protein kinase phosphatase during the cellular response to genotoxic stress. Inhibition of c-Jun N-terminal kinase activity and AP-1 dependent gene activation. J Biol Chem 270: 8377-80.
22. Liu Y, Shepherd EG, Nelin LD (2007) MAPK phosphatases-regulating the immune response. Nat Rev Immunol 7: 202-1.
23. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-delta deltac(t)) method. Methods 25: 402-8.
24. Lodish HF, Zhou B, Liu G, Chen CZ (2008)Micromanagement of the immune systembymicroRNAs. Nat Rev Immunol 8: 120-3.
25. Muralimanoharan S, Maloyan A, Mele J, Guo C,Myatt LG,Myatt L (2012) MIR-210 modulates mitochondrial respiration in placenta with preeclampsia. Placenta 33: 816-23.
26. Nelin LD, Chicoine LG, Reber KM, English BK, Young TL, Liu Y (2005) Cytokine-induced endothelial arginase expression is dependent on epidermal growth factor receptor. Am J Respir Cell MolBiol 33: 394-401.
27. Pasquinelli AE, Hunter S, Bracht J (2005) MicroRNAs: a developing story. Curr Opin Genet Dev 15: 200-5.
28. Pietra GG, Capron F, Stewart S, Leone O, Humbert M (2004) Pathologic assessment of vasculopathies in pulmonary hypertension. J Am CollCardiol 43: 25S-32.
29. Puisśegur MP, Mazure NM, Bertero T, Pradelli L, Grosso S, Robbe-Sermesant K, Maurin T, Lebrigand K, Cardinaud B, Hofman V, Fourre S, Magnone V, Ricci JE, Pouysségur J, Gounon P, Hofman P, Barbry P, Mari B (2011) MiR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity. Cell Death Differ 18: 465-78.
30. Shu J, Xia Z, Li L, Liang ET, Slipek N, Shen D, Foo J, Subramanian S, Steer CJ (2012) Dose-dependent differential mRNA target selection and regulation by let-7a-7f and miR-17-92 cluster microRNAs. RNA Biol 9: 1275-87.
31. Williams AH, Liu N, van Rooij E, Olson EN (2009) MicroRNA control of muscle development and disease. Curr Opin Cell Biol 21: 461-9.
32. Wong H, Dunsmore KE, Page K, Shanley TP (2005) Heat shockmediated regulation of MKP-1. Am J Physiol Cell Physiol 289: C1152-8.
33. Wu JJ, Bennett AM (2005) Essential role for mitogen-activated protein (MAP) kinase phosphatase-1 in stress-responsive MAP kinase and cell survival signaling. J Biol Chem 280: 16461-6.
34. Yang S, Banerjee S, Freitas Ad, Cui H, Xie N, Abraham E, Liu G (2012) MiR-21 regulates chonic hypoxia-induced pulmonary vascular remodeling. Am J Physiol Lung Cell Mol Physiol 15: L521-9.
35. Zhang Z, Sun H, Dai H, Walsh RM, Imakura M, Schelter J, Burchard J, Dai X, Chang AN, Diaz RL, Marszalek JR, Bartz SR, Carleton M, Cleary MA, Linsley PS, Grandori C (2009) MicroRNA miR-210 modulates cellular response to hypoxia though the MYC antagonist MNT. Cell Cycle 8: 2756-68.