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Volumn 17, Issue 10, 2013, Pages 1291-1299

Epigenetic repression of bone morphogenetic protein receptor II expression in scleroderma

Author keywords

BMPRII; Endothelial cells; Epigenetics; Scleroderma; Vasculopathy

Indexed keywords

BONE MORPHOGENETIC PROTEIN RECEPTOR 2; PRIMER DNA; SMALL INTERFERING RNA;

EID: 84888341033     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12105     Document Type: Article
Times cited : (75)

References (41)
  • 1
    • 0033498335 scopus 로고    scopus 로고
    • Autoimmunity and vascular involvement in systemic sclerosis (SSc)
    • Kahaleh MB, LeRoy EC. Autoimmunity and vascular involvement in systemic sclerosis (SSc). Autoimmunity. 1999; 31: 195-214.
    • (1999) Autoimmunity , vol.31 , pp. 195-214
    • Kahaleh, M.B.1    LeRoy, E.C.2
  • 2
    • 0029999963 scopus 로고    scopus 로고
    • Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma
    • Sgonc R, Gruschwitz MS, Dietrich H, et al. Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma. J Clin Invest. 1996; 98: 785-92.
    • (1996) J Clin Invest , vol.98 , pp. 785-792
    • Sgonc, R.1    Gruschwitz, M.S.2    Dietrich, H.3
  • 3
    • 69149085602 scopus 로고    scopus 로고
    • The manifestations of vasculopathy in systemic sclerosis and its evidence-based therapy
    • Strange G, Nash P. The manifestations of vasculopathy in systemic sclerosis and its evidence-based therapy. Int J Rheum Dis. 2009; 12: 192-206.
    • (2009) Int J Rheum Dis , vol.12 , pp. 192-206
    • Strange, G.1    Nash, P.2
  • 4
    • 75649127963 scopus 로고    scopus 로고
    • Bone morphogenetic protein receptors and signal transduction
    • Miyazono K, Kamiya Y, Morikawa M. Bone morphogenetic protein receptors and signal transduction. J Biochem. 2010; 147: 35-51.
    • (2010) J Biochem , vol.147 , pp. 35-51
    • Miyazono, K.1    Kamiya, Y.2    Morikawa, M.3
  • 5
    • 32544438253 scopus 로고    scopus 로고
    • BMPR2 gene rearrangements account for a significant proportion of mutations in familial and idiopathic pulmonary arterial hypertension
    • Aldred MA, Vijayakrishnan J, James V, et al. BMPR2 gene rearrangements account for a significant proportion of mutations in familial and idiopathic pulmonary arterial hypertension. Hum Mutat. 2006; 27: 212-3.
    • (2006) Hum Mutat , vol.27 , pp. 212-213
    • Aldred, M.A.1    Vijayakrishnan, J.2    James, V.3
  • 6
    • 2942574709 scopus 로고    scopus 로고
    • Pathologic assessment of vasculopathies in pulmonary hypertension
    • Pietra GG, Capron F, Stewart S, et al. Pathologic assessment of vasculopathies in pulmonary hypertension. J Am Coll Cardiol. 2004; 43: 25S-32S.
    • (2004) J Am Coll Cardiol , vol.43
    • Pietra, G.G.1    Capron, F.2    Stewart, S.3
  • 7
    • 84861175847 scopus 로고    scopus 로고
    • BMPR-II deficiency elicits pro-proliferative and anti-apoptotic responses through the activation of TGFbeta-TAK1-MAPK pathways in PAH
    • Nasim MT, Ogo T, Chowdhury HM, et al. BMPR-II deficiency elicits pro-proliferative and anti-apoptotic responses through the activation of TGFbeta-TAK1-MAPK pathways in PAH. Hum Mol Genet. 2012; 21: 2548-58.
    • (2012) Hum Mol Genet , vol.21 , pp. 2548-2558
    • Nasim, M.T.1    Ogo, T.2    Chowdhury, H.M.3
  • 8
    • 0037046175 scopus 로고    scopus 로고
    • Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor
    • Atkinson C, Stewart S, Upton PD, et al. Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor. Circulation. 2002; 105: 1672-8.
    • (2002) Circulation , vol.105 , pp. 1672-1678
    • Atkinson, C.1    Stewart, S.2    Upton, P.D.3
  • 9
    • 0036844311 scopus 로고    scopus 로고
    • Pulmonary hypertension in scleroderma spectrum of disease: lack of bone morphogenetic protein receptor 2 mutations
    • Morse J, Barst R, Horn E, et al. Pulmonary hypertension in scleroderma spectrum of disease: lack of bone morphogenetic protein receptor 2 mutations. J Rheumatol. 2002; 29: 2379-81.
    • (2002) J Rheumatol , vol.29 , pp. 2379-2381
    • Morse, J.1    Barst, R.2    Horn, E.3
  • 10
    • 0029009988 scopus 로고
    • A method for the isolation and serial propagation of keratinocytes, endothelial cells, and fibroblasts from a single punch biopsy of human skin
    • Normand J, Karasek MA. A method for the isolation and serial propagation of keratinocytes, endothelial cells, and fibroblasts from a single punch biopsy of human skin. In Vitro Cell Dev Biol Anim. 1995; 31: 447-55.
    • (1995) In Vitro Cell Dev Biol Anim , vol.31 , pp. 447-455
    • Normand, J.1    Karasek, M.A.2
  • 11
    • 67651210932 scopus 로고    scopus 로고
    • BMPRII is a direct target of miR-21
    • Qin W, Zhao B, Shi Y, et al. BMPRII is a direct target of miR-21. Acta Biochim Biophys Sin. 2009; 41: 618-23.
    • (2009) Acta Biochim Biophys Sin , vol.41 , pp. 618-623
    • Qin, W.1    Zhao, B.2    Shi, Y.3
  • 12
    • 33745918328 scopus 로고    scopus 로고
    • Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts
    • Wang Y, Fan PS, Kahaleh B. Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts. Arthritis Rheum. 2006; 54: 2271-9.
    • (2006) Arthritis Rheum , vol.54 , pp. 2271-2279
    • Wang, Y.1    Fan, P.S.2    Kahaleh, B.3
  • 13
    • 67749116469 scopus 로고    scopus 로고
    • FOXO3a regulates oxygen-responsive expression of tumor necrosis factor receptor 2 in human dermal microvascular endothelial cells
    • Ding B, Kirkiles-Smith NC, Pober JS. FOXO3a regulates oxygen-responsive expression of tumor necrosis factor receptor 2 in human dermal microvascular endothelial cells. J Biol Chem. 2009; 284: 19331-9.
    • (2009) J Biol Chem , vol.284 , pp. 19331-19339
    • Ding, B.1    Kirkiles-Smith, N.C.2    Pober, J.S.3
  • 14
    • 65049091914 scopus 로고    scopus 로고
    • siRNA down-regulation of the PATZ1 gene in human glioma cells increases their sensitivity to apoptotic stimuli
    • Tritz R, Mueller BM, Hickey MJ, et al. siRNA down-regulation of the PATZ1 gene in human glioma cells increases their sensitivity to apoptotic stimuli. Cancer Ther. 2008; 6: 865-76.
    • (2008) Cancer Ther , vol.6 , pp. 865-876
    • Tritz, R.1    Mueller, B.M.2    Hickey, M.J.3
  • 15
    • 36148992947 scopus 로고    scopus 로고
    • Human collagen Krox up-regulates type I collagen expression in normal and scleroderma fibroblasts through interaction with Sp1 and Sp3 transcription factors
    • Kypriotou M, Beauchef G, Chadjichristos C, et al. Human collagen Krox up-regulates type I collagen expression in normal and scleroderma fibroblasts through interaction with Sp1 and Sp3 transcription factors. J Biol Chem. 2007; 282: 32000-14.
    • (2007) J Biol Chem , vol.282 , pp. 32000-32014
    • Kypriotou, M.1    Beauchef, G.2    Chadjichristos, C.3
  • 16
    • 53549129493 scopus 로고    scopus 로고
    • Microvessel density and CpG island methylation of the THBS2 gene in malignant ovarian tumors
    • Czekierdowski A, Czekierdowska S, Danilos J, et al. Microvessel density and CpG island methylation of the THBS2 gene in malignant ovarian tumors. J Physiol Pharmacol. 2008; 59(Suppl. 4): 53-65.
    • (2008) J Physiol Pharmacol , vol.59 , Issue.SUPPL. 4 , pp. 53-65
    • Czekierdowski, A.1    Czekierdowska, S.2    Danilos, J.3
  • 17
    • 0037642249 scopus 로고    scopus 로고
    • Methylation of adjacent CpG sites affects Sp1/Sp3 binding and activity in the p21(Cip1) promoter
    • Zhu WG, Srinivasan K, Dai Z, et al. Methylation of adjacent CpG sites affects Sp1/Sp3 binding and activity in the p21(Cip1) promoter. Mol Cell Biol. 2003; 23: 4056-65.
    • (2003) Mol Cell Biol , vol.23 , pp. 4056-4065
    • Zhu, W.G.1    Srinivasan, K.2    Dai, Z.3
  • 18
    • 84977494689 scopus 로고    scopus 로고
    • EGR1 is essential for transcriptional regulation of BMPR2
    • Gaddipati R, West J, Loyd J, et al. EGR1 is essential for transcriptional regulation of BMPR2. AJMB. 2011; 1: 131-9.
    • (2011) AJMB , vol.1 , pp. 131-139
    • Gaddipati, R.1    West, J.2    Loyd, J.3
  • 19
    • 0026604019 scopus 로고
    • Sequential dermal microvascular and perivascular changes in the development of scleroderma
    • Prescott RJ, Freemont AJ, Jones CJ, et al. Sequential dermal microvascular and perivascular changes in the development of scleroderma. J Pathol. 1992; 166: 255-63.
    • (1992) J Pathol , vol.166 , pp. 255-263
    • Prescott, R.J.1    Freemont, A.J.2    Jones, C.J.3
  • 21
    • 0025951772 scopus 로고
    • Structural features of interstitial lung disease in systemic sclerosis
    • Harrison NK, Myers AR, Corrin B, et al. Structural features of interstitial lung disease in systemic sclerosis. Am Rev Respir Dis. 1991; 144: 706-13.
    • (1991) Am Rev Respir Dis , vol.144 , pp. 706-713
    • Harrison, N.K.1    Myers, A.R.2    Corrin, B.3
  • 22
    • 1642473157 scopus 로고    scopus 로고
    • The transforming growth factor-beta superfamily of receptors
    • de Caestecker M. The transforming growth factor-beta superfamily of receptors. Cytokine Growth Factor Rev. 2004; 15: 1-11.
    • (2004) Cytokine Growth Factor Rev , vol.15 , pp. 1-11
    • de Caestecker, M.1
  • 23
    • 79958768845 scopus 로고    scopus 로고
    • Homomeric and heteromeric complexes among TGF-beta and BMP receptors and their roles in signaling
    • Ehrlich M, Horbelt D, Marom B, et al. Homomeric and heteromeric complexes among TGF-beta and BMP receptors and their roles in signaling. Cell Signal. 2011; 23: 1424-32.
    • (2011) Cell Signal , vol.23 , pp. 1424-1432
    • Ehrlich, M.1    Horbelt, D.2    Marom, B.3
  • 24
    • 33644865928 scopus 로고    scopus 로고
    • Bone morphogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension
    • Teichert-Kuliszewska K, Kutryk MJ, Kuliszewski MA, et al. Bone morphogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension. Circ Res. 2006; 98: 209-17.
    • (2006) Circ Res , vol.98 , pp. 209-217
    • Teichert-Kuliszewska, K.1    Kutryk, M.J.2    Kuliszewski, M.A.3
  • 25
    • 27644484777 scopus 로고    scopus 로고
    • BMP-2 prevents apoptosis of the N1511 chondrocytic cell line through PI3K/Akt-mediated NF-kappaB activation
    • Sugimori K, Matsui K, Motomura H, et al. BMP-2 prevents apoptosis of the N1511 chondrocytic cell line through PI3K/Akt-mediated NF-kappaB activation. J Bone Miner Metab. 2005; 23: 411-9.
    • (2005) J Bone Miner Metab , vol.23 , pp. 411-419
    • Sugimori, K.1    Matsui, K.2    Motomura, H.3
  • 26
    • 71749120773 scopus 로고    scopus 로고
    • GDF5 and BMP2 inhibit apoptosis via activation of BMPR2 and subsequent stabilization of XIAP
    • Liu Z, Shen J, Pu K, et al. GDF5 and BMP2 inhibit apoptosis via activation of BMPR2 and subsequent stabilization of XIAP. Biochim Biophys Acta. 2009; 1793: 1819-27.
    • (2009) Biochim Biophys Acta , vol.1793 , pp. 1819-1827
    • Liu, Z.1    Shen, J.2    Pu, K.3
  • 27
    • 50349096148 scopus 로고    scopus 로고
    • Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension
    • Hong KH, Lee YJ, Lee E, et al. Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension. Circulation. 2008; 118: 722-30.
    • (2008) Circulation , vol.118 , pp. 722-730
    • Hong, K.H.1    Lee, Y.J.2    Lee, E.3
  • 28
    • 57349146222 scopus 로고    scopus 로고
    • Effects of bone morphogenic proteins and transforming growth factor-beta on In-vitro production of endothelin-1 by human pulmonary microvascular endothelial cells
    • Star GP, Giovinazzo M, Langleben D. Effects of bone morphogenic proteins and transforming growth factor-beta on In-vitro production of endothelin-1 by human pulmonary microvascular endothelial cells. Vascul Pharmacol. 2009; 50: 45-50.
    • (2009) Vascul Pharmacol , vol.50 , pp. 45-50
    • Star, G.P.1    Giovinazzo, M.2    Langleben, D.3
  • 29
    • 84871719403 scopus 로고    scopus 로고
    • ALK2 and BMPR2 knockdown and endothelin-1 production by pulmonary microvascular endothelial cells
    • Star GP, Giovinazzo M, Langleben D. ALK2 and BMPR2 knockdown and endothelin-1 production by pulmonary microvascular endothelial cells. Microvasc Res. 2013; 85: 46-53.
    • (2013) Microvasc Res , vol.85 , pp. 46-53
    • Star, G.P.1    Giovinazzo, M.2    Langleben, D.3
  • 30
    • 67449146883 scopus 로고    scopus 로고
    • Emerging role of bone morphogenetic proteins in angiogenesis
    • David L, Feige JJ, Bailly S. Emerging role of bone morphogenetic proteins in angiogenesis. Cytokine Growth Factor Rev. 2009; 20: 203-12.
    • (2009) Cytokine Growth Factor Rev , vol.20 , pp. 203-212
    • David, L.1    Feige, J.J.2    Bailly, S.3
  • 31
    • 59849099675 scopus 로고    scopus 로고
    • Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathways
    • de Jesus Perez VA, Alastalo TP, Wu JC, et al. Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathways. J Cell Biol. 2009; 184: 83-99.
    • (2009) J Cell Biol , vol.184 , pp. 83-99
    • De Jesus Perez, V.A.1    Alastalo, T.P.2    Wu, J.C.3
  • 32
    • 0042881023 scopus 로고    scopus 로고
    • Primary pulmonary hypertension after amfepramone (diethylpropion) with BMPR2 mutation
    • Abramowicz MJ, Van Haecke P, Demedts M, et al. Primary pulmonary hypertension after amfepramone (diethylpropion) with BMPR2 mutation. Eur Respir J. 2003; 22: 560-2.
    • (2003) Eur Respir J , vol.22 , pp. 560-562
    • Abramowicz, M.J.1    Van Haecke, P.2    Demedts, M.3
  • 33
    • 40749102181 scopus 로고    scopus 로고
    • Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature
    • Frank DB, Lowery J, Anderson L, et al. Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature. Am J Physiol Lung Cell Mol Physiol. 2008; 294: L98-109.
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.294
    • Frank, D.B.1    Lowery, J.2    Anderson, L.3
  • 34
    • 0028026729 scopus 로고
    • Micronutrient antioxidant status in patients with primary Raynaud's phenomenon and systemic sclerosis
    • Herrick AL, Rieley F, Schofield D, et al. Micronutrient antioxidant status in patients with primary Raynaud's phenomenon and systemic sclerosis. J Rheumatol. 1994; 21: 1477-83.
    • (1994) J Rheumatol , vol.21 , pp. 1477-1483
    • Herrick, A.L.1    Rieley, F.2    Schofield, D.3
  • 35
    • 0035149214 scopus 로고    scopus 로고
    • Oxidative stress in scleroderma: maintenance of scleroderma fibroblast phenotype by the constitutive up-regulation of reactive oxygen species generation through the NADPH oxidase complex pathway
    • Sambo P, Baroni SS, Luchetti M, et al. Oxidative stress in scleroderma: maintenance of scleroderma fibroblast phenotype by the constitutive up-regulation of reactive oxygen species generation through the NADPH oxidase complex pathway. Arthritis Rheum. 2001; 44: 2653-64.
    • (2001) Arthritis Rheum , vol.44 , pp. 2653-2664
    • Sambo, P.1    Baroni, S.S.2    Luchetti, M.3
  • 36
    • 0034049907 scopus 로고    scopus 로고
    • Correlation between increased nitric oxide production and markers of endothelial activation in systemic sclerosis: findings with the soluble adhesion molecules E-selectin, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1
    • Andersen GN, Caidahl K, Kazzam E, et al. Correlation between increased nitric oxide production and markers of endothelial activation in systemic sclerosis: findings with the soluble adhesion molecules E-selectin, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1. Arthritis Rheum. 2000; 43: 1085-93.
    • (2000) Arthritis Rheum , vol.43 , pp. 1085-1093
    • Andersen, G.N.1    Caidahl, K.2    Kazzam, E.3
  • 37
    • 33745620189 scopus 로고    scopus 로고
    • Serum levels of 8-isoprostane, a marker of oxidative stress, are elevated in patients with systemic sclerosis
    • Ogawa F, Shimizu K, Muroi E, et al. Serum levels of 8-isoprostane, a marker of oxidative stress, are elevated in patients with systemic sclerosis. Rheumatology. 2006; 45: 815-8.
    • (2006) Rheumatology , vol.45 , pp. 815-818
    • Ogawa, F.1    Shimizu, K.2    Muroi, E.3
  • 38
    • 27744474113 scopus 로고    scopus 로고
    • Platelet-derived growth factor and reactive oxygen species (ROS) regulate Ras protein levels in primary human fibroblasts via ERK1/2. Amplification of ROS and Ras in systemic sclerosis fibroblasts
    • Svegliati S, Cancello R, Sambo P, et al. Platelet-derived growth factor and reactive oxygen species (ROS) regulate Ras protein levels in primary human fibroblasts via ERK1/2. Amplification of ROS and Ras in systemic sclerosis fibroblasts. J Biol Chem. 2005; 280: 36474-82.
    • (2005) J Biol Chem , vol.280 , pp. 36474-36482
    • Svegliati, S.1    Cancello, R.2    Sambo, P.3
  • 39
    • 33847047461 scopus 로고    scopus 로고
    • Epigenetics: a landscape takes shape
    • Goldberg AD, Allis CD, Bernstein E. Epigenetics: a landscape takes shape. Cell. 2007; 128: 635-8.
    • (2007) Cell , vol.128 , pp. 635-638
    • Goldberg, A.D.1    Allis, C.D.2    Bernstein, E.3
  • 40
    • 33748095194 scopus 로고    scopus 로고
    • Epigenetics of complex diseases: from general theory to laboratory experiments
    • Schumacher A, Petronis A. Epigenetics of complex diseases: from general theory to laboratory experiments. Curr Top Microbiol Immunol. 2006; 310: 81-115.
    • (2006) Curr Top Microbiol Immunol , vol.310 , pp. 81-115
    • Schumacher, A.1    Petronis, A.2
  • 41
    • 34249337761 scopus 로고    scopus 로고
    • Perceptions of epigenetics
    • Bird A. Perceptions of epigenetics. Nature. 2007; 447: 396-8.
    • (2007) Nature , vol.447 , pp. 396-398
    • Bird, A.1


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