Apelin/APJ signaling is a critical regulator of statin effects in vascular endothelial cells-brief report

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 32, Issue 11, 2012, Pages 2640-2643

  McLean, Danielle L ^a   Kim, Jongmin ^a   Kang, Yujung ^a   Shi, Hong ^b   Atkins, G Brandon ^b   Jain, Mukesh K ^b   Chun, Hyung J ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APELIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; KRUPPEL LIKE FACTOR 2; ROSUVASTATIN; SIMVASTATIN; STATIN (PROTEIN); THROMBOMODULIN; APLN PROTEIN, HUMAN; APLN PROTEIN, MOUSE; APLNR PROTEIN, HUMAN; APLNR PROTEIN, MOUSE; FLUINDOSTATIN; FLUOROBENZENE; G PROTEIN COUPLED RECEPTOR; INDOLE DERIVATIVE; KLF2 PROTEIN, HUMAN; KLF2 PROTEIN, MOUSE; KRUPPEL LIKE FACTOR; MONOUNSATURATED FATTY ACID; NOS3 PROTEIN, HUMAN; PYRIMIDINE DERIVATIVE; SIGNAL PEPTIDE; SULFONAMIDE; THBD PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ARTICLE; CELL ADHESION; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; GROWTH INHIBITION; HUMAN; HUMAN CELL; MEDIATOR; MONOCYTE; MOUSE; NONHUMAN; PLEIOTROPY; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; VASCULAR ENDOTHELIUM; ANIMAL; CELL STRAIN COS1; CERCOPITHECUS; COCULTURE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; RNA INTERFERENCE; TIME; UMBILICAL VEIN ENDOTHELIAL CELL;

ANIMALS; CELL ADHESION; CERCOPITHECUS AETHIOPS; COCULTURE TECHNIQUES; COS CELLS; FATTY ACIDS, MONOUNSATURATED; FLUOROBENZENES; GENE EXPRESSION REGULATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INDOLES; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; MICE, KNOCKOUT; MONOCYTES; NITRIC OXIDE SYNTHASE TYPE III; PYRIMIDINES; RECEPTORS, G-PROTEIN-COUPLED; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SIMVASTATIN; SULFONAMIDES; THROMBOMODULIN; TIME FACTORS; TRANSFECTION;

EID: 84871887199     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.112.300317     Document Type: Article

References (21)

1. Chun HJ, Ali ZA, Kojima Y, et al. Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis. J Clin Invest. 2008;118:3343-3354.
2. Chandra SM, Razavi H, Kim J, Agrawal R, Kundu RK, de Jesus Perez V, Zamanian RT, Quertermous T, Chun HJ. Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension. Arterioscler Thromb Vasc Biol. 2011;31:814-820.
3. Sadowitz B, Maier KG, Gahtan V. Basic science review: Statin therapy-Part I: The pleiotropic effects of statins in cardiovascular disease. Vasc Endovascular Surg. 2010;44:241-251.
4. Wang CY, Liu PY, Liao JK. Pleiotropic effects of statin therapy: molecular mechanisms and clinical results. Trends Mol Med. 2008;14:37-44.
5. Sen-Banerjee S, Mir S, Lin Z, Hamik A, Atkins GB, Das H, Banerjee P, Kumar A, Jain MK. Kruppel-like factor 2 as a novel mediator of statin effects in endothelial cells. Circulation. 2005;112:720-726.
6. Parmar KM, Nambudiri V, Dai G, Larman HB, Gimbrone MA Jr, García-Cardeña G. Statins exert endothelial atheroprotective effects via the KLF2 transcription factor. J Biol Chem. 2005;280:26714-26719.
7. Masamura K, Oida K, Kanehara H, Suzuki J, Horie S, Ishii H, Miyamori I. Pitavastatin-induced thrombomodulin expression by endothelial cells acts via inhibition of small G proteins of the Rho family. Arterioscler Thromb Vasc Biol. 2003;23:512-517.
8. Kadoglou NP, Sailer N, Kapelouzou A, Lampropoulos S, Vitta I, Kostakis A, Liapis CD. Effects of atorvastatin on apelin, visfatin (nampt), ghrelin and early carotid atherosclerosis in patients with type 2 diabetes. Acta Diabetol. 2012;49:269-276.
9. Tasci I, Erdem G, Ozgur G, Tapan S, Dogru T, Genc H, Acikel C, Ozgurtas T, Sonmez A. LDL-cholesterol lowering increases plasma apelin in isolated hypercholesterolemia. Atherosclerosis. 2009;204:222-228.
10. Mahabeleshwar GH, Kawanami D, Sharma N, et al. The myeloid transcription factor KLF2 regulates the host response to polymicrobial infection and endotoxic shock. Immunity. 2011;34:715-728.
11. Boon RA, Leyen TA, Fontijn RD, Fledderus JO, Baggen JM, Volger OL, van Nieuw Amerongen GP, Horrevoets AJ. KLF2-induced actin shear fbers control both alignment to fow and JNK signaling in vascular endothelium. Blood. 2010;115:2533-2542.
12. Huddleson JP, Ahmad N, Srinivasan S, Lingrel JB. Induction of KLF2 by fuid shear stress requires a novel promoter element activated by a phosphatidylinositol 3-kinase-dependent chromatin-remodeling pathway. J Biol Chem. 2005;280:23371-23379.
13. Dekker RJ, Boon RA, Rondaij MG, Kragt A, Volger OL, Elderkamp YW, Meijers JC, Voorberg J, Pannekoek H, Horrevoets AJ. KLF2 provokes a gene expression pattern that establishes functional quiescent differentiation of the endothelium. Blood. 2006;107:4354-4363.
14. Lin Z, Kumar A, SenBanerjee S, Staniszewski K, Parmar K, Vaughan DE, Gimbrone MA Jr, Balasubramanian V, García-Cardeña G, Jain MK. Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function. Circ Res. 2005;96:e48-e57.
15. Lin SJ, Hsieh FY, Chen YH, Lin CC, Kuan II, Wang SH, Wu CC, Chien HF, Lin FY, Chen YL. Atorvastatin induces thrombomodulin expression in the aorta of cholesterol-fed rabbits and in TNFalpha-treated human aortic endothelial cells. Histol Histopathol. 2009;24:1147-1159.
16. Schmidt TS, McNeill E, Douglas G, Crabtree MJ, Hale AB, Khoo J, O'Neill CA, Cheng A, Channon KM, Alp NJ. Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular infammation in apolipoprotein E-knockout mice. Clin Sci. 2010;119:131-142.
17. Shen B, Smith RS Jr, Hsu YT, Chao L, Chao J. Kruppel-like factor 4 is a novel mediator of Kallistatin in inhibiting endothelial infammation via increased endothelial nitric-oxide synthase expression. J Biol Chem. 2009;284:35471-35478.
18. Ramesh S, Morrell CN, Tarango C, Thomas GD, Yuhanna IS, Girardi G, Herz J, Urbanus RT, de Groot PG, Thorpe PE, Salmon JE, Shaul PW, Mineo C. Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via |32GPI and apoER2. J Clin Invest. 2011;121:120-131.
19. Habata Y, Fujii R, Hosoya M, Fukusumi S, Kawamata Y, Hinuma S, Kitada C, Nishizawa N, Murosaki S, Kurokawa T, Onda H, Tatemoto K, Fujino M. Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum. Biochim Biophys Acta. 1999;1452:25-35.
20. Reaux A, De Mota N, Skultetyova I, Lenkei Z, El Messari S, Gallatz K, Corvol P, Palkovits M, Llorens-Cortès C. Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain. J Neurochem. 2001;77:1085-1096.
21. Meadows SM, Salanga MC, Krieg PA. Kruppel-like factor 2 cooperates with the ETS family protein ERG to activate Flk1 expression during vascular development. Development. 2009;136:1115-1125.