Inhibition of microRNA-17 improves lung and heart function in experimental pulmonary hypertension

American Journal of Respiratory and Critical Care Medicine

Volumn 185, Issue 4, 2012, Pages 409-419

  Pullamsetti, Soni S ^a   Doebele, Carmen ^b   Fischer, Ariane ^b   Savai, Rajkumar ^a   Kojonazarov, Baktybek ^c   Dahal, Bhola K ^c   Ghofrani, Hossein A ^c   Weissmann, Norbert ^c   Grimminger, Friedrich ^c   Bonauer, Angelika ^b   Seeger, Werner ^c   Zeiher, Andreas M ^b   Dimmeler, Stefanie ^b   Schermuly, Ralph T ^a,c  

^a MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

^b GOETHE UNIVERSITY   (Germany)

^c JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

Author keywords

Antagomir; MicroRNA; Pulmonary hypertension; Smooth muscle cell; Vascular remodeling

Indexed keywords

MICRORNA; MICRORNA 17; MICRORNA 21; PROTEIN P21; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE CLUSTER; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HEART FUNCTION; HEART OUTPUT; HEART RIGHT VENTRICLE HYPERTROPHY; HEART RIGHT VENTRICLE PRESSURE; HEART VENTRICLE REMODELING; HOMEOSTASIS; HYPOXIA; LUNG BLOOD VESSEL; LUNG FUNCTION; LUNG VASCULAR RESISTANCE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PULMONARY ARTERY; PULMONARY HYPERTENSION; SMOOTH MUSCLE FIBER; SYSTOLE; SYSTOLIC BLOOD PRESSURE; UPREGULATION;

AIRWAY REMODELING; ANIMALS; BLOTTING, WESTERN; CARDIAC OUTPUT; CELLS, CULTURED; DISEASE MODELS, ANIMAL; HUMANS; HYPERTENSION, PULMONARY; MICE; MICRORNAS; OLIGORIBONUCLEOTIDES; PULMONARY ARTERY; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VASCULAR RESISTANCE; VENTRICULAR FUNCTION, RIGHT;

EID: 84857379176     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201106-1093OC     Document Type: Article

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