Epigenetics and imprinting in human disease

International Journal of Developmental Biology

Volumn 58, Issue 2-4, 2014, Pages 291-298

  Kalish, Jennifer M ^a   Jiang, Connie ^a   Bartolomei, Marisa S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Beckwith Wiedemann syndrome; DNA methylation; Genomic imprinting; Russell silver syndrome

Indexed keywords

UNTRANSLATED RNA;

ARTICLE; BECKWITH WIEDEMANN SYNDROME; CDKN1C GENE; DNA METHYLATION; EMBRYO DEVELOPMENT; EPIGENETICS; GENE; GENE CLUSTER; GENE EXPRESSION; GENE FREQUENCY; GENE FUNCTION; GENE MUTATION; GENE SILENCING; GENOME IMPRINTING; HAPPY PUPPET SYNDROME; HUMAN; INFERTILITY THERAPY; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRADER WILLI SYNDROME; PRIORITY JOURNAL; SILVER RUSSELL SYNDROME; UNIPARENTAL DISOMY; DISEASES; GENETICS;

DISEASE; DNA METHYLATION; EPIGENOMICS; GENOMIC IMPRINTING; HUMANS;

EID: 84904165952     PISSN: 02146282     EISSN: None     Source Type: Journal    
DOI: 10.1387/ijdb.140077mb     Document Type: Article

References (78)

1. ALGAR, E., DAGAR, V., SEBAJ, M. and PACHTER, N. (2011). An 11p15 Imprinting Centre Region 2 Deletion in a Family with Beckwith Wiedemann Syndrome Provides Insights into Imprinting Control at Cdkn1c. PLoS One 6: e29034.
2. ANGRIST, M., BOLK, S., BENTLEY, K., NALLASAMY, S., HALUSHKA, M.K. and CHAKRAVARTI, A. (1998). Genomic Structure of the Gene for the Sh2 and Pleckstrin Homology Domain-Containing Protein Grb10 and Evaluation of Its Role in Hirschsprung Disease. Oncogene 17: 3065-3070.
3. ANKOLKAR, M., SALVI, V., WARKE, H., VUNDINTI, B.R. and BALASINOR, N.H. (2013). Methylation Status of Imprinted Genes Dlk1-Gtl2, Mest (Peg1), Zac (Plagl1), and Line-1 Elements in Spermatozoa of Normozoospermic Men, Unlike H19 Imprinting Control Regions, Is Not Associated with Idiopathic Recurrent Spontaneous Miscarriages. Fertil. Steril. 99: 1668-1673.
4. ARNAUD, P., MONK, D., HITCHINS, M., GORDON, E., DEAN, W., BEECHEY, C.V., PETERS, J., CRAIGEN, W., PREECE, M., STANIER, P. et al., (2003). Conserved Methylation Imprints in the Human and Mouse Grb10 Genes with Divergent Allelic Expression Suggests Differential Reading of the Same Mark. Hum Mol Genet 12: 1005-1019.
5. AZZI, S., ABI HABIB, W. and NETCHINE, I. (2014). Beckwith-Wiedemann and Russell-Silver Syndromes: From New Molecular Insights to the Comprehension of Imprinting Regulation. Curr Opin Endocrinol Diabetes Obes 21: 30-38.
6. BARTOLOMEI, M.S. (2009). Genomic Imprinting: Employing and Avoiding Epigenetic Processes. Genes Dev 23: 2124-2133.
7. BARTOLOMEI, M.S. and FERGUSON-SMITH, A.C. (2011). Mammalian Genomic Imprinting. CSH Perspect. Biol 3. (doi: 10.1101/cshperspect.a002592).
8. BARTON, S.C., SURANI, M.A. and NORRIS, M.L. (1984). Role of Paternal and Maternal Genomes in Mouse Development. Nature 311: 374-376.
9. BERLAND, S., APPELBACK, M., BRULAND, O., BEYGO, J., BUITING, K., MACKAY, D.J., KAREN TEMPLE, I. and HOUGE, G. (2013). Evidence for Anticipation in Beckwith-Wiedemann Syndrome. Eur J Hum Genet: EJHG 21: 1344-1348.
10. BULLMAN, H., LEVER, M., ROBINSON, D.O., MACKAY, D.J., HOLDER, S.E. and WAKELING, E.L. (2008). Mosaic Maternal Uniparental Disomy of Chromosome 11 in a Patient with Silver-Russell Syndrome. J Med Genet 45: 396-399.
11. CASPARY, T., CLEARY, M.A., PERLMAN, E.J., ZHANG, P., ELLEDGE, S.J. and TIL-GHMAN, S.M. (1999). Oppositely Imprinted Genes P57(Kip2) and Igf2 Interact in a Mouse Model for Beckwith-Wiedemann Syndrome. Genes Dev 13: 3115-3124.
12. CASSIDY, S.B., SCHWARTZ, S., MILLER, J.L. and DRISCOLL, D.J. (2012). Prader-Willi Syndrome. Genet Med 14: 10-26.
13. CHANG, A.S., MOLEY, K.H., WANGLER, M., FEINBERG, A.P. and DEBAUN, M.R. (2005). Association between Beckwith-Wiedemann Syndrome and Assisted Reproductive Technology: A Case Series of 19 Patients. Fertil. Steril. 83: 349-354.
14. CHEN, Z., ROBBINS, K.M., WELLS, K.D. and RIVERA, R.M. (2013). Large Offspring Syndrome: A Bovine Model for the Human Loss-of-Imprinting Overgrowth Syndrome Beckwith-Wiedemann. Epigenetics 8: 591-601.
15. CHOUFANI, S., SHUMAN, C. and WEKSBERG, R. (2013). Molecular Findings in Beckwith-Wiedemann Syndrome. American Journal of Medical Genetics Part C, Seminars in Medical Genetics 163: 131-140.
16. DE WAAL, E., MAK, W., CALHOUN, S., STEIN, P., ORD, T., KRAPP, C., COUTI-FARIS, C., SCHULTZ, R.M. and BARTOLOMEI, M.S. (2014). In vitro Culture Increases the Frequency of Stochastic Epigenetic Errors at Imprinted Genes in Placental Tissues from Mouse Concepti Produced through Assisted Reproductive Technologies. Biol Reprod 90: 22.
17. DEBAUN, M.R. and TUCKER, M.A. (1998). Risk of Cancer During the First Four Years of Life in Children from the Beckwith-Wiedemann Syndrome Registry. J. Pediatrics 132: 398-400.
18. DOCHERTY, L.E., POOLE, R.L., MATTOCKS, C.J., LEHMANN, A., TEMPLE, I.K. and MACKAY, D.J. (2010). Further Refinement of the Critical Minimal Genetic Region for the Imprinting Disorder 6q24 Transient Neonatal Diabetes. Diabeto-logia 53: 2347-2351.
19. DOWDY, S.C., GOSTOUT, B.S., SHRIDHAR, V., WU, X., SMITH, D.I., PODRATZ, K.C. and JIANG, S.W. (2005). Biallelic Methylation and Silencing of Paternally Expressed Gene 3 (Peg3) in Gynecologic Cancer Cell Lines. Gynecol Oncol 99: 126-134.
20. EGGENSCHWILER, J., LUDWIG, T., FISHER, P., LEIGHTON, P.A., TILGHMAN, S.M. and EFSTRATIADIS, A. (1997). Mouse Mutant Embryos Overexpressing Igf-Ii Exhibit Phenotypic Features of the Beckwith-Wiedemann and Simpson-Golabi-Behmel Syndromes. Genes Dev 11: 3128-3142.
21. EL HAJJ, N. and HAAF, T. (2013). Epigenetic Disturbances in in vitro Cultured Gametes and Embryos: Implications for Human Assisted Reproduction. Fertil Steril 99: 632-641.
22. ENGEL, N., WEST, A.G., FELSENFELD, G. and BARTOLOMEI, M.S. (2004). Antagonism between DNA Hypermethylation and Enhancer-Blocking Activity at the H19 Dmd Is Uncovered by Cpg Mutations. Nat Genet 36: 883-888.
23. GAO, Y., ZHANG, H.D., LIN, J.S., ZHANG, M.P. and ZHANG, R.G. (2010). [The Imprinting Status of Genetic Imprinted Gene Peg10 in Human Hepatocellular Carcinomas]. Zhonghua Gan Zang Bing Za Zhi 18: 894-899.
24. GOGIEL, M., BEGEMANN, M., SPENGLER, S., SOELLNER, L., GORETZLEHNER, U., EGGERMANN, T. and STROBL-WILDEMANN, G. (2013). Genome-Wide Paternal Uniparental Disomy Mosaicism in a Woman with Beckwith-Wiedemann Syndrome and Ovarian Steroid Cell Tumour. Eur. J. Human Genet. 21: 788-791.
25. GRACE, K.S. and SINCLAIR, K.D. (2009). Assisted Reproductive Technology, Epigenetics, and Long-Term Health: A Developmental Time Bomb Still Ticking. Semin Reprod Med 27: 409-416.
26. GU, T.P., GUO, F., YANG, H., WU, H.P., XU, G.F., LIU, W., XIE, Z.G., SHI, L., HE, X., JIN, S.G. et al., (2011). The Role of Tet3 DNA Dioxygenase in Epigenetic Reprogramming by Oocytes. Nature 477: 606-610.
27. HUANG, J., ZHANG, X., ZHANG, M., ZHU, J.D., ZHANG, Y.L., LIN, Y., WANG, K.S., QI, X.F., ZHANG, Q., LIU, G.Z. et al., (2007). Up-Regulation of Dlk1 as an Imprinted Gene Could Contribute to Human Hepatocellular Carcinoma. Carci-nogenesis 28: 1094-103.
28. HYSI, P.G., YOUNG, T.L., MACKEY, D.A., ANDREW, T., FERNANDEZMEDARDE, A., SOLOUKI, A.M., HEWITT, A.W., MACGREGOR, S., VINGERLING, J.R., LI, Y.J. et al., (2010). A Genome-Wide Association Study for Myopia and Refractive Error Identifies a Susceptibility Locus at 15q25. Nat Genet 42: 902-905.
29. IGLESIAS-PLATAS, I., COURT, F., CAMPRUBI, C., SPARAGO, A., GUILLAUMET-ADKINS, A., MARTIN-TRUJILLO, A., RICCIO, A., MOORE, G.E. and MONK, D. (2013). Imprinting at the Plagl1 Domain Is Contained within a 70Kb Ctcf/ Cohesin-Mediated Non-Allelic Chromatin Loop. Nucleic Acid. Res. 41: 2171-2179.
30. INBAR-FEIGENBERG, M., CHOUFANI, S., CYTRYNBAUM, C., CHEN, Y.A., STEELE, L., SHUMAN, C., RAY, P.N. and WEKSBERG, R. (2013). Mosaicism for Genome-Wide Paternal Uniparental Disomy with Features of Multiple Imprinting Disorders: Diagnostic and Management Issues. Am. J. Medical Genet. Part A 161A: 13-20.
31. JACOB, K., ROBINSON, W. and LEFEBVRE, L. (2013). Beckwith-Wiedemann and Silver-Russell Syndromes: Opposite Developmental Imbalances in Imprinted Regulators of Placental Function and Embryonic Growth. Clinical Genet. 84: 326-334.
32. JORGENSEN, L.H., SELLATHURAI, J., DAVIS, E.E., THEDCHANAMOORTHY, T., AL-BADER, R.W., JENSEN, C.H. and SCHRODER, H.D. (2013). Delta-Like 1 Homolog (Dlk1): A Marker for Rhabdomyosarcomas Implicated in Skeletal Muscle Regeneration. PLoS One 8: e60692.
33. KALISH, J.M., CONLIN, L.K., BHATTI, T.R., DUBBS, H.A., HARRIS, M.C., IZUMI, K., MOSTOUFI-MOAB, S., MULCHANDANI, S., SAITTA, S., STATES, L.J. et al., (2013). Clinical Features of Three Girls with Mosaic Genome-Wide Paternal Uni-parental Isodisomy. American journal of medical genetics Part A 161A: 1929-1939.
34. KAMIKIHARA, T., ARIMA, T., KATO, K., MATSUDA, T., KATO, H., DOUCHI, T., NA-GATA, Y., NAKAO, M. and WAKE, N. (2005). Epigenetic Silencing of the Imprinted Gene Zac by DNA Methylation Is an Early Event in the Progression of Human Ovarian Cancer. Int J Cancer 115: 690-700.
35. KANEDA, M., OKANO, M., HATA, K., SADO, T., TSUJIMOTO, N., LI, E. and SASAKI, H. (2004). Essential Role for De Novo DNA Methyltransferase Dnmt3a in Paternal and Maternal Imprinting. Nature 429: 900-903.
36. KANTAPUTRA, P.N., SITTIWANGKUL, R., SONSUWAN, N., ROMANELLI, V., TENORIO, J. and LAPUNZINA, P. (2013). A Novel Mutation in Cdkn1c in Sibs with Beckwith-Wiedemann Syndrome and Cleft Palate, Sensorineural Hearing Loss, and Supernumerary Flexion Creases. Am. J. Medical Genet. Part A 161A: 192-197.
37. KAWAKAMI, T., CHANO, T., MINAMI, K., OKABE, H., OKADA, Y. and OKAMOTO, K. (2006). Imprinted Dlk1 Is a Putative Tumor Suppressor Gene and Inactivated by Epimutation at the Region Upstream of Gtl2 in Human Renal Cell Carcinoma. Hum Mol Genet 15: 821-830.
38. KENIRY, A., OXLEY, D., MONNIER, P., KYBA, M., DANDOLO, L., SMITS, G. and REIK, W. (2012). The H19 Lincrna Is a Developmental Reservoir of Mir-675 That Suppresses Growth and Igf1r. Nat Cell Biol 14: 659-665.
39. KOBAYASHI, S., KOHDA, T., MIYOSHI, N., KUROIWA, Y., AISAKA, K., TSUTSUMI, O., KANEKO-ISHINO, T. and ISHINO, F. (1997). Human Peg1/Mest, an Imprinted Gene on Chromosome 7. Hum Mol Genet 6: 781-786.
40. LAPRISE, S.L. (2009). Implications of Epigenetics and Genomic Imprinting in Assisted Reproductive Technologies. Mol Reprod Dev 76: 1006-1018.
41. LATOS, P.A., PAULER, F.M., KOERNER, M.V., SENERGIN, H.B., HUDSON, Q.J., STOCSITS, R.R., ALLHOFF, W., STRICKER, S.H., KLEMENT, R.M., WARCZOK, K.E. et al., (2012). Airn Transcriptional Overlap, but Not Its Lncrna Products, Induces Imprinted Igf2r Silencing. Science 338: 1469-1472.
42. LECUMBERRI, B., FERNANDEZ-REBOLLO, E., SENTCHORDI, L., SAAVEDRA, P., BERNAL-CHICO, A., PALLARDO, L.F., BUSTOS, J.M., CASTANO, L., DE SANTIAGO, M., HIORT, O. et al., (2010). Coexistence of Two Different Pseudo-hypoparathyroidism Subtypes (Ia and Ib) in the Same Kindred with Independent Gs{Alpha} Coding Mutations and Gnas Imprinting Defects. J Med Genet 47: 276-280.
43. LEE, J.T. and BARTOLOMEI, M.S. (2013). X-Inactivation, Imprinting, and Long Noncoding Rnas in Health and Disease. Cell 152: 1308-1323.
44. LEWIS, A., MITSUYA, K., UMLAUF, D., SMITH, P., DEAN, W., WALTER, J., HIG-GINS, M., FEIL, R. and REIK, W. (2004). Imprinting on Distal Chromosome 7 in the Placenta Involves Repressive Histone Methylation Independent of DNA Methylation. Nat Genet 36: 1291-1295.
45. LI, X., ITO, M., ZHOU, F., YOUNGSON, N., ZUO, X., LEDER, P. and FERGUSON-SMITH, A.C. (2008). A Maternal-Zygotic Effect Gene, Zfp57, Maintains Both Maternal and Paternal Imprints. Dev Cell 15: 547-557.
46. LINGLART, A., MAUPETIT-MEHOUAS, S. and SILVE, C. (2013). Gnas -Related Loss-of-Function Disorders and the Role of Imprinting. Horm Res Paediatr 119-129.
47. LUCIFERO, D., MANN, M.R., BARTOLOMEI, M.S. and TRASLER, J.M. (2004). Gene-Specific Timing and Epigenetic Memory in Oocyte Imprinting. Hum Mol Genet 13: 839-849.
48. MABB, A.M., JUDSON, M.C., ZYLKA, M.J. and PHILPOT, B.D. (2011). Angelman Syndrome: Insights into Genomic Imprinting and Neurodevelopmental Phenotypes. Trends Neurosci. 34: 293-303.
49. MACKAY, D.J., CALLAWAY, J.L., MARKS, S.M., WHITE, H.E., ACERINI, C.L., BOONEN, S.E., DAYANIKLI, P., FIRTH, H.V., GOODSHIP, J.A., HAEMERS, A.P. et al., (2008). Hypomethylation of Multiple Imprinted Loci in Individuals with Transient Neonatal Diabetes Is Associated with Mutations in Zfp57. Nat Genet 40: 949-951.
50. MCGRATH, J. and SOLTER, D. (1984). Inability of Mouse Blastomere Nuclei Transferred to Enucleated Zygotes to Support Development in Vitro. Science 226: 1317-1319.
51. MONK, D., SANCHES, R., ARNAUD, P., APOSTOLIDOU, S., HILLS, F.A., ABUA-MERO, S., MURRELL, A., FRIESS, H., REIK, W., STANIER, P. et al., (2006). Imprinting of Igf2 P0 Transcript and Novel Alternatively Spliced Ins-Igf2 Isoforms Show Differences between Mouse and Human. Hum Mol Genet 15: 1259-1269.
52. NAGANO, T., MITCHELL, J.A., SANZ, L.A., PAULER, F.M., FERGU-SONSMITH, A.C., FEIL, R. and FRASER, P. (2008). The Air Noncoding Rna Epigenetically Silences Transcription by Targeting G9a to Chromatin. Science 322: 1717-1720.
53. NAKAMURA, T., LIU, Y.J., NAKASHIMA, H., UMEHARA, H., INOUE, K., MATOBA, S., TACHIBANA, M., OGURA, A., SHINKAI, Y. and NAKANO, T. (2012). Pgc7 Binds Histone H3k9me2 to Protect against Conversion of 5mc to 5hmc in Early Embryos. Nature 486: 415-419.
54. ODOM, L.N. and SEGARS, J. (2010). Imprinting Disorders and Assisted Reproductive Technology. Curr Opin Endocrinol Diabetes Obes 17: 517-522.
55. OKINO, K., KONISHI, H., DOI, D., YONEYAMA, K., OTA, Y., JIN, E., KAWANAMI, O. and TAKESHITA, T. (2005). Up-Regulation of Growth Factor Receptor-Bound Protein 10 in Cervical Squamous Cell Carcinoma. Oncol Rep 13: 1069-1074.
56. PETTENATI, M.J., HAINES, J.L., HIGGINS, R.R., WAPPNER, R.S., PALMER, C.G. and WEAVER, D.D. (1986). Wiedemann-Beckwith Syndrome: Presentation of Clinical and Cytogenetic Data on 22 New Cases and Review of the Literature. Hum Genet. 74: 143-154.
57. QUENNEVILLE, S., VERDE, G., CORSINOTTI, A., KAPOPOULOU, A., JAKO-BSSON, J., OFFNER, S., BAGLIVO, I., PEDONE, P.V., GRIMALDI, G., RICCIO, A. et al., (2011). In Embryonic Stem Cells, Zfp57/Kap1 Recognize a Methylated Hexanucleotide to Affect Chromatin and DNA Methylation of Imprinting Control Regions. Mol Cell 44: 361-372.
58. ROMANELLI, V., BELINCHON, A., BENITO-SANZ, S., MARTINEZ-GLEZ, V., GRACIA-BOUTHELIER, R., HEATH, K.E., CAMPOS-BARROS, A., GARCIAMINAUR, S., FERNANDEZ, L., MENESES, H. et al., (2010). Cdkn1c (P57(Kip2)) Analysis in Beckwith-Wiedemann Syndrome (Bws) Patients: Genotype-Phenotype Correlations, Novel Mutations, and Polymorphisms. Am J Med Genet A 152A: 1390-1397.
59. SOLTER, D. (1988). Differential Imprinting and Expression of Maternal and Paternal Genomes. Annu Rev Genet 22: 127-146.
60. SOLTER, D. (1998). Imprinting. Int J Dev Biol 42: 951-954.
61. SPARAGO, A., CERRATO, F., VERNUCCI, M., FERRERO, G.B., SILENGO, M.C. and RICCIO, A. (2004). Microdeletions in the Human H19 Dmr Result in Loss of Igf2 Imprinting and Beckwith-Wiedemann Syndrome. Nature Genet. 36: 958-960.
62. SUN, F.L., DEAN, W.L., KELSEY, G., ALLEN, N.D. and REIK, W. (1997). Transactivation of Igf2 in a Mouse Model of Beckwith-Wiedemann Syndrome. Nature 389: 809-815.
63. SUTTON, V.R. and SHAFFER, L.G. (2000). Search for Imprinted Regions on Chromosome 14: Comparison of Maternal and Paternal Upd Cases with Cases of Chromosome 14 Deletion. Am. J. Med. Genet. 93: 381-387.
64. TAKAMARU, H., YAMAMOTO, E., SUZUKI, H., NOJIMA, M., MARUYAMA, R., YAMANO, H.O., YOSHIKAWA, K., KIMURA, T., HARADA, T., ASHIDA, M. et al., (2012). Aberrant Methylation of Rasgrf1 Is Associated with an Epigenetic Field Defect and Increased Risk of Gastric Cancer. Cancer Prev Res (Phila) 5: 1203-1212.
65. TARNOWSKI, M., SCHNEIDER, G., AMANN, G., CLARK, G., HOUGHTON, P., BARR, F.G., KENNER, L., RATAJCZAK, M.Z. and KUCIA, M. (2012). Rasgrf1 Regulates Proliferation and Metastatic Behavior of Human Alveolar Rhabdomyosarcomas. Int J Oncol 41: 995-1004.
66. THORVALDSEN, J.L., DURAN, K.L. and BARTOLOMEI, M.S. (1998). Deletion of the H19 Differentially Methylated Domain Results in Loss of Imprinted Expression of H19 and Igf2. Genes & Development 12: 3693-3702.
67. THORVALDSEN, J.L., FEDORIW, A.M., NGUYEN, S. and BARTOLOMEI, M.S. (2006). Developmental Profile of H19 Differentially Methylated Domain (Dmd) Deletion Alleles Reveals Multiple Roles of the Dmd in Regulating Allelic Expression and DNA Methylation at the Imprinted H19/Igf2 Locus. Molec. Cell. Biol. 26: 1245-1258.
68. TROUILLARD, O., AGUIRRE-CRUZ, L., HOANG-XUAN, K., MARIE, Y., DELA-TTRE, J.Y. and SANSON, M. (2004). Parental 19q Loss and Peg3 Expression in Oligodendrogliomas. Cancer Genet Cytogenet 151: 182-183.
69. TSOU, A.P., CHUANG, Y.C., SU, J.Y., YANG, C.W., LIAO, Y.L., LIU, W.K., CHIU, J.H. and CHOU, C.K. (2003). Overexpression of a Novel Imprinted Gene, Peg10, in Human Hepatocellular Carcinoma and in Regenerating Mouse Livers. J Biomed Sci 10: 625-635.
70. TURAN, S. and BASTEPE, M. (2013). The Gnas Complex Locus and Human Diseases Associated with Loss-of-Function Mutations or Epimutations within This Imprinted Gene. Horm Res Paediatr 80: 229-241.
71. UMLAUF, D., GOTO, Y., CAO, R., CERQUEIRA, F., WAGSCHAL, A., ZHANG, Y. and FEIL, R. (2004). Imprinting Along the Kcnq1 Domain on Mouse Chromosome 7 Involves Repressive Histone Methylation and Recruitment of Polycomb Group Complexes. Nat Genet 36: 1296-1300.
72. VAN DEN VEYVER, I.B., NORMAN, B., TRAN, C.Q., BOURJAC, J. and SLIM, R. (2001). The Human Homologue (Peg3) of the Mouse Paternally Expressed Gene 3 (Peg3) Is Maternally Imprinted but Not Mutated in Women with Familial Recurrent Hydatidiform Molar Pregnancies. J Soc Gynecol Investig 8: 305-313.
73. VERMEIDEN, J.P. and BERNARDUS, R.E. (2013). Are Imprinting Disorders More Prevalent after Human in vitro Fertilization or Intracytoplasmic Sperm Injection? Fertil. Steril. 99: 642-651.
74. WEAVER, J.R., SARKISIAN, G., KRAPP, C., MAGER, J., MANN, M.R. and BARTOLO-MEI, M.S. (2010). Domain-Specify Response of Imprinted Genes to Reduced Dnmt1. Mol Cell Biol 30: 3916-3928.
75. WEAVER, J.R., SUSIARJO, M. and BARTOLOMEI, M.S. (2009). Imprinting and Epigenetic Changes in the Early Embryo. Mamm Genome 20: 532-543.
76. WILLIAMSON, C., BLAKE, A., THOMAS, S., BEECHEY, C., HANCOCK, J., CA-TTANACH, B. and PETERS, J. (2014). World Wide Web Site - Mouse Imprinting Data and References, http://Www.Har.Mrc.Ac.Uk/Research/Genomic_Imprinting/, (ed. Oxfordshire: MRC Harwell.
77. YOSHIMIZU, T., MIROGLIO, A., RIPOCHE, M.A., GABORY, A., VERNUCCI, M., RICCIO, A., COLNOT, S., GODARD, C., TERRIS, B., JAMMES, H. et al., (2008). The H19 Locus Acts in vivo as a Tumor Suppressor. Proc Natl Acad Sci U S A 105: 12417-12422.
78. ZHU, Q., WANG, L., XIAO, Z., XIAO, F., LUO, J., ZHANG, X., PENG, X., WANG, X. and SUN, H. (2013). Decreased Expression of Ras-Grf1 in the Brain Tissue of the Intractable Epilepsy Patients and Experimental Rats. Brain Res 1493: 99-109.