HSC Aging and Senescent Immune Remodeling

Trends in Immunology

Volumn 36, Issue 12, 2015, Pages 815-824

  Denkinger, Michael D ^a,b   Leins, Hanna ^a,c   Schirmbeck, Reinhold ^c   Florian, Maria Carolina ^a   Geiger, Hartmut ^a,d  

^a UNIVERSITY OF ULM   (Germany)

^b Geriatric Center Ulm Alb Donau   (Germany)

^c UNIVERSITY HOSPITAL ULM   (Germany)

^d CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; B LYMPHOCYTE; CELL AGING; CELL DIFFERENTIATION; HEMATOPOIETIC STEM CELL; HUMAN; IMMUNE SYSTEM; NONHUMAN; REVIEW; SENESCENT IMMUNE REMODELING; STEM CELL; T LYMPHOCYTE; ANIMAL; IMMUNOLOGY;

ANIMALS; B-LYMPHOCYTES; CELL AGING; CELL DIFFERENTIATION; HEMATOPOIETIC STEM CELLS; HUMANS; IMMUNE SYSTEM; T-LYMPHOCYTES;

EID: 84949724849     PISSN: 14714906     EISSN: 14714981     Source Type: Journal    
DOI: 10.1016/j.it.2015.10.008     Document Type: Review

References (99)

1. WHO World Report on Ageing and Health 2015, World Health Organization.
2. West L.A., et al. 65+ in the United States: 2010 2014, United States Census Bureau.
3. Lucado J., et al. Clostridium difficile Infections (CDI) in Hospital Stays, 2009 Statistical Brief 124 2012, Agency for Healthcare Research and Quality.
4. Loo V.G., et al. A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N. Engl. J. Med. 2005, 353:2442-2449.
5. Jain S., et al. Community-acquired pneumonia requiring hospitalization among u.s. adults. N. Engl. J. Med. 2015, 373:415-427.
6. Vergis E.N., et al. Pneumonia in long-term care: a prospective case-control study of risk factors and impact on survival. Arch. Intern. Med. 2001, 161:2378-2381.
7. Simonsen L., et al. Impact of influenza vaccination on seasonal mortality in the US elderly population. Arch. Intern. Med. 2005, 165:265-272.
8. Nguyen A.M., Noymer A. Influenza mortality in the United States, 2009 pandemic: burden, timing and age distribution. PLoS ONE 2013, 8:e64198.
9. Skowronski D.M., et al. Immuno-epidemiologic correlates of pandemic H1N1 surveillance observations: higher antibody and lower cell-mediated immune responses with advanced age. J. Infect. Dis. 2011, 203:158-167.
10. Hottes T.S., et al. Influenza vaccine effectiveness in the elderly based on administrative databases: change in immunization habit as a marker for bias. PLoS ONE 2011, 6:e22618.
11. Darvishian M., et al. After adjusting for bias in meta-analysis seasonal influenza vaccine remains effective in community-dwelling elderly. J. Clin. Epidemiol. 2014, 67:734-744.
12. Makinodan T. Studies on the influence of age on immune response to understand the biology of immunosenescence. Exp. Gerontol. 1998, 33:27-38.
13. Vallejo A.N. Immune remodeling: lessons from repertoire alterations during chronological aging and in immune-mediated disease. Trends Mol. Med. 2007, 13:94-102.
14. Lang P.O., et al. Reversing T cell immunosenescence: why, who, and how. Age 2013, 35:609-620.
15. Ferguson F.G., et al. Immune parameters in a longitudinal study of a very old population of Swedish people: a comparison between survivors and nonsurvivors. J. Gerontol. A Biol. Sci. Med. Sci. 1995, 50:B378-B382.
16. Strindhall J., et al. No Immune Risk Profile among individuals who reach 100 years of age: findings from the Swedish NONA immune longitudinal study. Exp. Gerontol. 2007, 42:753-761.
17. Franceschi C., et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann. N. Y. Acad. Sci. 2000, 908:244-254.
18. Hayashi M., et al. Whole-body in vivo monitoring of inflammatory diseases exploiting human interleukin 6-luciferase transgenic mice. Mol. Cell Biol. 2015, 35:3590-3601.
19. Sansoni P., et al. Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians. Blood 1993, 82:2767-2773.
20. Ginaldi L., et al. Immunophenotypical changes of T lymphocytes in the elderly. Gerontology 2000, 46:242-248.
21. Ventevogel M.S., Sempowski G.D. Thymic rejuvenation and aging. Curr. Opin. Immunol. 2013, 25:516-522.
22. Douek D.C., et al. Changes in thymic function with age and during the treatment of HIV infection. Nature 1998, 396:690-695.
23. Dutilh B.E., de Boer R.J. Decline in excision circles requires homeostatic renewal or homeostatic death of naive T cells. J. Theor. Biol. 2003, 224:351-358.
24. den Braber I., et al. Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans. Immunity 2012, 36:288-297.
25. Westera L., et al. Lymphocyte maintenance during healthy aging requires no substantial alterations in cellular turnover. Aging Cell 2015, 14:219-227.
26. Sauce D., et al. Lymphopenia-driven homeostatic regulation of naive T cells in elderly and thymectomized young adults. J. Immunol. 2012, 189:5541-5548.
27. Britanova O.V., et al. Age-related decrease in TCR repertoire diversity measured with deep and normalized sequence profiling. J. Immunol. 2014, 192:2689-2698.
28. Johnson P.L., et al. A population biological approach to understanding the maintenance and loss of the T-cell repertoire during aging. Immunology 2014, 142:167-175.
29. Sikora E. Activation-induced and damage-induced cell death in aging human T cells. Mech. Ageing Dev. 2015, 2. Published online April 2015. 10.1016/j.mad.2015.03.011.
30. - cells with ageing. Clin. Exp. Immunol. 1998, 112:48-51.
31. - lymphocytes during aging. Exp. Gerontol. 2004, 39:539-544.
32. Wikby A., et al. Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study. Exp. Gerontol. 2002, 37:445-453.
33. Vescovini R., et al. Intense antiextracellular adaptive immune response to human cytomegalovirus in very old subjects with impaired health and cognitive and functional status. J. Immunol. 2010, 184:3242-3249.
34. Pawelec G., et al. Human immunosenescence: is it infectious?. Immunol. Rev. 2005, 205:257-268.
35. Cicin-Sain L., et al. Cytomegalovirus infection impairs immune responses and accentuates T-cell pool changes observed in mice with aging. PLoS Pathog 2012, 8:e1002849.
36. Sansoni P., et al. New advances in CMV and immunosenescence. Exp. Gerontol. 2014, 55:54-62.
37. Bartlett D.B., et al. The age-related increase in low-grade systemic inflammation (inflammaging) is not driven by cytomegalovirus infection. Aging Cell 2012, 11:912-915.
38. + regulatory T cells accumulate in the very elderly and correlate with superior 8-year survival. J. Gerontol. A Biol. Sci. Med. Sci. 2015, 70:917-923.
39. Valmori D., et al. A peripheral circulating compartment of natural naive CD4 Tregs. J. Clin. Invest. 2005, 115:1953-1962.
40. + T cells with ageing. Clin. Exp. Immunol. 2000, 120:267-273.
41. Sandmand M., et al. Is ageing associated with a shift in the balance between type 1 and type 2 cytokines in humans?. Clin. Exp. Immunol. 2002, 127:107-114.
42. Uciechowski P., et al. TH1 and TH2 cell polarization increases with aging and is modulated by zinc supplementation. Exp. Gerontol. 2008, 43:493-498.
43. Goronzy J.J., Weyand C.M. Understanding immunosenescence to improve responses to vaccines. Nat. Immunol. 2013, 14:428-436.
44. Gibson K.L., et al. B-cell diversity decreases in old age and is correlated with poor health status. Aging Cell 2009, 8:18-25.
45. Wang C., et al. Effects of aging, cytomegalovirus infection, and EBV infection on human B cell repertoires. J. Immunol. 2014, 192:603-611.
46. Franceschi C., Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J. Gerontol. A Biol. Sci. Med. Sci. 2014, 69(Suppl. 1):S4-S9.
47. Michaud M., et al. Proinflammatory cytokines, aging, and age-related diseases. J. Am. Med. Dir. Assoc. 2013, 14:877-882.
48. + Study. Mech. Ageing Dev. 2012, 133:456-466.
49. Wikby A., et al. The immune risk phenotype is associated with IL-6 in the terminal decline stage: findings from the Swedish NONA immune longitudinal study of very late life functioning. Mech. Ageing Dev. 2006, 127:695-704.
50. Giunta B., et al. Inflammaging as a prodrome to Alzheimer's disease. J. Neuroinflammation 2008, 5:51.
51. Youm Y.H., et al. Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging. Cell Metab. 2013, 18:519-532.
52. Baker D.J., et al. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 2011, 479:232-236.
53. Dykstra B., et al. Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells. J. Exp. Med. 2011, 208:2691-2703.
54. Florian M.C., et al. Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell 2012, 10:520-530.
55. McKerrell T., et al. Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis. Cell Reports 2015, 10:1239-1245.
56. + T-cell immune responses. Blood 2006, 107:2855-2862.
57. Gruver A.L., et al. Immunosenescence of ageing. J. Pathol. 2007, 211:144-156.
58. Lescale C., et al. Reduced EBF expression underlies loss of B-cell potential of hematopoietic progenitors with age. Aging Cell 2010, 9:410-419.
59. Li G., et al. Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity. Nat. Med. 2012, 18:1518-1524.
60. Bissels U., et al. MicroRNAs are shaping the hematopoietic landscape. Haematologica 2012, 97:160-167.
61. Rossi L., et al. The sixth sense: hematopoietic stem cells detect danger through purinergic signaling. Blood 2012, 120:2365-2375.
62. Esplin B.L., et al. Chronic exposure to a TLR ligand injures hematopoietic stem cells. J. Immunol. 2011, 186:5367-5375.
63. Baldridge M.T., et al. Inflammatory signals regulate hematopoietic stem cells. Trends Immunol. 2011, 32:57-65.
64. Pronk C.J., et al. Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors. J. Exp. Med. 2011, 208:1563-1570.
65. Walter D., et al. Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells. Nature 2015, 520:549-552.
66. Shao L., et al. Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner. Blood 2014, 123:3105-3115.
67. Khoo M.L., et al. Gene profiling reveals association between altered Wnt signaling and loss of T-cell potential with age in human hematopoietic stem cells. Aging Cell 2014, 13:744-754.
68. Cairney C.J., et al. A systems biology approach to Down syndrome: identification of Notch/Wnt dysregulation in a model of stem cells aging. Biochim. Biophys. Acta 2009, 1792:353-363.
69. Florian M.C., et al. A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing. Nature 2013, 503:392-396.
70. Aoyama K., et al. The interaction of the Wnt and Notch pathways modulates natural killer versus T cell differentiation. Stem Cells 2007, 25:2488-2497.
71. Li J., et al. WNT5A antagonizes WNT/beta-catenin signaling and is frequently silenced by promoter CpG methylation in esophageal squamous cell carcinoma. Cancer Biol. Ther. 2010, 10:617-624.
72. Muller L., Pawelec G. Aging and immunity - impact of behavioral intervention. Brain Behav. Immun. 2014, 39:8-22.
73. Shimizu K., et al. Effect of moderate exercise training on T-helper cell subpopulations in elderly people. Exerc. Immunol. Rev. 2008, 14:24-37.
74. Kohut M.L., Senchina D.S. Reversing age-associated immunosenescence via exercise. Exerc. Immunol. Rev. 2004, 10:6-41.
75. Phillips J.A., et al. IL-7 gene therapy in aging restores early thymopoiesis without reversing involution. J. Immunol. 2004, 173:4867-4874.
76. Min D., et al. Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging. Blood 2007, 109:2529-2537.
77. Dudakov J.A., et al. Interleukin-22 drives endogenous thymic regeneration in mice. Science 2012, 336:91-95.
78. Dixit V.D., et al. Ghrelin promotes thymopoiesis during aging. J. Clin. Invest. 2007, 117:2778-2790.
79. Lynch H.E., et al. Thymic involution and immune reconstitution. Trends Immunol. 2009, 30:366-373.
80. Chen C., et al. mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci. Signal. 2009, 2:ra75.
81. Villeda S.A., et al. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nat. Med. 2014, 20:659-663.
82. + T cells in aged humans. Exp. Gerontol. 2008, 43:266-274.
83. Desai A., et al. Leukocyte function in the aging immune system. J. Leukoc. Biol. 2010, 87:1001-1009.
84. Lages C.S., et al. Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation. J. Immunol. 2008, 181:1835-1848.
85. Rossi D.J., et al. Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:9194-9199.
86. Kamminga L.M., et al. Impaired hematopoietic stem cell functioning after serial transplantation and during normal aging. Stem Cells 2005, 23:82-92.
87. Xing Z., et al. Increased hematopoietic stem cell mobilization in aged mice. Blood 2006, 108:2190-2197.
88. Ciocca M.L., et al. Cutting edge: asymmetric memory T cell division in response to rechallenge. J. Immunol. 2012, 188:4145-4148.
89. Satoh Y., et al. The Satb1 protein directs hematopoietic stem cell differentiation toward lymphoid lineages. Immunity 2013, 38:1105-1115.
90. Tzeng Y.S., et al. Loss of Cxcl12/Sdf-1 in adult mice decreases the quiescent state of hematopoietic stem/progenitor cells and alters the pattern of hematopoietic regeneration after myelosuppression. Blood 2011, 117:429-439.
91. Bayod S., et al. Wnt pathway regulation by long-term moderate exercise in rat hippocampus. Brain Res. 2014, 1543:38-48.
92. H2 differentiation in Wnt-dependent manner. PLoS Biol. 2010, 8:e1000296.
93. Senchina D.S., Kohut M.L. Immunological outcomes of exercise in older adults. Clin. Interv. aging 2007, 2:3-16.
94. Costarelli L., et al. Distinctive modulation of inflammatory and metabolic parameters in relation to zinc nutritional status in adult overweight/obese subjects. J. Nutr. Biochem. 2010, 21:432-437.
95. Putics A., et al. Zinc supplementation boosts the stress response in the elderly: Hsp70 status is linked to zinc availability in peripheral lymphocytes. Exp. Gerontol. 2008, 43:452-461.
96. Leow L., et al. Vitamin D, innate immunity and outcomes in community acquired pneumonia. Respirology 2011, 16:611-616.
97. Mane J., et al. A mixture of Lactobacillus plantarum CECT 7315 and CECT 7316 enhances systemic immunity in elderly subjects. A dose-response, double-blind, placebo-controlled, randomized pilot trial. Nutr. Hosp. 2011, 26:228-235.
98. Cheng C.W., et al. Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. Cell Stem cell 2014, 14:810-823.
99. Brandhorst S., et al. A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance, and healthspan. Cell Metab. 2015, 22:86-99.