Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner

Blood

Volumn 123, Issue 20, 2014, Pages 3105-3115

  Shao, Lijian ^a   Feng, Wei ^a   Li, Hongliang ^a,b   Gardner, David ^a   Luo, Yi ^a   Wang, Yong ^c   Liu, Lingbo ^c,e   Meng, Aimin ^b   Sharpless, Norman E ^d   Zhou, Daohong ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b INSTITUTE OF RADIATION MEDICINE   (China)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ARF PROTEIN; BETA GALACTOSIDASE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; MESSENGER RNA; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BONE MARROW SUPPRESSION; CELL ISOLATION; CELL RENEWAL; CONTROLLED STUDY; ENZYME ACTIVITY; GENE DELETION; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IN VITRO STUDY; MOUSE; NONHUMAN; PREMATURE AGING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION EXPOSURE; SENESCENCE; TELOMERE SHORTENING; WHOLE BODY RADIATION; WILD TYPE;

ANIMALS; BONE MARROW; CELL AGING; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P16; GENE KNOCKOUT TECHNIQUES; HEMATOPOIETIC STEM CELLS; MICE; MICE, INBRED C57BL; TELOMERE; WHOLE-BODY IRRADIATION;

EID: 84901400033     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-07-515619     Document Type: Article

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