메뉴 건너뛰기




Volumn 117, Issue 10, 2007, Pages 2778-2790

Ghrelin promotes thymopoiesis during aging

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN; GROWTH HORMONE SECRETAGOGUE RECEPTOR; LEPTIN;

EID: 34948853362     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI30248     Document Type: Article
Times cited : (184)

References (58)
  • 1
    • 20344371900 scopus 로고    scopus 로고
    • Insights into thymic aging and regeneration
    • Taub, D.D., and Longo, D.L. 2005. Insights into thymic aging and regeneration. Immunol. Rev. 205:72-93.
    • (2005) Immunol. Rev , vol.205 , pp. 72-93
    • Taub, D.D.1    Longo, D.L.2
  • 2
    • 1142275269 scopus 로고    scopus 로고
    • Age related changes in lymphocyte development and function
    • Linton, P.E., and Dorshkind, K. 2004. Age related changes in lymphocyte development and function. Nat. Immunol. 5:133-139.
    • (2004) Nat. Immunol , vol.5 , pp. 133-139
    • Linton, P.E.1    Dorshkind, K.2
  • 3
    • 17144418549 scopus 로고    scopus 로고
    • Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen
    • Haynes, L., Eaton, S.M., Burns, E.M., Randall, T.D., and Swain, S.L. 2005. Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen. J. Exp. Med. 201:845-851.
    • (2005) J. Exp. Med , vol.201 , pp. 845-851
    • Haynes, L.1    Eaton, S.M.2    Burns, E.M.3    Randall, T.D.4    Swain, S.L.5
  • 4
    • 33646546302 scopus 로고    scopus 로고
    • Aging of the immune system: How much can the adaptive immune system adapt?
    • Weng, N.P. 2006. Aging of the immune system: how much can the adaptive immune system adapt? Immunity. 24:495-499.
    • (2006) Immunity , vol.24 , pp. 495-499
    • Weng, N.P.1
  • 6
    • 33644842282 scopus 로고    scopus 로고
    • From stem cell to T cell: One route or many?
    • Bhandoola, A., and Sambandam, A. 2006. From stem cell to T cell: one route or many? Nat. Rev. Immunol. 6:117-126.
    • (2006) Nat. Rev. Immunol , vol.6 , pp. 117-126
    • Bhandoola, A.1    Sambandam, A.2
  • 7
    • 2942700206 scopus 로고    scopus 로고
    • Reduction in the developmental potential of intrathymic T cell progenitors with age
    • Min, H., Montecino-Rodriguez, E., and Dorshkind, K. 2004. Reduction in the developmental potential of intrathymic T cell progenitors with age. J. Immunol. 173:245-250.
    • (2004) J. Immunol , vol.173 , pp. 245-250
    • Min, H.1    Montecino-Rodriguez, E.2    Dorshkind, K.3
  • 8
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima, M., et al. 1999. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 402:656-660.
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1
  • 9
    • 18844404431 scopus 로고    scopus 로고
    • Development of growth hormone secretagogue
    • Smith, R.G. 2005. Development of growth hormone secretagogue. Endocr. Rev. 26:346-360.
    • (2005) Endocr. Rev , vol.26 , pp. 346-360
    • Smith, R.G.1
  • 10
    • 15544385058 scopus 로고    scopus 로고
    • Ghrelin: Structure and function
    • Kojima, M., and Kengawa, K. 2005. Ghrelin: structure and function. Physiol. Rev. 85:495-522.
    • (2005) Physiol. Rev , vol.85 , pp. 495-522
    • Kojima, M.1    Kengawa, K.2
  • 11
    • 3042735648 scopus 로고    scopus 로고
    • The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans
    • Gnanapavan, S., et al. 2002. The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J. Clin. Endocrinol. Metab. 87:2988-2991.
    • (2002) J. Clin. Endocrinol. Metab , vol.87 , pp. 2988-2991
    • Gnanapavan, S.1
  • 12
    • 3242749843 scopus 로고    scopus 로고
    • Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells
    • doi:10.1172/JCI200421134
    • Dixit, V.D., et al. 2004. Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. J. Clin. Invest. 114:57-66. doi:10.1172/JCI200421134.
    • (2004) J. Clin. Invest , vol.114 , pp. 57-66
    • Dixit, V.D.1
  • 13
    • 27544497632 scopus 로고    scopus 로고
    • Ghrelin and immunity: A young player in an old field
    • Dixit, V.D., and Taub, D.D. 2005. Ghrelin and immunity: a young player in an old field. Exp. Gerontol. 40:900-910.
    • (2005) Exp. Gerontol , vol.40 , pp. 900-910
    • Dixit, V.D.1    Taub, D.D.2
  • 14
    • 2442419837 scopus 로고    scopus 로고
    • Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells
    • Li, W.G., et al. 2004. Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells. Circulation. 109:2221-2226.
    • (2004) Circulation , vol.109 , pp. 2221-2226
    • Li, W.G.1
  • 16
    • 33645069631 scopus 로고    scopus 로고
    • Therapeutic action of ghrelin in a mouse model of colitis
    • Gonzalez-Rey, E., Chorny, A., and Delgado, M. 2006. Therapeutic action of ghrelin in a mouse model of colitis. Gastroenterology. 130:1707-1720.
    • (2006) Gastroenterology , vol.130 , pp. 1707-1720
    • Gonzalez-Rey, E.1    Chorny, A.2    Delgado, M.3
  • 17
    • 0041706227 scopus 로고    scopus 로고
    • Therapeutic effects of ghrelin on endotoxic shock in rats
    • Chang, L., et al. 2005. Therapeutic effects of ghrelin on endotoxic shock in rats. Eur. J. Pharmacol. 473:171-176.
    • (2005) Eur. J. Pharmacol , vol.473 , pp. 171-176
    • Chang, L.1
  • 18
    • 0034651657 scopus 로고    scopus 로고
    • Leukemia inhibitory factor, oncostatin M, IL-6 and stem cell factor mRNA expression in human thymus increases with age and are associated with thymic atrophy
    • Sempowski, G.D., et al. 2000. Leukemia inhibitory factor, oncostatin M, IL-6 and stem cell factor mRNA expression in human thymus increases with age and are associated with thymic atrophy. J. Immunol. 164:2180-2187.
    • (2000) J. Immunol , vol.164 , pp. 2180-2187
    • Sempowski, G.D.1
  • 19
    • 8544266027 scopus 로고    scopus 로고
    • Strategies to enhance T-cell reconstitution in immunocompromised patients
    • van den Brink, M.R., Alpdogan, O., and Boyd, R.L. 2004. Strategies to enhance T-cell reconstitution in immunocompromised patients. Nat. Rev. Immunol. 4:856-867.
    • (2004) Nat. Rev. Immunol , vol.4 , pp. 856-867
    • van den Brink, M.R.1    Alpdogan, O.2    Boyd, R.L.3
  • 20
    • 20144387499 scopus 로고    scopus 로고
    • Age-dependent incidence, time course, and consequences of thymic renewal in adults
    • doi:10.1172/JCI200522492
    • Hakim, F.T., et al. 2005. Age-dependent incidence, time course, and consequences of thymic renewal in adults. J. Clin. Invest. 115:930-939. doi:10.1172/JCI200522492.
    • (2005) J. Clin. Invest , vol.115 , pp. 930-939
    • Hakim, F.T.1
  • 21
    • 23844486206 scopus 로고    scopus 로고
    • Effects of castration on thymocyte development in two different models of thymic involution
    • Heng, T.S., et al. 2005. Effects of castration on thymocyte development in two different models of thymic involution. J. Immunol. 175:2982-2993.
    • (2005) J. Immunol , vol.175 , pp. 2982-2993
    • Heng, T.S.1
  • 22
    • 0024319314 scopus 로고
    • Luteinizing hormone-releasing hormone (LHRH) agonist restoration of age-associated decline of thymus weight, thymic LHRH receptors, and thymocyte proliferative capacity
    • Marchetti, B., et al. 1989. Luteinizing hormone-releasing hormone (LHRH) agonist restoration of age-associated decline of thymus weight, thymic LHRH receptors, and thymocyte proliferative capacity. Endocrinology. 125:1037-1045.
    • (1989) Endocrinology , vol.125 , pp. 1037-1045
    • Marchetti, B.1
  • 23
    • 0037388551 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone attenuates pregnancy-associated thymic involution and modulates the expression of antiproliferative gene product prohibitin
    • Dixit, V.D., Sridaran, R., Edmonsond, M.A., Taub, D., and Thompson, W.E. 2003. Gonadotropin-releasing hormone attenuates pregnancy-associated thymic involution and modulates the expression of antiproliferative gene product prohibitin. Endocrinology. 144:1496-1505.
    • (2003) Endocrinology , vol.144 , pp. 1496-1505
    • Dixit, V.D.1    Sridaran, R.2    Edmonsond, M.A.3    Taub, D.4    Thompson, W.E.5
  • 24
    • 23444461765 scopus 로고    scopus 로고
    • Activation of thymic regeneration in mice and humans following androgen blockade
    • Sutherland, J.S., et al. 2005. Activation of thymic regeneration in mice and humans following androgen blockade. J. Immunol. 175:2741-2753.
    • (2005) J. Immunol , vol.175 , pp. 2741-2753
    • Sutherland, J.S.1
  • 25
    • 0027056862 scopus 로고
    • Role of neuroendocrine hormones in murine T cell development. Growth hormone exerts thymopoietic effects in vivo
    • Murphy, W.J., Durum, S.K., and Longo, D.L. 1992. Role of neuroendocrine hormones in murine T cell development. Growth hormone exerts thymopoietic effects in vivo. J. Immunol. 149:3851-3857.
    • (1992) J. Immunol , vol.149 , pp. 3851-3857
    • Murphy, W.J.1    Durum, S.K.2    Longo, D.L.3
  • 26
    • 0036153393 scopus 로고    scopus 로고
    • Age-associated loss of bone marrow hematopoietic cells is reversed by GH and accompanies thymic reconstitution
    • French, R., et al. 2002. Age-associated loss of bone marrow hematopoietic cells is reversed by GH and accompanies thymic reconstitution. Endocrinology. 143:690-699.
    • (2002) Endocrinology , vol.143 , pp. 690-699
    • French, R.1
  • 27
    • 0031734077 scopus 로고    scopus 로고
    • Effects of insulin-like growth factor administration and bone marrow transplantation on thymopoiesis in aged mice
    • Montecino-Rodriguez, E., Clark, R., and Dorshkind, K. 1998. Effects of insulin-like growth factor administration and bone marrow transplantation on thymopoiesis in aged mice. Endocrinology. 139:4120-4126.
    • (1998) Endocrinology , vol.139 , pp. 4120-4126
    • Montecino-Rodriguez, E.1    Clark, R.2    Dorshkind, K.3
  • 28
    • 0035869414 scopus 로고    scopus 로고
    • Immune enhancing effect of a growth hormone secretagogue
    • Koo, G.C., et al. 2001. Immune enhancing effect of a growth hormone secretagogue. J. Immunol. 166:4195-4201.
    • (2001) J. Immunol , vol.166 , pp. 4195-4201
    • Koo, G.C.1
  • 29
    • 16444377660 scopus 로고    scopus 로고
    • Dependence of self-tolerance on TRAF6-directed development of thymic stroma
    • Akiyama, T., et al. 2005. Dependence of self-tolerance on TRAF6-directed development of thymic stroma. Science. 308:248-251.
    • (2005) Science , vol.308 , pp. 248-251
    • Akiyama, T.1
  • 30
    • 33845239216 scopus 로고    scopus 로고
    • Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells
    • Gray, D.H., et al. 2006. Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells. Blood. 108:3777-3785.
    • (2006) Blood , vol.108 , pp. 3777-3785
    • Gray, D.H.1
  • 31
    • 0037012030 scopus 로고    scopus 로고
    • Age-associated thymic atrophy is linked to a decline in IL-7 production
    • Andrew, D., and Aspinall, R. 2002. Age-associated thymic atrophy is linked to a decline in IL-7 production. Exp. Gerontol. 37:455-463.
    • (2002) Exp. Gerontol , vol.37 , pp. 455-463
    • Andrew, D.1    Aspinall, R.2
  • 32
    • 0032741972 scopus 로고    scopus 로고
    • Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice
    • Howard, J.K., et al. 1999. Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J. Clin. Invest. 104:1051-1059.
    • (1999) J. Clin. Invest , vol.104 , pp. 1051-1059
    • Howard, J.K.1
  • 33
    • 33745302179 scopus 로고    scopus 로고
    • Leptin selectively augments thymopoiesis in leptin deficiency and lipopolysaccharide-induced thymic atrophy
    • Hick, R.W., et al. 2006. Leptin selectively augments thymopoiesis in leptin deficiency and lipopolysaccharide-induced thymic atrophy. J. Immunol. 177:169-176.
    • (2006) J. Immunol , vol.177 , pp. 169-176
    • Hick, R.W.1
  • 34
    • 14844303460 scopus 로고    scopus 로고
    • Controlling the thymic microenvironment
    • Gray, D.H., et al. 2005. Controlling the thymic microenvironment. Curr. Opin. Immunol. 17:137-143.
    • (2005) Curr. Opin. Immunol , vol.17 , pp. 137-143
    • Gray, D.H.1
  • 35
    • 17444372347 scopus 로고    scopus 로고
    • Changes in the thymic function with age and during the treatment of HIV infection
    • Douek, D.C., et al. 1998. Changes in the thymic function with age and during the treatment of HIV infection. Nature. 396:690-695.
    • (1998) Nature , vol.396 , pp. 690-695
    • Douek, D.C.1
  • 36
  • 37
    • 21044451726 scopus 로고    scopus 로고
    • The influence of age on T cell generation and TCR diversity
    • Naylor, K., et al. 2005. The influence of age on T cell generation and TCR diversity. J. Immunol. 174:7446-7452.
    • (2005) J. Immunol , vol.174 , pp. 7446-7452
    • Naylor, K.1
  • 38
    • 0035898387 scopus 로고    scopus 로고
    • Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development
    • Lind, E.F., Prockop, S.E., Porritt, H.E., and Petrie, H.T. 2001. Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development. J. Exp. Med. 194:127-134.
    • (2001) J. Exp. Med , vol.194 , pp. 127-134
    • Lind, E.F.1    Prockop, S.E.2    Porritt, H.E.3    Petrie, H.T.4
  • 39
    • 0347089094 scopus 로고    scopus 로고
    • T-cell development made simple
    • Zuniga-Pflucker, J.C. 2004. T-cell development made simple. Nat. Rev. Immunol. 4:67-72.
    • (2004) Nat. Rev. Immunol , vol.4 , pp. 67-72
    • Zuniga-Pflucker, J.C.1
  • 40
    • 6344226099 scopus 로고    scopus 로고
    • IL-7 gene therapy in aging restores early thymopoiesis without reversing involution
    • Phillips, J.A., et al. 2004. IL-7 gene therapy in aging restores early thymopoiesis without reversing involution. J. Immunol. 173:4867-4874.
    • (2004) J. Immunol , vol.173 , pp. 4867-4874
    • Phillips, J.A.1
  • 41
    • 33644842282 scopus 로고    scopus 로고
    • From stem cell to T cell: One route or many?
    • Bhandoola, A., and Sambandam, A. 2006. From stem cell to T cell: one route or many? Nat. Rev. Immunol. 6:117-126.
    • (2006) Nat. Rev. Immunol , vol.6 , pp. 117-126
    • Bhandoola, A.1    Sambandam, A.2
  • 42
    • 0028929565 scopus 로고
    • Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine
    • von Freeden-Jeffry, U., et al. 1995. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J. Exp. Med. 181:1519-1525.
    • (1995) J. Exp. Med , vol.181 , pp. 1519-1525
    • von Freeden-Jeffry, U.1
  • 43
    • 3843124199 scopus 로고    scopus 로고
    • Exogenous IL-7 increases recent thymic emigrants in peripheral lymphoid tissue without enhanced thymic function
    • Chu, Y.W., et al. 2004. Exogenous IL-7 increases recent thymic emigrants in peripheral lymphoid tissue without enhanced thymic function. Blood. 104:1110-1119.
    • (2004) Blood , vol.104 , pp. 1110-1119
    • Chu, Y.W.1
  • 44
    • 33646937694 scopus 로고    scopus 로고
    • Thymic output and functionality of the IL-7/IL-7 receptor system in centenarians: Implications for the neolymphogenesis at the limit of human life
    • Nasi, M., et al. 2006. Thymic output and functionality of the IL-7/IL-7 receptor system in centenarians: implications for the neolymphogenesis at the limit of human life. Aging Cell. 5:167-175.
    • (2006) Aging Cell , vol.5 , pp. 167-175
    • Nasi, M.1
  • 45
    • 1342282246 scopus 로고    scopus 로고
    • IL-12 inhibits thymic involution by enhancing IL-7- and IL-2-induced thymocyte proliferation
    • Li, L., et al. 2004. IL-12 inhibits thymic involution by enhancing IL-7- and IL-2-induced thymocyte proliferation. J. Immunol. 172:2909-2916.
    • (2004) J. Immunol , vol.172 , pp. 2909-2916
    • Li, L.1
  • 46
    • 0028168081 scopus 로고
    • Insight into the mechanism of TCR-V beta 8+/CD8+ T cell-mediated MOPC-315 tumor eradication
    • Mokyr, M.B., Prokhorova, A., Rubin, M., and Bluestone, J.A. 1994. Insight into the mechanism of TCR-V beta 8+/CD8+ T cell-mediated MOPC-315 tumor eradication. J. Immunol. 153:3123-3134.
    • (1994) J. Immunol , vol.153 , pp. 3123-3134
    • Mokyr, M.B.1    Prokhorova, A.2    Rubin, M.3    Bluestone, J.A.4
  • 47
    • 33745210354 scopus 로고    scopus 로고
    • Ghrelin and the growth hormone secretagogue receptor constitute a novel autocrine pathway in astrocytoma motility
    • Dixit, V.D., et al. 2006. Ghrelin and the growth hormone secretagogue receptor constitute a novel autocrine pathway in astrocytoma motility. J. Biol. Chem. 281:16681-16690.
    • (2006) J. Biol. Chem , vol.281 , pp. 16681-16690
    • Dixit, V.D.1
  • 48
    • 0037370002 scopus 로고    scopus 로고
    • T cell repertoire development in humans with SCID after nonablative allogeneic marrow transplantation
    • Sarzotti, M., et al. 2003. T cell repertoire development in humans with SCID after nonablative allogeneic marrow transplantation. J. Immunol. 170:2711-2718.
    • (2003) J. Immunol , vol.170 , pp. 2711-2718
    • Sarzotti, M.1
  • 49
    • 0031051184 scopus 로고    scopus 로고
    • Evidence for superantigenic activity during murine malaria infection
    • Pied, S., et al. 1997. Evidence for superantigenic activity during murine malaria infection. Int. Immunol. 9:17-25.
    • (1997) Int. Immunol , vol.9 , pp. 17-25
    • Pied, S.1
  • 50
    • 0242580169 scopus 로고    scopus 로고
    • Deletion of ghrelin impairs neither growth nor appetite
    • Sun, Y., Ahmed, S., and Smith, R.G. 2003. Deletion of ghrelin impairs neither growth nor appetite. Mol. Cell. Biol. 23:7973-7981.
    • (2003) Mol. Cell. Biol , vol.23 , pp. 7973-7981
    • Sun, Y.1    Ahmed, S.2    Smith, R.G.3
  • 51
    • 1842480284 scopus 로고    scopus 로고
    • Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor
    • Sun, Y., Wang, P., Zheng, H., and Smith, R.G. 2004. Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. Proc. Natl. Acad. Sci. U. S. A. 101:4679-4684.
    • (2004) Proc. Natl. Acad. Sci. U. S. A , vol.101 , pp. 4679-4684
    • Sun, Y.1    Wang, P.2    Zheng, H.3    Smith, R.G.4
  • 52
    • 31044451759 scopus 로고    scopus 로고
    • Mice lacking ghrelin receptors resist the development of diet-induced obesity
    • doi:10.1172/JCI26002
    • Zigman, J.M., et al. 2005. Mice lacking ghrelin receptors resist the development of diet-induced obesity. J. Clin. Invest. 115:3564-3572. doi:10.1172/JCI26002.
    • (2005) J. Clin. Invest , vol.115 , pp. 3564-3572
    • Zigman, J.M.1
  • 53
    • 31044452189 scopus 로고    scopus 로고
    • Absence of ghrelin protects against early-onset obesity
    • doi:10.1172/JCI26003
    • Wortley, K.E., et al. 2005. Absence of ghrelin protects against early-onset obesity. J. Clin. Invest. 115:3573-3578. doi:10.1172/JCI26003.
    • (2005) J. Clin. Invest , vol.115 , pp. 3573-3578
    • Wortley, K.E.1
  • 54
    • 33947192136 scopus 로고    scopus 로고
    • Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging
    • Min, D., et al. 2007. Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging. Blood. 109:2529-2537.
    • (2007) Blood , vol.109 , pp. 2529-2537
    • Min, D.1
  • 55
    • 33745977363 scopus 로고    scopus 로고
    • Growth hormone secretagogue receptor antagonists as anti-obesity therapies? Still an open question
    • Zhao, H., and Liu, G. 2006. Growth hormone secretagogue receptor antagonists as anti-obesity therapies? Still an open question. Curr. Opin. Drug Discov. Devel. 9:509-515.
    • (2006) Curr. Opin. Drug Discov. Devel , vol.9 , pp. 509-515
    • Zhao, H.1    Liu, G.2
  • 56
    • 33748354456 scopus 로고    scopus 로고
    • Vaccination against weight gain
    • Zorrilla, E.P., et al. 2006. Vaccination against weight gain. Proc. Natl. Acad. Sci. U. S. A. 103:13226-13231.
    • (2006) Proc. Natl. Acad. Sci. U. S. A , vol.103 , pp. 13226-13231
    • Zorrilla, E.P.1
  • 57
    • 33344479006 scopus 로고    scopus 로고
    • Ghrelin controls hippocampal spine synapse density and memory performance
    • Diano, S., et al. 2006. Ghrelin controls hippocampal spine synapse density and memory performance. Nat. Neurosci. 9:381-388.
    • (2006) Nat. Neurosci , vol.9 , pp. 381-388
    • Diano, S.1
  • 58
    • 33748664379 scopus 로고    scopus 로고
    • Drug insight: The functions of ghrelin and its potential as a multitherapeutic hormone
    • Kojima, M., and Kangawa, K. 2006. Drug insight: the functions of ghrelin and its potential as a multitherapeutic hormone. Nat. Clin. Pract. Endocrinol. Metab. 2:80-88.
    • (2006) Nat. Clin. Pract. Endocrinol. Metab , vol.2 , pp. 80-88
    • Kojima, M.1    Kangawa, K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.