A systems biology approach to Down syndrome: Identification of Notch/Wnt dysregulation in a model of stem cells aging

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1792, Issue 4, 2009, Pages 353-363

  Cairney, C J ^a   Sanguinetti, G ^b   Ranghini, E ^c   Chantry, A D ^c   Nostro, M C ^d   Bhattacharyya, A ^e   Svendsen, C N ^e   Keith, W N ^a   Bellantuono, I ^c  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

^d UNIVERSITY HEALTH NETWORK   (Canada)

^e UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Aging; Gene expression; Hematopoietic; Neural; Notch signaling; Progenitor; Senescence; Stem cell; Trisomy 21

Indexed keywords

NOTCH RECEPTOR; WNT PROTEIN;

ALZHEIMER DISEASE; ANGIOGENESIS; ARTICLE; CELL AGING; CELL CYCLE S PHASE; CHILD; DISEASE ASSOCIATION; DNA REPAIR; DOWN SYNDROME; GENE EXPRESSION REGULATION; GENE REPRESSION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHESIS; INFLAMMATION; LEUKEMIA; MYELODYSPLASTIC SYNDROME; NEURAL STEM CELL; PHYLOGENETIC TREE; PRESCHOOL CHILD; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SYSTEMS BIOLOGY; T LYMPHOCYTE; TRISOMY 21;

AGED; AGED, 80 AND OVER; CELL AGING; CHILD, PRESCHOOL; DOWN SYNDROME; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; INFANT; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; STEM CELLS; SYSTEMS BIOLOGY; WNT PROTEINS;

EID: 64249129157     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbadis.2009.01.015     Document Type: Article

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