Tumor necrosis factor restricts hematopoietic stem cell activity in mice: Involvement of two distinct receptors

Journal of Experimental Medicine

Volumn 208, Issue 18, 2011, Pages 1563-1570

  Pronk, Cornelis J H ^a,b,c   Veiby, Ole Petter ^d   Bryder, David ^b   Jacobsen, Sten Eirik W ^a,e,f  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c LUND UNIVERSITY HOSPITAL   (Sweden)

^d The Takeda Oncology Company   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW DEPRESSION; CELL ACTIVITY; CONTROLLED STUDY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; INFLAMMATORY DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; BONE MARROW TRANSPLANTATION; CROSSES, GENETIC; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELLS; HEMOGLOBINURIA, PAROXYSMAL; HOMEOSTASIS; MICE; MICE, KNOCKOUT; PHENOTYPE; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE II; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79961138056     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20110752     Document Type: Article

References (33)

1. Aalto, K., V. Honkanen, and P. Lahdenne. 2011. Iron status during anti-TNF therapy in children with juvenile idiopathic arthritis. Clin. Rheumatol. 30:115-119.
2. Adolfsson, J., O.J. Borge, D. Bryder, K. Theilgaard-Mönch, I. Astrand-Grundström, E. Sitnicka, Y. Sasaki, and S.E. Jacobsen. 2001. Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity. Immunity. 15:659-669.
3. Aggarwal, B.B. 2003. Signalling pathways of the TNF superfamily: a double-edged sword. Nat. Rev. Immunol. 3:745-756.
4. Allsopp, R.C., S. Cheshier, and I.L. Weissman. 2001. Telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cells. J. Exp. Med. 193:917-924.
5. Bagby, G.C., and G. Meyers. 2007. Bone marrow failure as a risk factor for clonal evolution: prospects for leukemia prevention. Hematology (Am Soc Hematol Educ Program). 2007:40-46.
6. Benveniste, P., C. Cantin, D. Hyam, and N.N. Iscove. 2003. Hematopoietic stem cells engraft in mice with absolute efficiency. Nat. Immunol. 4:708-713.
7. Bradley, J.R. 2008. TNF-mediated inflammatory disease. J. Pathol. 214:149-160.
8. Bryder, D., V. Ramsfjell, I. Dybedal, K. Theilgaard-Mönch, C.M. Högerkorp, J. Adolfsson, O.J. Borge, and S.E. Jacobsen. 2001. Self-renewal of multipotent long-term repopulating hematopoietic stem cells is negatively regulated by FAS and tumor necrosis factor receptor activation. J. Exp. Med. 194:941-952.
9. Buza-Vidas, N., J. Antonchuk, H. Qian, R. Månsson, S. Luc, S. Zandi, K. Anderson, S. Takaki, J.M. Nygren, C.T. Jensen, and S.E. Jacobsen. 2006. Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK. Genes Dev. 20:2018-2023.
10. Cheng, T., N. Rodrigues, H. Shen, Y. Yang, D. Dombkowski, M. Sykes, and D.T. Scadden. 2000. Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science. 287:1804-1808.
11. Domen, J., K.L. Gandy, and I.L. Weissman. 1998. Systemic overexpression of BCL-2 in the hematopoietic system protects transgenic mice from the consequences of lethal irradiation. Blood. 91:2272-2282.
12. Dufour, C., A. Corcione, J. Svahn, R. Haupt, V. Poggi, A.N. Béka'ssy, R. Scimè, A. Pistorio, and V. Pistoia. 2003. TNF-alpha and IFN-gamma are overexpressed in the bone marrow of Fanconi anemia patients and TNF-alpha suppresses erythropoiesis in vitro. Blood. 102:2053-2059.
13. Dufour, C., R. Giacchino, P. Ghezzi, R. Tonelli, E. Ferretti, A. Pitto, V. Pistoia, T. Lanza, and J. Svahn. 2009. Etanercept as a salvage treatment for refractory aplastic anemia. Pediatr. Blood Cancer. 52:522-525.
14. Dybedal, I., D. Bryder, A. Fossum, L.S. Rusten, and S.E. Jacobsen. 2001. Tumor necrosis factor (TNF)-mediated activation of the p55 TNF receptor negatively regulates maintenance of cycling reconstituting human hematopoietic stem cells. Blood. 98:1782-1791.
15. Ferrara, J.L., J.E. Levine, P. Reddy, and E. Holler. 2009. Graft-versus-host disease. Lancet. 373:1550-1561.
16. Grell, M., E. Douni, H. Wajant, M. Löhden, M. Clauss, B. Maxeiner, S. Georgopoulos, W. Lesslauer, G. Kollias, K. Pfizenmaier, and P. Scheurich. 1995. The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor. Cell. 83:793-802.
17. Harrison, D.E., and C.P. Lerner. 1991. Most primitive hematopoietic stem cells are stimulated to cycle rapidly after treatment with 5-fluorouracil. Blood. 78:1237-1240.
18. Hock, H., M.J. Hamblen, H.M. Rooke, J.W. Schindler, S. Saleque, Y. Fujiwara, and S.H. Orkin. 2004. Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature. 431:1002-1007.
19. Larsson, J., and S. Karlsson. 2005. The role of Smad signaling in hematopoiesis. Oncogene. 24:5676-5692.
20. Milsom, M.D., B. Schiedlmeier, J. Bailey, M.O. Kim, D. Li, M. Jansen, A.M. Ali, M. Kirby, C. Baum, L.J. Fairbairn, and D.A. Williams. 2009. Ectopic HOXB4 overcomes the inhibitory effect of tumor necrosis factor-alpha on Fanconi anemia hematopoietic stem and progenitor cells. Blood. 113:5111-5120.
21. Okamoto, M., G. Ohe, T. Oshikawa, H. Nishikawa, S. Furuichi, H. Yoshida, and M. Sato. 2000. Induction of cytokines and killer cell activities by cisplatin and 5-fluorouracil in head and neck cancer patients. Anticancer Drugs. 11:165-173.
22. Peschon, J.J., D.S. Torrance, K.L. Stocking, M.B. Glaccum, C. Otten, C.R. Willis, K. Charrier, P.J. Morrissey, C.B. Ware, and K.M. Mohler. 1998. TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation. J. Immunol. 160:943-952.
23. Rebel, V.I., S. Hartnett, G.R. Hill, S.B. Lazo-Kallanian, J.L. Ferrara, and C.A. Sieff. 1999. Essential role for the p55 tumor necrosis factor receptor in regulating hematopoiesis at a stem cell level. J. Exp. Med. 190:1493-1504.
24. Scott, B.L., A. Ramakrishnan, B. Storer, P.S. Becker, S. Petersdorf, E.H. Estey, and H.J. Deeg. 2010. Prolonged responses in patients with MDS and CMML treated with azacitidine and etanercept. Br. J. Haematol. 148:944-947.
25. Seita, J., and I.L. Weissman. 2010. Hematopoietic stem cell: self-renewal versus differentiation. Wiley Interdiscip Rev Syst Biol Med. 2:640-653.
26. Szilvassy, S.J., R.K. Humphries, P.M. Lansdorp, A.C. Eaves, and C.J. Eaves. 1990. Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy. Proc. Natl. Acad. Sci. USA. 87:8736-8740.
27. Tartaglia, L.A., D. Pennica, and D.V. Goeddel. 1993. Ligand passing: the 75-kDa tumor necrosis factor (TNF) receptor recruits TNF for signaling by the 55-kDa TNF receptor. J. Biol. Chem. 268:18542-18548.
28. Thorén, L.A., K. Liuba, D. Bryder, J.M. Nygren, C.T. Jensen, H. Qian, J. Antonchuk, and S.E. Jacobsen. 2008. Kit regulates maintenance of quiescent hematopoietic stem cells. J. Immunol. 180:2045-2053.
29. Wiedmann, M.W., J. Mössner, C. Baerwald, and M. Pierer. 2009. TNF alpha inhibition as treatment modality for certain rheumatologic and gastrointestinal diseases. Endocr. Metab. Immune Disord. Drug Targets. 9:295-314.
30. Xun, C.Q., J.S. Thompson, C.D. Jennings, S.A. Brown, and M.B. Widmer. 1994. Effect of total body irradiation, busulfan-cyclophosphamide, or cyclophosphamide conditioning on inflammatory cytokine release and development of acute and chronic graft-versus-host disease in H-2-incompatible transplanted SCID mice. Blood. 83:2360-2367.
31. Yang, L., I. Dybedal, D. Bryder, L. Nilsson, E. Sitnicka, Y. Sasaki, and S.E. Jacobsen. 2005. IFN-gamma negatively modulates self-renewal of repopulating human hemopoietic stem cells. J. Immunol. 174:752-757.
32. Yonemura, Y., H. Ku, F. Hirayama, L.M. Souza, and M. Ogawa. 1996. Interleukin 3 or interleukin 1 abrogates the reconstituting ability of hematopoietic stem cells. Proc. Natl. Acad. Sci. USA. 93:4040-4044.
33. Zhang, Y., A. Harada, H. Bluethmann, J.B. Wang, S. Nakao, N. Mukaida, and K. Matsushima. 1995. Tumor necrosis factor (TNF) is a physiologic regulator of hematopoietic progenitor cells: increase of early hematopoietic progenitor cells in TNF receptor p55-deficient mice in vivo and potent inhibition of progenitor cell proliferation by TNF alpha in vitro. Blood. 86:2930-2937.